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The map label for this gene is trpE [H]

Identifier: 220919274

GI number: 220919274

Start: 4681362

End: 4682876

Strand: Direct

Name: trpE [H]

Synonym: A2cp1_4195

Alternate gene names: 220919274

Gene position: 4681362-4682876 (Clockwise)

Preceding gene: 220919273

Following gene: 220919275

Centisome position: 93.08

GC content: 76.57

Gene sequence:

>1515_bases
GTGCGCGTCGAGATCGACGCCGACACCGAGACGCCGGTCTCGGCGTTCCTGAAGCTCTCGCGCGGCGAGCGCCACGCGTT
CCTCCTCGAGTCGGTGGAGGGCGGGGAGCGGAGCGCGCGCTTCACGTTCCTGGGCGCGGCGCCGCGGGCGCTGCTCCGCT
GGAAGCTGGGCGACCCCGGCGATCCCATCGCCGCGCTCCGCGCCGCGCTCGCCACGCACCGGGCGGTGCGGGTGCCCGGC
GTCCCGCGCTTCTCCGGCGGCTTCATGGGCCACGTCTCCTACGACGCGGTCCGCCTGTTCGAGCCGCGCGTCCCCATCGC
GAAGGCCGACGAGCTGGGCTTCCCCGACGTCCTGCTCATGGACTTCGACGAGCTGGTGGCGTTCGACAACCGCCGCCACT
CGCTCCACGTCATCTGCGAGGTGCGCTGCGACGAGGGCGACGACCCGCGCGCGCTCTACGCCGACGCGGTCCGCCGCATC
CGCCGCCGCCTGGCGGTGCTGGCGCGGCCGCTCTCCGATCGCCGCCCGCGCCGGGCCGGGCCGCCGGCGGTGCTCGCGCC
GCGGGTCCGCCGCGAGGCGTTCGAGGCGGCGGTGCGGCGCGCCAAGGAGTACGTCACCGCCGGCGACTGCCAGCAGATCG
TCCTCTCCCAGCGCTTCGACGCCGAGACCTCGCTCCCGCCGTTCGAGATCTACCGGGCGCTCCGCCGCGTGAACCCCTCG
CCGTACCTGTTCTTCGTGAAGGACGGGCCGCGCGCGCTGGTCGGCTCGTCGCCGGAGACGCTGGTGAAGCTCGAGGACGG
CGAGGTGACGCTGCGGCCCATCGCCGGCACGCGCCCGCGCGGCGCGGACGCGGCCGAGGACCAGGCGCTCGAGGCCGAGC
TGCGCGCCGACCCGAAGGAGAACGCCGAGCACGTCATGCTGGTGGACCTCGGGCGCAACGACGTGGGGCGGGTGTCCGCC
ACCGGCACCGTGAAGGTCGCCGCGCTGAAGACGGTGGAGCGCTACTCGCACGTGATGCACCTCGTCTCGGAGGTGCGCGG
GCGGCTCGCCCCCGGCCGCACGGCGGTGGACGTGCTCCGGGCCGGCTTCCCCGCCGGCACGCTCTCCGGCTCGCCCAAGG
TGCGGGCCATGGAGATCATCGACGCGCTCGAGCCGGCCCGCCGCGGCCCCTACGGCGGCGCGGTGGGCTACTTCGACCGC
GGCGGCGACATGGAGATGTGCATCGCGATCCGCACGCTGCTCGCGAACGGCCGGCGCGTGTCGGTGCAGTCCGGCGCCGG
CATCGTCTACGACTCCGACCCGGCCGCCGAGTACCAGGAGACCGTCAACAAGGCGCGCGCGGTGTTCACCGCGGTGGCGC
AGGCCGAGGCGCGCGGGCTGGACGCGCCGCCGGCTGCCGCGCCCCGCGGGCGCGCCGGCGCGCAGAAGGCGCAGGCGGCC
CCCGCGCGGCAGCGGCGCGCGGCCGGATCGCGCGGCCGCCGCGCGGCGCCGCGCGGGAAGGGGGCGAGGCGATGA

Upstream 100 bases:

>100_bases
GACGGCATGACGGTGCGTCTTTGGCAAGTCCGCTGAGCTGCGGACCACCCCCGATCTCCAGACCTTCCTCTCCCTCTGCA
GCCCCGGCCGCGCGGTCCCG

Downstream 100 bases:

>100_bases
GCGGCGCGCGCCCGGTCCGGCTGCTGCTGGTGGACAACTACGACAGCTTCACCTTCAACCTGGTGCAGTACCTGGGCGAG
CTGGGCGCCGAGGTGGAGGT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MRVEIDADTETPVSAFLKLSRGERHAFLLESVEGGERSARFTFLGAAPRALLRWKLGDPGDPIAALRAALATHRAVRVPG
VPRFSGGFMGHVSYDAVRLFEPRVPIAKADELGFPDVLLMDFDELVAFDNRRHSLHVICEVRCDEGDDPRALYADAVRRI
RRRLAVLARPLSDRRPRRAGPPAVLAPRVRREAFEAAVRRAKEYVTAGDCQQIVLSQRFDAETSLPPFEIYRALRRVNPS
PYLFFVKDGPRALVGSSPETLVKLEDGEVTLRPIAGTRPRGADAAEDQALEAELRADPKENAEHVMLVDLGRNDVGRVSA
TGTVKVAALKTVERYSHVMHLVSEVRGRLAPGRTAVDVLRAGFPAGTLSGSPKVRAMEIIDALEPARRGPYGGAVGYFDR
GGDMEMCIAIRTLLANGRRVSVQSGAGIVYDSDPAAEYQETVNKARAVFTAVAQAEARGLDAPPAAAPRGRAGAQKAQAA
PARQRRAAGSRGRRAAPRGKGARR

Sequences:

>Translated_504_residues
MRVEIDADTETPVSAFLKLSRGERHAFLLESVEGGERSARFTFLGAAPRALLRWKLGDPGDPIAALRAALATHRAVRVPG
VPRFSGGFMGHVSYDAVRLFEPRVPIAKADELGFPDVLLMDFDELVAFDNRRHSLHVICEVRCDEGDDPRALYADAVRRI
RRRLAVLARPLSDRRPRRAGPPAVLAPRVRREAFEAAVRRAKEYVTAGDCQQIVLSQRFDAETSLPPFEIYRALRRVNPS
PYLFFVKDGPRALVGSSPETLVKLEDGEVTLRPIAGTRPRGADAAEDQALEAELRADPKENAEHVMLVDLGRNDVGRVSA
TGTVKVAALKTVERYSHVMHLVSEVRGRLAPGRTAVDVLRAGFPAGTLSGSPKVRAMEIIDALEPARRGPYGGAVGYFDR
GGDMEMCIAIRTLLANGRRVSVQSGAGIVYDSDPAAEYQETVNKARAVFTAVAQAEARGLDAPPAAAPRGRAGAQKAQAA
PARQRRAAGSRGRRAAPRGKGARR
>Mature_504_residues
MRVEIDADTETPVSAFLKLSRGERHAFLLESVEGGERSARFTFLGAAPRALLRWKLGDPGDPIAALRAALATHRAVRVPG
VPRFSGGFMGHVSYDAVRLFEPRVPIAKADELGFPDVLLMDFDELVAFDNRRHSLHVICEVRCDEGDDPRALYADAVRRI
RRRLAVLARPLSDRRPRRAGPPAVLAPRVRREAFEAAVRRAKEYVTAGDCQQIVLSQRFDAETSLPPFEIYRALRRVNPS
PYLFFVKDGPRALVGSSPETLVKLEDGEVTLRPIAGTRPRGADAAEDQALEAELRADPKENAEHVMLVDLGRNDVGRVSA
TGTVKVAALKTVERYSHVMHLVSEVRGRLAPGRTAVDVLRAGFPAGTLSGSPKVRAMEIIDALEPARRGPYGGAVGYFDR
GGDMEMCIAIRTLLANGRRVSVQSGAGIVYDSDPAAEYQETVNKARAVFTAVAQAEARGLDAPPAAAPRGRAGAQKAQAA
PARQRRAAGSRGRRAAPRGKGARR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=398, Percent_Identity=40.9547738693467, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788114, Length=391, Percent_Identity=35.5498721227622, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082077, Length=259, Percent_Identity=28.957528957529, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786809, Length=347, Percent_Identity=28.5302593659942, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=466, Percent_Identity=41.6309012875536, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324361, Length=287, Percent_Identity=27.8745644599303, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54713; Mature: 54713

Theoretical pI: Translated: 10.57; Mature: 10.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVEIDADTETPVSAFLKLSRGERHAFLLESVEGGERSARFTFLGAAPRALLRWKLGDPG
CEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHEEECCCCCC
DPIAALRAALATHRAVRVPGVPRFSGGFMGHVSYDAVRLFEPRVPIAKADELGFPDVLLM
CHHHHHHHHHHHHCEEECCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCEEEC
DFDELVAFDNRRHSLHVICEVRCDEGDDPRALYADAVRRIRRRLAVLARPLSDRRPRRAG
CHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCC
PPAVLAPRVRREAFEAAVRRAKEYVTAGDCQQIVLSQRFDAETSLPPFEIYRALRRVNPS
CCCHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
PYLFFVKDGPRALVGSSPETLVKLEDGEVTLRPIAGTRPRGADAAEDQALEAELRADPKE
CEEEEEECCCCEECCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCC
NAEHVMLVDLGRNDVGRVSATGTVKVAALKTVERYSHVMHLVSEVRGRLAPGRTAVDVLR
CCCEEEEEECCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AGFPAGTLSGSPKVRAMEIIDALEPARRGPYGGAVGYFDRGGDMEMCIAIRTLLANGRRV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
SVQSGAGIVYDSDPAAEYQETVNKARAVFTAVAQAEARGLDAPPAAAPRGRAGAQKAQAA
EEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCC
PARQRRAAGSRGRRAAPRGKGARR
CHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVEIDADTETPVSAFLKLSRGERHAFLLESVEGGERSARFTFLGAAPRALLRWKLGDPG
CEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHEEECCCCCC
DPIAALRAALATHRAVRVPGVPRFSGGFMGHVSYDAVRLFEPRVPIAKADELGFPDVLLM
CHHHHHHHHHHHHCEEECCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCEEEC
DFDELVAFDNRRHSLHVICEVRCDEGDDPRALYADAVRRIRRRLAVLARPLSDRRPRRAG
CHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCC
PPAVLAPRVRREAFEAAVRRAKEYVTAGDCQQIVLSQRFDAETSLPPFEIYRALRRVNPS
CCCHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
PYLFFVKDGPRALVGSSPETLVKLEDGEVTLRPIAGTRPRGADAAEDQALEAELRADPKE
CEEEEEECCCCEECCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCC
NAEHVMLVDLGRNDVGRVSATGTVKVAALKTVERYSHVMHLVSEVRGRLAPGRTAVDVLR
CCCEEEEEECCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AGFPAGTLSGSPKVRAMEIIDALEPARRGPYGGAVGYFDRGGDMEMCIAIRTLLANGRRV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
SVQSGAGIVYDSDPAAEYQETVNKARAVFTAVAQAEARGLDAPPAAAPRGRAGAQKAQAA
EEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCC
PARQRRAAGSRGRRAAPRGKGARR
CHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2404959 [H]