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The map label for this gene is rmlD [H]

Identifier: 220919525

GI number: 220919525

Start: 4949604

End: 4950500

Strand: Direct

Name: rmlD [H]

Synonym: A2cp1_4446

Alternate gene names: 220919525

Gene position: 4949604-4950500 (Clockwise)

Preceding gene: 220919520

Following gene: 220919526

Centisome position: 98.41

GC content: 77.37

Gene sequence:

>897_bases
GTGCGGATCGCGATCACCGGGGCAAACGGACTGCTGGGCGGCGCCGCGGTCGGGCTGGCGGCGGCGGCGGGACACGACGT
GCTGGGGATCGGGCGCGGTCCGTGCCGGCTGCCCCCGGGCGGCCTCGGCTGGGCGGACGCGGATCTCGCCGATGGGCGCT
CGGTCGAGAGCGCGCTGCTGGCGTTCCGGGCCGAGGCGGTGCTCCACGCGGGCGCCATGACCGACGTGGACGGCTGCGAG
CGCGAGCCGGAGGCGGCCTGGCGCGCGAACGTGGGCGGCACCGAGCAGGTGGCGCGCGCCTGCCGGGCGCTCGGGGCGCG
GCTGGTGGCGGTCTCGACCGACTACGTGTTCGACGGCACGCGGGGTGGCTACGGCGAGGACGACCTGCCGAACCCGCGCG
GCGCCTACGCGCGCACCAAGCGCTGCGGCGAGGAGGCGGCGCTGGTGATCGCGCCGGACGCGGCGGTGGCGCGGGTGGCG
GTGGTGTACAGCGGCCGCCGGGGCGCGAAGCCGACGTTCGCCACGCAGGTGGTGGAGAAGCTCTCGCGCGGCGAGGCGGT
GAAGGCGTTCTCCGACCAGGTGGTCTCGCCGACGCTCGCCGAGAGCGCGGCGGAGATGACGCTCGAGCTGCTCCTCGAGC
ACGGCTACCGCGGCGTGCTCCACACCGCCGGCGCGACCGCGCTCGACCGGGTGGACTTCGCCCGCCGCGTGGCGGCGCGC
TTCGGCCTCTCGGGCGAGATCGTCCCGGTGAAGACGGCCGACGTGAAGCTGCTCGCGCCGCGACCGCTCCGGAGCGGCCT
CGACGTCTCGCGGGCGGCGGCGCTGCTGCGGTCGCGGCCGCTCCCCATCGACGTCGCGCTGGACCGCTTCCACGCGCAGT
GGGCGGCGCGGGGGTAG

Upstream 100 bases:

>100_bases
CCACCAGGGGGAGCGCCTTTCATGCCCGGGAGGCATGGTGCCCGCGCCGGGTCGGACGGCGCTCGTTTGCCGCAGCGCGG
TTCGGCGGTAGGCTCGCCGC

Downstream 100 bases:

>100_bases
CAGGCAGCCGGCCCGGCCGCAGGTCCCCGGCGCCGGCTGGCGGCGAAGCGCGGGCGGCGGGTGCCGCAATTGACGCGAGC
CGCCCCGCCCCCTACGCTCC

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRIAITGANGLLGGAAVGLAAAAGHDVLGIGRGPCRLPPGGLGWADADLADGRSVESALLAFRAEAVLHAGAMTDVDGCE
REPEAAWRANVGGTEQVARACRALGARLVAVSTDYVFDGTRGGYGEDDLPNPRGAYARTKRCGEEAALVIAPDAAVARVA
VVYSGRRGAKPTFATQVVEKLSRGEAVKAFSDQVVSPTLAESAAEMTLELLLEHGYRGVLHTAGATALDRVDFARRVAAR
FGLSGEIVPVKTADVKLLAPRPLRSGLDVSRAAALLRSRPLPIDVALDRFHAQWAARG

Sequences:

>Translated_298_residues
MRIAITGANGLLGGAAVGLAAAAGHDVLGIGRGPCRLPPGGLGWADADLADGRSVESALLAFRAEAVLHAGAMTDVDGCE
REPEAAWRANVGGTEQVARACRALGARLVAVSTDYVFDGTRGGYGEDDLPNPRGAYARTKRCGEEAALVIAPDAAVARVA
VVYSGRRGAKPTFATQVVEKLSRGEAVKAFSDQVVSPTLAESAAEMTLELLLEHGYRGVLHTAGATALDRVDFARRVAAR
FGLSGEIVPVKTADVKLLAPRPLRSGLDVSRAAALLRSRPLPIDVALDRFHAQWAARG
>Mature_298_residues
MRIAITGANGLLGGAAVGLAAAAGHDVLGIGRGPCRLPPGGLGWADADLADGRSVESALLAFRAEAVLHAGAMTDVDGCE
REPEAAWRANVGGTEQVARACRALGARLVAVSTDYVFDGTRGGYGEDDLPNPRGAYARTKRCGEEAALVIAPDAAVARVA
VVYSGRRGAKPTFATQVVEKLSRGEAVKAFSDQVVSPTLAESAAEMTLELLLEHGYRGVLHTAGATALDRVDFARRVAAR
FGLSGEIVPVKTADVKLLAPRPLRSGLDVSRAAALLRSRPLPIDVALDRFHAQWAARG

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=280, Percent_Identity=28.9285714285714, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI11034825, Length=280, Percent_Identity=28.9285714285714, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1788352, Length=161, Percent_Identity=31.055900621118, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 30964; Mature: 30964

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAITGANGLLGGAAVGLAAAAGHDVLGIGRGPCRLPPGGLGWADADLADGRSVESALL
CEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AFRAEAVLHAGAMTDVDGCEREPEAAWRANVGGTEQVARACRALGARLVAVSTDYVFDGT
HHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCEEEEEECCEEEECC
RGGYGEDDLPNPRGAYARTKRCGEEAALVIAPDAAVARVAVVYSGRRGAKPTFATQVVEK
CCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCHHHHHEEEEECCCCCCCCHHHHHHHHH
LSRGEAVKAFSDQVVSPTLAESAAEMTLELLLEHGYRGVLHTAGATALDRVDFARRVAAR
HHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEHHCCCHHHHHHHHHHHHHHH
FGLSGEIVPVKTADVKLLAPRPLRSGLDVSRAAALLRSRPLPIDVALDRFHAQWAARG
HCCCCCEEEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIAITGANGLLGGAAVGLAAAAGHDVLGIGRGPCRLPPGGLGWADADLADGRSVESALL
CEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AFRAEAVLHAGAMTDVDGCEREPEAAWRANVGGTEQVARACRALGARLVAVSTDYVFDGT
HHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCEEEEEECCEEEECC
RGGYGEDDLPNPRGAYARTKRCGEEAALVIAPDAAVARVAVVYSGRRGAKPTFATQVVEK
CCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCHHHHHEEEEECCCCCCCCHHHHHHHHH
LSRGEAVKAFSDQVVSPTLAESAAEMTLELLLEHGYRGVLHTAGATALDRVDFARRVAAR
HHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEHHCCCHHHHHHHHHHHHHHH
FGLSGEIVPVKTADVKLLAPRPLRSGLDVSRAAALLRSRPLPIDVALDRFHAQWAARG
HCCCCCEEEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]