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The map label for this gene is cbs [H]

Identifier: 220918932

GI number: 220918932

Start: 4274998

End: 4276377

Strand: Direct

Name: cbs [H]

Synonym: A2cp1_3846

Alternate gene names: 220918932

Gene position: 4274998-4276377 (Clockwise)

Preceding gene: 220918929

Following gene: 220918933

Centisome position: 85.0

GC content: 68.26

Gene sequence:

>1380_bases
ATGGCCTACCACGAGACCGTCCTCTCCGCGATCGGGCACACGCCGCTCGTCCGCCTGCAGAAGCTCACCGGTCCCGACGA
CGCGACCGTGCTCGTGAAGCTCGAGTACCTGAACCCCGGCGGCTCCATCAAGGACCGCATGGCGGTGCACATCCTCGAGA
AGGCGGAGCGCTCGGGGCTGCTGCGGCCGGGCGGCACCATCGTCGAGAACACCAGCGGCAACACCGGCGTGGGCCTGGCC
ATGGCGGCGGCGGTGAAGGGGTACCGCTGCGTGTTCACCATGCCGGACAAGATGTCGAAGGAGAAGCAGGACACGCTGAA
GGCGTTCGGCGCGAAGGTGATCGTGACGCCGACCAACGTGCCGGCCGACTCGCCCGACAGCTACTACTCGGTGGCCAAGC
GCATCGCGGCGGAGACGCCCAACAGCTTCTACGTGAACCAGTACCACAGCCTCGACAACGTCGAGGCCCACTACCAGCTC
ACCGCCCCCGAGATCTGGGAGCAGACCGGCGGCCGGCTCGACGCGTTCGTGGCCGGCCTGGGCACCGGCGGGACCATGAG
CGGCTGCGGGAAGTTCTTCAAGGAGAAGGCCCCCGCCATCCTCAACGTCGGCGTGGACCCGATCGGCTCGGTGTACCACT
CGATGTTCAAGACCGGGAAGCTCTCGCAGCCCCACGTCTACAAGGTGGAGGGCATCGGCGAGGACATGATGTGCGGCGCG
ATGGACCTCTCGGTCCTCGACGACGTCCGCCAGGTGAACGACGCCGAGGCGTTCGTGATGGCGCGCCGGCTCGCCCGCGA
GGAGGGCGTCCTCGCCGGCGGCTCCTCCGGGGCGGCGGTGCACGTCGCGGTGAAGCTCGCGAAGGAGCTCGGCAAGGGCA
AGGTGATCGTGGTGCCGCTGCCCGACGGCGGGCGCGCCTACATCTCCAAGTTCTACTCGGACGAGTGGATGCGCGACAAC
GGCTTCCCGGTGGGCGCGGGCGGCCCGGTGTCCGCCGCCACCGTGAAGGACGTGCTCGGCCGCCGCCGCGGCGAGGTCAT
CTCCGCGCGCAAGACCGACAAGGTCGAGGCGGTGGTGAAGAAGATGAAGGAGCACGACATCTCGCAGATGCCGGTGGTGG
ACGACACCGGCCGCGCCATCGGGATGATCCACGAGTACGACCTGCTCAACTTCCTCATCGAGGGGAAGCACCGCCTCACC
GAGGTGGTCGAGCCGCTGGTGCAACCGCTGCAGGGCGTGGTGGAGCCGGAGACGGCGCTCTCGCGCCTCCGCGACATCTT
CAACGACGATCACGTGGCGGTGGTGAAGGAGGGCGATCGGGTCACCGGCATCGTGACCAAGATCGACCTCATCGAGTTCC
TGGCGCAGCGGCTCCGCTAG

Upstream 100 bases:

>100_bases
CCTAGGGGTCGCGCCGCGCCGGTCCGGCGCGTTGACGCGGGTCACGCCGCCTGCCTATAACGCCGGGATTCCCGTCGATC
TTTCCGGATCCGGAGCCCCC

Downstream 100 bases:

>100_bases
CCGCCCCGCCCTCCCACGGAGCGACCATGGCCGACGCCGAGACGAAGCCCGGGTTCGACACCCTCGCCATCCACGCCGGC
CAGGCGCCGGATCCGACCAC

Product: Pyridoxal-5'-phosphate-dependent protein beta subunit

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAYHETVLSAIGHTPLVRLQKLTGPDDATVLVKLEYLNPGGSIKDRMAVHILEKAERSGLLRPGGTIVENTSGNTGVGLA
MAAAVKGYRCVFTMPDKMSKEKQDTLKAFGAKVIVTPTNVPADSPDSYYSVAKRIAAETPNSFYVNQYHSLDNVEAHYQL
TAPEIWEQTGGRLDAFVAGLGTGGTMSGCGKFFKEKAPAILNVGVDPIGSVYHSMFKTGKLSQPHVYKVEGIGEDMMCGA
MDLSVLDDVRQVNDAEAFVMARRLAREEGVLAGGSSGAAVHVAVKLAKELGKGKVIVVPLPDGGRAYISKFYSDEWMRDN
GFPVGAGGPVSAATVKDVLGRRRGEVISARKTDKVEAVVKKMKEHDISQMPVVDDTGRAIGMIHEYDLLNFLIEGKHRLT
EVVEPLVQPLQGVVEPETALSRLRDIFNDDHVAVVKEGDRVTGIVTKIDLIEFLAQRLR

Sequences:

>Translated_459_residues
MAYHETVLSAIGHTPLVRLQKLTGPDDATVLVKLEYLNPGGSIKDRMAVHILEKAERSGLLRPGGTIVENTSGNTGVGLA
MAAAVKGYRCVFTMPDKMSKEKQDTLKAFGAKVIVTPTNVPADSPDSYYSVAKRIAAETPNSFYVNQYHSLDNVEAHYQL
TAPEIWEQTGGRLDAFVAGLGTGGTMSGCGKFFKEKAPAILNVGVDPIGSVYHSMFKTGKLSQPHVYKVEGIGEDMMCGA
MDLSVLDDVRQVNDAEAFVMARRLAREEGVLAGGSSGAAVHVAVKLAKELGKGKVIVVPLPDGGRAYISKFYSDEWMRDN
GFPVGAGGPVSAATVKDVLGRRRGEVISARKTDKVEAVVKKMKEHDISQMPVVDDTGRAIGMIHEYDLLNFLIEGKHRLT
EVVEPLVQPLQGVVEPETALSRLRDIFNDDHVAVVKEGDRVTGIVTKIDLIEFLAQRLR
>Mature_458_residues
AYHETVLSAIGHTPLVRLQKLTGPDDATVLVKLEYLNPGGSIKDRMAVHILEKAERSGLLRPGGTIVENTSGNTGVGLAM
AAAVKGYRCVFTMPDKMSKEKQDTLKAFGAKVIVTPTNVPADSPDSYYSVAKRIAAETPNSFYVNQYHSLDNVEAHYQLT
APEIWEQTGGRLDAFVAGLGTGGTMSGCGKFFKEKAPAILNVGVDPIGSVYHSMFKTGKLSQPHVYKVEGIGEDMMCGAM
DLSVLDDVRQVNDAEAFVMARRLAREEGVLAGGSSGAAVHVAVKLAKELGKGKVIVVPLPDGGRAYISKFYSDEWMRDNG
FPVGAGGPVSAATVKDVLGRRRGEVISARKTDKVEAVVKKMKEHDISQMPVVDDTGRAIGMIHEYDLLNFLIEGKHRLTE
VVEPLVQPLQGVVEPETALSRLRDIFNDDHVAVVKEGDRVTGIVTKIDLIEFLAQRLR

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=472, Percent_Identity=40.8898305084746, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI295821200, Length=472, Percent_Identity=40.8898305084746, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI4557415, Length=472, Percent_Identity=40.8898305084746, Blast_Score=330, Evalue=2e-90,
Organism=Escherichia coli, GI1788754, Length=303, Percent_Identity=40.2640264026403, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=37.3376623376623, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=44.6808510638298, Blast_Score=244, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=45.0920245398773, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=40.7051282051282, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI115535073, Length=313, Percent_Identity=42.1725239616613, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=38.7622149837134, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=38.6666666666667, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=317, Percent_Identity=37.2239747634069, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=36.322869955157, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71996324, Length=332, Percent_Identity=23.4939759036145, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=498, Percent_Identity=37.9518072289157, Blast_Score=280, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=35.6287425149701, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24643623, Length=465, Percent_Identity=39.5698924731183, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI20129101, Length=465, Percent_Identity=39.5698924731183, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49657; Mature: 49525

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00901 CYS_SYNTHASE ; PS00283 SOYBEAN_KUNITZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYHETVLSAIGHTPLVRLQKLTGPDDATVLVKLEYLNPGGSIKDRMAVHILEKAERSGL
CCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
LRPGGTIVENTSGNTGVGLAMAAAVKGYRCVFTMPDKMSKEKQDTLKAFGAKVIVTPTNV
CCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCC
PADSPDSYYSVAKRIAAETPNSFYVNQYHSLDNVEAHYQLTAPEIWEQTGGRLDAFVAGL
CCCCCHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCEEEEECCHHHHHHCCCCEEHHHEEC
GTGGTMSGCGKFFKEKAPAILNVGVDPIGSVYHSMFKTGKLSQPHVYKVEGIGEDMMCGA
CCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHCH
MDLSVLDDVRQVNDAEAFVMARRLAREEGVLAGGSSGAAVHVAVKLAKELGKGKVIVVPL
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHHHCCCCEEEEEC
PDGGRAYISKFYSDEWMRDNGFPVGAGGPVSAATVKDVLGRRRGEVISARKTDKVEAVVK
CCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
KMKEHDISQMPVVDDTGRAIGMIHEYDLLNFLIEGKHRLTEVVEPLVQPLQGVVEPETAL
HHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHH
SRLRDIFNDDHVAVVKEGDRVTGIVTKIDLIEFLAQRLR
HHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AYHETVLSAIGHTPLVRLQKLTGPDDATVLVKLEYLNPGGSIKDRMAVHILEKAERSGL
CHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
LRPGGTIVENTSGNTGVGLAMAAAVKGYRCVFTMPDKMSKEKQDTLKAFGAKVIVTPTNV
CCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCC
PADSPDSYYSVAKRIAAETPNSFYVNQYHSLDNVEAHYQLTAPEIWEQTGGRLDAFVAGL
CCCCCHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCEEEEECCHHHHHHCCCCEEHHHEEC
GTGGTMSGCGKFFKEKAPAILNVGVDPIGSVYHSMFKTGKLSQPHVYKVEGIGEDMMCGA
CCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHCH
MDLSVLDDVRQVNDAEAFVMARRLAREEGVLAGGSSGAAVHVAVKLAKELGKGKVIVVPL
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHHHCCCCEEEEEC
PDGGRAYISKFYSDEWMRDNGFPVGAGGPVSAATVKDVLGRRRGEVISARKTDKVEAVVK
CCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
KMKEHDISQMPVVDDTGRAIGMIHEYDLLNFLIEGKHRLTEVVEPLVQPLQGVVEPETAL
HHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHH
SRLRDIFNDDHVAVVKEGDRVTGIVTKIDLIEFLAQRLR
HHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]