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The map label for this gene is mdmC [H]

Identifier: 220918950

GI number: 220918950

Start: 4299970

End: 4300647

Strand: Direct

Name: mdmC [H]

Synonym: A2cp1_3865

Alternate gene names: 220918950

Gene position: 4299970-4300647 (Clockwise)

Preceding gene: 220918949

Following gene: 220918951

Centisome position: 85.5

GC content: 75.81

Gene sequence:

>678_bases
ATGGGATCACCTGACGTGAAGGCGTTCGGCGCGGCGGACCCGGAGCTGGCGGCCTGGGCCGCGGCCACCTACCGGCCCGA
GGACGAGGTGCTGCGCGGCATCCGCGAGCGCTCGATCGCCGCGGGCCTGCCGGCCATCCAGGTCGGCGCCATGGATGGGC
TCCACCTCGAGGTGCTGGCGCGCGCCTGCGGCTGGCGGAGCGCGGTGGAGATCGGTACGCTCGGCGGCTACAGCGGCGTC
TGCCTGCTCCGCGGCATGGGCGAGCGCGGGCGCCTGGACACGTTCGAGCTCGACCCCGGGCGCGCCGCCCTGGCGCGCCG
CCACTTCGAGGAGGCCGGCGTGGCGGACCGGGTGCGGGTGCACGTGGGCCCGGCGCTGGAGCGGCTGGCGGCCGTCGAGG
CCGAGGGGCCGTTCGACGTGGTGTTCATCGACGCGGACAAGAAGGGCTACCCGGCCTACCTGGACTGGGCCGCCGAGCAC
CTGCGCGTGGGCGGTGCCGTGCTCGCCGACAACACCTTCGGCTTCGGGCAGGTGCATCGGGCCCGCCCTCAGGGCGAGGA
CCCCGAGGCCATGGAGGCGCTGCGGACCTTCAGCGCACGGCTCGCGCAGGGCGGCCGCTTCCGCGCCACGCTGCTGCCCA
CCGGCGAGGGGCTCTCGCTCGGCGTGAAGGTGCGCTGA

Upstream 100 bases:

>100_bases
GCGCAGCCGGAGCGGGGCCGCGACGGCTCCGCCGGCGGGGCGAGGGCGCAGCCCTCGGGGGTGATTGCCCCACGGCCGCG
GCCGCGGCACATCCCGCTCC

Downstream 100 bases:

>100_bases
GAGAGCGTGAAGGAATCGGCCGGTGCCCCATGGACTGGGGCCGCCGGCCGTGATCTTCTCGGGGCGTGAGCGAACACGAC
GCGCCGCGGGTGGTGAGGCC

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MGSPDVKAFGAADPELAAWAAATYRPEDEVLRGIRERSIAAGLPAIQVGAMDGLHLEVLARACGWRSAVEIGTLGGYSGV
CLLRGMGERGRLDTFELDPGRAALARRHFEEAGVADRVRVHVGPALERLAAVEAEGPFDVVFIDADKKGYPAYLDWAAEH
LRVGGAVLADNTFGFGQVHRARPQGEDPEAMEALRTFSARLAQGGRFRATLLPTGEGLSLGVKVR

Sequences:

>Translated_225_residues
MGSPDVKAFGAADPELAAWAAATYRPEDEVLRGIRERSIAAGLPAIQVGAMDGLHLEVLARACGWRSAVEIGTLGGYSGV
CLLRGMGERGRLDTFELDPGRAALARRHFEEAGVADRVRVHVGPALERLAAVEAEGPFDVVFIDADKKGYPAYLDWAAEH
LRVGGAVLADNTFGFGQVHRARPQGEDPEAMEALRTFSARLAQGGRFRATLLPTGEGLSLGVKVR
>Mature_224_residues
GSPDVKAFGAADPELAAWAAATYRPEDEVLRGIRERSIAAGLPAIQVGAMDGLHLEVLARACGWRSAVEIGTLGGYSGVC
LLRGMGERGRLDTFELDPGRAALARRHFEEAGVADRVRVHVGPALERLAAVEAEGPFDVVFIDADKKGYPAYLDWAAEHL
RVGGAVLADNTFGFGQVHRARPQGEDPEAMEALRTFSARLAQGGRFRATLLPTGEGLSLGVKVR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=170, Percent_Identity=34.1176470588235, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25148771, Length=177, Percent_Identity=27.1186440677966, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23988; Mature: 23856

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPDVKAFGAADPELAAWAAATYRPEDEVLRGIRERSIAAGLPAIQVGAMDGLHLEVLA
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
RACGWRSAVEIGTLGGYSGVCLLRGMGERGRLDTFELDPGRAALARRHFEEAGVADRVRV
HHHCCCCCEEEECCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEE
HVGPALERLAAVEAEGPFDVVFIDADKKGYPAYLDWAAEHLRVGGAVLADNTFGFGQVHR
EECHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHC
ARPQGEDPEAMEALRTFSARLAQGGRFRATLLPTGEGLSLGVKVR
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEC
>Mature Secondary Structure 
GSPDVKAFGAADPELAAWAAATYRPEDEVLRGIRERSIAAGLPAIQVGAMDGLHLEVLA
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
RACGWRSAVEIGTLGGYSGVCLLRGMGERGRLDTFELDPGRAALARRHFEEAGVADRVRV
HHHCCCCCEEEECCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEE
HVGPALERLAAVEAEGPFDVVFIDADKKGYPAYLDWAAEHLRVGGAVLADNTFGFGQVHR
EECHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHC
ARPQGEDPEAMEALRTFSARLAQGGRFRATLLPTGEGLSLGVKVR
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]