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The map label for this gene is pcaK [H]

Identifier: 220919143

GI number: 220919143

Start: 4540205

End: 4541590

Strand: Direct

Name: pcaK [H]

Synonym: A2cp1_4063

Alternate gene names: 220919143

Gene position: 4540205-4541590 (Clockwise)

Preceding gene: 220919142

Following gene: 220919144

Centisome position: 90.27

GC content: 77.85

Gene sequence:

>1386_bases
ATGACCGCCCTGCCGGACAGCGCCACGGGTTCCCGGAGCGTGAACGTCACCGACCTCGTGGACGCGGGGCGGCTCGGGCG
CTTCCACCTGGGCGCGTTCGCGGTGCTGGGCGGCTGCCTGGTGATGGACGGGTTCGACCTGCAGGCCATGGGCTACGCCG
CGCCGGCGCTGGCGCGCGACTGGGGGCTGCCCATCGCCCGCCTCGGCCCGGTGTTCGGCGCCGGCCTGCTGGGCCTGTTC
CTCGGCTCGATCCTGGCCGGCATGGCGGCCGACCGGATCGGCCGCCGCCCGGTGCTGATCGGCTCGACCGCGGCGTTCGG
GGTCTTCACGCTCGCCACCGCGGCCGCCGGCTCCATGCCCTCGCTGCTCGCGGCCCGGTTCCTGGCCGGCCTCGGCCTCG
GCGCCATCATGCCGAACGCCACCGCGCTGGTGGGCGAGTACGCGCCGCGCCGGAACCGCGTCGCGACCATGATGATCGTG
ACGAACGGCTTCATGGTGGGCGCGGTCGCGGCCGGCGCGCTGTCCGCCTGGCTCGTCCCCGCGTACGGCTGGCGCGCGCC
GTTCTGGATCGGCGGCGCCATCCCGCTCGTCCTGCTCCCGCCCATGGCGCGCTGGCTGCCCGAGTCGCTGCAGCTCCTGG
CGGTCTCCGGGCGCCGGCCGGCGGAGCTGGCGCGCTGGCTGCGGCACGCCGCGCCGGGCGCACCGGTGGGCCCGGGCGTC
CGCTACACCGTGCGCGAGGCTCCGCGCCGCGGGTTCGTGCTCGTGGAGCTGCTCCGCGGCGGGCGCGCCGCCGCGACGGT
CCTGCTCTGGCTCGCGAACTTCGCGAACATGATCGTCATCTACGCGGTGGCGAGCTGGCTGCCCACGCTCGTGCGCGAGG
CGGGCTTCTCCACCGCGACCGCGGTCTGGGCCGGCACCGCGGTGCAGCTCGGCGGGCTCGTCGGCACGGTGGTGCTGGGC
CTCGTGCTCCAGCGGCTCGGCTTCGTGCCGGTGCTGGCGAGCTGCTTCGCGACGGCCGCGGCGTGCCTGCTCGTGCTGGG
CCGCCCCGGCCTCCCGCTCCCGGCGCTCCTCACCGTCGCGTTCGTGGTGGGCTGGGCGGTGCAGGGCGGCCAGCCCGGCC
TCAACGCGCTCGCCGCCACGTTCTACCCGACCGACCTCCGCTCCACCGGCATCGGCGCCGGGCTCGGCGTGGGCCGGCTG
GGCGGCTTCCTCGGCCCGCTGGTGGCGGGCGCGATCCTGGCGCGCGGCGGCGGCGCGCAGGGCGTGTTCCAGGCCGCCGC
GGTGCCGGCGGTCGCCTCCGCGCTCGTCATGCTCGCGCTGCGCCGGGCGGCCCCGGGCGTGGGCGCGCGCGCGCCGGAAG
GCCACGCGCCGGCCGCCGGACGATGA

Upstream 100 bases:

>100_bases
TGGGCATCCTGCTCACCTTCATGTTCCTCGGGAACATGGTCGCCGCGGTGGCGCTCGTGCCGGCGCTCTCCCGGCTCCTC
CTCCGGGAGGTCCCCGCCCG

Downstream 100 bases:

>100_bases
AGGCGCTTCCCGGCGCCTCCGCTCCCGGCTCGGTGGATTCACGGTGAGTGGATCCCGGCCCAGCGCAGCGCCTTCGCCGC
GGCCGGCGATGTCCGCCGCG

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTALPDSATGSRSVNVTDLVDAGRLGRFHLGAFAVLGGCLVMDGFDLQAMGYAAPALARDWGLPIARLGPVFGAGLLGLF
LGSILAGMAADRIGRRPVLIGSTAAFGVFTLATAAAGSMPSLLAARFLAGLGLGAIMPNATALVGEYAPRRNRVATMMIV
TNGFMVGAVAAGALSAWLVPAYGWRAPFWIGGAIPLVLLPPMARWLPESLQLLAVSGRRPAELARWLRHAAPGAPVGPGV
RYTVREAPRRGFVLVELLRGGRAAATVLLWLANFANMIVIYAVASWLPTLVREAGFSTATAVWAGTAVQLGGLVGTVVLG
LVLQRLGFVPVLASCFATAAACLLVLGRPGLPLPALLTVAFVVGWAVQGGQPGLNALAATFYPTDLRSTGIGAGLGVGRL
GGFLGPLVAGAILARGGGAQGVFQAAAVPAVASALVMLALRRAAPGVGARAPEGHAPAAGR

Sequences:

>Translated_461_residues
MTALPDSATGSRSVNVTDLVDAGRLGRFHLGAFAVLGGCLVMDGFDLQAMGYAAPALARDWGLPIARLGPVFGAGLLGLF
LGSILAGMAADRIGRRPVLIGSTAAFGVFTLATAAAGSMPSLLAARFLAGLGLGAIMPNATALVGEYAPRRNRVATMMIV
TNGFMVGAVAAGALSAWLVPAYGWRAPFWIGGAIPLVLLPPMARWLPESLQLLAVSGRRPAELARWLRHAAPGAPVGPGV
RYTVREAPRRGFVLVELLRGGRAAATVLLWLANFANMIVIYAVASWLPTLVREAGFSTATAVWAGTAVQLGGLVGTVVLG
LVLQRLGFVPVLASCFATAAACLLVLGRPGLPLPALLTVAFVVGWAVQGGQPGLNALAATFYPTDLRSTGIGAGLGVGRL
GGFLGPLVAGAILARGGGAQGVFQAAAVPAVASALVMLALRRAAPGVGARAPEGHAPAAGR
>Mature_460_residues
TALPDSATGSRSVNVTDLVDAGRLGRFHLGAFAVLGGCLVMDGFDLQAMGYAAPALARDWGLPIARLGPVFGAGLLGLFL
GSILAGMAADRIGRRPVLIGSTAAFGVFTLATAAAGSMPSLLAARFLAGLGLGAIMPNATALVGEYAPRRNRVATMMIVT
NGFMVGAVAAGALSAWLVPAYGWRAPFWIGGAIPLVLLPPMARWLPESLQLLAVSGRRPAELARWLRHAAPGAPVGPGVR
YTVREAPRRGFVLVELLRGGRAAATVLLWLANFANMIVIYAVASWLPTLVREAGFSTATAVWAGTAVQLGGLVGTVVLGL
VLQRLGFVPVLASCFATAAACLLVLGRPGLPLPALLTVAFVVGWAVQGGQPGLNALAATFYPTDLRSTGIGAGLGVGRLG
GFLGPLVAGAILARGGGAQGVFQAAAVPAVASALVMLALRRAAPGVGARAPEGHAPAAGR

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=427, Percent_Identity=26.463700234192, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI213021148, Length=455, Percent_Identity=22.8571428571429, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7662270, Length=215, Percent_Identity=26.046511627907, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI216548223, Length=171, Percent_Identity=29.2397660818713, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI8923870, Length=381, Percent_Identity=26.509186351706, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87081723, Length=387, Percent_Identity=39.0180878552972, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786229, Length=371, Percent_Identity=29.3800539083558, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082159, Length=392, Percent_Identity=28.8265306122449, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082231, Length=453, Percent_Identity=25.3863134657837, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082404, Length=410, Percent_Identity=22.1951219512195, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788074, Length=366, Percent_Identity=25.1366120218579, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI32564663, Length=429, Percent_Identity=24.9417249417249, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17565978, Length=332, Percent_Identity=24.6987951807229, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922874, Length=416, Percent_Identity=21.1538461538462, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46700; Mature: 46569

Theoretical pI: Translated: 12.06; Mature: 12.06

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPDSATGSRSVNVTDLVDAGRLGRFHLGAFAVLGGCLVMDGFDLQAMGYAAPALARD
CCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHH
WGLPIARLGPVFGAGLLGLFLGSILAGMAADRIGRRPVLIGSTAAFGVFTLATAAAGSMP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCH
SLLAARFLAGLGLGAIMPNATALVGEYAPRRNRVATMMIVTNGFMVGAVAAGALSAWLVP
HHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
AYGWRAPFWIGGAIPLVLLPPMARWLPESLQLLAVSGRRPAELARWLRHAAPGAPVGPGV
CCCCCCCEEECCCCHHHHCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCC
RYTVREAPRRGFVLVELLRGGRAAATVLLWLANFANMIVIYAVASWLPTLVREAGFSTAT
EEHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVWAGTAVQLGGLVGTVVLGLVLQRLGFVPVLASCFATAAACLLVLGRPGLPLPALLTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
FVVGWAVQGGQPGLNALAATFYPTDLRSTGIGAGLGVGRLGGFLGPLVAGAILARGGGAQ
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GVFQAAAVPAVASALVMLALRRAAPGVGARAPEGHAPAAGR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TALPDSATGSRSVNVTDLVDAGRLGRFHLGAFAVLGGCLVMDGFDLQAMGYAAPALARD
CCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHH
WGLPIARLGPVFGAGLLGLFLGSILAGMAADRIGRRPVLIGSTAAFGVFTLATAAAGSMP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCH
SLLAARFLAGLGLGAIMPNATALVGEYAPRRNRVATMMIVTNGFMVGAVAAGALSAWLVP
HHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
AYGWRAPFWIGGAIPLVLLPPMARWLPESLQLLAVSGRRPAELARWLRHAAPGAPVGPGV
CCCCCCCEEECCCCHHHHCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCC
RYTVREAPRRGFVLVELLRGGRAAATVLLWLANFANMIVIYAVASWLPTLVREAGFSTAT
EEHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVWAGTAVQLGGLVGTVVLGLVLQRLGFVPVLASCFATAAACLLVLGRPGLPLPALLTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
FVVGWAVQGGQPGLNALAATFYPTDLRSTGIGAGLGVGRLGGFLGPLVAGAILARGGGAQ
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GVFQAAAVPAVASALVMLALRRAAPGVGARAPEGHAPAAGR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]