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The map label for this gene is 221229442

Identifier: 221229442

GI number: 221229442

Start: 179283

End: 179915

Strand: Direct

Name: 221229442

Synonym: MLBr_00133

Alternate gene names: NA

Gene position: 179283-179915 (Clockwise)

Preceding gene: 221229441

Following gene: 221229443

Centisome position: 5.49

GC content: 46.13

Gene sequence:

>633_bases
ATGACCAATCGTACTCTGTCTAGGGAAGAAATCCGAAAGCTCGATCGCGACCTTCGGATACTTGTCGCAACGAATGGTAC
CCTCACGCGGGTTCTCAACGTGGTTGCTAACGAAGAGATCGTCGTCGATATTATCAATCAACAACTTCTCGATGTAGCCC
CGAAAATACCTGAATTAGAGAACTTGAAAATTGGTCGGATTCTTCAGCGTGACATCTTGCTTAAGGGCCAGAAATCAGGA
ATACTGTTTGTTGCTGCGGAATCATTGATTGTCATTGATTTATTGCCCACCGCAATTACCACGTACTTGACGAAGACCCA
TCATCCTATCGGCGAGATTATGGCAGCGAGCCGTATCGAGACTTATAAGGAGGACGCTCAGGTCTGGATAGGGGATTTAC
CGTGTTGGCTCGCAGACTACGGATATTGGGATTTACCAAAAAGAGCTGTTGGTCGCCGATACAGGATCATAGCTGGAGGT
CAACCGGTTATTATTACCACCGAGTATTTTCTTCGAAGTGTATTCCAAGACACTCCGCGTGAAGAACTCGATCGTTGCCA
GTATTCAAATGACATTGACACCAGGAGTGGAGATCGCTTTGTCCTTCATGGTCGAGTCTTTAAAAATCTCTAG

Upstream 100 bases:

>100_bases
GCCTGTGTCGAGCGTTATCTAAACCACGAATTCAACCGTCTAGACGCTACGGCATGAATGCCCACGTATGTGGGTTGTCC
ACTTTACCCCGGGATGAGCA

Downstream 100 bases:

>100_bases
TGCTAACAATGTCAGATTGCAGTCCTCGAGTCTGTGGAATGAAATTGCCTTGTGTGTAGTGTCACCAAATAGATATTTGT
TCGTTCGACAAGCCAGAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: 4-HB synthase; p-hydroxybenzoic acid synthase

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTNRTLSREEIRKLDRDLRILVATNGTLTRVLNVVANEEIVVDIINQQLLDVAPKIPELENLKIGRILQRDILLKGQKSG
ILFVAAESLIVIDLLPTAITTYLTKTHHPIGEIMAASRIETYKEDAQVWIGDLPCWLADYGYWDLPKRAVGRRYRIIAGG
QPVIITTEYFLRSVFQDTPREELDRCQYSNDIDTRSGDRFVLHGRVFKNL

Sequences:

>Translated_210_residues
MTNRTLSREEIRKLDRDLRILVATNGTLTRVLNVVANEEIVVDIINQQLLDVAPKIPELENLKIGRILQRDILLKGQKSG
ILFVAAESLIVIDLLPTAITTYLTKTHHPIGEIMAASRIETYKEDAQVWIGDLPCWLADYGYWDLPKRAVGRRYRIIAGG
QPVIITTEYFLRSVFQDTPREELDRCQYSNDIDTRSGDRFVLHGRVFKNL
>Mature_209_residues
TNRTLSREEIRKLDRDLRILVATNGTLTRVLNVVANEEIVVDIINQQLLDVAPKIPELENLKIGRILQRDILLKGQKSGI
LFVAAESLIVIDLLPTAITTYLTKTHHPIGEIMAASRIETYKEDAQVWIGDLPCWLADYGYWDLPKRAVGRRYRIIAGGQ
PVIITTEYFLRSVFQDTPREELDRCQYSNDIDTRSGDRFVLHGRVFKNL

Specific function: Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p-hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobact

COG id: COG3161

COG function: function code H; 4-hydroxybenzoate synthetase (chorismate lyase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate--pyruvate lyase type 2 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHBS_MYCLE (Q9CD83)

Other databases:

- EMBL:   AL583917
- PIR:   E86925
- RefSeq:   NP_301227.1
- ProteinModelPortal:   Q9CD83
- SMR:   Q9CD83
- EnsemblBacteria:   EBMYCT00000028485
- GeneID:   908439
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0133
- NMPDR:   fig|272631.1.peg.99
- Leproma:   ML0133
- GeneTree:   EBGT00050000018489
- HOGENOM:   HBG569014
- OMA:   LETHRPI
- ProtClustDB:   CLSK792184
- BioCyc:   MLEP272631:ML0133-MONOMER
- InterPro:   IPR002800

Pfam domain/function: PF01947 DUF98

EC number: NA

Molecular weight: Translated: 24045; Mature: 23914

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRTLSREEIRKLDRDLRILVATNGTLTRVLNVVANEEIVVDIINQQLLDVAPKIPELE
CCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
NLKIGRILQRDILLKGQKSGILFVAAESLIVIDLLPTAITTYLTKTHHPIGEIMAASRIE
CCHHHHHHHHHHHCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TYKEDAQVWIGDLPCWLADYGYWDLPKRAVGRRYRIIAGGQPVIITTEYFLRSVFQDTPR
HHHHHHHEEECCCCHHHHCCCCCCCCHHHHCCEEEEEECCCCEEEEHHHHHHHHHCCCCH
EELDRCQYSNDIDTRSGDRFVLHGRVFKNL
HHHHHHHCCCCCCCCCCCEEEEECHHHHCC
>Mature Secondary Structure 
TNRTLSREEIRKLDRDLRILVATNGTLTRVLNVVANEEIVVDIINQQLLDVAPKIPELE
CCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
NLKIGRILQRDILLKGQKSGILFVAAESLIVIDLLPTAITTYLTKTHHPIGEIMAASRIE
CCHHHHHHHHHHHCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TYKEDAQVWIGDLPCWLADYGYWDLPKRAVGRRYRIIAGGQPVIITTEYFLRSVFQDTPR
HHHHHHHEEECCCCHHHHCCCCCCCCHHHHCCEEEEEECCCCEEEEHHHHHHHHHCCCCH
EELDRCQYSNDIDTRSGDRFVLHGRVFKNL
HHHHHHHCCCCCCCCCCCEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002