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The map label for this gene is eccCa1 [H]

Identifier: 221229381

GI number: 221229381

Start: 65182

End: 67416

Strand: Reverse

Name: eccCa1 [H]

Synonym: MLBr_00053

Alternate gene names: 221229381

Gene position: 67416-65182 (Counterclockwise)

Preceding gene: 221229382

Following gene: 221229380

Centisome position: 2.06

GC content: 59.46

Gene sequence:

>2235_bases
ATGACGACGAAAAAGTTCACCCCGACTATCACCCGCGGACCGCGATTGACACCGGGCGAGATCAACATCACGCCGCCCGA
TGACCTCGGTCTTGAGATCCCACCATCGGGTATACAGAAGATTCTTCCCTATGTGATGGTCGGTTGCATAGTCGGCATGA
TCGCGATCATGGTGCTTGGCGGCACCAAGCAACTCTCGCCGTACATGCTGATGATGCCAATCATGATGGTCATGATGATG
GCCGGCGGCAGTGGTGGGGGGGGTGGTGGTAAAAAGGTTCCTGAGATCAACGCCGACCGTAAGGAATACTTGCGCTATCT
GGCCGGACTACGCGCTCGGGTGACATCCTCGGCCGCTTCGCAGGTGGCGTTCTTCAGTTATCACGCGCCCCACCCCCAAG
ATCTGCTGTCGATCGTAGGCACACAGCGGCAGTGGTCCCGGCCAGCGAACGCCGACTTCTACGCAGCTACCCGCATCGGT
GTCGGCGACCAACCCGCTGTGGATCGATTGCTGAAACCAGCCGTCGGCGGGGAACTGACAGCGAGCGGTGCAGCGCCTCA
GCCGTTCCTGGAACCGGTCAGCCACATGTGGGTAGTCAAATTTTTGCGGACCCACGGGCTGGTGCACGACTGCCCGAAAC
TGCTGCAAATGCGTACATTTCCGACAATCGCTGTCGGCGGAGACACGGCTGGGGCGGGCGGATTACTGACCGCGATGATC
TGTCACCTGGCCGTGTTCCATCCGCCGGACCTGCTGCAAATTCGGGTTCTCACCGAGAAACCCGACGATCCCAACTGGTC
CTGGCTGAAATGGCTGCCGCACATTCAGCACCCGACGGAAACCGACGCCGCCGGGGCGGCCCGAATGATCTTCACCCGCA
GTGACAGTCTGGCCGATCTGATGTCGCGCGGTCCGCATGCACCCGATTCGCTGCCCGGTGGCCCCTACGTCATCCTCGTG
GATCTGACCGGTGGCAAGGCGGGTTTCCCGCCCGACGGCAGAGCTGGTGTCACAGTGATCACGCTCGGCAATCACCGCAG
CTCGACCTACCGCATTAGAGTCAACAAGAACGGGACCGCCGACGACCGATTGCCTGGCCAAAGTTTCCGTCAAGTGACTT
CGACCGTCGACCACCTCTCTAAGGCAGAAGCCACCCGTATCGCTCGGAAGTTAGCCGGATGGTCGATCACCGGCACCATC
CTCGATAAAACGTCGCGCGTACAGAAGAAAGTGGCGACCGAATGGCACCAGCTAGTTGGTGCCAACACTGTCGAAGAGGT
GCTACCGAGCCGCTGGCGGATGTATACCGACAATGACCGGGACCGCCTCAAGATCCCTTTTGGGCACGAATTCAAGACCG
GCAATATCATGTACCTGGATATCAAGGAAGGCGCCGAGTTCGGCGGCGGACCGCACGGCATGCTGATCGGGACCACGGGA
TCAGGAAAATCTGAATTCCTTCGTACCCTGATCTTGTCATTGGTCGCAATGACACACCCGAACCAGGTGAACCTCTTGCT
TACCGACTTCAAAGGCGGTTCTACATTCCTGGGAATGGAGAAGCTTCCACACACCGCTGCTGTCGTCACAAACATGGCCG
AGGAAGCCGAACTGGTAAGCCGAATGGGTGAAGTGTTGACCGGCGAACTTGACCGACGCCAGAACATCCTTCGACAAGCC
GGCACCCTAGTCGGCGCGGCTGGCGCGCTCTCCGGGGTGGCCGAATACGAGAAGTACCGGGAGCGAGGCGCCAACCTAGC
ACCGCTACCAACACTTTTCGTCGTCGTAGACGAGTTCGCCGAGTTGCTGCAAAGTCACCCCGACTTCATCGGACTGTTCG
ACCGGATTTGCCGCGTCGGGAGGTCACTACGCGTGCATCTGTTGCTGGCCACCCAGTCGCTGCAAACTGGCGGGGTGCGC
ATCGACAAACTAGAACCCAACCTGACCTACCGCATCGCGCTGCGCACCACCAGCTCGGCAGAGTCCAAGGCGGTGATCGG
AACCCCAGAAGCGCAGTACATCACCAACAAGGAAAGCGGCGTCGGATTTCTCCGGATTGGCATGGAGGACCCCGTCAAGT
TCAGTTCCCTGTACACCGGTATCCCCTTCGTTCCGGCGATCGCAACGGAAACCAACGGTGACAGTAGTCCGTCCAGTCCG
TGGGCTAGCCGGAAAAAGGTGCATATCTACGAATTCACCGCCGCTCCAATCCTCGAATCGACGACAACGTCATGA

Upstream 100 bases:

>100_bases
GGCCTGTGCTCTCCAGAGACGCAGCTCTGTTAGAGCACGATACGCTGATCGCGGACCCAAGCCCACGGAAAGTACCAGCC
GGCTACTCTGGAGTGAGGCC

Downstream 100 bases:

>100_bases
TCCACGCTAGCTACGATGCAGTGGGGCACCACCTGTTTGCGGTAGGCGAAGCGATGGGGGAGTAACGGCGCCAATGACTG
CCGAACCGGAAGTACGCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component Ca1; Type VII secretion system protein eccCa1; T7SS protein eccCa1 [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MTTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCIVGMIAIMVLGGTKQLSPYMLMMPIMMVMMM
AGGSGGGGGGKKVPEINADRKEYLRYLAGLRARVTSSAASQVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIG
VGDQPAVDRLLKPAVGGELTASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMI
CHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMIFTRSDSLADLMSRGPHAPDSLPGGPYVILV
DLTGGKAGFPPDGRAGVTVITLGNHRSSTYRIRVNKNGTADDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGTI
LDKTSRVQKKVATEWHQLVGANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIGTTG
SGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQNILRQA
GTLVGAAGALSGVAEYEKYRERGANLAPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVR
IDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKFSSLYTGIPFVPAIATETNGDSSPSSP
WASRKKVHIYEFTAAPILESTTTS

Sequences:

>Translated_744_residues
MTTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCIVGMIAIMVLGGTKQLSPYMLMMPIMMVMMM
AGGSGGGGGGKKVPEINADRKEYLRYLAGLRARVTSSAASQVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIG
VGDQPAVDRLLKPAVGGELTASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMI
CHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMIFTRSDSLADLMSRGPHAPDSLPGGPYVILV
DLTGGKAGFPPDGRAGVTVITLGNHRSSTYRIRVNKNGTADDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGTI
LDKTSRVQKKVATEWHQLVGANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIGTTG
SGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQNILRQA
GTLVGAAGALSGVAEYEKYRERGANLAPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVR
IDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKFSSLYTGIPFVPAIATETNGDSSPSSP
WASRKKVHIYEFTAAPILESTTTS
>Mature_743_residues
TTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCIVGMIAIMVLGGTKQLSPYMLMMPIMMVMMMA
GGSGGGGGGKKVPEINADRKEYLRYLAGLRARVTSSAASQVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIGV
GDQPAVDRLLKPAVGGELTASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMIC
HLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMIFTRSDSLADLMSRGPHAPDSLPGGPYVILVD
LTGGKAGFPPDGRAGVTVITLGNHRSSTYRIRVNKNGTADDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGTIL
DKTSRVQKKVATEWHQLVGANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIGTTGS
GKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQNILRQAG
TLVGAAGALSGVAEYEKYRERGANLAPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRI
DKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKFSSLYTGIPFVPAIATETNGDSSPSSPW
ASRKKVHIYEFTAAPILESTTTS

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis [H]

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FtsK domain [H]

Homologues:

Organism=Escherichia coli, GI1787117, Length=219, Percent_Identity=27.8538812785388, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002543 [H]

Pfam domain/function: PF01580 FtsK_SpoIIIE [H]

EC number: NA

Molecular weight: Translated: 80596; Mature: 80465

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCIVGMIAIMVLG
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GTKQLSPYMLMMPIMMVMMMAGGSGGGGGGKKVPEINADRKEYLRYLAGLRARVTSSAAS
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIGVGDQPAVDRLLKPAVGGELT
HEEEEEECCCCHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEE
ASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
CHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMIFTRSDSLADL
HHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHH
MSRGPHAPDSLPGGPYVILVDLTGGKAGFPPDGRAGVTVITLGNHRSSTYRIRVNKNGTA
HHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCC
DDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGTILDKTSRVQKKVATEWHQLVG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHC
ANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIGTTG
CCHHHHHHHHHCEECCCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECC
SGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVS
CCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECHHHCCHHHHHHHHHHHHHHHHH
RMGEVLTGELDRRQNILRQAGTLVGAAGALSGVAEYEKYRERGANLAPLPTLFVVVDEFA
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTSSA
HHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEEEEEEECCCC
ESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKFSSLYTGIPFVPAIATETNGDSSPSSP
CCCEEECCCCHHEEECCCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCC
WASRKKVHIYEFTAAPILESTTTS
CCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCIVGMIAIMVLG
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GTKQLSPYMLMMPIMMVMMMAGGSGGGGGGKKVPEINADRKEYLRYLAGLRARVTSSAAS
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIGVGDQPAVDRLLKPAVGGELT
HEEEEEECCCCHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEE
ASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
CHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMIFTRSDSLADL
HHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHH
MSRGPHAPDSLPGGPYVILVDLTGGKAGFPPDGRAGVTVITLGNHRSSTYRIRVNKNGTA
HHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCC
DDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGTILDKTSRVQKKVATEWHQLVG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHC
ANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIGTTG
CCHHHHHHHHHCEECCCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECC
SGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVS
CCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECHHHCCHHHHHHHHHHHHHHHHH
RMGEVLTGELDRRQNILRQAGTLVGAAGALSGVAEYEKYRERGANLAPLPTLFVVVDEFA
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTSSA
HHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEEEEEEECCCC
ESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKFSSLYTGIPFVPAIATETNGDSSPSSP
CCCEEECCCCHHEEECCCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCC
WASRKKVHIYEFTAAPILESTTTS
CCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]