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The map label for this gene is sdhA [H]

Identifier: 220918223

GI number: 220918223

Start: 3451478

End: 3453394

Strand: Reverse

Name: sdhA [H]

Synonym: A2cp1_3126

Alternate gene names: 220918223

Gene position: 3453394-3451478 (Counterclockwise)

Preceding gene: 220918224

Following gene: 220918222

Centisome position: 68.67

GC content: 66.98

Gene sequence:

>1917_bases
GTGATCCTCGACGGAAAGGCACCTACCGGCCGCATCGAAGAGTCGTGGGACAAGTACCGCTTCGACCTGAAGCTGGTGAA
CCCCGCGAACAAGCGGAAGTTCAAGATCCTGGTGGTCGGCACCGGCCTCGCCGGCGCCTCGGCGGCCGCCACGCTCGGTG
AGCTCGGCTACAACGTGGAGACGTTCTGCTACCAGGACTCTCCGCGGCGCGCGCACTCCATCGCGGCGCAGGGCGGCATC
AACGCCGCGAAGAACTACCCGAACGACGGCGACAGCATCTACCGGCTGTTCTACGACACCATCAAGGGCGGCGACTTCCG
CGCCCGCGAGGCCGACGTGTGGCGCCTCGCGCAGGTCAGCAACAACATCATCGACCAGTGCGTCGCGCAGGGCGTGCCGT
TCGCGCGCGACTACGCCGGCTACCTGGACAACCGCTCCTTCGGCGGCGCGCAGGTGTCCCGCACCTTCTACGCGCGCGGT
CAGACCGGGCAGCAGCTCCTGCTCGGCGCGTACTCGGCGCTGTCCCGGCAGATCAAGGCCGGCACGGTGAAGCTGTTCCC
CCGCACCGAGATGCTGGACCTGGTGGTGGTGGACGGCGAGGCGAAGGGCATCACGGTCCGCGACCTGGTCACCGGGGAGA
TCCGCACGCACGTCGGCGACGCGGTGGTGCTCGCCACCGGCGGCTACGTGAACGTGTTCTACCTGTCCACGAACGCGATG
GGCTGCAGCGTCACCGCGATCTGGAAGGCGCACAAGAAGGGGGCGTACCTCGCGAACCCCTGCTTCACGCAGATCCACCC
GACGTGCATCCCGCAGGCGGGTGACTACCAGTCGAAGCTGACGCTCATGTCCGAGTCGCTCCGCAACGACGGCCGGATCT
GGGTGCCGAAGAAGAAGGAGGACTGCAACAAGCCGCCGAACGAGATCCCCGAGGAGGATCGCGACTACTACCTCGAGCGG
AAGTACCCGACGTTCGGCAACCTCGCCCCGCGCGACATCGCGTCCCGCGCCGCCAAGGAGCAGTGCGACGAGGGCCGCGG
CGTCGGCCCCGGCGGCCGCGGCGTCTACCTCGACTTCGCCGCCTCCATCAAGCGGCTGGGCGAGAACGTGGTCCGCGAGC
GCTACGGCAACCTGTTCGAGATGTACGAGCGGATCACCGACGAGAACGCGTACAAGCAGCCGATGCGCATCTACCCGGCC
CCGCACTACTCGATGGGCGGCCTCTGGGTGGACTACAACCTGATGAGCAACGTCCCCGGCCTGTTCGTGCTCGGCGAGGC
GAACTTCTCGGTCCACGGCGCGAATCGCCTGGGCGCGAGCGCGCTGATGCAGGGCCTGGCGGACGGCTACTTCGTCATCC
CGAACACCATCGCCGGCTACCTCGCGACGACCAAGCCCGGGAAGGTGAAGGCCGACCACCCCGAGTTCAAGAAGTCGGTG
GAGGAGGTGCAGGGCGCCTCCAAGAAGCTGCTCGGCATCAACGGCAAGAAGACCGTCACCGAGTTCATCCGAGAGCTCGG
CACGACGATGTGGGAGGACGTCGGCATGGCCCGGAGCAAGGAGTCGCTCACCAAGGCGCTCCAGAAGATCCCGGCCATCC
GCAAGGAGTTCTGGGAGAACGTGAAGGTCTCGGGCAAGGGTGAGGAGCTCAACCAGCAGCTCGAGAACGCCGGCCGCACC
GCCGACTTCCTCGAGTTCGCCGAGCTGCTCGCGCGCGACGCCCTGAACCGCGAGGAGTCCTGCGGCGGTCACTTCCGCGT
CGAGCACCAGTACCCGGACGGCGAGGCGAAGCGCGACGACGCGAACTTCTGCTACACGGCCGCCTGGGAGTTCAAGGGAA
TCGGCAAGGAGCCGGAGCTCCACAAGGAGCCGCTCAAGTTCGAGAACGTCCACCTCGCGGTGAGGAGCTACAAGTAA

Upstream 100 bases:

>100_bases
GGCGTGCTCGGCAAGACGCTGGCCGGGATCCTGCTGGTCGGCTTCGGCGCCATTCCGCTGCTCATCCTCGCCGGCATCGC
CGGGAACTAAGGGAGACACC

Downstream 100 bases:

>100_bases
TGAGCGCGCACGCTTCCGAGCACGGGACGATGAACCTGAAGCTCATCGTCTGGCGGCAGGCCGGTCCCAACGAGCCTGGA
CGCTTCGAGACCTACGACGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MILDGKAPTGRIEESWDKYRFDLKLVNPANKRKFKILVVGTGLAGASAAATLGELGYNVETFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALSRQIKAGTVKLFPRTEMLDLVVVDGEAKGITVRDLVTGEIRTHVGDAVVLATGGYVNVFYLSTNAM
GCSVTAIWKAHKKGAYLANPCFTQIHPTCIPQAGDYQSKLTLMSESLRNDGRIWVPKKKEDCNKPPNEIPEEDRDYYLER
KYPTFGNLAPRDIASRAAKEQCDEGRGVGPGGRGVYLDFAASIKRLGENVVRERYGNLFEMYERITDENAYKQPMRIYPA
PHYSMGGLWVDYNLMSNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPNTIAGYLATTKPGKVKADHPEFKKSV
EEVQGASKKLLGINGKKTVTEFIRELGTTMWEDVGMARSKESLTKALQKIPAIRKEFWENVKVSGKGEELNQQLENAGRT
ADFLEFAELLARDALNREESCGGHFRVEHQYPDGEAKRDDANFCYTAAWEFKGIGKEPELHKEPLKFENVHLAVRSYK

Sequences:

>Translated_638_residues
MILDGKAPTGRIEESWDKYRFDLKLVNPANKRKFKILVVGTGLAGASAAATLGELGYNVETFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALSRQIKAGTVKLFPRTEMLDLVVVDGEAKGITVRDLVTGEIRTHVGDAVVLATGGYVNVFYLSTNAM
GCSVTAIWKAHKKGAYLANPCFTQIHPTCIPQAGDYQSKLTLMSESLRNDGRIWVPKKKEDCNKPPNEIPEEDRDYYLER
KYPTFGNLAPRDIASRAAKEQCDEGRGVGPGGRGVYLDFAASIKRLGENVVRERYGNLFEMYERITDENAYKQPMRIYPA
PHYSMGGLWVDYNLMSNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPNTIAGYLATTKPGKVKADHPEFKKSV
EEVQGASKKLLGINGKKTVTEFIRELGTTMWEDVGMARSKESLTKALQKIPAIRKEFWENVKVSGKGEELNQQLENAGRT
ADFLEFAELLARDALNREESCGGHFRVEHQYPDGEAKRDDANFCYTAAWEFKGIGKEPELHKEPLKFENVHLAVRSYK
>Mature_638_residues
MILDGKAPTGRIEESWDKYRFDLKLVNPANKRKFKILVVGTGLAGASAAATLGELGYNVETFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALSRQIKAGTVKLFPRTEMLDLVVVDGEAKGITVRDLVTGEIRTHVGDAVVLATGGYVNVFYLSTNAM
GCSVTAIWKAHKKGAYLANPCFTQIHPTCIPQAGDYQSKLTLMSESLRNDGRIWVPKKKEDCNKPPNEIPEEDRDYYLER
KYPTFGNLAPRDIASRAAKEQCDEGRGVGPGGRGVYLDFAASIKRLGENVVRERYGNLFEMYERITDENAYKQPMRIYPA
PHYSMGGLWVDYNLMSNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPNTIAGYLATTKPGKVKADHPEFKKSV
EEVQGASKKLLGINGKKTVTEFIRELGTTMWEDVGMARSKESLTKALQKIPAIRKEFWENVKVSGKGEELNQQLENAGRT
ADFLEFAELLARDALNREESCGGHFRVEHQYPDGEAKRDDANFCYTAAWEFKGIGKEPELHKEPLKFENVHLAVRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=559, Percent_Identity=27.1914132379249, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1790597, Length=543, Percent_Identity=28.5451197053407, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786942, Length=560, Percent_Identity=27.5, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788928, Length=593, Percent_Identity=25.6323777403035, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17505833, Length=544, Percent_Identity=29.0441176470588, Blast_Score=180, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17550100, Length=550, Percent_Identity=29.2727272727273, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322701, Length=601, Percent_Identity=30.1164725457571, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322416, Length=603, Percent_Identity=29.1873963515755, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17137288, Length=556, Percent_Identity=28.7769784172662, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24655642, Length=556, Percent_Identity=28.7769784172662, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24655647, Length=556, Percent_Identity=28.7769784172662, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24663005, Length=573, Percent_Identity=26.0034904013962, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70827; Mature: 70827

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDGKAPTGRIEESWDKYRFDLKLVNPANKRKFKILVVGTGLAGASAAATLGELGYNVE
CEECCCCCCCCCHHCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCEE
TFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALSRQIKA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHCC
GTVKLFPRTEMLDLVVVDGEAKGITVRDLVTGEIRTHVGDAVVLATGGYVNVFYLSTNAM
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
GCSVTAIWKAHKKGAYLANPCFTQIHPTCIPQAGDYQSKLTLMSESLRNDGRIWVPKKKE
CCEEEEEEHHHCCCCEECCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHH
DCNKPPNEIPEEDRDYYLERKYPTFGNLAPRDIASRAAKEQCDEGRGVGPGGRGVYLDFA
HCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHH
ASIKRLGENVVRERYGNLFEMYERITDENAYKQPMRIYPAPHYSMGGLWVDYNLMSNVPG
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCCCEECCCCCCCCCCEEEEEHHHHCCCC
LFVLGEANFSVHGANRLGASALMQGLADGYFVIPNTIAGYLATTKPGKVKADHPEFKKSV
EEEEECCCEEEECCHHCCHHHHHHHHCCCEEEECCHHHHHEEECCCCCCCCCCHHHHHHH
EEVQGASKKLLGINGKKTVTEFIRELGTTMWEDVGMARSKESLTKALQKIPAIRKEFWEN
HHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
VKVSGKGEELNQQLENAGRTADFLEFAELLARDALNREESCGGHFRVEHQYPDGEAKRDD
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCC
ANFCYTAAWEFKGIGKEPELHKEPLKFENVHLAVRSYK
CCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MILDGKAPTGRIEESWDKYRFDLKLVNPANKRKFKILVVGTGLAGASAAATLGELGYNVE
CEECCCCCCCCCHHCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCEE
TFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALSRQIKA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHCC
GTVKLFPRTEMLDLVVVDGEAKGITVRDLVTGEIRTHVGDAVVLATGGYVNVFYLSTNAM
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
GCSVTAIWKAHKKGAYLANPCFTQIHPTCIPQAGDYQSKLTLMSESLRNDGRIWVPKKKE
CCEEEEEEHHHCCCCEECCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHH
DCNKPPNEIPEEDRDYYLERKYPTFGNLAPRDIASRAAKEQCDEGRGVGPGGRGVYLDFA
HCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHH
ASIKRLGENVVRERYGNLFEMYERITDENAYKQPMRIYPAPHYSMGGLWVDYNLMSNVPG
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCCCEECCCCCCCCCCEEEEEHHHHCCCC
LFVLGEANFSVHGANRLGASALMQGLADGYFVIPNTIAGYLATTKPGKVKADHPEFKKSV
EEEEECCCEEEECCHHCCHHHHHHHHCCCEEEECCHHHHHEEECCCCCCCCCCHHHHHHH
EEVQGASKKLLGINGKKTVTEFIRELGTTMWEDVGMARSKESLTKALQKIPAIRKEFWEN
HHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
VKVSGKGEELNQQLENAGRTADFLEFAELLARDALNREESCGGHFRVEHQYPDGEAKRDD
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCC
ANFCYTAAWEFKGIGKEPELHKEPLKFENVHLAVRSYK
CCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]