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The map label for this gene is panC

Identifier: 221229505

GI number: 221229505

Start: 301478

End: 302419

Strand: Direct

Name: panC

Synonym: MLBr_00230

Alternate gene names: 221229505

Gene position: 301478-302419 (Clockwise)

Preceding gene: 221229504

Following gene: 221229506

Centisome position: 9.22

GC content: 62.53

Gene sequence:

>942_bases
ATGACGAACAGTCGGCAGCCGGCATTCAACCCGGGCGAGCTCAATGTGTACTCGACGCCCCGTGACGTCACCAATGTCAG
CAGCGCGTTGCGCCACACCGGCCGCCGGGTGATGCTGGTGCCGACGATGGGTGCGCTGCACAACGGGCACCTGGCCCTGG
TGCGTGCGGCTAAACGTGTGCCTGGTTCGGTGGTTGTGGTGTCGATCTTCGTTAACCCGCTGCAATTCGGCGCCGCGGAA
GACCTCGACACTTACCCATGTACCTTCGACGATGATTTGGCTCTACTGCGCGCAGAAGATGTCGAGATCGTGTTCACGCC
GACTGCCGCGGCGATGTATCCGCACGGATTGCGTACCACCGTACGCCCCGGGGCGTTAGCGTTCGAGCTCGAAGGTGGTC
CGCGGCCAAACCATTTCGACGGTGTGCTAACCGTCGTGCTCAAACTACTCCAGATCGTGCGGCCTGACCGAGTTTTCTTC
GGGGAGAAAGATTACCAGCAGCTGGTCCTGATCCGGCAGATGGTAGCCGATCTGAACGTCGACGTCGTCGTGGTCGGCGT
CCCGACCGTGCGCGAAGTCGATGGGCTGGCGATGTCGTCACGCAACTGCTACCTGGATCCTGTGCAGCGCGATCTGGCCG
CAGCGCTGTCGGCGGCGTTGACGGCCGGGGCGCACGCAGCGACAGGGGGGGCACAGGCTGCGCTGGACGCAGCCCGCGCG
GTGCTGGACGCTACGCCCGGCCTTGTGGTCGATTACGTGGAGCTACGCGATGCTGGGCTCGGCCCGATGCGCGACAACAC
GTTCGGCCGGTTGCTAGTGGCAGCCAGGCTTGGTGCCACTAGACTACTCGACAATATTTCGATTGAGATCGGAAATTTCT
CCGGCATCGCTAGTCCGGACGAATGTCGGGTTGAACACGCCCAAACACCTTGGATGAAGTGA

Upstream 100 bases:

>100_bases
TGCGGATTGGCCCAGAATTGGCCCAGGCTTATCGGGTTAATGCCCTACGGAAGACTCAGCGTGCCCATGCTCCCTACGAT
GTCGTCGAAGCGCTGGCGCC

Downstream 100 bases:

>100_bases
TGTTACGGACGATGCTAAAGTCTAAGATTCATCGCGCCACCGTCACGCAGGCTTATCTGCACTATGTCGGTTCGGTGACC
ATCGATGCCGATTTGATGGG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTNSRQPAFNPGELNVYSTPRDVTNVSSALRHTGRRVMLVPTMGALHNGHLALVRAAKRVPGSVVVVSIFVNPLQFGAAE
DLDTYPCTFDDDLALLRAEDVEIVFTPTAAAMYPHGLRTTVRPGALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFF
GEKDYQQLVLIRQMVADLNVDVVVVGVPTVREVDGLAMSSRNCYLDPVQRDLAAALSAALTAGAHAATGGAQAALDAARA
VLDATPGLVVDYVELRDAGLGPMRDNTFGRLLVAARLGATRLLDNISIEIGNFSGIASPDECRVEHAQTPWMK

Sequences:

>Translated_313_residues
MTNSRQPAFNPGELNVYSTPRDVTNVSSALRHTGRRVMLVPTMGALHNGHLALVRAAKRVPGSVVVVSIFVNPLQFGAAE
DLDTYPCTFDDDLALLRAEDVEIVFTPTAAAMYPHGLRTTVRPGALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFF
GEKDYQQLVLIRQMVADLNVDVVVVGVPTVREVDGLAMSSRNCYLDPVQRDLAAALSAALTAGAHAATGGAQAALDAARA
VLDATPGLVVDYVELRDAGLGPMRDNTFGRLLVAARLGATRLLDNISIEIGNFSGIASPDECRVEHAQTPWMK
>Mature_312_residues
TNSRQPAFNPGELNVYSTPRDVTNVSSALRHTGRRVMLVPTMGALHNGHLALVRAAKRVPGSVVVVSIFVNPLQFGAAED
LDTYPCTFDDDLALLRAEDVEIVFTPTAAAMYPHGLRTTVRPGALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFFG
EKDYQQLVLIRQMVADLNVDVVVVGVPTVREVDGLAMSSRNCYLDPVQRDLAAALSAALTAGAHAATGGAQAALDAARAV
LDATPGLVVDYVELRDAGLGPMRDNTFGRLLVAARLGATRLLDNISIEIGNFSGIASPDECRVEHAQTPWMK

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=270, Percent_Identity=45.9259259259259, Blast_Score=204, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6322046, Length=258, Percent_Identity=36.8217054263566, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_MYCLE (O69524)

Other databases:

- EMBL:   AL583917
- EMBL:   AL023093
- PIR:   F86937
- RefSeq:   NP_301290.1
- ProteinModelPortal:   O69524
- SMR:   O69524
- EnsemblBacteria:   EBMYCT00000028572
- GeneID:   908653
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0230
- NMPDR:   fig|272631.1.peg.162
- Leproma:   ML0230
- GeneTree:   EBGT00050000016962
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   MLEP272631:ML0230-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 33586; Mature: 33455

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: ACT_SITE 50-50 BINDING 75-75 BINDING 75-75 BINDING 167-167 BINDING 190-190

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSRQPAFNPGELNVYSTPRDVTNVSSALRHTGRRVMLVPTMGALHNGHLALVRAAKRV
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHC
PGSVVVVSIFVNPLQFGAAEDLDTYPCTFDDDLALLRAEDVEIVFTPTAAAMYPHGLRTT
CCCEEEEEEEECHHHCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCHHHHCCCCCCCC
VRPGALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQMVADLNV
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCC
DVVVVGVPTVREVDGLAMSSRNCYLDPVQRDLAAALSAALTAGAHAATGGAQAALDAARA
CEEEECCCCHHHHCCCEECCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VLDATPGLVVDYVELRDAGLGPMRDNTFGRLLVAARLGATRLLDNISIEIGNFSGIASPD
HHHCCCCCEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCH
ECRVEHAQTPWMK
HHHHHHCCCCCCC
>Mature Secondary Structure 
TNSRQPAFNPGELNVYSTPRDVTNVSSALRHTGRRVMLVPTMGALHNGHLALVRAAKRV
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHC
PGSVVVVSIFVNPLQFGAAEDLDTYPCTFDDDLALLRAEDVEIVFTPTAAAMYPHGLRTT
CCCEEEEEEEECHHHCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCHHHHCCCCCCCC
VRPGALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQMVADLNV
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCC
DVVVVGVPTVREVDGLAMSSRNCYLDPVQRDLAAALSAALTAGAHAATGGAQAALDAARA
CEEEECCCCHHHHCCCEECCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VLDATPGLVVDYVELRDAGLGPMRDNTFGRLLVAARLGATRLLDNISIEIGNFSGIASPD
HHHCCCCCEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCH
ECRVEHAQTPWMK
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002