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The map label for this gene is atoC [H]

Identifier: 220918575

GI number: 220918575

Start: 3889273

End: 3890640

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_3483

Alternate gene names: 220918575

Gene position: 3889273-3890640 (Clockwise)

Preceding gene: 220918571

Following gene: 220918576

Centisome position: 77.33

GC content: 73.39

Gene sequence:

>1368_bases
ATGCCGGCGACGGTGCTCGTCGTGGACGACGAACGCAACATCCAGCTCACGCTCTCGCGCGCGCTCTCCATGGAGGGCTA
CGCGGTCGAGACGGCCTCCGGCGGCCGCGAGGCGCTCGAGAAGATCGCCGCACTGCCGGTGGACGTGGTGGTCATGGATG
TGCGGATGCCCGACCTGGACGGACTGGCAGTCCTCCAGCGGGCACGCGAGACCCGCCCGGAGCTGCCCATCGTGATCATG
TCCGGGCACGGCTCGATCGACACCGTGCGCAGCGCCTTCAAGCTCGGCGCCTTCGACTACCTCGAGAAGCCCATCACCGA
GAAGGAGAAGCTGCTCGTCGCGGTGAAGAACGCGCTCGCGCTCGAGTCGCTCCGCGCCGAGAACGCGGCGCTGCGCCGCG
CGGCGGGCCAGGGCCAGCTCGAGATGATCGGCGGCGGCCCGGCCATGCAGCGGCTGTTCGACCTGGTGCGCCGCACCGCG
CCCTCCGAGGGCCGCGTGCTCATCACCGGCGAGAACGGCACCGGCAAGGAGCTGGTGGCCCGCGCCATCCACGAGCAGTC
GCGGCGGCGCGACCGGCCCTTCGTGAAGCTGAACTGCGCCGCGGTGCCGGCCGAGCTGATCGAGAGCGAGCTGTTCGGCC
ACGAGCGCGGCGCGTTCACCGGGGCGGTGGCGGCGCGGCGCGGCCGGTTCGAGCAGGCCGACGGCGGGACGCTGTTCCTC
GACGAGGTGGGCGACATGCCCGCCGCCATGCAGGCGAAGGTGCTGCGCGTGCTGCAGGAGGGCGAGCTGGAGCGGGTGGG
CGGCCAGCAGACGCTGCGCTGCGACGTGCGGGTGGTGGCCGCCACCAACAAGGACCTGCAGGCCGAGGTGGCCGCGGGCC
GGTTCCGTGAGGACCTCTACTACCGGCTCAACGTCGTGCCCATCCACACCCCGGCGCTGCGCGATCACAAGGAGGACGTG
CCCGAGCTGGCGGCGCGCTTCCTGGCCGAGGCCTGCGAGCGGAACGGCCGCCGCGCCATGCGCCTCGGCCGCGACGCGGT
CGCCGCGCTCCAGACGCACGACTGGCCCGGCAACGTGCGCGAGCTGCGCAACCTGGTGGAGCGGCTCGCCATCCTCTGCG
ACGGCCCGGAGATCGGCGCCGAGGACGTGGTGGCGATGCTGCCCGGCGCCCGCCGCCCGCGCGGCGATCGGCTGCGCGCC
GGCGCCGCGTTCCACGAGCTGGTCGAGGAGGCGGAGCGCGAGATCGTGCTCGCGGCCCTCGAGGCGCACCAGGACAACGT
GTCGGACACGGCCCGCGCCCTCGGCCTGGAGCGGAGCCACCTCTACAAGAAGATGCGCGCGCTCGGCATCAAGCGCGGCG
CCGAGTAG

Upstream 100 bases:

>100_bases
ACAAGTCTGGGAACTTGGGGACGCCCGCTTATTGGCTCCATTCGGAACGCCTGTCAAAGGATTTCCTCGTCGCGGAACCA
TCCGGGATTAACATCCCCGC

Downstream 100 bases:

>100_bases
CCGCCCGCCCGCCCCCGCCCGGCCGTGTCGCCCCGGCCACGGCGGCCGTGTCGCGGCGGACACGCGCGCCAAGGAATCCG
CTGGGCCGCCGCGCGTTCCA

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPATVLVVDDERNIQLTLSRALSMEGYAVETASGGREALEKIAALPVDVVVMDVRMPDLDGLAVLQRARETRPELPIVIM
SGHGSIDTVRSAFKLGAFDYLEKPITEKEKLLVAVKNALALESLRAENAALRRAAGQGQLEMIGGGPAMQRLFDLVRRTA
PSEGRVLITGENGTGKELVARAIHEQSRRRDRPFVKLNCAAVPAELIESELFGHERGAFTGAVAARRGRFEQADGGTLFL
DEVGDMPAAMQAKVLRVLQEGELERVGGQQTLRCDVRVVAATNKDLQAEVAAGRFREDLYYRLNVVPIHTPALRDHKEDV
PELAARFLAEACERNGRRAMRLGRDAVAALQTHDWPGNVRELRNLVERLAILCDGPEIGAEDVVAMLPGARRPRGDRLRA
GAAFHELVEEAEREIVLAALEAHQDNVSDTARALGLERSHLYKKMRALGIKRGAE

Sequences:

>Translated_455_residues
MPATVLVVDDERNIQLTLSRALSMEGYAVETASGGREALEKIAALPVDVVVMDVRMPDLDGLAVLQRARETRPELPIVIM
SGHGSIDTVRSAFKLGAFDYLEKPITEKEKLLVAVKNALALESLRAENAALRRAAGQGQLEMIGGGPAMQRLFDLVRRTA
PSEGRVLITGENGTGKELVARAIHEQSRRRDRPFVKLNCAAVPAELIESELFGHERGAFTGAVAARRGRFEQADGGTLFL
DEVGDMPAAMQAKVLRVLQEGELERVGGQQTLRCDVRVVAATNKDLQAEVAAGRFREDLYYRLNVVPIHTPALRDHKEDV
PELAARFLAEACERNGRRAMRLGRDAVAALQTHDWPGNVRELRNLVERLAILCDGPEIGAEDVVAMLPGARRPRGDRLRA
GAAFHELVEEAEREIVLAALEAHQDNVSDTARALGLERSHLYKKMRALGIKRGAE
>Mature_454_residues
PATVLVVDDERNIQLTLSRALSMEGYAVETASGGREALEKIAALPVDVVVMDVRMPDLDGLAVLQRARETRPELPIVIMS
GHGSIDTVRSAFKLGAFDYLEKPITEKEKLLVAVKNALALESLRAENAALRRAAGQGQLEMIGGGPAMQRLFDLVRRTAP
SEGRVLITGENGTGKELVARAIHEQSRRRDRPFVKLNCAAVPAELIESELFGHERGAFTGAVAARRGRFEQADGGTLFLD
EVGDMPAAMQAKVLRVLQEGELERVGGQQTLRCDVRVVAATNKDLQAEVAAGRFREDLYYRLNVVPIHTPALRDHKEDVP
ELAARFLAEACERNGRRAMRLGRDAVAALQTHDWPGNVRELRNLVERLAILCDGPEIGAEDVVAMLPGARRPRGDRLRAG
AAFHELVEEAEREIVLAALEAHQDNVSDTARALGLERSHLYKKMRALGIKRGAE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=42.7312775330396, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=46.1538461538462, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=43.3760683760684, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=40.9502262443439, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI87082117, Length=361, Percent_Identity=44.0443213296399, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1789087, Length=361, Percent_Identity=45.7063711911357, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=44.6875, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789233, Length=316, Percent_Identity=40.5063291139241, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786524, Length=323, Percent_Identity=38.390092879257, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=40.5660377358491, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1787583, Length=315, Percent_Identity=37.1428571428571, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI87081858, Length=310, Percent_Identity=31.2903225806452, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789828, Length=271, Percent_Identity=35.0553505535055, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790552, Length=147, Percent_Identity=31.9727891156463, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787229, Length=120, Percent_Identity=34.1666666666667, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49846; Mature: 49715

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATVLVVDDERNIQLTLSRALSMEGYAVETASGGREALEKIAALPVDVVVMDVRMPDLD
CCEEEEEEECCCCEEEEEEHHHCCCCEEEECCCCCHHHHHHHHCCCEEEEEEEECCCCCC
GLAVLQRARETRPELPIVIMSGHGSIDTVRSAFKLGAFDYLEKPITEKEKLLVAVKNALA
HHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
LESLRAENAALRRAAGQGQLEMIGGGPAMQRLFDLVRRTAPSEGRVLITGENGTGKELVA
HHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
RAIHEQSRRRDRPFVKLNCAAVPAELIESELFGHERGAFTGAVAARRGRFEQADGGTLFL
HHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEE
DEVGDMPAAMQAKVLRVLQEGELERVGGQQTLRCDVRVVAATNKDLQAEVAAGRFREDLY
ECCCCCCHHHHHHHHHHHHCCCHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCE
YRLNVVPIHTPALRDHKEDVPELAARFLAEACERNGRRAMRLGRDAVAALQTHDWPGNVR
EEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHCCCCCCCHH
ELRNLVERLAILCDGPEIGAEDVVAMLPGARRPRGDRLRAGAAFHELVEEAEREIVLAAL
HHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAHQDNVSDTARALGLERSHLYKKMRALGIKRGAE
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PATVLVVDDERNIQLTLSRALSMEGYAVETASGGREALEKIAALPVDVVVMDVRMPDLD
CEEEEEEECCCCEEEEEEHHHCCCCEEEECCCCCHHHHHHHHCCCEEEEEEEECCCCCC
GLAVLQRARETRPELPIVIMSGHGSIDTVRSAFKLGAFDYLEKPITEKEKLLVAVKNALA
HHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
LESLRAENAALRRAAGQGQLEMIGGGPAMQRLFDLVRRTAPSEGRVLITGENGTGKELVA
HHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
RAIHEQSRRRDRPFVKLNCAAVPAELIESELFGHERGAFTGAVAARRGRFEQADGGTLFL
HHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEE
DEVGDMPAAMQAKVLRVLQEGELERVGGQQTLRCDVRVVAATNKDLQAEVAAGRFREDLY
ECCCCCCHHHHHHHHHHHHCCCHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCE
YRLNVVPIHTPALRDHKEDVPELAARFLAEACERNGRRAMRLGRDAVAALQTHDWPGNVR
EEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHCCCCCCCHH
ELRNLVERLAILCDGPEIGAEDVVAMLPGARRPRGDRLRAGAAFHELVEEAEREIVLAAL
HHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAHQDNVSDTARALGLERSHLYKKMRALGIKRGAE
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]