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The map label for this gene is ethA [H]

Identifier: 221229388

GI number: 221229388

Start: 86708

End: 88192

Strand: Direct

Name: ethA [H]

Synonym: MLBr_00065

Alternate gene names: 221229388

Gene position: 86708-88192 (Clockwise)

Preceding gene: 221229386

Following gene: 221229396

Centisome position: 2.65

GC content: 54.48

Gene sequence:

>1485_bases
ATGGTTGTTATGGCTGAGACCGAGTACCTGGATGTTGTCATCGTGGGCGCCGGTATCTCCGGCGTGAGCGCAGCCTGGCA
CCTGCAGGATCGTTGTCCGAACAAGAGCTATGTTATCCTGGAAAAGCGGGCCGGCATGGGTGGCACCTGGGATTTGTTTC
GGTACCCTGGCATTCGTTCGGACTCCGATATGTACACGCTGGGTTTTCGATTTCGTCCATGGACCAAGTGTCAAGCAATT
GCCGATGGTAAGCCCATCCTCGAATACATTAAGAGCACCGCCGTCATGCATGGCATCGACAAGTACATCCGGCTTAACCA
CAAAGTCACCGGCGCCGACTGGTCGAGTATAGAAAATCGCTGGACCGTGCAGGTTGAAAACAACGGCACACCCCGCATGA
TCTCTTGCTCATTTTTGTTTTTGTGCAGCGGCTACTATAACTATGAGCAGGGCTATGCGCCGACCTTCCTTGGCTCGGAG
GATTTCACCGGTCCGATTATTCATCCGCAGCACTGGCCAGAGGATCTCGATTACGCCGCTAAGAACATCGTCGTGATAGG
TAGTGGCGCCACTGCAGTCACTTTGGTTCCGGCGCTTGCGAATTCGGGTGCCAAGCACGTCACGATGTTGCAGCGCTCCC
CCACCTACATTGTTTCTCAGCCGGCCAAGGACAAAATTGCCGCCAGGCTCAATCGGTGGCTACCCGACAAGTATGCGTAC
ACCGCTGTCCGCTGGAAGAATATCCTGCGGCAATCGGCTCTGTACGGAGCCTGTCAGAAGTGGCCGCAGCGGATGCGAAA
CATTCTGTTGGGCCACGTGGCACGCCGACTTCCCAAGGGCTATGATGTGCAAAAACACTTCGGTCCGCATTATAACCCGT
GGGAGCAACGGCTGTGTCTGGTACCGGACGGTGACTTGTTCCGAGCTATTCGCAAGGGTACAGTGGATATGGTCACGGAT
GCCATTGACCGGTTTACCTCGACCGGCATCCGGCTCAAGTCGGGGAATGAGTTGCGAGCCGACATTATCGTCACTGCCAC
CGGATTGAACCTGCAACTGTTTGGTGGTGCTGTCGCAACTGTTGATGGACAGCCGGTGGATCTCGCTCAGACGATGTCGT
ACAAGGGCATGATGCTGTCTGGCCTACCCAATATGATATATACTGTAGGATACACTAATGCGTCGTGGACATTGAAGGCA
GACCTGGTATCAGAATTCTTCTGTCGGTTGCTAAATTATATGAACGCCAACGATTTTGATACTGTGGCAGTGGAGTATCC
GGGTTCCGACGTCGAAGAGCGGCCGTTCATGGATTTCACCCCCGGTTATGTGCTGCGCTCACTCGACGCGTTACCCAAGC
AGGGTTCCCGCACGCCATGGCGATTAAACCAGAACTACCTGCGCGACATCCGGTTGATCCGCCGCGGCAAGGTCGCTGAT
GAAGGTCTCCTTTTTGCCAAAAAGACTACTCCCGTTACGGTTTAG

Upstream 100 bases:

>100_bases
TGCGAAGTTTGTCCGGCAGTGGAATTTATCACGATAGGTAGCTTACCCCACGTCGAGAATTTCAACGCAACGTTGACGAC
TTCGACACAGCGTTGATATT

Downstream 100 bases:

>100_bases
GGCGATAGCGAGTACGGTGGGAGCGGGTTAAGCGGGCTGCCAGCATTCAGCCGTAGTAGCTGAGCCGGGGGTCACTACAA
TTAGACGACGACAATGCCGT

Product: putative monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAI
ADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSE
DFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAY
TAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTD
AIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKA
DLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVAD
EGLLFAKKTTPVTV

Sequences:

>Translated_494_residues
MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAI
ADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSE
DFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAY
TAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTD
AIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKA
DLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVAD
EGLLFAKKTTPVTV
>Mature_494_residues
MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAI
ADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSE
DFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAY
TAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTD
AIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKA
DLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVAD
EGLLFAKKTTPVTV

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17555726, Length=393, Percent_Identity=22.64631043257, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55543; Mature: 55543

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRS
CEEEEECCEEEEEEEECCCCCCCEEEEHHHCCCCCCEEEEEECCCCCCCCHHHCCCCCCC
DSDMYTLGFRFRPWTKCQAIADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENR
CCCEEEEEEEECCCHHHHEECCCHHHHHHHHHHHHHHHHHHHHEECCEECCCCHHCCCCE
WTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAA
EEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAY
CCEEEEECCCCEEEEEHHHHCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCCCCHHHH
TAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHCEEEE
VPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVAT
CCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEECCEEEEECCEEEE
VDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDFD
ECCCCCCHHHHHCCCCEEECCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCC
TVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVAD
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHCCCCCC
EGLLFAKKTTPVTV
CCEEEEECCCCCCC
>Mature Secondary Structure
MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRS
CEEEEECCEEEEEEEECCCCCCCEEEEHHHCCCCCCEEEEEECCCCCCCCHHHCCCCCCC
DSDMYTLGFRFRPWTKCQAIADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENR
CCCEEEEEEEECCCHHHHEECCCHHHHHHHHHHHHHHHHHHHHEECCEECCCCHHCCCCE
WTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAA
EEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAY
CCEEEEECCCCEEEEEHHHHCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCCCCHHHH
TAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHCEEEE
VPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVAT
CCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEECCEEEEECCEEEE
VDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDFD
ECCCCCCHHHHHCCCCEEECCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCC
TVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVAD
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHCCCCCC
EGLLFAKKTTPVTV
CCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]