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The map label for this gene is trpC [H]

Identifier: 220919277

GI number: 220919277

Start: 4684494

End: 4685276

Strand: Direct

Name: trpC [H]

Synonym: A2cp1_4198

Alternate gene names: 220919277

Gene position: 4684494-4685276 (Clockwise)

Preceding gene: 220919276

Following gene: 220919278

Centisome position: 93.14

GC content: 79.31

Gene sequence:

>783_bases
GTGACGGTCCTCGACGGCATCCTGGCCCGGAAGGTCGACGAGGTGGCCGCCCGCCGCGCGGCCGAACCCGACGCGGCGCT
GGCCGCGCGCGCCGCCGCCGCCCCCCCGCCACGCGGGTTCGAGGCGGCGCTCTCGCCGCGCGGCGGCCCGCTGCGCGTCA
TCGCCGAGGTGAAGCGCGCCAGCCCCTCCGCCGGCGCCATCCGCGCCGGCCTCGACGCGGTGGCCCAGGCGCGCCGCTAC
GCCGCCGCCGGCGCTGCGGCCATCTCGGTCCTCACCGACGGCCCCGGCTTCGGCGGCTCGCTCGACGACCTGATGGCGGT
CCGCGCCGCGGTGGACGTGCCGCTGCTCCGCAAGGACTTCGTGGTGGACCGGTACCAGCTCCTCGAGGCCCGCGCCGCCG
GCGCCGACGCGGCGCTGCTCATCGTGGCCGGGTTGGCGCAGGACGACCTGCGGCGGCTGCTCGACGGCTGCGGCGAGCTG
GGGCTCGCGGCGCTGGTCGAGGTCCACGACGACGCCGAGGCCGAGCGCGCGCTCGCGGCCGGCGCGCGCATCGTCGGCGT
CAACAACCGCAACCTCCACACCTTCCACGTGGACCTCGCCACCTCCGAGCGCATCCTGCCGTCGCTCCCGGCGGCGGTGA
AGGGCGTGGCGGAGAGCGGCGTGCGCACCCCGGAGGACGCGGCCCGGCTGCGCCGCGCCGGGGCCGCGAACCTGCTGGTG
GGCGAGGCGCTGGTGCGCGCCGAGGACCCGGCCGCGCTGCTGCGCGCGCTGGGCGAGGCGTGA

Upstream 100 bases:

>100_bases
AGGACCTGCGCGACGGCGTGGCGCGCGCCGCCCGGTCCATCGACTCGGGCGCCGCCCGCGAGAAGCTGCGGCAGCTGGTG
GCCGCCACCACGGTGCCGGC

Downstream 100 bases:

>100_bases
TGGCGCCGCCGCCCAGGGTGAAGATCTGCGGGGTGACCCGGCTCGAGGACGCGCTCGAGGCCGCACGGCTGGGCGCGGAC
GCGGTTGGCTTCAACTTCTG

Product: Indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTVLDGILARKVDEVAARRAAEPDAALAARAAAAPPPRGFEAALSPRGGPLRVIAEVKRASPSAGAIRAGLDAVAQARRY
AAAGAAAISVLTDGPGFGGSLDDLMAVRAAVDVPLLRKDFVVDRYQLLEARAAGADAALLIVAGLAQDDLRRLLDGCGEL
GLAALVEVHDDAEAERALAAGARIVGVNNRNLHTFHVDLATSERILPSLPAAVKGVAESGVRTPEDAARLRRAGAANLLV
GEALVRAEDPAALLRALGEA

Sequences:

>Translated_260_residues
MTVLDGILARKVDEVAARRAAEPDAALAARAAAAPPPRGFEAALSPRGGPLRVIAEVKRASPSAGAIRAGLDAVAQARRY
AAAGAAAISVLTDGPGFGGSLDDLMAVRAAVDVPLLRKDFVVDRYQLLEARAAGADAALLIVAGLAQDDLRRLLDGCGEL
GLAALVEVHDDAEAERALAAGARIVGVNNRNLHTFHVDLATSERILPSLPAAVKGVAESGVRTPEDAARLRRAGAANLLV
GEALVRAEDPAALLRALGEA
>Mature_259_residues
TVLDGILARKVDEVAARRAAEPDAALAARAAAAPPPRGFEAALSPRGGPLRVIAEVKRASPSAGAIRAGLDAVAQARRYA
AAGAAAISVLTDGPGFGGSLDDLMAVRAAVDVPLLRKDFVVDRYQLLEARAAGADAALLIVAGLAQDDLRRLLDGCGELG
LAALVEVHDDAEAERALAAGARIVGVNNRNLHTFHVDLATSERILPSLPAAVKGVAESGVRTPEDAARLRRAGAANLLVG
EALVRAEDPAALLRALGEA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=38.3141762452107, Blast_Score=139, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=41.8518518518518, Blast_Score=191, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 26579; Mature: 26447

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLDGILARKVDEVAARRAAEPDAALAARAAAAPPPRGFEAALSPRGGPLRVIAEVKRA
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHC
SPSAGAIRAGLDAVAQARRYAAAGAAAISVLTDGPGFGGSLDDLMAVRAAVDVPLLRKDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHH
VVDRYQLLEARAAGADAALLIVAGLAQDDLRRLLDGCGELGLAALVEVHDDAEAERALAA
HHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHC
GARIVGVNNRNLHTFHVDLATSERILPSLPAAVKGVAESGVRTPEDAARLRRAGAANLLV
CCEEEECCCCCEEEEEEECCCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHH
GEALVRAEDPAALLRALGEA
HHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
TVLDGILARKVDEVAARRAAEPDAALAARAAAAPPPRGFEAALSPRGGPLRVIAEVKRA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHC
SPSAGAIRAGLDAVAQARRYAAAGAAAISVLTDGPGFGGSLDDLMAVRAAVDVPLLRKDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHH
VVDRYQLLEARAAGADAALLIVAGLAQDDLRRLLDGCGELGLAALVEVHDDAEAERALAA
HHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHC
GARIVGVNNRNLHTFHVDLATSERILPSLPAAVKGVAESGVRTPEDAARLRRAGAANLLV
CCEEEECCCCCEEEEEEECCCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHH
GEALVRAEDPAALLRALGEA
HHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA