Click here to switch to the map view.

The map label for this gene is mraY

Identifier: 220918993

GI number: 220918993

Start: 4347425

End: 4348567

Strand: Direct

Name: mraY

Synonym: A2cp1_3908

Alternate gene names: 220918993

Gene position: 4347425-4348567 (Clockwise)

Preceding gene: 220918992

Following gene: 220918994

Centisome position: 86.44

GC content: 66.49

Gene sequence:

>1143_bases
ATGCTCTACCACCTCCTCTACCCGCTGGCCTACAAGCTCAGCCTCCTCAACGTCCTCCGCTACCCGTCGTTCCGCATCGT
GGCGGCGGGCCTCACCGCCATGGTGCTGGGCCTGCTGCTCGGGCCGATCTTCATCGAGCGGATGCGGGTGCTGCAGTACG
GCTCGACCAACGTCCGCGAGGACACGCCGGACACGCACAAGAAGAAGGCGGGCACGCCGTCGATGGGCGGCGCGCTGATC
CTCGCGTCGGTCGCGATCGCCACCCTGCTGTTCGCGGACCTCGCGAACCGCTTCGTGTGGGCGGCGCTGCTCGTGACGCT
GGGCTACGGCGCCATCGGCTTCACCGACGACTGGCTCAAGATCTCGAAGAAGAACTCGAAGGGCCTGGCCGGCAAGAAGA
AGCTCGTGCTGCAGGTGCTGGTGGTGGTGGTGGTCTACTACGCCTGCCTGACCGACTGGCGCTTCCACGTCGAGCACCGC
TTCCCGTGGGTGTTCGTGGGCAGCTACGTGGACCTCCACGTCACCCTGCCGTTCGTGCCCTCCCGGCTCTTCAACCCGGA
CCTCGGCTTCCTGTACCTGCCGTTCATGGTGTTCGTGGTGATCGCCACCTCGAACGCGGTGAACCTGACCGACGGCCTGG
ACGGCCTCGCCATCGGCCCGACCGTCGTGTCGGCCATGACGTTCCTGGCGCTGTCCTACGTGGCGGGCGCCACCATCGCC
GGGTTCAGCCTGGCCGAGTACCTGCGGGTGCCGTACATCCCCGGCGCGGAGGAGCTGGGCGTGTTCTGCTCGGCCATCTT
CGGCGCGGGCGTGGCGTTCCTCTGGTACAACACCTATCCGGCGTCGGTGTTCATGGGCGACGTGGGCTCGCTCGCCCTGG
GGGGCGGCCTCGGCATGATGGCGGTGCTCACCAAGAACGAGTTCGCGAGCGCCATCCTGCACGGCGTCTTCCTGACCGAG
ACGGTGAGCGTCATCCTCCAGGTCTGGTCGTTCAAGACCACCGGCAAGCGCATCTTCCGGATGGCGCCCATCCACCACCA
CTACGAGCTGAAGGGGTGGGCGGAGCCGAAGATCATCGTCCGCTTCTGGATCATCTCGGTGATGCTGGCGCTGGTTGCGC
TGCTCTCCATCAAGCTGAGGTAG

Upstream 100 bases:

>100_bases
CGTCGCGTTCGTGCGCGAGCGGCTCCGTCCCACCGACGTCCTGCTCGTGAAGGGGAGCCGCGGCATGAAGCTCGAGCGGC
TCGTCGAGGCCCTGCGCTAG

Downstream 100 bases:

>100_bases
CCGTGGCCGCACCGGACCTGAAGGGCACGAGGGTGACGGTGGTGGGGCTCGCGAAGAGCGGCGTCGCCGCCGCGCGGCTC
TGCGCCCGCGAGGGCGCGCG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MLYHLLYPLAYKLSLLNVLRYPSFRIVAAGLTAMVLGLLLGPIFIERMRVLQYGSTNVREDTPDTHKKKAGTPSMGGALI
LASVAIATLLFADLANRFVWAALLVTLGYGAIGFTDDWLKISKKNSKGLAGKKKLVLQVLVVVVVYYACLTDWRFHVEHR
FPWVFVGSYVDLHVTLPFVPSRLFNPDLGFLYLPFMVFVVIATSNAVNLTDGLDGLAIGPTVVSAMTFLALSYVAGATIA
GFSLAEYLRVPYIPGAEELGVFCSAIFGAGVAFLWYNTYPASVFMGDVGSLALGGGLGMMAVLTKNEFASAILHGVFLTE
TVSVILQVWSFKTTGKRIFRMAPIHHHYELKGWAEPKIIVRFWIISVMLALVALLSIKLR

Sequences:

>Translated_380_residues
MLYHLLYPLAYKLSLLNVLRYPSFRIVAAGLTAMVLGLLLGPIFIERMRVLQYGSTNVREDTPDTHKKKAGTPSMGGALI
LASVAIATLLFADLANRFVWAALLVTLGYGAIGFTDDWLKISKKNSKGLAGKKKLVLQVLVVVVVYYACLTDWRFHVEHR
FPWVFVGSYVDLHVTLPFVPSRLFNPDLGFLYLPFMVFVVIATSNAVNLTDGLDGLAIGPTVVSAMTFLALSYVAGATIA
GFSLAEYLRVPYIPGAEELGVFCSAIFGAGVAFLWYNTYPASVFMGDVGSLALGGGLGMMAVLTKNEFASAILHGVFLTE
TVSVILQVWSFKTTGKRIFRMAPIHHHYELKGWAEPKIIVRFWIISVMLALVALLSIKLR
>Mature_380_residues
MLYHLLYPLAYKLSLLNVLRYPSFRIVAAGLTAMVLGLLLGPIFIERMRVLQYGSTNVREDTPDTHKKKAGTPSMGGALI
LASVAIATLLFADLANRFVWAALLVTLGYGAIGFTDDWLKISKKNSKGLAGKKKLVLQVLVVVVVYYACLTDWRFHVEHR
FPWVFVGSYVDLHVTLPFVPSRLFNPDLGFLYLPFMVFVVIATSNAVNLTDGLDGLAIGPTVVSAMTFLALSYVAGATIA
GFSLAEYLRVPYIPGAEELGVFCSAIFGAGVAFLWYNTYPASVFMGDVGSLALGGGLGMMAVLTKNEFASAILHGVFLTE
TVSVILQVWSFKTTGKRIFRMAPIHHHYELKGWAEPKIIVRFWIISVMLALVALLSIKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=380, Percent_Identity=46.8421052631579, Blast_Score=311, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_ANAD2 (B8J8E5)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002494297.1
- GeneID:   7297248
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_3908
- HOGENOM:   HBG708263
- ProtClustDB:   PRK00108
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 41679; Mature: 41679

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1fde8dc0)-; HASH(0x20621098)-; HASH(0x203600a8)-; HASH(0x20844cec)-; HASH(0x202a1ca8)-; HASH(0x20002554)-; HASH(0x2057a324)-; HASH(0x1da7da68)-; HASH(0x1fb59fb0)-; HASH(0x209da678)-; HASH(0x20757530)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYHLLYPLAYKLSLLNVLRYPSFRIVAAGLTAMVLGLLLGPIFIERMRVLQYGSTNVRE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTPDTHKKKAGTPSMGGALILASVAIATLLFADLANRFVWAALLVTLGYGAIGFTDDWLK
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ISKKNSKGLAGKKKLVLQVLVVVVVYYACLTDWRFHVEHRFPWVFVGSYVDLHVTLPFVP
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCEEEEEEECCCCC
SRLFNPDLGFLYLPFMVFVVIATSNAVNLTDGLDGLAIGPTVVSAMTFLALSYVAGATIA
HHHCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GFSLAEYLRVPYIPGAEELGVFCSAIFGAGVAFLWYNTYPASVFMGDVGSLALGGGLGMM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHCCCCCHHHCCCCHHH
AVLTKNEFASAILHGVFLTETVSVILQVWSFKTTGKRIFRMAPIHHHYELKGWAEPKIIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEECCCCCCCHHHH
RFWIISVMLALVALLSIKLR
HHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLYHLLYPLAYKLSLLNVLRYPSFRIVAAGLTAMVLGLLLGPIFIERMRVLQYGSTNVRE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTPDTHKKKAGTPSMGGALILASVAIATLLFADLANRFVWAALLVTLGYGAIGFTDDWLK
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ISKKNSKGLAGKKKLVLQVLVVVVVYYACLTDWRFHVEHRFPWVFVGSYVDLHVTLPFVP
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCEEEEEEECCCCC
SRLFNPDLGFLYLPFMVFVVIATSNAVNLTDGLDGLAIGPTVVSAMTFLALSYVAGATIA
HHHCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GFSLAEYLRVPYIPGAEELGVFCSAIFGAGVAFLWYNTYPASVFMGDVGSLALGGGLGMM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHCCCCCHHHCCCCHHH
AVLTKNEFASAILHGVFLTETVSVILQVWSFKTTGKRIFRMAPIHHHYELKGWAEPKIIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEECCCCCCCHHHH
RFWIISVMLALVALLSIKLR
HHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA