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The map label for this gene is gfo [H]

Identifier: 220919033

GI number: 220919033

Start: 4399146

End: 4400270

Strand: Direct

Name: gfo [H]

Synonym: A2cp1_3948

Alternate gene names: 220919033

Gene position: 4399146-4400270 (Clockwise)

Preceding gene: 220919031

Following gene: 220919035

Centisome position: 87.47

GC content: 74.13

Gene sequence:

>1125_bases
ATGGCGCGCGAGCGGCGAAGGGAGCGCGGGCGGCGCACGGTCGGGTACGCGGTGGTCGGCCTCGGGCACATCGCGCAGGC
GGCGGTGCTGCCGGCCTTCGAGCACGCGCGGGGCACCTCGCGCCTCGCGGCGCTCGTCTCCGGCGACGCGACCAAGCGGA
AGGCGATCGGCAAGCGCCACGGCGTGCCGACGTTCGGGTACGAGGACCTCGACGACGTGTTCGCCCGCGAGGACGTGGAC
GCCGTCTACATCGCGCTGCCGAACACCGAGCACGCCGCCTGCGCCGTTCGCGCCGCGCGCGCGGGCGTGCACGTCCTCAC
CGAGAAGCCGATGGCGACCTCCGAGGAGGACTGCCGCGCGATGATCGCCGCCGCCGAGGAGGGCGGCGTGAAGCTGATGG
TGGCGTACCGTCTCCACTTCGATCCGGCCACGCTCGAGACGGTCGAGCTGGTGCGGGCCGGGAAGCTCGGCGAGCCGCGC
TTCTTCTCGTCCGACTTCTCCTACCAGGTGGAGCCGGGCAACATCCGCACCGACGCGCGCCTGGGCGGAGGCGCGATCTG
GGACCTCGGCCCGTACTGCGTGAACGCCGCGCGCTACCTGTTCGGCGCGGAGCCGATCGAGGTCTTCGCGATGGAGGCGC
TCGCCCGCGACCGGCGCTTCCACGGCGTGCCCGAGGCCTGGTCGGTCACGCTGCGCTTCCCCGACGAACGGCTGGCGACG
CTGACGTGCAGCTTCGGCGCCGCCCCCGTGGACACCTGCCGCCTGGTCGGCACGAAGGGCGACGTGCGCCTCGAGCCGGC
GTTCGAGTACGTCGGGAGCCTCGTCCGCCACCTCACCATCGACGAGCGCACCAGGACGAAGAAGTACCCGCCGTCCGACC
AGTTCGCGCCGGAGCTGGTCCATTTCTCGCGCTGCGTCCTCGAGGACCGCGAGCCCGAGCCGGACGGCTGGGAGGGGCTC
GCCGACGTGCGGATCATCGAGGCCGCGCTCCGCTCCGCGCGGGAGCGCCAGCCGGTGCGGCTCGAGCCGATCGAGCGCCG
CCGCCGGCCGCGGGCGGAGCAGGCCATGCACCGCCCGCCGGTGGCGAAGGCCGGCGTCGTGCACGCGCAGGCGCCGTCGC
AGTGA

Upstream 100 bases:

>100_bases
CGGGGGGTGCCGTCCGGCACGGCGCTCGCTCCCACGCTCGCCGGCGCCCGCCTGCACGATCCGCCGCGCGCGCCCATGTT
TCGCGCGCGAAGGAGCGCAC

Downstream 100 bases:

>100_bases
GGGCGTCGCCGGGGCGAGCTCGACCAGGCCACCCGCCCGCCATCTCGCGGGCGAGCGGCGTCCAGCGCCTCAGCCCCGCG
GCGGCTCGCCCGCCTGGCAG

Product: oxidoreductase domain-containing protein

Products: NA

Alternate protein names: GFOR [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MARERRRERGRRTVGYAVVGLGHIAQAAVLPAFEHARGTSRLAALVSGDATKRKAIGKRHGVPTFGYEDLDDVFAREDVD
AVYIALPNTEHAACAVRAARAGVHVLTEKPMATSEEDCRAMIAAAEEGGVKLMVAYRLHFDPATLETVELVRAGKLGEPR
FFSSDFSYQVEPGNIRTDARLGGGAIWDLGPYCVNAARYLFGAEPIEVFAMEALARDRRFHGVPEAWSVTLRFPDERLAT
LTCSFGAAPVDTCRLVGTKGDVRLEPAFEYVGSLVRHLTIDERTRTKKYPPSDQFAPELVHFSRCVLEDREPEPDGWEGL
ADVRIIEAALRSARERQPVRLEPIERRRRPRAEQAMHRPPVAKAGVVHAQAPSQ

Sequences:

>Translated_374_residues
MARERRRERGRRTVGYAVVGLGHIAQAAVLPAFEHARGTSRLAALVSGDATKRKAIGKRHGVPTFGYEDLDDVFAREDVD
AVYIALPNTEHAACAVRAARAGVHVLTEKPMATSEEDCRAMIAAAEEGGVKLMVAYRLHFDPATLETVELVRAGKLGEPR
FFSSDFSYQVEPGNIRTDARLGGGAIWDLGPYCVNAARYLFGAEPIEVFAMEALARDRRFHGVPEAWSVTLRFPDERLAT
LTCSFGAAPVDTCRLVGTKGDVRLEPAFEYVGSLVRHLTIDERTRTKKYPPSDQFAPELVHFSRCVLEDREPEPDGWEGL
ADVRIIEAALRSARERQPVRLEPIERRRRPRAEQAMHRPPVAKAGVVHAQAPSQ
>Mature_373_residues
ARERRRERGRRTVGYAVVGLGHIAQAAVLPAFEHARGTSRLAALVSGDATKRKAIGKRHGVPTFGYEDLDDVFAREDVDA
VYIALPNTEHAACAVRAARAGVHVLTEKPMATSEEDCRAMIAAAEEGGVKLMVAYRLHFDPATLETVELVRAGKLGEPRF
FSSDFSYQVEPGNIRTDARLGGGAIWDLGPYCVNAARYLFGAEPIEVFAMEALARDRRFHGVPEAWSVTLRFPDERLATL
TCSFGAAPVDTCRLVGTKGDVRLEPAFEYVGSLVRHLTIDERTRTKKYPPSDQFAPELVHFSRCVLEDREPEPDGWEGLA
DVRIIEAALRSARERQPVRLEPIERRRRPRAEQAMHRPPVAKAGVVHAQAPSQ

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Homo sapiens, GI7657212, Length=251, Percent_Identity=27.4900398406374, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082405, Length=282, Percent_Identity=25.886524822695, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693182, Length=291, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081947, Length=191, Percent_Identity=30.3664921465969, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24581117, Length=261, Percent_Identity=27.2030651340996, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24581115, Length=256, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008354
- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: =1.1.99.28 [H]

Molecular weight: Translated: 41385; Mature: 41253

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARERRRERGRRTVGYAVVGLGHIAQAAVLPAFEHARGTSRLAALVSGDATKRKAIGKRH
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHC
GVPTFGYEDLDDVFAREDVDAVYIALPNTEHAACAVRAARAGVHVLTEKPMATSEEDCRA
CCCCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCCHHHHHH
MIAAAEEGGVKLMVAYRLHFDPATLETVELVRAGKLGEPRFFSSDFSYQVEPGNIRTDAR
HHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHCCCCCCCCEECCCCCEEECCCCEEECCC
LGGGAIWDLGPYCVNAARYLFGAEPIEVFAMEALARDRRFHGVPEAWSVTLRFPDERLAT
CCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE
LTCSFGAAPVDTCRLVGTKGDVRLEPAFEYVGSLVRHLTIDERTRTKKYPPSDQFAPELV
EEECCCCCCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHH
HFSRCVLEDREPEPDGWEGLADVRIIEAALRSARERQPVRLEPIERRRRPRAEQAMHRPP
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHCCCC
VAKAGVVHAQAPSQ
CCCCCEEECCCCCC
>Mature Secondary Structure 
ARERRRERGRRTVGYAVVGLGHIAQAAVLPAFEHARGTSRLAALVSGDATKRKAIGKRH
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHC
GVPTFGYEDLDDVFAREDVDAVYIALPNTEHAACAVRAARAGVHVLTEKPMATSEEDCRA
CCCCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCCHHHHHH
MIAAAEEGGVKLMVAYRLHFDPATLETVELVRAGKLGEPRFFSSDFSYQVEPGNIRTDAR
HHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHCCCCCCCCEECCCCCEEECCCCEEECCC
LGGGAIWDLGPYCVNAARYLFGAEPIEVFAMEALARDRRFHGVPEAWSVTLRFPDERLAT
CCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE
LTCSFGAAPVDTCRLVGTKGDVRLEPAFEYVGSLVRHLTIDERTRTKKYPPSDQFAPELV
EEECCCCCCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHH
HFSRCVLEDREPEPDGWEGLADVRIIEAALRSARERQPVRLEPIERRRRPRAEQAMHRPP
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHCCCC
VAKAGVVHAQAPSQ
CCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537789; 8472911; 8994968 [H]