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The map label for this gene is hpt [H]

Identifier: 221229494

GI number: 221229494

Start: 285599

End: 286240

Strand: Direct

Name: hpt [H]

Synonym: MLBr_00214

Alternate gene names: 221229494

Gene position: 285599-286240 (Clockwise)

Preceding gene: 221229493

Following gene: 221229495

Centisome position: 8.74

GC content: 56.54

Gene sequence:

>642_bases
GTGGTTTTTCGCAGGGCAGCATGGCACGCTTTGCTCGTGGCCCAGAGCTTCTCGGCGATTAACCCCGGACCGACGGCAGA
GTTGTACCTGGGTGATATCAAGTCGGTCATGCTCACCCAGGAGCAGATTCAGGCTAGGATTGCCGAGCTCGGCGCCCAAA
TCGGCCACGACTATCGTGACCGTTCGCCTGCTAGTGACCAGGATCTGCTGTTGGTCACCGTGCTTAAGGGAGCGGTGATC
TTCGTCACTGACCTGGCGCGTGCGATTCCACTGCCAACTCAGTTCGAATTCATGGCCGTTAGTTCGTATGGATCCTCGAT
GTCCTCGTCGGGTGTGGTGCGGATTCTCAAGGATCTTGATCGCGATATCCACGATCGCAACGTGTTGATAGTCGAGGACG
TCGTGGATTCAGGTCTGACCTTGTCTTGGTTGCTGCGGAACTTGGCAACCCGTCGTCCGCAGTCGTTGCAGGTGTGCACG
CTGCTGCGCAAGCCCGATGCGCTACGTGCCAATGTCGATATCACTTATGTGGGTTTCGACATTCCCAACGACTTCGTCGT
GGGCTATGGACTGGATTACGACGAGCGTTACCGTGACCTGCCCTATATCGGTATGCTGGATCCCCGTGTCTACCAGCAAT
AG

Upstream 100 bases:

>100_bases
TGCGCGGACAGCGTTTGATCGCCAGCCGGTACGACGGCGTACTGACCTTGCACTGCGCGCCCGTTTAGCGGCCCTTAGCG
GGTCCTGATGCCGGGTCGCC

Downstream 100 bases:

>100_bases
CCGCTAGTCCATCTCCCACACCGCGGTCATCGAGGAGCTCACTGTCTGCTGGCCAGCGTCCTTGATGTGTTGTCCGGGGC
GTGGATATTGCCCTCGAGCG

Product: putative hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRDRSPASDQDLLLVTVLKGAVI
FVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLDRDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCT
LLRKPDALRANVDITYVGFDIPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ

Sequences:

>Translated_213_residues
MVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRDRSPASDQDLLLVTVLKGAVI
FVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLDRDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCT
LLRKPDALRANVDITYVGFDIPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ
>Mature_213_residues
MVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRDRSPASDQDLLLVTVLKGAVI
FVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLDRDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCT
LLRKPDALRANVDITYVGFDIPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=188, Percent_Identity=32.9787234042553, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4504483, Length=187, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI87081689, Length=170, Percent_Identity=51.1764705882353, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17510817, Length=189, Percent_Identity=31.7460317460317, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 23874; Mature: 23874

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRD
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RSPASDQDLLLVTVLKGAVIFVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLD
CCCCCCCCEEHEEEHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHC
RDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCTLLRKPDALRANVDITYVGFD
CCCCCCCEEEEEHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECEEEEEEEEE
IPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ
CCCCEEEEECCCHHHHHCCCCEECCCCCHHHCC
>Mature Secondary Structure
MVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRD
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RSPASDQDLLLVTVLKGAVIFVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLD
CCCCCCCCEEHEEEHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHC
RDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCTLLRKPDALRANVDITYVGFD
CCCCCCCEEEEEHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECEEEEEEEEE
IPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ
CCCCEEEEECCCHHHHHCCCCEECCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]