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The map label for this gene is dacC [H]

Identifier: 220919035

GI number: 220919035

Start: 4400944

End: 4403175

Strand: Direct

Name: dacC [H]

Synonym: A2cp1_3950

Alternate gene names: 220919035

Gene position: 4400944-4403175 (Clockwise)

Preceding gene: 220919033

Following gene: 220919036

Centisome position: 87.51

GC content: 77.82

Gene sequence:

>2232_bases
ATGCAGCCCACCGTGCCCTCCTCCTCCCGTCCCCTCTTCCCGCCCGCCCTGCTCGCCGCGGCGCTCGCCGCCGCCGTCGT
CCCCGCCGCCGCGCTCGCCGCGCCTCCGCCCCCGGTGCCCACCGCCGACGCGCCGTCCCGCGAGGCCGCCCGCGCGCTCA
CCGCGATCGTGGACGGCTCGCCGCTCGCCGGCGCGCGGGTCGGGATCCTCGTCTCGGCAATCGACACGGGCGAGGTGGTC
TACGCGCGCGACCCCGACGTCCTGCTCAACCCGGCGTCCAACGTGAAGCTGGTGACGAGCGCCGCCGCGCTGGCGCGGCT
CGGGCCCGAGTACCGATTCGCGACCGAGGTCCTGGCCGAGCCGAAGGGTGGCGCGGCGCGGGCGCTCTACGTGCGGGGCA
AGGGCGATCCCTCGATCGTGACCGAGCGGCTCTGGGCCATGGCGGGCGACCTCCAGCACCTCGGCGTGAAGCGCGTCGGC
GAGCTGGTGGTGGACGAGGGCTTCTTCGACGGCGAGCGGACCGGGCCCGGCTACGACCAGGAGGAGGGCGATCGCGCGTA
CCTCGCGCCCGCCGGCGCGCTGTCGCTCAACTTCAACGCGGTGGCGGTGCACGTCGGACCGGGCGACCGGCGCGGCGCGC
GCGGCCGGGTGGAGCTCGAGCCCGCCAGCGACTACCTCGAGATCGAGAACCGCACCACCACCGTGCGCGCGGGCTCGCCG
CGGCGAGTGATCATCGAGTCGGTCGCGCGCGGCGGCAAGCAGCGGATCGTGGTGAAGGGGCGCGTGCCGCTCGGCAGCCG
GGTGCAGCCGCAGTGGCGCCGCATCGAGGACCCGGCGCTCTACCTCGGCCACACGCTGGCGCGGCTGCTCGAGCTGCGCG
GGGTGAAGGTTGGGAAGGTGCGCGCCGGCGCGACGCCCGAGGGCGCGCGGCTGGTGCTCGTGGCGCAGTCGGACCCGCTC
GGCGAGCTCGTGCGCCGGCTCAACAAGACCTCGAACAACTTCGTGGCCGAGCAGCTCCTGAAGACGCTCGGCGCCGAGGT
GAAGGGCGCGCCCGGGACCTGGCCGAAGGGCGTGCAGGTGGTGGAGGAGTTCCTGGCCGAGGCCGGCGTGCCGCGCGGCA
CGTACGTCATGAAGAACGGCTCGGGCCTGAACGACACGAACCGCTTCAGCGCCCGGCAGCTCGTGACGCTGCTCCGCGCC
ATGTACGCGCGGTTCCCGCTCCAGCCCGAGTACCTCTCCTCGCTGCCGGTGGCCGGCCGCGACGGCACCATCCGCTGGCG
GATGGAGGGCACCGAGGCCGCCGGCCGGCTCCGCGCCAAGACCGGCACGCTCGAGAACGTCACCAGCCTCTCCGGCTACG
TGGAGGACGGCGCGCACCGGACGCTCGCGTTCGCGGTGCTGGTGAACGACTACCCGGGCCGCTCCGCCGGCGTGCGCCGC
GCCGTCGACGCGCTCGGCGCCGCGCTGGCCGCGAGCGGCGGCCCGCCGGCGGGCCTCGCGGCGGCGGTGGCGCAGGGCAA
GGAGCCGGGGCCGGCGGCCGTCGTGCCGGTCGCCGCGACGCTGGACCTCGCGCGCTCGGCGCAGCCGTACTACGCGCTCG
CCCGCACCGGCGACCCGCGCAACGAGCCGTTCCTGCGCGGCGCGCTGCGGGCCGAGAGCGACCCCGCGCTCCGGCTCGCC
ATCGCCGAGGCGGTGTACCTGTCCGACCCCGAGGGCGAGGCGGCGCGGCGGAGCTTCCTCGACCAGGTCACCCCCGACGC
GCGCGTCCTCGGGCGGCTCTGGTCGGCCCTGGGGACCGAGGAGCCGCCGCCGGTCGTCCCCTCCCTCGCCGAGCTCGCCG
GCGAGGGCGTGCCGGAGGCGCTCGCGAAGCTGGTCGAGCTCGCGCCCGCCGCCGCGCTCGACGGTGCGCTCGCGGCCCGC
CTCGCCGAGGCGCTCGCCGGCGTGGCCGCGTCCGCGCCCGACGAGCTCGTCCAGGCGCTCCGGGCCGCGCGGGCGTCCGA
CGCGGACGCCGCCGTCGGCGCGCTCGGCGCCGGGCTGGCGCGCAGCGACGAGCGCGAGCACCCCTTCCCGCCCGCGCTCG
CCGCGCTCGCCGGCCGGCAGGACGAGCTCGGGGCCTACGCCCGCACGCTAGGCCCACGGCTCGAGGAGGCCCGCCACGCC
GCCGAGGCGGTCCGCGCCGCGCCGGCGCTCGTGCCCGTCGGCGGGACGGTCGTGCCGGCCTCCGGGCGGTAG

Upstream 100 bases:

>100_bases
GGGACCCTCCCGTCAACGCGGCCCCGAAATACCCCCCGCCCGCCCGGGCGTTCACCTGGGCGCGCGCTCGCCTGCGCGTC
CACCGCCCGCCCATCCGATA

Downstream 100 bases:

>100_bases
GCCGGGGCCCCGGCGTCGCCGATGTCAGGGGGGGCGGCTAGGCTCCAGCCTTCACTCACGACGCCTGCGTCCAGCGCAGG
CCACGCAGGGGAGAGCGACG

Product: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 4a; PBP-4a [H]

Number of amino acids: Translated: 743; Mature: 743

Protein sequence:

>743_residues
MQPTVPSSSRPLFPPALLAAALAAAVVPAAALAAPPPPVPTADAPSREAARALTAIVDGSPLAGARVGILVSAIDTGEVV
YARDPDVLLNPASNVKLVTSAAALARLGPEYRFATEVLAEPKGGAARALYVRGKGDPSIVTERLWAMAGDLQHLGVKRVG
ELVVDEGFFDGERTGPGYDQEEGDRAYLAPAGALSLNFNAVAVHVGPGDRRGARGRVELEPASDYLEIENRTTTVRAGSP
RRVIIESVARGGKQRIVVKGRVPLGSRVQPQWRRIEDPALYLGHTLARLLELRGVKVGKVRAGATPEGARLVLVAQSDPL
GELVRRLNKTSNNFVAEQLLKTLGAEVKGAPGTWPKGVQVVEEFLAEAGVPRGTYVMKNGSGLNDTNRFSARQLVTLLRA
MYARFPLQPEYLSSLPVAGRDGTIRWRMEGTEAAGRLRAKTGTLENVTSLSGYVEDGAHRTLAFAVLVNDYPGRSAGVRR
AVDALGAALAASGGPPAGLAAAVAQGKEPGPAAVVPVAATLDLARSAQPYYALARTGDPRNEPFLRGALRAESDPALRLA
IAEAVYLSDPEGEAARRSFLDQVTPDARVLGRLWSALGTEEPPPVVPSLAELAGEGVPEALAKLVELAPAAALDGALAAR
LAEALAGVAASAPDELVQALRAARASDADAAVGALGAGLARSDEREHPFPPALAALAGRQDELGAYARTLGPRLEEARHA
AEAVRAAPALVPVGGTVVPASGR

Sequences:

>Translated_743_residues
MQPTVPSSSRPLFPPALLAAALAAAVVPAAALAAPPPPVPTADAPSREAARALTAIVDGSPLAGARVGILVSAIDTGEVV
YARDPDVLLNPASNVKLVTSAAALARLGPEYRFATEVLAEPKGGAARALYVRGKGDPSIVTERLWAMAGDLQHLGVKRVG
ELVVDEGFFDGERTGPGYDQEEGDRAYLAPAGALSLNFNAVAVHVGPGDRRGARGRVELEPASDYLEIENRTTTVRAGSP
RRVIIESVARGGKQRIVVKGRVPLGSRVQPQWRRIEDPALYLGHTLARLLELRGVKVGKVRAGATPEGARLVLVAQSDPL
GELVRRLNKTSNNFVAEQLLKTLGAEVKGAPGTWPKGVQVVEEFLAEAGVPRGTYVMKNGSGLNDTNRFSARQLVTLLRA
MYARFPLQPEYLSSLPVAGRDGTIRWRMEGTEAAGRLRAKTGTLENVTSLSGYVEDGAHRTLAFAVLVNDYPGRSAGVRR
AVDALGAALAASGGPPAGLAAAVAQGKEPGPAAVVPVAATLDLARSAQPYYALARTGDPRNEPFLRGALRAESDPALRLA
IAEAVYLSDPEGEAARRSFLDQVTPDARVLGRLWSALGTEEPPPVVPSLAELAGEGVPEALAKLVELAPAAALDGALAAR
LAEALAGVAASAPDELVQALRAARASDADAAVGALGAGLARSDEREHPFPPALAALAGRQDELGAYARTLGPRLEEARHA
AEAVRAAPALVPVGGTVVPASGR
>Mature_743_residues
MQPTVPSSSRPLFPPALLAAALAAAVVPAAALAAPPPPVPTADAPSREAARALTAIVDGSPLAGARVGILVSAIDTGEVV
YARDPDVLLNPASNVKLVTSAAALARLGPEYRFATEVLAEPKGGAARALYVRGKGDPSIVTERLWAMAGDLQHLGVKRVG
ELVVDEGFFDGERTGPGYDQEEGDRAYLAPAGALSLNFNAVAVHVGPGDRRGARGRVELEPASDYLEIENRTTTVRAGSP
RRVIIESVARGGKQRIVVKGRVPLGSRVQPQWRRIEDPALYLGHTLARLLELRGVKVGKVRAGATPEGARLVLVAQSDPL
GELVRRLNKTSNNFVAEQLLKTLGAEVKGAPGTWPKGVQVVEEFLAEAGVPRGTYVMKNGSGLNDTNRFSARQLVTLLRA
MYARFPLQPEYLSSLPVAGRDGTIRWRMEGTEAAGRLRAKTGTLENVTSLSGYVEDGAHRTLAFAVLVNDYPGRSAGVRR
AVDALGAALAASGGPPAGLAAAVAQGKEPGPAAVVPVAATLDLARSAQPYYALARTGDPRNEPFLRGALRAESDPALRLA
IAEAVYLSDPEGEAARRSFLDQVTPDARVLGRLWSALGTEEPPPVVPSLAELAGEGVPEALAKLVELAPAAALDGALAAR
LAEALAGVAASAPDELVQALRAARASDADAAVGALGAGLARSDEREHPFPPALAALAGRQDELGAYARTLGPRLEEARHA
AEAVRAAPALVPVGGTVVPASGR

Specific function: Catalyzes DD-carboxypeptidase and transpeptidation reactions [H]

COG id: COG2027

COG function: function code M; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)

Gene ontology:

Cell location: Secreted (Probable). Note=May be anchored in the membrane via a C-terminal amphiphatic alpha helix [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S13 family [H]

Homologues:

Organism=Escherichia coli, GI1789573, Length=422, Percent_Identity=26.5402843601896, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR000667 [H]

Pfam domain/function: PF02113 Peptidase_S13 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 77137; Mature: 77137

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTVPSSSRPLFPPALLAAALAAAVVPAAALAAPPPPVPTADAPSREAARALTAIVDGS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
PLAGARVGILVSAIDTGEVVYARDPDVLLNPASNVKLVTSAAALARLGPEYRFATEVLAE
CCCCCEEEEEEEEECCCCEEEECCCCEEECCCCCCEEHHHHHHHHHCCCCHHHHHHHHHC
PKGGAARALYVRGKGDPSIVTERLWAMAGDLQHLGVKRVGELVVDEGFFDGERTGPGYDQ
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EEGDRAYLAPAGALSLNFNAVAVHVGPGDRRGARGRVELEPASDYLEIENRTTTVRAGSP
CCCCEEEECCCCEEEEECEEEEEEECCCCCCCCCCEEEECCCCCCEEECCCEEEEECCCC
RRVIIESVARGGKQRIVVKGRVPLGSRVQPQWRRIEDPALYLGHTLARLLELRGVKVGKV
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEE
RAGATPEGARLVLVAQSDPLGELVRRLNKTSNNFVAEQLLKTLGAEVKGAPGTWPKGVQV
ECCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHH
VEEFLAEAGVPRGTYVMKNGSGLNDTNRFSARQLVTLLRAMYARFPLQPEYLSSLPVAGR
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
DGTIRWRMEGTEAAGRLRAKTGTLENVTSLSGYVEDGAHRTLAFAVLVNDYPGRSAGVRR
CCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHH
AVDALGAALAASGGPPAGLAAAVAQGKEPGPAAVVPVAATLDLARSAQPYYALARTGDPR
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCCEEEEECCCCC
NEPFLRGALRAESDPALRLAIAEAVYLSDPEGEAARRSFLDQVTPDARVLGRLWSALGTE
CCCHHHHHHCCCCCCCEEEEEHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCC
EPPPVVPSLAELAGEGVPEALAKLVELAPAAALDGALAARLAEALAGVAASAPDELVQAL
CCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RAARASDADAAVGALGAGLARSDEREHPFPPALAALAGRQDELGAYARTLGPRLEEARHA
HHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCHHHHHHHHH
AEAVRAAPALVPVGGTVVPASGR
HHHHHHCCCEEECCCEEECCCCC
>Mature Secondary Structure
MQPTVPSSSRPLFPPALLAAALAAAVVPAAALAAPPPPVPTADAPSREAARALTAIVDGS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
PLAGARVGILVSAIDTGEVVYARDPDVLLNPASNVKLVTSAAALARLGPEYRFATEVLAE
CCCCCEEEEEEEEECCCCEEEECCCCEEECCCCCCEEHHHHHHHHHCCCCHHHHHHHHHC
PKGGAARALYVRGKGDPSIVTERLWAMAGDLQHLGVKRVGELVVDEGFFDGERTGPGYDQ
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EEGDRAYLAPAGALSLNFNAVAVHVGPGDRRGARGRVELEPASDYLEIENRTTTVRAGSP
CCCCEEEECCCCEEEEECEEEEEEECCCCCCCCCCEEEECCCCCCEEECCCEEEEECCCC
RRVIIESVARGGKQRIVVKGRVPLGSRVQPQWRRIEDPALYLGHTLARLLELRGVKVGKV
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEE
RAGATPEGARLVLVAQSDPLGELVRRLNKTSNNFVAEQLLKTLGAEVKGAPGTWPKGVQV
ECCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHH
VEEFLAEAGVPRGTYVMKNGSGLNDTNRFSARQLVTLLRAMYARFPLQPEYLSSLPVAGR
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
DGTIRWRMEGTEAAGRLRAKTGTLENVTSLSGYVEDGAHRTLAFAVLVNDYPGRSAGVRR
CCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHH
AVDALGAALAASGGPPAGLAAAVAQGKEPGPAAVVPVAATLDLARSAQPYYALARTGDPR
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCCEEEEECCCCC
NEPFLRGALRAESDPALRLAIAEAVYLSDPEGEAARRSFLDQVTPDARVLGRLWSALGTE
CCCHHHHHHCCCCCCCEEEEEHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCC
EPPPVVPSLAELAGEGVPEALAKLVELAPAAALDGALAARLAEALAGVAASAPDELVQAL
CCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RAARASDADAAVGALGAGLARSDEREHPFPPALAALAGRQDELGAYARTLGPRLEEARHA
HHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCHHHHHHHHH
AEAVRAAPALVPVGGTVVPASGR
HHHHHHCCCEEECCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7711903; 9384377 [H]