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The map label for this gene is fabG [C]

Identifier: 221229558

GI number: 221229558

Start: 403715

End: 404629

Strand: Reverse

Name: fabG [C]

Synonym: MLBr_00315

Alternate gene names: 221229558

Gene position: 404629-403715 (Counterclockwise)

Preceding gene: 221229561

Following gene: 221229557

Centisome position: 12.38

GC content: 61.75

Gene sequence:

>915_bases
ATGGCCAAGTGGACCACCGCGGACATTCCCGACCAGACGGGTCGTGTCGCCGTCATTACCGGCGCCAACACCGGCCTCGG
CTATCAGACCGCGCTGGCACTCGCCGAGCATGGTGCCCATGTGGTGTTGGCGGTGCGCAATCTCGACAAGGGCAAGGACG
CTGCCGCACGCATCACGGCCACTAGCGCACAGAACAACGTTGCGCTGCAAGAGCTCGACTTAGCGTCGTTGGAGTCTGTG
CGCGCCGCAGCAAAGCAACTACGGTCCGACTACGACCACATCGACTTGCTGATCAACAACGCCGGGGTGATGTGGACACC
GAAGTCGACCACCAAGGACGGTTTCGAGTTGCAGTTCGGCACCAACCACTTAGGTCACTTTGCCTTCACCGGCTTGCTGC
TGGATCGGCTGCTGCCGATCGTCGGTTCGCGGGTGATAACTGTCAGCAGCCTCAGTCACCGCCTGTTCGCTGACATTCAT
TTCAACGATCTGCAGTGGGAATGCAACTACAACCGGGTCGCCGCCTATGGGCAATCCAAGCTAGCCAACCTACTGTTCAC
TTACGAACTGCAGCGACGACTGGCCACCCGACAAACGACGATCGCTGTGGCCGCCCATCCCGGTGGCTCACGCACCGAAC
TGACCAGGACTCTGCCCGCGCTGATTGCGCCCATTTTTTCGGTGGCCGAACTGTTCCTCACCCAGGATGCAGCAACCGGC
GCACTACCGACCCTGCGGGCTGCCACCGATGCGGCAGTGCTCGGCGGGCAGTATTTCGGACCAGACGGGTTCGCAGAAAT
ACGGGGCCACCCCAAAGTTGTGGCGTCCAACGGCAAGTCCCACGACGTTGACCGGCAGCTCCGGCTGTGGGCGGTCTCCG
AAGAACTCACCGGGGTGGTCTATCCGGTCGGCTGA

Upstream 100 bases:

>100_bases
GGACATTGCACAGCGGGGCTAGCGTTCCGTATGGTTTCACAATCAACCAATCAACCGGAGCGTTCGCCCCGCTTACTGTA
ACAAGCTTGAGGAGCTATTC

Downstream 100 bases:

>100_bases
TCGACAAAATGAGCCAGACTGACCAGCACTCAAATTAGATTTTAGATTATTTTAAATTTTAGATTGGAGTGACCGGTACC
TCATCTATGCGTCTATGCGC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVRNLDKGKDAAARITATSAQNNVALQELDLASLESV
RAAAKQLRSDYDHIDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIH
FNDLQWECNYNRVAAYGQSKLANLLFTYELQRRLATRQTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATG
ALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWAVSEELTGVVYPVG

Sequences:

>Translated_304_residues
MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVRNLDKGKDAAARITATSAQNNVALQELDLASLESV
RAAAKQLRSDYDHIDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIH
FNDLQWECNYNRVAAYGQSKLANLLFTYELQRRLATRQTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATG
ALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWAVSEELTGVVYPVG
>Mature_303_residues
AKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVRNLDKGKDAAARITATSAQNNVALQELDLASLESVR
AAAKQLRSDYDHIDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIHF
NDLQWECNYNRVAAYGQSKLANLLFTYELQRRLATRQTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATGA
LPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWAVSEELTGVVYPVG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=309, Percent_Identity=42.7184466019417, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI166795268, Length=299, Percent_Identity=40.8026755852843, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI186928839, Length=300, Percent_Identity=42.6666666666667, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI10190746, Length=304, Percent_Identity=37.828947368421, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI7706523, Length=298, Percent_Identity=37.9194630872483, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI19923931, Length=266, Percent_Identity=41.7293233082707, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI193804850, Length=306, Percent_Identity=36.2745098039216, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI146231950, Length=293, Percent_Identity=36.518771331058, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193207620, Length=308, Percent_Identity=30.5194805194805, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558006, Length=258, Percent_Identity=34.4961240310078, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17532791, Length=305, Percent_Identity=30.8196721311475, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17532805, Length=309, Percent_Identity=31.3915857605178, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71992402, Length=264, Percent_Identity=32.9545454545455, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI72001364, Length=216, Percent_Identity=33.7962962962963, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17505416, Length=245, Percent_Identity=32.2448979591837, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17535059, Length=260, Percent_Identity=31.1538461538462, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32565532, Length=206, Percent_Identity=31.5533980582524, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115533174, Length=292, Percent_Identity=29.7945205479452, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533172, Length=292, Percent_Identity=29.4520547945205, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324820, Length=330, Percent_Identity=29.0909090909091, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28573296, Length=299, Percent_Identity=41.8060200668896, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19921754, Length=295, Percent_Identity=41.0169491525424, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI22024069, Length=303, Percent_Identity=39.6039603960396, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24586328, Length=294, Percent_Identity=39.7959183673469, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45554248, Length=253, Percent_Identity=43.0830039525692, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24640117, Length=253, Percent_Identity=43.0830039525692, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161076371, Length=259, Percent_Identity=39.3822393822394, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129347, Length=298, Percent_Identity=34.8993288590604, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI45553409, Length=287, Percent_Identity=31.7073170731707, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647948, Length=287, Percent_Identity=31.7073170731707, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647946, Length=287, Percent_Identity=31.7073170731707, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24656154, Length=260, Percent_Identity=34.6153846153846, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19922628, Length=260, Percent_Identity=34.6153846153846, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24647931, Length=274, Percent_Identity=33.9416058394161, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32737; Mature: 32606

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVRNLDKGKDAAARITA
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEE
TSAQNNVALQELDLASLESVRAAAKQLRSDYDHIDLLINNAGVMWTPKSTTKDGFELQFG
ECCCCCCCHHHHCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCCCCEEEEEC
TNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSK
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCEEEEEEEECCEEEEECCCEEECCCHHH
LANLLFTYELQRRLATRQTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATG
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWAVSEELTGVV
CCCHHHHHCCHHHCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCEEE
YPVG
EECC
>Mature Secondary Structure 
AKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVRNLDKGKDAAARITA
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEE
TSAQNNVALQELDLASLESVRAAAKQLRSDYDHIDLLINNAGVMWTPKSTTKDGFELQFG
ECCCCCCCHHHHCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCCCCEEEEEC
TNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSK
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCEEEEEEEECCEEEEECCCEEECCCHHH
LANLLFTYELQRRLATRQTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATG
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWAVSEELTGVV
CCCHHHHHCCHHHCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCEEE
YPVG
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]