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The map label for this gene is guaB3

Identifier: 221229593

GI number: 221229593

Start: 482283

End: 483395

Strand: Direct

Name: guaB3

Synonym: MLBr_00388

Alternate gene names: NA

Gene position: 482283-483395 (Clockwise)

Preceding gene: 221229592

Following gene: 221229594

Centisome position: 14.76

GC content: 63.61

Gene sequence:

>1113_bases
ATGGGCCGCGTGGCCCGTCGAACATATGAGCTCCGTGAGATCAGCATCGTGCCGTCGCGTCGCACTCGCTCGTCGAAAGA
CGTGTCGACGGCTTGGCAACTCGACGCCTACCGGTTCGAGATCCCCGTCGTGGCACACCCGACCGATGCGTTAGTGTCGC
CGGAGTTCGCCATCGAGCTGGGCCGGCTTGGTGGGCTGGGTGTGCTCAACGGTGAGGGGCTGATTGGCCGCCATGCTGAT
GTCGGTGCCAAGGTCGCACAGTTGATCGAGGCTGCCGAGAAAGAGCCTGAACCGGCGACTGCGGTCTGTTTGCTGCAGGA
ACTGCATGCTGCGCCGCTGAATCCGGACCTGCTGGGTTCGGCGGTAGCTCGGATTCGGGAGGCGGGAGTGACCACTGCAG
TGCGAGTCAGCCCGCAAAATGCCCAAGTGTTGACGCCGGTGTTGCTCGCTGCCGGAATTGACCTACTGGTCGTCCAGGGT
TCCATCGTCTCGGCCGAGTGTGTTGCCAGCGGTGGTGAACCACTCAACCTGAAAACATTCATCTCTGAGCTCGACGTTCC
GGTGGTCGCTGGCGGTGTGCTCGACCACCGCACGGCGCTGCACCTGATGCGCACCGGCGCGGCTGGCGTGATCGTCGGCT
ATGGCTCCACTAGAGGGGCCACTACCTCCGATGAAGTGTTAGGCATCAGCGTGCCGATGGCTACGGCGATCGCCGACGCG
GCTGCTGCGCGGCGCGAATACCTCGATGAGACCGGTGGTCGCTACGTCCACGTGCTGGCCGACGGCGATATCTACACGTC
TGGCGAGTTGGCCAAAGCTATTGCCTGTGGTGCCGACGCGGTGGTGCTGGGTACACCGTTGGCCCAAAGTGCCGAGGCAC
TCGGCGGCGGGTGGTTCTGGCCGGCCGCGGCGGCGCACCCGTCTCTGCCACGCGGGGCGTTGCTACAGACCGCTGTCGGT
GAGCGACCGTCATTGCAGCAGGTTTTGAACGGGCCCTCCGACAACCCATTCGGCACCCTGAATCTTGTTGGTGGTCTGCG
CCGATCTATGGCTAAGGCCGGCTATTGCGACCTCAAGGAATTCCAGAAGGTCGGTCTGATCGTCAGCATCTGA

Upstream 100 bases:

>100_bases
CGCCCGCCGGACTCAAAGAGAGCCACCCGCACGACGTTGCGATGACTGTCGAAGCCCCCAACTATTACCCGCGTTGACGC
CCGACATGGTCGAGATAGGG

Downstream 100 bases:

>100_bases
GGTTCGGTCGCCAAACGTGCGACCAGCCCGCACGCTGGTGCCTAAGGCGGGTCATACTGGGGCGATGAAGCCGGATTATG
ACGTCTTAATCATCGGTTCA

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHAD
VGAKVAQLIEAAEKEPEPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQG
SIVSAECVASGGEPLNLKTFISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIADA
AAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVG
ERPSLQQVLNGPSDNPFGTLNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI

Sequences:

>Translated_370_residues
MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHAD
VGAKVAQLIEAAEKEPEPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQG
SIVSAECVASGGEPLNLKTFISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIADA
AAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVG
ERPSLQQVLNGPSDNPFGTLNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI
>Mature_369_residues
GRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHADV
GAKVAQLIEAAEKEPEPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQGS
IVSAECVASGGEPLNLKTFISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIADAA
AARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVGE
RPSLQQVLNGPSDNPFGTLNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI

Specific function: Unknown

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y388_MYCLE (Q49721)

Other databases:

- EMBL:   U00015
- EMBL:   AL583918
- PIR:   D86957
- PIR:   S72812
- RefSeq:   NP_301378.1
- ProteinModelPortal:   Q49721
- SMR:   Q49721
- EnsemblBacteria:   EBMYCT00000028527
- GeneID:   909090
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0388
- NMPDR:   fig|272631.1.peg.250
- Leproma:   ML0388
- GeneTree:   EBGT00050000017422
- HOGENOM:   HBG284613
- ProtClustDB:   PRK08649
- BioCyc:   MLEP272631:ML0388-MONOMER
- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01304

Pfam domain/function: PF00478 IMPDH

EC number: 1.1.1.205

Molecular weight: Translated: 38394; Mature: 38263

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIEL
CCCHHHHHEEEEEEEECCCCCCCCCCCCCHHEEECEEEEEEEEEECCCCCCCCCHHHHHH
GRLGGLGVLNGEGLIGRHADVGAKVAQLIEAAEKEPEPATAVCLLQELHAAPLNPDLLGS
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
AVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQGSIVSAECVASGGEPLNLKTF
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCEEEHHHHHCCCCCCCHHHH
ISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIADA
HHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHH
AAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQSAEALGGGWFW
HHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCC
PAAAAHPSLPRGALLQTAVGERPSLQQVLNGPSDNPFGTLNLVGGLRRSMAKAGYCDLKE
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHH
FQKVGLIVSI
HHHCCCEEEC
>Mature Secondary Structure 
GRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIEL
CCHHHHHEEEEEEEECCCCCCCCCCCCCHHEEECEEEEEEEEEECCCCCCCCCHHHHHH
GRLGGLGVLNGEGLIGRHADVGAKVAQLIEAAEKEPEPATAVCLLQELHAAPLNPDLLGS
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
AVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQGSIVSAECVASGGEPLNLKTF
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCEEEHHHHHCCCCCCCHHHH
ISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIADA
HHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHH
AAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQSAEALGGGWFW
HHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCC
PAAAAHPSLPRGALLQTAVGERPSLQQVLNGPSDNPFGTLNLVGGLRRSMAKAGYCDLKE
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHH
FQKVGLIVSI
HHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002