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The map label for this gene is sucC

Identifier: 221229456

GI number: 221229456

Start: 218485

End: 219666

Strand: Direct

Name: sucC

Synonym: MLBr_00155

Alternate gene names: 221229456

Gene position: 218485-219666 (Clockwise)

Preceding gene: 221229454

Following gene: 221229457

Centisome position: 6.69

GC content: 59.31

Gene sequence:

>1182_bases
ATGGATCTTTTCGAGTATCAAGCTAAGGAATTGTTCGCCAAGCACGGCGTCCCTGGCATACAAGGACGGGTGACCGACAG
CGCGGAAGGCGCTAAGACCATCGCCATGGAGATTGGTCGTCCCGTAATGGTGAAAGCTCAGGTAAAAACAGGCGGGCGAG
GCAAAGCGGGTGGCGTCAAATATGCTGCCACCCCAGAAGAAGCCTACCAACAGGCCAAGAACATTCTTGGCCTGGACATA
AAAGGCCATATTGTCAAGAAATTGCTGGTGGTCGAAGCTAGCGACATCGCCGAGGAATACTATCTCTCCTTCCTGCTCGA
CCGTGCCAACCGAACATACCTTGCGATGTGCTCGGTGGAAGGCGGCATGGAAATCGAAGAGGTGGCCGCCACCAAGCCTG
AGCGACTGGCCAAGGTCTCGGTGGACGCGGTAAAGGGTGTAGATTTAGCCTGCGCACGCTCTATTGCGCAGCAGGGCCAT
CTGCCGGCTGAGGTGCTCGACGCCGCCGCGGCCACCATCGCCAAGTTGTGGGAACTCTTTGTAGCCGAGGACGCCACCCT
GGTGGAGGTCAACCCGTTGGTGCGCACTCCCTCCCGCGGGTACGGAAGCTCGGGCAAGATTTTGGCGCTGGACGGCAAGG
TCACTCTTGATGCCAACGCCCGCTTCCGCCAGCCCGGCCATGCCGAGTTCGAAGATCGCGCGGCCACTGATCCGCTGGAG
TGGAAGGCCAAGCAGCACAACCTCAACTACATCAAGCTCGACGGTGAGGTGGGGATCATCGGTAACGGCGCGGGTCTGAC
CATGTCGACCTTCGACGTCGTCGCCTATGCAGGGGAACAGCACGGGGGGGTTAAGCCGGCCAACTTCCTCGATATCGGTG
GCGGCGCTTCCGCTGAGGTGATGGCTGCCAGTCTGGACGTAGTTCTGGGCGACGTTCAGGTCAAGAGCGTGTTCGTCAAC
ATATTCGGTGGGATTACCACATGTGACACCGTCGCTACCGGAATTGTCAAGGCATTGGAAATCTTGGGTGATGAGGCCAA
CAAGCCTTTAGTGGTGCGCCTGGACGGCAATAACGTCGGTGAAGGCCGACGCATCCTGGCCGAGGCCAACCATCCGCTAG
TGATGCTGGTCCCGACGATGGACGAGGCCGCTAACAAGGCCGCCGAGTTGGCCCGCACTTGA

Upstream 100 bases:

>100_bases
CGGTGACAGCCACCGTTTGGGTATGTGACTACAGTTTCATCGTGCGAGTTGCCAAATTGGAACCGCCTACACTATTGGCC
AATGCGAAGACAGCGAGCCC

Downstream 100 bases:

>100_bases
AAGGACTTGACTGAAAGATATGGCGATTTTCCTCACTAAAGACAACACAGTCATCGTCCAGGGTATCACTGGCAGCGAGG
CTGCCGTTCACACCGCCCGC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDLFEYQAKELFAKHGVPGIQGRVTDSAEGAKTIAMEIGRPVMVKAQVKTGGRGKAGGVKYAATPEEAYQQAKNILGLDI
KGHIVKKLLVVEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVSVDAVKGVDLACARSIAQQGH
LPAEVLDAAAATIAKLWELFVAEDATLVEVNPLVRTPSRGYGSSGKILALDGKVTLDANARFRQPGHAEFEDRAATDPLE
WKAKQHNLNYIKLDGEVGIIGNGAGLTMSTFDVVAYAGEQHGGVKPANFLDIGGGASAEVMAASLDVVLGDVQVKSVFVN
IFGGITTCDTVATGIVKALEILGDEANKPLVVRLDGNNVGEGRRILAEANHPLVMLVPTMDEAANKAAELART

Sequences:

>Translated_393_residues
MDLFEYQAKELFAKHGVPGIQGRVTDSAEGAKTIAMEIGRPVMVKAQVKTGGRGKAGGVKYAATPEEAYQQAKNILGLDI
KGHIVKKLLVVEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVSVDAVKGVDLACARSIAQQGH
LPAEVLDAAAATIAKLWELFVAEDATLVEVNPLVRTPSRGYGSSGKILALDGKVTLDANARFRQPGHAEFEDRAATDPLE
WKAKQHNLNYIKLDGEVGIIGNGAGLTMSTFDVVAYAGEQHGGVKPANFLDIGGGASAEVMAASLDVVLGDVQVKSVFVN
IFGGITTCDTVATGIVKALEILGDEANKPLVVRLDGNNVGEGRRILAEANHPLVMLVPTMDEAANKAAELART
>Mature_393_residues
MDLFEYQAKELFAKHGVPGIQGRVTDSAEGAKTIAMEIGRPVMVKAQVKTGGRGKAGGVKYAATPEEAYQQAKNILGLDI
KGHIVKKLLVVEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVSVDAVKGVDLACARSIAQQGH
LPAEVLDAAAATIAKLWELFVAEDATLVEVNPLVRTPSRGYGSSGKILALDGKVTLDANARFRQPGHAEFEDRAATDPLE
WKAKQHNLNYIKLDGEVGIIGNGAGLTMSTFDVVAYAGEQHGGVKPANFLDIGGGASAEVMAASLDVVLGDVQVKSVFVN
IFGGITTCDTVATGIVKALEILGDEANKPLVVRLDGNNVGEGRRILAEANHPLVMLVPTMDEAANKAAELART

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=406, Percent_Identity=35.9605911330049, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI157779135, Length=396, Percent_Identity=36.8686868686869, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI294862256, Length=371, Percent_Identity=37.466307277628, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1786948, Length=377, Percent_Identity=42.1750663129974, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17539378, Length=404, Percent_Identity=35.3960396039604, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17567829, Length=384, Percent_Identity=36.71875, Blast_Score=225, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6321683, Length=408, Percent_Identity=35.2941176470588, Blast_Score=233, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21356231, Length=403, Percent_Identity=34.7394540942928, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI281361397, Length=408, Percent_Identity=34.8039215686275, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI281361395, Length=408, Percent_Identity=34.8039215686275, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161078106, Length=408, Percent_Identity=34.5588235294118, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24645208, Length=408, Percent_Identity=34.5588235294118, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_MYCLB (B8ZU00)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002502872.1
- ProteinModelPortal:   B8ZU00
- SMR:   B8ZU00
- EnsemblBacteria:   EBMYCT00000085747
- GeneID:   7326277
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017263
- HOGENOM:   HBG315432
- OMA:   IFINILG
- ProtClustDB:   PRK00696
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 41607; Mature: 41607

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLFEYQAKELFAKHGVPGIQGRVTDSAEGAKTIAMEIGRPVMVKAQVKTGGRGKAGGVK
CCHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEEHHHCCCCEEEEEEECCCCCCCCCCEE
YAATPEEAYQQAKNILGLDIKGHIVKKLLVVEASDIAEEYYLSFLLDRANRTYLAMCSVE
EECCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GGMEIEEVAATKPERLAKVSVDAVKGVDLACARSIAQQGHLPAEVLDAAAATIAKLWELF
CCCCHHHHHCCCHHHHHHEEHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VAEDATLVEVNPLVRTPSRGYGSSGKILALDGKVTLDANARFRQPGHAEFEDRAATDPLE
HCCCCEEEEECCCEECCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCHH
WKAKQHNLNYIKLDGEVGIIGNGAGLTMSTFDVVAYAGEQHGGVKPANFLDIGGGASAEV
CCHHHCCCCEEEECCEEEEEECCCCCEEEHEEEEEECCCCCCCCCCCCEEECCCCCCHHH
MAASLDVVLGDVQVKSVFVNIFGGITTCDTVATGIVKALEILGDEANKPLVVRLDGNNVG
HHEEEEEEECCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
EGRRILAEANHPLVMLVPTMDEAANKAAELART
CCCEEEEECCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MDLFEYQAKELFAKHGVPGIQGRVTDSAEGAKTIAMEIGRPVMVKAQVKTGGRGKAGGVK
CCHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEEHHHCCCCEEEEEEECCCCCCCCCCEE
YAATPEEAYQQAKNILGLDIKGHIVKKLLVVEASDIAEEYYLSFLLDRANRTYLAMCSVE
EECCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GGMEIEEVAATKPERLAKVSVDAVKGVDLACARSIAQQGHLPAEVLDAAAATIAKLWELF
CCCCHHHHHCCCHHHHHHEEHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VAEDATLVEVNPLVRTPSRGYGSSGKILALDGKVTLDANARFRQPGHAEFEDRAATDPLE
HCCCCEEEEECCCEECCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCHH
WKAKQHNLNYIKLDGEVGIIGNGAGLTMSTFDVVAYAGEQHGGVKPANFLDIGGGASAEV
CCHHHCCCCEEEECCEEEEEECCCCCEEEHEEEEEECCCCCCCCCCCCEEECCCCCCHHH
MAASLDVVLGDVQVKSVFVNIFGGITTCDTVATGIVKALEILGDEANKPLVVRLDGNNVG
HHEEEEEEECCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
EGRRILAEANHPLVMLVPTMDEAANKAAELART
CCCEEEEECCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA