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The map label for this gene is accD4 [H]

Identifier: 221229415

GI number: 221229415

Start: 131896

End: 133449

Strand: Direct

Name: accD4 [H]

Synonym: MLBr_00102

Alternate gene names: 221229415

Gene position: 131896-133449 (Clockwise)

Preceding gene: 221229414

Following gene: 221229428

Centisome position: 4.04

GC content: 59.2

Gene sequence:

>1554_bases
ATGATTATGAAGAGTACAGCCGAGAAGCTGGCTGAGCTTCGCGTTCGGCTGGAGTTGGCCAACGAGCCCGGAGGTGAAAA
GGCCGCCGCCAAGCGCGACAAGAAGAATATCCCAAGTGCCCGTGCCCGCATCTACGCGTTGGTCGATCCGGGCACGTTTC
TTGAGATCGGCGCGCTGACGCGCACTCCGGGTGATCCCAACGCGCTCTACGGCGATGGTGTTGTCACCGGACACGGCCTC
ATTAACGGCCGGCAGGTCGGGGTGTTCTCGCACGACCAGACGGTGTTCGGTGGCACGGTCGGTGAGATGTTCGGCCGCAA
AGTGGCCCGGCTCATGGAGTGGTGCGCGATGGCTGGATGCCCGATTGTCGGCATTAACGACTCTGGTGGTGCACGCATCC
AAGATGCGGTGACCTCGTTGGCATGGTACGCCGAGTTGGGTCGCCGACACGAGCTACTGAGTGGAATTGTGCCGCAGATC
TCTATTGTTTTGGGAAAATGCGCTGGGGGAGCGGTGTATTCGCCGATCCAGACTGACTTGGTGGTTGCGGTGCGTGGCCA
GGGTTACATGTTTGTCACCGGCCCTGACGTCATCAAGGACGTGACCGGAGAAGAGGTGAGCTTAGATGAGCTGGGCGGCG
TCGACTCCCAGGCTAAGTACGGCAACATCCACCAGGTGGTGGAGTCTGAGGCGGCCGCATTCGGTTACGTGCGGGATTTC
CTGTCATTTCTGCCGCCCAACTGCTTCGACAAAGCGCCGATCGTGAACCCTGGCCTGGAGCCTGAGATCATGGCACATGA
CCTCGAGTTAGACTCAATCGTGCCGGATTCAGACAATACGGCATATGACATGCGTGAGGTTCTGCTACGGATTTTCGATG
ATGGCCATTTCCTGGACGTCGCCGCACAAGCCGGACAGGCCATCATCACCGGCTATGCCCGTGTTGACGGCCGCACTGTG
GGTGTGGTGGCTAACCAGCCTATGCACCTGTCTGGGGCGATTGACAATGAAGCCTCCGACAAGGCTGCGCGGTTTATCCG
GTTCTGTGACGCTTTCAATATCCCGTTGGTTTTCGTGGTAGACACGCCTGGGTTCTTGCCGGGGGTAGAGCAGGAGAAAA
ACGGTATTATCAAGCGCGGCGGTCGGTTCCTTTATGCGGTAGTGGAGGCCGATGTACCGAAGGTGACGATCACGATTCGC
AAGTCTTATGGCGGCGCGTACGCGGTGATGGGATCCAAGCAGCTGGCCGCCGACCTGAACTTTGCCTGGCCGACCGCGCG
CATCGCCGTGATCGGCGCTGACGGTGCCGCGCAGCTCTTAATGAAACGCTTCCCAGATCCGAGTTCGCCGGACGTCCAGG
CGATCCGCAAGACCTTCGTTGACAATTACAATCTCAACATGGCGATCCCGTGGATTGCTGCCGAGCGCGGGTTCATCGAC
GCTGTGGTTGAGCCGCACCAAACCAGGCTGTTGCTGCGCAAGTCATTACATCTGTTGCGCGACAAGCAGCAGTGGTGGCG
GGTGGGACGTAAGCACGGACTCATCCCGTTATAG

Upstream 100 bases:

>100_bases
GCGAGCACATCCAGGCCATCGACGAACCGATCATCGCTAAGGTGGGCGAACATATGAGCCAGGCGTTGAACAAGATTGAG
GCTGAGCAGAAGGCGCCCAA

Downstream 100 bases:

>100_bases
GGCGATTTTTGCTGGAGGGCACAAGGCCTGTCGGCTTTCAATAAAGTGCTATCGTATGCGCTATTTTTTCAAACGCACAT
TGGTGTATGTTTCGTGGCTT

Product: putative acyl CoA carboxylase beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSARARIYALVDPGTFLEIGALTRTPGDPNALYGDGVVTGHGL
INGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGIVPQI
SIVLGKCAGGAVYSPIQTDLVVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEAAAFGYVRDF
LSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTAYDMREVLLRIFDDGHFLDVAAQAGQAIITGYARVDGRTV
GVVANQPMHLSGAIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIR
KSYGGAYAVMGSKQLAADLNFAWPTARIAVIGADGAAQLLMKRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFID
AVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL

Sequences:

>Translated_517_residues
MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSARARIYALVDPGTFLEIGALTRTPGDPNALYGDGVVTGHGL
INGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGIVPQI
SIVLGKCAGGAVYSPIQTDLVVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEAAAFGYVRDF
LSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTAYDMREVLLRIFDDGHFLDVAAQAGQAIITGYARVDGRTV
GVVANQPMHLSGAIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIR
KSYGGAYAVMGSKQLAADLNFAWPTARIAVIGADGAAQLLMKRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFID
AVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL
>Mature_517_residues
MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSARARIYALVDPGTFLEIGALTRTPGDPNALYGDGVVTGHGL
INGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGIVPQI
SIVLGKCAGGAVYSPIQTDLVVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEAAAFGYVRDF
LSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTAYDMREVLLRIFDDGHFLDVAAQAGQAIITGYARVDGRTV
GVVANQPMHLSGAIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIR
KSYGGAYAVMGSKQLAADLNFAWPTARIAVIGADGAAQLLMKRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFID
AVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=510, Percent_Identity=43.7254901960784, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=42.0754716981132, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI11545863, Length=507, Percent_Identity=31.5581854043393, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147362, Length=519, Percent_Identity=41.6184971098266, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI25147359, Length=519, Percent_Identity=41.6184971098266, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17552936, Length=503, Percent_Identity=30.0198807157058, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24586065, Length=507, Percent_Identity=30.7692307692308, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56021; Mature: 56021

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSARARIYALVDPGTFLEIGALT
CCCCHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCEE
RTPGDPNALYGDGVVTGHGLINGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGC
CCCCCCCCEECCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCC
PIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGIVPQISIVLGKCAGGAVYSPIQTDL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEAAAFGYVRDF
EEEEECCCEEEEECHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTAYDMREVLLRIFDDGHFLDV
HHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEH
AAQAGQAIITGYARVDGRTVGVVANQPMHLSGAIDNEASDKAARFIRFCDAFNIPLVFVV
HHHCCCEEEEEEEEECCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEE
DTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLAADLN
CCCCCCCCCCHHHCCHHHCCCEEEEEEEECCCCEEEEEEEECCCCEEEEECCHHHHCCCC
FAWPTARIAVIGADGAAQLLMKRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFID
CCCCCEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
AVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSARARIYALVDPGTFLEIGALT
CCCCHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCEE
RTPGDPNALYGDGVVTGHGLINGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGC
CCCCCCCCEECCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCC
PIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGIVPQISIVLGKCAGGAVYSPIQTDL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEAAAFGYVRDF
EEEEECCCEEEEECHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTAYDMREVLLRIFDDGHFLDV
HHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEH
AAQAGQAIITGYARVDGRTVGVVANQPMHLSGAIDNEASDKAARFIRFCDAFNIPLVFVV
HHHCCCEEEEEEEEECCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEE
DTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLAADLN
CCCCCCCCCCHHHCCHHHCCCEEEEEEEECCCCEEEEEEEECCCCEEEEECCHHHHCCCC
FAWPTARIAVIGADGAAQLLMKRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFID
CCCCCEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
AVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]