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The map label for this gene is ppiD [C]

Identifier: 220919567

GI number: 220919567

Start: 5002726

End: 5003790

Strand: Direct

Name: ppiD [C]

Synonym: A2cp1_4488

Alternate gene names: 220919567

Gene position: 5002726-5003790 (Clockwise)

Preceding gene: 220919566

Following gene: 220919568

Centisome position: 99.47

GC content: 70.89

Gene sequence:

>1065_bases
ATGCTGCGTCGCATCGTCCTCCTCGGCCTCGTCGCGCTGGCGGCCACCGCCTGCCAGCCCGGGTCGAAGGACTCGAAGAA
GTCCGGCCCCGCCGTCGCCACCGGCAACGGCTTCACCATCACCGCCGGCGAGCTGAAGGCGCGCCTCGACGAGCAGTCGC
CGTTCATCCGCGCCCGCTACTCCACGCTCGAGCGCAAGAAGGAGTTCCTCGACAACCTGATCCGGTTCGAGGTGCTGGCG
CGCGAGGCCGAGCGGCAGGGCCTGGCGAACGACCCCGACGTCCAGCTCACGCTGAAGAAGGTGATGGTCCAGAAGCTCGT
CCAGAAGAACTTCCAGGACGCGAACGGCGCCGCCGCCGAGGCGCTGCCGGAGGCCGACCTGCAGAAGTACTACGACGAGC
ACAAGGCCGAGTACTACCGGCCGCGCCGCGTGCGCCTCGCCGCCATCGTGTGGAACGCGCCCGCCGGCAGCCCCGAGCGC
GCCGCGAAGGTCGCGCTGGCGAAGAAGGCGCTCGCGAAGCTGAAGGCGGAGGAGAAGAAGAACACGCTCGCCTTCGCGCA
GCTCGTGAACGAGTTCTCCGAGGACGCGGTCAGCAAGGCCACCGCCGGCGACCTCGGCTTCAAGTCGCGCGAGGACCTCG
AGAAGGCGTACTCGAAGGAGTTCGCCGACGTCACCTTCAACCTGCAGCCCGGCGCGACCAGCGGCGTCCTCGAGACCGCG
AACGCCGTCTACCTGGTGAAGGGCACCGGCGAGCAGGACGAGCTGAACCGGACGTTCGAGCAGGTGAAGGCGCAGATCCA
GACCAAGCTCTATCGCGAGAAGAAGACCAAGGAGTTCGACGGGTGGCTGAAGAAGCTGCGCGACGACGCCAAGGTCAGCA
TCGACGAGAAGGCGCTCGAGGCGGTGGAGGTCTCGGCCGCCGCGCCGGCCGGCATGGGCGGCATGCCCGGCATGCCGGGG
ATGCCCGGCGGCCACGGCCCCATGGGCGCCGGCCCCCGCCCCATGGGCGCGCCCGCGCCCGCGCCGGCCGCCGCGCCGGC
CCCGGCCCCCGCCCCGGCGAAGTGA

Upstream 100 bases:

>100_bases
GCTCGGAAAGCGCGCGCTCCGCTGCTCGCCGGGGGGAACACGGCAGGCGCCCCGCGCGTTCGCACCCACGGTCCTTTTCC
CACCTCAAGGAGCATCGACC

Downstream 100 bases:

>100_bases
CGTGCGCCCGGCCCTCGCGCCCATCCTGATCGCGACCGCGCTCGCCGCCGGCTGCGGCCGCTGCGGCGGCGCGCGCTCCG
GCGAGCGCCCCGCGCCCGGC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: Ppic-Type Peptidyl-Prolyl Cis-Trans Isomerase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MLRRIVLLGLVALAATACQPGSKDSKKSGPAVATGNGFTITAGELKARLDEQSPFIRARYSTLERKKEFLDNLIRFEVLA
REAERQGLANDPDVQLTLKKVMVQKLVQKNFQDANGAAAEALPEADLQKYYDEHKAEYYRPRRVRLAAIVWNAPAGSPER
AAKVALAKKALAKLKAEEKKNTLAFAQLVNEFSEDAVSKATAGDLGFKSREDLEKAYSKEFADVTFNLQPGATSGVLETA
NAVYLVKGTGEQDELNRTFEQVKAQIQTKLYREKKTKEFDGWLKKLRDDAKVSIDEKALEAVEVSAAAPAGMGGMPGMPG
MPGGHGPMGAGPRPMGAPAPAPAAAPAPAPAPAK

Sequences:

>Translated_354_residues
MLRRIVLLGLVALAATACQPGSKDSKKSGPAVATGNGFTITAGELKARLDEQSPFIRARYSTLERKKEFLDNLIRFEVLA
REAERQGLANDPDVQLTLKKVMVQKLVQKNFQDANGAAAEALPEADLQKYYDEHKAEYYRPRRVRLAAIVWNAPAGSPER
AAKVALAKKALAKLKAEEKKNTLAFAQLVNEFSEDAVSKATAGDLGFKSREDLEKAYSKEFADVTFNLQPGATSGVLETA
NAVYLVKGTGEQDELNRTFEQVKAQIQTKLYREKKTKEFDGWLKKLRDDAKVSIDEKALEAVEVSAAAPAGMGGMPGMPG
MPGGHGPMGAGPRPMGAPAPAPAAAPAPAPAPAK
>Mature_354_residues
MLRRIVLLGLVALAATACQPGSKDSKKSGPAVATGNGFTITAGELKARLDEQSPFIRARYSTLERKKEFLDNLIRFEVLA
REAERQGLANDPDVQLTLKKVMVQKLVQKNFQDANGAAAEALPEADLQKYYDEHKAEYYRPRRVRLAAIVWNAPAGSPER
AAKVALAKKALAKLKAEEKKNTLAFAQLVNEFSEDAVSKATAGDLGFKSREDLEKAYSKEFADVTFNLQPGATSGVLETA
NAVYLVKGTGEQDELNRTFEQVKAQIQTKLYREKKTKEFDGWLKKLRDDAKVSIDEKALEAVEVSAAAPAGMGGMPGMPG
MPGGHGPMGAGPRPMGAPAPAPAAAPAPAPAPAK

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 38060; Mature: 38060

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRIVLLGLVALAATACQPGSKDSKKSGPAVATGNGFTITAGELKARLDEQSPFIRARY
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEHHHHHHHHCCCCCHHHHHH
STLERKKEFLDNLIRFEVLAREAERQGLANDPDVQLTLKKVMVQKLVQKNFQDANGAAAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALPEADLQKYYDEHKAEYYRPRRVRLAAIVWNAPAGSPERAAKVALAKKALAKLKAEEKK
HCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NTLAFAQLVNEFSEDAVSKATAGDLGFKSREDLEKAYSKEFADVTFNLQPGATSGVLETA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCHHHCC
NAVYLVKGTGEQDELNRTFEQVKAQIQTKLYREKKTKEFDGWLKKLRDDAKVSIDEKALE
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AVEVSAAAPAGMGGMPGMPGMPGGHGPMGAGPRPMGAPAPAPAAAPAPAPAPAK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRRIVLLGLVALAATACQPGSKDSKKSGPAVATGNGFTITAGELKARLDEQSPFIRARY
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEHHHHHHHHCCCCCHHHHHH
STLERKKEFLDNLIRFEVLAREAERQGLANDPDVQLTLKKVMVQKLVQKNFQDANGAAAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALPEADLQKYYDEHKAEYYRPRRVRLAAIVWNAPAGSPERAAKVALAKKALAKLKAEEKK
HCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NTLAFAQLVNEFSEDAVSKATAGDLGFKSREDLEKAYSKEFADVTFNLQPGATSGVLETA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCHHHCC
NAVYLVKGTGEQDELNRTFEQVKAQIQTKLYREKKTKEFDGWLKKLRDDAKVSIDEKALE
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AVEVSAAAPAGMGGMPGMPGMPGGHGPMGAGPRPMGAPAPAPAAAPAPAPAPAK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA