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The map label for this gene is ykoH [H]

Identifier: 220918949

GI number: 220918949

Start: 4297997

End: 4299775

Strand: Direct

Name: ykoH [H]

Synonym: A2cp1_3864

Alternate gene names: 220918949

Gene position: 4297997-4299775 (Clockwise)

Preceding gene: 220918948

Following gene: 220918950

Centisome position: 85.46

GC content: 75.44

Gene sequence:

>1779_bases
GTGCCGCCGACTCCGGATCGCCGACGGCTCCTCGAACGGCTGGGCGCGCTGCTGGACGACGCGGCGCGGAGGGGATCGCT
CCCCGAGGCCGCCACGCTGCGCGACGGGCTGCGCACGCTCGCCGAGGACCAGGCGGTCGCCGAGGCGGTGGCGGACAGCG
CCGGCACGCTGGTGGTGGTGCTCGATCGCGAGGGGCGCGTGGTCCGCTGGAACCGCACCTGCACGCGGGTGACCGGCTGG
CGCGCGGGCGAGATCGTCGGCCGGCCGTTCTGGGACGTGCTGCTGCTGCCCGAGGAGCGCGACGGGATCCGCAAGGCGTT
CTCGCGGATGCTCGCCCGGGACTTCCCGAACCAGCAGGAGGTGCACTGGCGCACCCGCGACGGCGAGGCGCGCCTCATCG
CCTGGTCCAACGCCGCGCTGTTCGACGCCGCCGGCGAGGTGGACCGCATCGTCTCGACCGGCATCGACGTGACCGACCGC
ACCCGGGCCGAGACGGCGCTGCGCCGGCAGGCGCGCCGGCTGGAGGCGCTGGCCGAGGCCTCCCGCGTGTTCGCGGCCGG
GCTCGACTACAAGACCACGCTCGACACCGTGGCGCGGCGGCTCTCCGAGCTCATCGGGGACGGCGCGCTCATCCGCGTGG
TCTCCGAGGACGGCGAGTGGCTGGTGCCGGTGGCCGTCTACCACCCGTCCCCCGAGCGCGCCGCGCTGCGCCGCAGGGTG
CTGCTCGCGTCCCCGCAGCGCACCGGCGAGGGCATCACCGCCGGCGTCCTCGCCTCCGGGAAGCCCCTGCGCATCCCGCA
CCTCACCCGCGAGATCATCCGCAACGAGATGAAGCCGGAGTACCTGCCCTACCTCGAGGGCGTCTCCAGCCTGCTCATCG
CGCCGCTGGAGCAGCGCCGCACCGTGGTCGGGCACCTCACGCTCATGCGCGACGCGGGCGGCGCCCCGTACACCTCGGAG
GACGAGGCGCTGCTCGAGGACCTCGCCCACCGGGCCGCGCAGGCGCTCGAGAACGCGCGGCTCTACGGCGAGGCGCAGGC
GGCGGTGGCCGCCCGCGACGAGTTCCTCTCCATCGCCTCGCACGAGCTGCGCACCCCGCTCACCGCGCTGCGCCTCGCGC
TCGAGAACATGCGCCGGGTGGCGAGCCGCGAGGCGCTCGAGTCGCTCCCGGCCGCCTACGTCGAGCGCGTGCTCGCCACC
GCCGAGCGGCAGGGGCAGCGGCTCGAGAAGCTGGTGGCCGCGCTGCTCGACGTGTCGCGGATCCACATGGGCCGGCTGGA
GCTCGAGATCGAGGACGTGGACCTCGGCCACGCGGTGTCCGAGGCGGTCGCGCAGGTGGAGGACGAGGCGGCGCAGGCGG
GCTCGCAGGTGACCGTGCAGGGGGAGCCGGTGCGCGGCCGCTGGGACCGGCTGCGCATCTCGCAGGTGGCGACGAACCTG
CTCTCCAACGCGGTGAAGTACGGGGCCGGCAAGCCGGTGGAGGTCTCGTTCGGCACGCGCGACGGGCGCGCGTACCTGCG
GGTGCGCGACCAGGGCATCGGCATCGACCCGGCCGACCAGCGGCAGATCTTCGAGCGCTTCGAGCGGGCGGTGTCGTCGC
GCAACTACGGCGGGCTCGGGCTGGGCCTGTACATCGTGAAGCGGATCGTGGAGGCGCACGGCGGGGCGGTCCGGGTCGAG
AGCGCGCCGGGCGAGGGCGCCGCGTTCGAGGTGACGCTGCCGCTCCGGCCGGCCGTGCCGCTCCCGGGCGGCGAGGCCGC
GCCGCCGGTGCAGCACTGA

Upstream 100 bases:

>100_bases
GTGGACCGCTTCGTCTCCATCTACCCGGACCACGTCCCGCCGACCTCGCTCATCCGCGAGTTCATCGGCGGGAGCGGGTT
CGAGTACTGAGAGGTCTCCC

Downstream 100 bases:

>100_bases
CGCGCCCTTCCCGCCGAGGGCAGCGCGCCGCCAGGCGCGCCCGCGGGGACTTCGCGCGAGCCCGCGCAGGCGGGCGCGCG
GGGTCACGGGCCCCGCGCAG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MPPTPDRRRLLERLGALLDDAARRGSLPEAATLRDGLRTLAEDQAVAEAVADSAGTLVVVLDREGRVVRWNRTCTRVTGW
RAGEIVGRPFWDVLLLPEERDGIRKAFSRMLARDFPNQQEVHWRTRDGEARLIAWSNAALFDAAGEVDRIVSTGIDVTDR
TRAETALRRQARRLEALAEASRVFAAGLDYKTTLDTVARRLSELIGDGALIRVVSEDGEWLVPVAVYHPSPERAALRRRV
LLASPQRTGEGITAGVLASGKPLRIPHLTREIIRNEMKPEYLPYLEGVSSLLIAPLEQRRTVVGHLTLMRDAGGAPYTSE
DEALLEDLAHRAAQALENARLYGEAQAAVAARDEFLSIASHELRTPLTALRLALENMRRVASREALESLPAAYVERVLAT
AERQGQRLEKLVAALLDVSRIHMGRLELEIEDVDLGHAVSEAVAQVEDEAAQAGSQVTVQGEPVRGRWDRLRISQVATNL
LSNAVKYGAGKPVEVSFGTRDGRAYLRVRDQGIGIDPADQRQIFERFERAVSSRNYGGLGLGLYIVKRIVEAHGGAVRVE
SAPGEGAAFEVTLPLRPAVPLPGGEAAPPVQH

Sequences:

>Translated_592_residues
MPPTPDRRRLLERLGALLDDAARRGSLPEAATLRDGLRTLAEDQAVAEAVADSAGTLVVVLDREGRVVRWNRTCTRVTGW
RAGEIVGRPFWDVLLLPEERDGIRKAFSRMLARDFPNQQEVHWRTRDGEARLIAWSNAALFDAAGEVDRIVSTGIDVTDR
TRAETALRRQARRLEALAEASRVFAAGLDYKTTLDTVARRLSELIGDGALIRVVSEDGEWLVPVAVYHPSPERAALRRRV
LLASPQRTGEGITAGVLASGKPLRIPHLTREIIRNEMKPEYLPYLEGVSSLLIAPLEQRRTVVGHLTLMRDAGGAPYTSE
DEALLEDLAHRAAQALENARLYGEAQAAVAARDEFLSIASHELRTPLTALRLALENMRRVASREALESLPAAYVERVLAT
AERQGQRLEKLVAALLDVSRIHMGRLELEIEDVDLGHAVSEAVAQVEDEAAQAGSQVTVQGEPVRGRWDRLRISQVATNL
LSNAVKYGAGKPVEVSFGTRDGRAYLRVRDQGIGIDPADQRQIFERFERAVSSRNYGGLGLGLYIVKRIVEAHGGAVRVE
SAPGEGAAFEVTLPLRPAVPLPGGEAAPPVQH
>Mature_591_residues
PPTPDRRRLLERLGALLDDAARRGSLPEAATLRDGLRTLAEDQAVAEAVADSAGTLVVVLDREGRVVRWNRTCTRVTGWR
AGEIVGRPFWDVLLLPEERDGIRKAFSRMLARDFPNQQEVHWRTRDGEARLIAWSNAALFDAAGEVDRIVSTGIDVTDRT
RAETALRRQARRLEALAEASRVFAAGLDYKTTLDTVARRLSELIGDGALIRVVSEDGEWLVPVAVYHPSPERAALRRRVL
LASPQRTGEGITAGVLASGKPLRIPHLTREIIRNEMKPEYLPYLEGVSSLLIAPLEQRRTVVGHLTLMRDAGGAPYTSED
EALLEDLAHRAAQALENARLYGEAQAAVAARDEFLSIASHELRTPLTALRLALENMRRVASREALESLPAAYVERVLATA
ERQGQRLEKLVAALLDVSRIHMGRLELEIEDVDLGHAVSEAVAQVEDEAAQAGSQVTVQGEPVRGRWDRLRISQVATNLL
SNAVKYGAGKPVEVSFGTRDGRAYLRVRDQGIGIDPADQRQIFERFERAVSSRNYGGLGLGLYIVKRIVEAHGGAVRVES
APGEGAAFEVTLPLRPAVPLPGGEAAPPVQH

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=30.1960784313725, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788713, Length=244, Percent_Identity=29.9180327868852, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=28.4132841328413, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=34.6456692913386, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=33.4763948497854, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=31.4393939393939, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=268, Percent_Identity=32.4626865671642, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787894, Length=237, Percent_Identity=30.8016877637131, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=30.6382978723404, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789808, Length=229, Percent_Identity=30.5676855895196, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081816, Length=263, Percent_Identity=31.9391634980989, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=27.8969957081545, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=30.9734513274336, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=228, Percent_Identity=23.6842105263158, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=26.7543859649123, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=26.3157894736842, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790551, Length=244, Percent_Identity=29.9180327868852, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=31.1965811965812, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64870; Mature: 64738

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPTPDRRRLLERLGALLDDAARRGSLPEAATLRDGLRTLAEDQAVAEAVADSAGTLVVV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LDREGRVVRWNRTCTRVTGWRAGEIVGRPFWDVLLLPEERDGIRKAFSRMLARDFPNQQE
ECCCCCEEEECCCCHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
VHWRTRDGEARLIAWSNAALFDAAGEVDRIVSTGIDVTDRTRAETALRRQARRLEALAEA
EEEEECCCCEEEEEECCCHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SRVFAAGLDYKTTLDTVARRLSELIGDGALIRVVSEDGEWLVPVAVYHPSPERAALRRRV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHH
LLASPQRTGEGITAGVLASGKPLRIPHLTREIIRNEMKPEYLPYLEGVSSLLIAPLEQRR
HHCCCCCCCCCCEEEHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHH
TVVGHLTLMRDAGGAPYTSEDEALLEDLAHRAAQALENARLYGEAQAAVAARDEFLSIAS
HHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRTPLTALRLALENMRRVASREALESLPAAYVERVLATAERQGQRLEKLVAALLDVSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHMGRLELEIEDVDLGHAVSEAVAQVEDEAAQAGSQVTVQGEPVRGRWDRLRISQVATNL
HHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHH
LSNAVKYGAGKPVEVSFGTRDGRAYLRVRDQGIGIDPADQRQIFERFERAVSSRNYGGLG
HHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCH
LGLYIVKRIVEAHGGAVRVESAPGEGAAFEVTLPLRPAVPLPGGEAAPPVQH
HHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PPTPDRRRLLERLGALLDDAARRGSLPEAATLRDGLRTLAEDQAVAEAVADSAGTLVVV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LDREGRVVRWNRTCTRVTGWRAGEIVGRPFWDVLLLPEERDGIRKAFSRMLARDFPNQQE
ECCCCCEEEECCCCHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
VHWRTRDGEARLIAWSNAALFDAAGEVDRIVSTGIDVTDRTRAETALRRQARRLEALAEA
EEEEECCCCEEEEEECCCHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SRVFAAGLDYKTTLDTVARRLSELIGDGALIRVVSEDGEWLVPVAVYHPSPERAALRRRV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHH
LLASPQRTGEGITAGVLASGKPLRIPHLTREIIRNEMKPEYLPYLEGVSSLLIAPLEQRR
HHCCCCCCCCCCEEEHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHH
TVVGHLTLMRDAGGAPYTSEDEALLEDLAHRAAQALENARLYGEAQAAVAARDEFLSIAS
HHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRTPLTALRLALENMRRVASREALESLPAAYVERVLATAERQGQRLEKLVAALLDVSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHMGRLELEIEDVDLGHAVSEAVAQVEDEAAQAGSQVTVQGEPVRGRWDRLRISQVATNL
HHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHH
LSNAVKYGAGKPVEVSFGTRDGRAYLRVRDQGIGIDPADQRQIFERFERAVSSRNYGGLG
HHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCH
LGLYIVKRIVEAHGGAVRVESAPGEGAAFEVTLPLRPAVPLPGGEAAPPVQH
HHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]