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The map label for this gene is glmS

Identifier: 221229580

GI number: 221229580

Start: 462988

End: 464865

Strand: Direct

Name: glmS

Synonym: MLBr_00371

Alternate gene names: 221229580

Gene position: 462988-464865 (Clockwise)

Preceding gene: 221229577

Following gene: 221229581

Centisome position: 14.17

GC content: 61.87

Gene sequence:

>1878_bases
ATGTGTGGACTTGTCGGCTACGTCGGGCAGCGCCCTGCCTGCGGGGTCGTCATGGATGCGCTGCGCAGGATGGAGTACCG
CGGCTACGACTCGTCGGGAATCGCGCTGATCAACGGCAGTGCCAAATCGGGCAATCTGACCGTTCGTCGTCGTGCTGGTC
GACTTTCCAATTTGGAGTCGGTGTTGGCGGAGATGGTTCCGGCGTCGCTGGCCGGCAACGTCGGCCTCGGCCATATCCGG
TGGGCCACCCATGGTCGCCCCACCGACCGCAACGCGCATCCGCACCGCGACGCCACCGGCAAGATCGCCGTCGTCCACAA
CGGCATCATCGAGAATTTCCCCTCCCTTCGCCATGAGTTGGAGATCGCCGGAGTAGAGTTCGTCAGCGACACCGACACCG
AGGTAGCTGTGCATTTGGTGGCACAGGCTTACTGCGCTGGCGAGACGGCCGGTGATTTCGTCGGGTCCGTGCTGGCGGTG
CTGCGCCGGCTACAGGGCCACTTCACTCTGGTGTTCGCCAACGCCGACGAGCCCGGTACCATTGTGGCCGCGCGCCGCTC
CACCCCGCTAGTGCTCGGGATCGGCGACGGGGAGATGTTCGTCGGTTCCGACGTGGCCGCGTTCATCGAACACACCCGGC
AGGCGGTCGAGCTTGGTCAGGACCAGGCTGTGGTGATCACTGCAGATGGTTACCGAATCAGCGACTTCGATGGCAACGAT
GACGCTGTAAACGCTCGCACATTTCATATCGACTGGGACCTGGCCGCTGCCGAAAAGGGCGGCTACGAGTACTTCATGCT
CAAGGAAATCGCTGAGCAGCCCGACGCGGTAGTCGACACGCTACTTGGGCATTTCACTGGTGGACGGATTGTGCTCGACG
AACAGCGATTGAGCGATCAGGAACTCCGCGAGATCGATAAGGTGTTTGTGGTCGCTTGCGGTACTGCCTATCATTCCGGC
TTGTTGGCCAAATATACGATCGAGCACTGGACGCGGCTGCCTGTTGAGGTGGAGCTAGCCAGCGAATTTCGCTACCGGGA
TCCTGTTCTGGACCGCAGCACACTGGTGGTAGCCATTTCGCAGTCCGGTGAAACCGCTGATACTTTAGAAGCTGTCCGGC
ACGCTAAAGAGCAGAAGGCCAAGGTGCTGGCGATTTGCAACACCAACGGCTCCCAAATCCCACGTGAGTGCGACGCGGTG
CTGTATACTCGCGCTGGCCCGGAGATCGGCGTCGCCTCAACGAAAACCTTTCTGGCTCAGGTCGCCGCCAACTACCTCCT
TGGGCTGGCGTTGGCGCAGGCCCGCGGCACTAAGTACCCCGATGAGGTGCAGCGCGAGTACCGCGAGCTGGAAGCGATGC
CCGACCTGGTGGCCCGGGTCATCGCGGGGATGGGCCCCGTGGCCGATTTGGCTTACCGGTTCGCTCAGTCGACGACCGTG
CTGTTCCTGGGTCGCCATGTCGGGTACCCGGTGGCGTTGGAAGGTGCGCTGAAACTCAAGGAATTGGCCTACATGCACGC
CGAGGGGTTCGCCGCCGGCGAGCTCAAGCACGGACCCATCGCGCTGATCGAAGAAAACCTGCCGGTAATCGTCGTCATGC
CCTCGCCCAAGGGATCGGCGATGCTGCATGCTAAGCTGCTGAGCAACATTCGTGAAATTCAGACCCGCGGAGCGGTGACC
ATTGTGATCGCGGAGGAAGGCGACGACACGGTACGTCTCTACGCCGATCACCTGATCGAACTCCCCGCGGTGTCAACACT
TTTGCAGCCGCTGCTGTCGACCATCCCGCTGCAGGTGTTCGCCGCGTCTGTGGCGCAGGCTCGCGGCTACGACGTTGACA
AACCGCGAAATCTGGCCAAGTCCGTCACCGTTGAGTAA

Upstream 100 bases:

>100_bases
CGAATTGGCCGGTAGGTTAACGTGACTTGTAATCCATACACTGCACCGATCAGCCCTGTGTACCTGTCTACTGCACTGGC
TGCACTACCCTGACAGGGTT

Downstream 100 bases:

>100_bases
CTGGCGCTGGGTGGTAGCGATGTCGGCAATGCGTGGCTGGCATCGACTAGATACTCGGGTGCCAACCGACCACATCCACT
GGATGCACCAGCGGTTCTCT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIR
WATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAV
LRRLQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGND
DAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSG
LLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAV
LYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTV
LFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSAMLHAKLLSNIREIQTRGAVT
IVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE

Sequences:

>Translated_625_residues
MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIR
WATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAV
LRRLQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGND
DAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSG
LLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAV
LYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTV
LFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSAMLHAKLLSNIREIQTRGAVT
IVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE
>Mature_625_residues
MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIR
WATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAV
LRRLQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGND
DAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSG
LLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAV
LYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTV
LFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSAMLHAKLLSNIREIQTRGAVT
IVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=35.9826589595376, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI205277386, Length=693, Percent_Identity=34.4877344877345, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1790167, Length=627, Percent_Identity=42.902711323764, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1788651, Length=143, Percent_Identity=30.0699300699301, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=725, Percent_Identity=33.7931034482759, Blast_Score=353, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17532897, Length=439, Percent_Identity=37.5854214123007, Blast_Score=275, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=37.0114942528736, Blast_Score=268, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=36.0091743119266, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=28.9954337899543, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6323730, Length=235, Percent_Identity=31.4893617021277, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357745, Length=700, Percent_Identity=35.2857142857143, Blast_Score=397, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_MYCLE (P40831)

Other databases:

- EMBL:   U00020
- EMBL:   AL583918
- PIR:   C86955
- PIR:   S72993
- RefSeq:   NP_301365.1
- ProteinModelPortal:   P40831
- SMR:   P40831
- MEROPS:   C44.971
- EnsemblBacteria:   EBMYCT00000029244
- GeneID:   909050
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0371
- NMPDR:   fig|272631.1.peg.237
- Leproma:   ML0371
- GeneTree:   EBGT00050000016850
- HOGENOM:   HBG645312
- OMA:   ITIVIAE
- ProtClustDB:   PRK00331
- BioCyc:   MLEP272631:ML0371-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67561; Mature: 67561

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS

Important sites: ACT_SITE 2-2 ACT_SITE 620-620

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLES
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHH
VLAEMVPASLAGNVGLGHIRWATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHEL
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHCCHHHHHHE
EIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAVLRRLQGHFTLVFANADEPGT
EEECEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCE
IVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGND
EEEEECCCCEEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCC
DAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQ
CCEEEEEEEEEEEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHCCCCEEEEEHHHCCHH
ELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAIS
HHHHHHHEEEEEECHHHHCCCCEEEEHHHHHCCCEEEEEHHHCCCCCCCCCCCEEEEEEE
QSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQ
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHCEEEEECCCCCCCCCHHHHHHHH
VAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEE
LFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSA
EEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCH
MLHAKLLSNIREIQTRGAVTIVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVF
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AASVAQARGYDVDKPRNLAKSVTVE
HHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRRRAGRLSNLES
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHH
VLAEMVPASLAGNVGLGHIRWATHGRPTDRNAHPHRDATGKIAVVHNGIIENFPSLRHEL
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHCCHHHHHHE
EIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAVLRRLQGHFTLVFANADEPGT
EEECEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCE
IVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGND
EEEEECCCCEEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCC
DAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRLSDQ
CCEEEEEEEEEEEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHCCCCEEEEEHHHCCHH
ELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAIS
HHHHHHHEEEEEECHHHHCCCCEEEEHHHHHCCCEEEEEHHHCCCCCCCCCCCEEEEEEE
QSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQ
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHCEEEEECCCCCCCCCHHHHHHHH
VAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVARVIAGMGPVADLAYRFAQSTTV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEE
LFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSA
EEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCH
MLHAKLLSNIREIQTRGAVTIVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPLQVF
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AASVAQARGYDVDKPRNLAKSVTVE
HHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002