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The map label for this gene is relA [H]

Identifier: 221229645

GI number: 221229645

Start: 595616

End: 597979

Strand: Direct

Name: relA [H]

Synonym: MLBr_00491

Alternate gene names: 221229645

Gene position: 595616-597979 (Clockwise)

Preceding gene: 221229644

Following gene: 221229647

Centisome position: 18.23

GC content: 59.73

Gene sequence:

>2364_bases
GTGGCGGACGACCAAGGTACGGCGCAAGCTTTGCAACCAGTTCAGGTGGTCCCCGGCCCTGCTGTTGAGGCACCGGAGAC
GCCGGTCGAAACCCTGAAGACTTCTAGCAGTGCGTCTCGTCGGGTCCGGGCTCGGTTGGCCCGTCGGATGACCGCTCAAC
GCAGCACCATCAGTCCCGTGCTCGAGCCGCTGGTGGCTGTGCATAAAGAGTTTTATCCCAAGGCAAACCTTTCGATAGTG
CAGCGAGCCTTTGAAGTCGCCGACCAACGGCACGCCAGTCAACTGCGGCGTTCCGGTGATCCGTACATCACCCATCCGCT
GGCCGTTGCCAACATTTTGGCTGAGTTGGGCATGGATATCACTACCCTGGTGGCTGCGCTACTGCACGACACGGTCGAGG
ACACCGGTTACACGCTCGAGGCACTGTCCGAAGAATTTGGCGACGAGGTAGGCCATCTCGTCGACGGGGTGACCAAGCTG
GATCGGGTGGTGCTGGGCAGTGCTGCCGAGGGCGAGACCATCCGCAAGATGATTACCGCAATGGCCCGTGATCCACGGGT
GTTGGTTATCAAGGTGGCCGACCGGTTGCATAACATGCGCACCATGCGCTTCCTGCCTCCGGAAAAGCAGGCGCGCAAGG
CCCGTGAGACATTGGAAGTCATTGCACCACTAGCGCATAGGCTAGGTATGGCCAGTGTTAAGTGGGAGTTGGAAGACCTG
TCTTTCGCGATCTTGCATCCCAAAAAATACGAGGAGATCGTACGGCTGGTAGCGGGCCGTGCACCGTCCCGCGATACCTA
CCTGGCCAAGGTCCGTGCCGAGATCATAAGTACCCTGGGTGCGTCGAAAATCAAGGCGACGGTGGAGGGCCGGCCCAAGC
ATTACTGGTCGATTTATCAGAAAATGATCGTCAAGGGGCGAGACTTCGACGATATTCACGACTTGGTCGGCATCCGTATC
CTGTGCGACGAGATCCGCGACTGCTATGCCGCTGTCGGCGTGGTGCATTCGTTGTGGCAGCCGATGGCGGGACGGTTTAA
AGACTACATTGCTCAGCCGAGGTATGGTGTGTACCAGTCGTTGCACACCACGGTCGTTGGGCCCGAGGGCAAGCCTTTGG
AAGTACAGATTCGTACCCGCGATATGCACCGTACCGCCGAATACGGCATAGCAGCGCACTGGCGCTATAAAGAAGCCAAG
GGCCGCAACGGTGTTCTGCATCCACATGCAGCCGCAGAGATCGACGATATGGCCTGGATGCGGCAGCTTCTCGACTGGCA
ACGAGAGGCCGCCGAACCAGGTGAGTTCTTGGAGTCGTTGCGTTACGACCTTGCAGTGCAAGAGATTTTTGTGTTCACTC
CTAAAGGGGACGTCATCACGTTGCCGACTGGGTCAACGCCGGTGGACTTTGCCTATGCGGTGCACACCGAGGTCGGGCAC
CGATGCATTGGTGCCAGAGTCAACGGACGACTGGTGGCGCTGGAGCGCAAGCTGGAAAACGGGGAATTCGTAGAGATTTT
CACATCCAAAGCTCCCAATGCCGGGCCTTCGCGGGATTGGCAGCAGTTCGTGGTGTCGCCGCGCGCTAAGACGAAGATCC
GTCAATGGTTCGCCAAGGAGCGGCGTGAGGAAGCACTGGAGGCTGGTAAGGATGCGATGGCCCGCGAGGTACGTCGCGGT
GGACTTCCTTTGCAGCGCTTGGTGAATGGTGAGTCCATGGCGGCAGTGGCCCGTGAGCTACATTACATTGACGTGTCCGC
ACTGTATACCGCAATTGGTGAAGGACACGTGTCTGCCCGGCACGTCGTGCAGCGGCTGTTGGCCGAGTTGGGCGGTATCG
ATCAGGCTGAAGAGGAACTGGCCGAACGGTCCACACCGACGACCATGCTGCGCCGTCAACGCAGCACCGATGATGTCGGG
GTTTCGGTCCCCGGCGCCCCAGGTGTGCTGACTAAGCTAGCCAAATGCTGCACGCCGGTACCTGGCGATGCGATCATGGG
GTTCGTTACCCGCGGCGGCGGGGTTAGTGTGCACCGCACCGACTGCACCAACACGGCATCGCTGCAGCAGCAGGCCGAGC
GCATCATCGAGGTGTTGTGGGCGCCGTCGTCGTCGTCGGTGTTTCTGGTGGCGATTCAGGTGGAGGCGCTCGACCGGCAT
CGGCTGCTGTTGGACATAACACGCGCGTTAGCCGACGAAAGGGTGGACATTCTATCGGCGTCGGTCACCACGTCGGGTGA
CCGGGTGGCGATCAGCCGGTTTACCTTCGAGATGGGTGACCCCAAGCACCTCGGACATCTGCTCAATGTGGTCCGCAATG
TCGAAGGCGTTTACGATGTCTATCGGGTGATGTCTGCGTCTTGA

Upstream 100 bases:

>100_bases
CTAGCCTCGCTATCTGGGTACTTCCCCTCCGTGCTGGAATGGCTTGGGAGAAGCAGGTCAATCGGACTCAGGGATATCCT
TAAGGTCGGAGGTGACCAAC

Downstream 100 bases:

>100_bases
CGTTCGGGTGGTTACTCGGCAAATCCCCCTCTGCTTTGACGTGGATGACCGGACGGCTTTAGTCGAGCCGCAGCGACTCG
ATGGTAACTTCGGTGGCTGG

Product: putative GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRARLARRMTAQRSTISPVLEPLVAVHKEFYPKANLSIV
QRAFEVADQRHASQLRRSGDPYITHPLAVANILAELGMDITTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKL
DRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDL
SFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRI
LCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAK
GRNGVLHPHAAAEIDDMAWMRQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGH
RCIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALEAGKDAMAREVRRG
GLPLQRLVNGESMAAVARELHYIDVSALYTAIGEGHVSARHVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRSTDDVG
VSVPGAPGVLTKLAKCCTPVPGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAERIIEVLWAPSSSSVFLVAIQVEALDRH
RLLLDITRALADERVDILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVMSAS

Sequences:

>Translated_787_residues
MADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRARLARRMTAQRSTISPVLEPLVAVHKEFYPKANLSIV
QRAFEVADQRHASQLRRSGDPYITHPLAVANILAELGMDITTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKL
DRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDL
SFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRI
LCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAK
GRNGVLHPHAAAEIDDMAWMRQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGH
RCIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALEAGKDAMAREVRRG
GLPLQRLVNGESMAAVARELHYIDVSALYTAIGEGHVSARHVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRSTDDVG
VSVPGAPGVLTKLAKCCTPVPGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAERIIEVLWAPSSSSVFLVAIQVEALDRH
RLLLDITRALADERVDILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVMSAS
>Mature_786_residues
ADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRARLARRMTAQRSTISPVLEPLVAVHKEFYPKANLSIVQ
RAFEVADQRHASQLRRSGDPYITHPLAVANILAELGMDITTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKLD
RVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDLS
FAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRIL
CDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKG
RNGVLHPHAAAEIDDMAWMRQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHR
CIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALEAGKDAMAREVRRGG
LPLQRLVNGESMAAVARELHYIDVSALYTAIGEGHVSARHVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRSTDDVGV
SVPGAPGVLTKLAKCCTPVPGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAERIIEVLWAPSSSSVFLVAIQVEALDRHR
LLLDITRALADERVDILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVMSAS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=136, Percent_Identity=39.7058823529412, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1790082, Length=729, Percent_Identity=39.0946502057613, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=38.0607814761216, Blast_Score=484, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 87267; Mature: 87136

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRARLARRMTAQRSTISPV
CCCCCCCHHHCCCCEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEPLVAVHKEFYPKANLSIVQRAFEVADQRHASQLRRSGDPYITHPLAVANILAELGMDI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCH
TTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKLDRVVLGSAAEGETIRKMITA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDL
HCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHC
SFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGASKIKATVEGRPKHYWSIYQ
EEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHEEEEECCCCHHHHHHHH
KMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWM
HHHEEECCCCCCEEEEEECCHHHHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHHHHHH
RQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGH
HHHHHHHHHCCCHHHHHHHHHHHHEEEHEEEECCCCCEEEECCCCCCCCHHHHHHHHHCC
RCIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKE
HHCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
RREEALEAGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYIDVSALYTAIGEGHVSAR
HHHHHHHHCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
HVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRSTDDVGVSVPGAPGVLTKLAKCCTPV
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCHHHHHHHHHCCCC
PGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAERIIEVLWAPSSSSVFLVAIQVEALDRH
CCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEHHHHH
RLLLDITRALADERVDILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDV
HHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
YRVMSAS
HHHHHCC
>Mature Secondary Structure 
ADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRARLARRMTAQRSTISPV
CCCCCCHHHCCCCEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEPLVAVHKEFYPKANLSIVQRAFEVADQRHASQLRRSGDPYITHPLAVANILAELGMDI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCH
TTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKLDRVVLGSAAEGETIRKMITA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDL
HCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHC
SFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGASKIKATVEGRPKHYWSIYQ
EEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHEEEEECCCCHHHHHHHH
KMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWM
HHHEEECCCCCCEEEEEECCHHHHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHHHHHH
RQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGH
HHHHHHHHHCCCHHHHHHHHHHHHEEEHEEEECCCCCEEEECCCCCCCCHHHHHHHHHCC
RCIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKE
HHCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
RREEALEAGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYIDVSALYTAIGEGHVSAR
HHHHHHHHCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
HVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRSTDDVGVSVPGAPGVLTKLAKCCTPV
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCHHHHHHHHHCCCC
PGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAERIIEVLWAPSSSSVFLVAIQVEALDRH
CCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEHHHHH
RLLLDITRALADERVDILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDV
HHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
YRVMSAS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]