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The map label for this gene is sucD [H]

Identifier: 221229457

GI number: 221229457

Start: 219686

End: 220588

Strand: Direct

Name: sucD [H]

Synonym: MLBr_00156

Alternate gene names: 221229457

Gene position: 219686-220588 (Clockwise)

Preceding gene: 221229456

Following gene: 221229458

Centisome position: 6.72

GC content: 56.92

Gene sequence:

>903_bases
ATGGCGATTTTCCTCACTAAAGACAACACAGTCATCGTCCAGGGTATCACTGGCAGCGAGGCTGCCGTTCACACCGCCCG
CATGCTCAAGGCGGGAACCCAAATCGTGGGCGGCGTCAATGCCCGCAAGGCAGGCACCAATGTAACGCATGAGGACAAAC
ACGGCCGGATCATCACACTGCCAGTGTTTGGCACCGTGGCCGAAGCCATCGAAAACACCGGCGCCGACGTCTCGATCATA
TTTGTGCCGCCGCGGTTTGCCAAAGAAGCCATTATCGAGGCCGTCGAAGCAGAAATTCCGCTGCTGGTCATCATCACTGA
GGGAATTCCGGTGCAAGACAGTGTATATGCATGGGCCTACAATCTCAACAAAGGTACTAAGACTCGCATAATCGGCCCGA
ACTGCCCCGGTATCATTACTCCCGGCCAGTCGTTGGTTGGCATTACTCCAGCTACCATCACCGGAGCAGGTCCGATTGGT
TTGGTGTCTAAGTCGGGCACCTTGACCTACCAGATGATGTTCGAGCTCAGCGATTTCGGCTTCTCGACCGCAATCGGTAT
CGGTGGTGACCCGGTGATTGGTACCACGCACATCGACGCCATCGAAGCCTTCGAACAGGATCCCGACACCAAAATCATCG
TCATGATCGGCGAGATCGGGGGGGATGCCGAAGAGCGTGCGGCAGACTACATCAAAGCTAACGTGTCCAAGCCCGTTGTA
GGATACGTCGCGGGATTCACTGCGCCGGAAGGTAAGACGATGGGCCATGCTGGTGCCATCGTGTCCGGCTCGTCGGGCAC
TGCGGCTGTCAAGAAGGACGCCTTAGAGGCAGCGGGAGTCAAAGTCGGTAAGACTCCGTCGGAGACGGCTGTGTTGGTCC
GCGAGATTCTGTGCACCCTGTAA

Upstream 100 bases:

>100_bases
GAGGCCAACCATCCGCTAGTGATGCTGGTCCCGACGATGGACGAGGCCGCTAACAAGGCCGCCGAGTTGGCCCGCACTTG
AAAGGACTTGACTGAAAGAT

Downstream 100 bases:

>100_bases
TGGGCTGGCGCAGACCTCTTCCGCCGCTACACTGCAGCGGTCAGTTTTTCGAATAGTCCCTTGATGTAACCGGGGACCTC
ATCCTCGGAGCGATCCGGTA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAIFLTKDNTVIVQGITGSEAAVHTARMLKAGTQIVGGVNARKAGTNVTHEDKHGRIITLPVFGTVAEAIENTGADVSII
FVPPRFAKEAIIEAVEAEIPLLVIITEGIPVQDSVYAWAYNLNKGTKTRIIGPNCPGIITPGQSLVGITPATITGAGPIG
LVSKSGTLTYQMMFELSDFGFSTAIGIGGDPVIGTTHIDAIEAFEQDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAVKKDALEAAGVKVGKTPSETAVLVREILCTL

Sequences:

>Translated_300_residues
MAIFLTKDNTVIVQGITGSEAAVHTARMLKAGTQIVGGVNARKAGTNVTHEDKHGRIITLPVFGTVAEAIENTGADVSII
FVPPRFAKEAIIEAVEAEIPLLVIITEGIPVQDSVYAWAYNLNKGTKTRIIGPNCPGIITPGQSLVGITPATITGAGPIG
LVSKSGTLTYQMMFELSDFGFSTAIGIGGDPVIGTTHIDAIEAFEQDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAVKKDALEAAGVKVGKTPSETAVLVREILCTL
>Mature_299_residues
AIFLTKDNTVIVQGITGSEAAVHTARMLKAGTQIVGGVNARKAGTNVTHEDKHGRIITLPVFGTVAEAIENTGADVSIIF
VPPRFAKEAIIEAVEAEIPLLVIITEGIPVQDSVYAWAYNLNKGTKTRIIGPNCPGIITPGQSLVGITPATITGAGPIGL
VSKSGTLTYQMMFELSDFGFSTAIGIGGDPVIGTTHIDAIEAFEQDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVVG
YVAGFTAPEGKTMGHAGAIVSGSSGTAAVKKDALEAAGVKVGKTPSETAVLVREILCTL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=48.972602739726, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI38569423, Length=258, Percent_Identity=31.0077519379845, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI38569421, Length=258, Percent_Identity=31.0077519379845, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786949, Length=299, Percent_Identity=50.5016722408027, Blast_Score=277, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17550194, Length=290, Percent_Identity=51.7241379310345, Blast_Score=250, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17553126, Length=301, Percent_Identity=48.1727574750831, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17557344, Length=254, Percent_Identity=28.740157480315, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17551266, Length=255, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=46.9387755102041, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21356559, Length=300, Percent_Identity=48, Blast_Score=253, Evalue=9e-68,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=48.2758620689655, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI281363477, Length=252, Percent_Identity=30.5555555555556, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281363475, Length=252, Percent_Identity=30.5555555555556, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363473, Length=252, Percent_Identity=30.5555555555556, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30954; Mature: 30823

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIFLTKDNTVIVQGITGSEAAVHTARMLKAGTQIVGGVNARKAGTNVTHEDKHGRIITL
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCEEEEE
PVFGTVAEAIENTGADVSIIFVPPRFAKEAIIEAVEAEIPLLVIITEGIPVQDSVYAWAY
ECHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEE
NLNKGTKTRIIGPNCPGIITPGQSLVGITPATITGAGPIGLVSKSGTLTYQMMFELSDFG
ECCCCCEEEEECCCCCEEECCCCCEEEECCCEEECCCCEEEEECCCCEEEEEEEEHHCCC
FSTAIGIGGDPVIGTTHIDAIEAFEQDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
CEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAVKKDALEAAGVKVGKTPSETAVLVREILCTL
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AIFLTKDNTVIVQGITGSEAAVHTARMLKAGTQIVGGVNARKAGTNVTHEDKHGRIITL
EEEEECCCEEEEEECCCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCEEEEE
PVFGTVAEAIENTGADVSIIFVPPRFAKEAIIEAVEAEIPLLVIITEGIPVQDSVYAWAY
ECHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEE
NLNKGTKTRIIGPNCPGIITPGQSLVGITPATITGAGPIGLVSKSGTLTYQMMFELSDFG
ECCCCCEEEEECCCCCEEECCCCCEEEECCCEEECCCCEEEEECCCCEEEEEEEEHHCCC
FSTAIGIGGDPVIGTTHIDAIEAFEQDPDTKIIVMIGEIGGDAEERAADYIKANVSKPVV
CEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAVKKDALEAAGVKVGKTPSETAVLVREILCTL
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]