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The map label for this gene is eccCb1 [H]

Identifier: 221229380

GI number: 221229380

Start: 63315

End: 65108

Strand: Reverse

Name: eccCb1 [H]

Synonym: MLBr_00052

Alternate gene names: 221229380

Gene position: 65108-63315 (Counterclockwise)

Preceding gene: 221229381

Following gene: 221229379

Centisome position: 1.99

GC content: 59.48

Gene sequence:

>1794_bases
ATGACTGCCGAACCGGAAGTACGCGCGCTTCGCGAGGTAGTACTCGAGCAACTCGGCACCGGTGAATCCCTTGCATACAA
GATGTGGTTGCCACCGCTGCTCGATCCGTTACCACTGAATGAACTCATAGAGCGTGACAGCAACAGACATCCGCTGCACT
TTGCGTTGGGCATCATGGATGAGCCGCGGCGGCACCGCCAGGACATCTGGGGCGTTGATCTTTCCGGGGCGGGCGGCAAC
ATTGGCATCGGGGGCGCGCCGCAAACCGGGAAGACAACCCTTCTGCAGACCATGGTGATGTCAGCGGCTGCCACGCACTC
ACCGCGGGACGTCCAGTTCTACTGCATCGATCTCGGTGGTGGCGGGCTGATCTACCTGGAAAACCTGCCGCACGTCGGCG
GGGTAGCGAACCGATCAGAGCCCGACCGAATTAACCGAGTGATCGCCGAGGCGCAAGCCGTTATGCGTCAACGAGAAATC
ACCTTCAAAGAAAACCGGGTCGGCTCGATGGCAGCGTATCGGCAACTGCGCACGAACCGCAGCCATCCCGTCGCGGCCGA
CCCGTTCGGCGATGTATTTCTAATCATCGACGGTTGGTCAGCATTTACCAGTGAGTTTCCCGACCTCGAAGCGGCGGTCC
AGGATCTAGCCGCACAGGGGCTTTCGTTCGGCGTCCACACGGTGATCACCACACCACGCTGGACAGAACTGCGGTCGCGC
GTTCGTGACTACTTGGGCACCAAGATCGAATTCCGACTCGGCGACGTCAACGACACTCAGATCGACCGCATTGCTCGGGA
TATCCCGGCAAATCGTCCGGGCCGAGCCATTTCGGTTGAGAAGCACCACCTGATGATGGGGGTGCCTAGGTTCGACGGCG
CGCACAGCGCCGACGACCTGGTGGACGCGATGACAGCCGGGGTGGCGCAAATCGCAGCTAAAACCACTGAACAAGCACCC
AGGGTTCGGGTTCTGCCGTCGCAAGTATACCTGCAAGAGATCGACCCGAACCCGCCCGGACCGGATTCCGACTACCGCAC
CCGCTGGACGATTCCTGTCGGAGTACGCGAAACCGATCTGTCGGTGGCCTACGCTCACATGAGTTCGAATCCGCACTTAC
TGATCTTCGGGAACTCCAAATCGGGTAAGACACGCATCGTGCATGCGATCGCGCGAGCCATCTGTGCTCGGAACAGTCCG
AAACAAGTGCGGTTCATGCTCGCCGACTACAGGTCGAGTTTGCTGGACGCAGTACCGGACAGCCACCTACTCGACGCGGG
TGCGATCAACCGCAACAGTGCAAGCTTGGACGAGGCCATCCGAGCCCTGACGACTAACCTGAAGAAAAGGTTGCCACCGG
CTGACCTGACAACCGCACAGGTGCGGTCGCGATCGTGGTGGAGCGGATTTGATGTGGTGCTGCTAGTCGACGATTGGCAC
ATGATCGTCAGCGCGGCCGGCAGTGCACCGCCCATGGGCCCACTCGCCCCGTTATTGCCAGCGGCTCCGGATATCGGGTT
GCATATTCTTGTCACCTGTTTGATGAGCCAGGCATACAAAGCAACTATGGACAAGTTCGTCGGCAGTGCATTCGGGGCGG
GAGCTCCGACCATCTTCCTTTCTGGTGACAAGCAGGAATTCCCCTCCTCCGAGATCAAGGTCAAGCGACGGCCTCCTGGC
CAGGCATTTATGGTCTCACCGGAGGCCAAAGAGGTTATCCAGGCGGTCTACGTCGATCCTCCAGAAGTCGATCCTCCAAA
AGAAGTGTTCGCAGTACCACCAGCAAGCAGTTAA

Upstream 100 bases:

>100_bases
ATCCTCGAATCGACGACAACGTCATGATCCACGCTAGCTACGATGCAGTGGGGCACCACCTGTTTGCGGTAGGCGAAGCG
ATGGGGGAGTAACGGCGCCA

Downstream 100 bases:

>100_bases
GATAATTTCATTACCCAACGGAGGAAACTGGCCACCGACAACCACACCAAAACGGGGACACGGCGAACTATTGGACTGTT
TTTTCGGGGAGATACATTCC

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component Cb1; Type VII secretion system protein EccCb1; T7SS protein EccCb1 [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MTAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIERDSNRHPLHFALGIMDEPRRHRQDIWGVDLSGAGGN
IGIGGAPQTGKTTLLQTMVMSAAATHSPRDVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREI
TFKENRVGSMAAYRQLRTNRSHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLSFGVHTVITTPRWTELRSR
VRDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEKHHLMMGVPRFDGAHSADDLVDAMTAGVAQIAAKTTEQAP
RVRVLPSQVYLQEIDPNPPGPDSDYRTRWTIPVGVRETDLSVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNSP
KQVRFMLADYRSSLLDAVPDSHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTTAQVRSRSWWSGFDVVLLVDDWH
MIVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQAYKATMDKFVGSAFGAGAPTIFLSGDKQEFPSSEIKVKRRPPG
QAFMVSPEAKEVIQAVYVDPPEVDPPKEVFAVPPASS

Sequences:

>Translated_597_residues
MTAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIERDSNRHPLHFALGIMDEPRRHRQDIWGVDLSGAGGN
IGIGGAPQTGKTTLLQTMVMSAAATHSPRDVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREI
TFKENRVGSMAAYRQLRTNRSHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLSFGVHTVITTPRWTELRSR
VRDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEKHHLMMGVPRFDGAHSADDLVDAMTAGVAQIAAKTTEQAP
RVRVLPSQVYLQEIDPNPPGPDSDYRTRWTIPVGVRETDLSVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNSP
KQVRFMLADYRSSLLDAVPDSHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTTAQVRSRSWWSGFDVVLLVDDWH
MIVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQAYKATMDKFVGSAFGAGAPTIFLSGDKQEFPSSEIKVKRRPPG
QAFMVSPEAKEVIQAVYVDPPEVDPPKEVFAVPPASS
>Mature_596_residues
TAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIERDSNRHPLHFALGIMDEPRRHRQDIWGVDLSGAGGNI
GIGGAPQTGKTTLLQTMVMSAAATHSPRDVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREIT
FKENRVGSMAAYRQLRTNRSHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLSFGVHTVITTPRWTELRSRV
RDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEKHHLMMGVPRFDGAHSADDLVDAMTAGVAQIAAKTTEQAPR
VRVLPSQVYLQEIDPNPPGPDSDYRTRWTIPVGVRETDLSVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNSPK
QVRFMLADYRSSLLDAVPDSHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTTAQVRSRSWWSGFDVVLLVDDWHM
IVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQAYKATMDKFVGSAFGAGAPTIFLSGDKQEFPSSEIKVKRRPPGQ
AFMVSPEAKEVIQAVYVDPPEVDPPKEVFAVPPASS

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). May link the cytosolic components of the system with the membrane components. Responsible for multiple suppressive effects on macrophages and req

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 FtsK domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002543 [H]

Pfam domain/function: PF01580 FtsK_SpoIIIE [H]

EC number: NA

Molecular weight: Translated: 65180; Mature: 65049

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIERDSNRHPLHFALGIMD
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEECCCC
EPRRHRQDIWGVDLSGAGGNIGIGGAPQTGKTTLLQTMVMSAAATHSPRDVQFYCIDLGG
CCHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREITFKENRVGSMAAYRQLRTNR
CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHCCC
SHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLSFGVHTVITTPRWTELRSR
CCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
VRDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEKHHLMMGVPRFDGAHSADDL
HHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCCCCCCCHHHH
VDAMTAGVAQIAAKTTEQAPRVRVLPSQVYLQEIDPNPPGPDSDYRTRWTIPVGVRETDL
HHHHHHHHHHHHHHHHHCCCCEEECCHHHHHEECCCCCCCCCCCCCEEEEEECCCEECCC
SVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNSPKQVRFMLADYRSSLLDAVPD
EEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
SHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTTAQVRSRSWWSGFDVVLLVDDWH
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCHH
MIVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQAYKATMDKFVGSAFGAGAPTIFL
EEHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
SGDKQEFPSSEIKVKRRPPGQAFMVSPEAKEVIQAVYVDPPEVDPPKEVFAVPPASS
CCCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHCCCCCCCCCCHHEEECCCCCC
>Mature Secondary Structure 
TAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIERDSNRHPLHFALGIMD
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEECCCC
EPRRHRQDIWGVDLSGAGGNIGIGGAPQTGKTTLLQTMVMSAAATHSPRDVQFYCIDLGG
CCHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREITFKENRVGSMAAYRQLRTNR
CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHCCC
SHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLSFGVHTVITTPRWTELRSR
CCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
VRDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEKHHLMMGVPRFDGAHSADDL
HHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCCCCCCCHHHH
VDAMTAGVAQIAAKTTEQAPRVRVLPSQVYLQEIDPNPPGPDSDYRTRWTIPVGVRETDL
HHHHHHHHHHHHHHHHHCCCCEEECCHHHHHEECCCCCCCCCCCCCEEEEEECCCEECCC
SVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNSPKQVRFMLADYRSSLLDAVPD
EEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
SHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTTAQVRSRSWWSGFDVVLLVDDWH
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCHH
MIVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQAYKATMDKFVGSAFGAGAPTIFL
EEHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
SGDKQEFPSSEIKVKRRPPGQAFMVSPEAKEVIQAVYVDPPEVDPPKEVFAVPPASS
CCCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHCCCCCCCCCCHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]