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The map label for this gene is mutS [H]

Identifier: 220917646

GI number: 220917646

Start: 2822174

End: 2823967

Strand: Direct

Name: mutS [H]

Synonym: A2cp1_2547

Alternate gene names: 220917646

Gene position: 2822174-2823967 (Clockwise)

Preceding gene: 220917642

Following gene: 220917651

Centisome position: 56.11

GC content: 78.48

Gene sequence:

>1794_bases
ATGGCCGACCCCTCCGCCCTCCTCCGCGCCCGCCTGGCCGAGCGCGCCGCCCGCGTCGCCCGGCTCGACGGCGCCGACGC
CTGGGTCGCCCGCGCGCGCCTCGCGGTGGCCGTCGGCGCGGTCGCGATGGCGGTGCTGGTGTTCGGGACCCACGCGCTCC
ACGCGCGCTGGCTCGCCCTCCCCGCGGCGGCGTTCCTCGCGCTCGTCGTCGTCCACGACCGCGTGTTCCACGCCCGCGAC
CGGGCGCGCCGCGCGGTCGCGTTCCACCAGGCCGGGCTCGACCGCATCGAGGGCCGCTTCGCGGGGCACGGCACCGCCGG
CGAGCGCTTCACGGATCCGGCCCACCCGTACGCCGAGGACCTCGACCTGTTCGGCCCCGGCTCGCTGTTCGAGCTGCTCT
GCGCCGCCCGGACGCGCGCCGGCGAGGACCGGCTCGCCGCGTGGCTGCGCGCGCCCGCGGACGCCGCCGAGGTGCGGGCC
CGCCAGGCCGCGGTGCGCGAGCTGGCGCCGCGGCTCGACCTGCGCGAGGACCTCGCCGTCCTCGGCGAGGACGTGCGCGC
CGCGGTGGATCCCGCGCGGCTCGCGGCCTGGGGCGAGGCGCCGAGGCTGCTCCCGGCGTTCGTGGTGCCGGCCGCGCTCG
CGCTCGCCGCCGCGGCGGTCGCGACCGCCTGGGCCTGGGGCGCGGGCTACGGCCCGGTGCCGTTCCTCGCGGCGCTGCTG
GCGACCTGGGCGTTCGGCCGCGCGCTCCGCGATCCCATCGCGCGCGTGCTGGGCGGCGCCGGGCGCCCGGCGGCGGAGCT
GCGGGTGCTGTCGCTCCTGCTGGCGCGGCTCGAGCGCGAGCCGTTCGGCGATCCGCGGCTGCTCCGGCTGCAGCAGATGC
TGGGCGTCCAGCCGAAGGACGGCGGCCGGGCGTCGGCGCGCATCGCCCGCCTGGAGCGGCTGGCCGCGCGGGCGGAGTGG
GCGCACAACCAGGTGTTCGCCCCGGTGGCGTTCGCGCTGCAGTGGACGCCGCTCCACGCGGCGCTGGTCGAGCGCTGGCG
CGCGGCGCACGGCGGGGCGGTGCGCGGCTGGCTGGAGGCGGTGGCCGACCTCGAGGCGCTGTCGTCGCTGGCCGGCTACG
CGTTCGAGCACCCCGCGGACGCGTTCCCGGAGGTGGTCGATCCCGGCGCGGAGCCGCGCGCGCTGCTCGACGGCGACGCG
GTCCGCCACCCGCTCCTCGCGGCGGCGGTCGCGAACGACGTGCGCCTGGGCGGCGACGCGCCGGCGGTGCTGCTCGTCTC
CGGCTCCAACATGTCGGGGAAGAGCACGTACCTCCGCACGGTGGGCGTGAACGTGGTGCTCGCGCTCGCCGGCGCGCCGG
TGCGGGCGGCGCGGCTGCGGCTCACGCCGGTGCAGCTCGGCGCCACGCTGCGCATCCAGGACTCGCTCCAGGCCGGCAAG
TCGCGCTTCTACGCGGAGATCACCCGGCTGAAGCAGCTCATGGACCTCGCCGGCGGTCGCTTCCCGCTGCTGTTCCTGCT
CGACGAGATCCTGCACGGCACGAACAGCCACGATCGCCGCATCGGCGCCGAGGCGGTGGTCCGCGGGCTGGTGGCGCGCG
GCGCGCTCGGGCTCGTGACCACGCACGACCTCGCCCTCACCGAGCTCGCCGGCCAGGACGGCGCGCTCGGCAACGCGCAC
TTCGAGGACCAGGTGCAGGGCGGCGAGATCGCGTTCGACTACCGGCTGCGGCCGGGCGTGGTCGGCCACTCCAACGCCCT
CGCGCTCATGCGCGCGGTGGGGCTGCGGGTGTGA

Upstream 100 bases:

>100_bases
GGGGTGCCGCCTCCGGCGGGGTGCCGCCCGCACGGCGCCGTCCGGACGAAGCGCGATCGCGCGACACGGACGGGGACGTC
CGGGGTAGTTTCGCCTCGAC

Downstream 100 bases:

>100_bases
GCGGTCCGCAGGGCCGGCTCACTCCTCGACGGTGAGCACCTCGACGCCGTCCTCGGTCACCGCCACGGTGTGCTCGAACT
GCGCCGAGCGCTTCCCGTCG

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MADPSALLRARLAERAARVARLDGADAWVARARLAVAVGAVAMAVLVFGTHALHARWLALPAAAFLALVVVHDRVFHARD
RARRAVAFHQAGLDRIEGRFAGHGTAGERFTDPAHPYAEDLDLFGPGSLFELLCAARTRAGEDRLAAWLRAPADAAEVRA
RQAAVRELAPRLDLREDLAVLGEDVRAAVDPARLAAWGEAPRLLPAFVVPAALALAAAAVATAWAWGAGYGPVPFLAALL
ATWAFGRALRDPIARVLGGAGRPAAELRVLSLLLARLEREPFGDPRLLRLQQMLGVQPKDGGRASARIARLERLAARAEW
AHNQVFAPVAFALQWTPLHAALVERWRAAHGGAVRGWLEAVADLEALSSLAGYAFEHPADAFPEVVDPGAEPRALLDGDA
VRHPLLAAAVANDVRLGGDAPAVLLVSGSNMSGKSTYLRTVGVNVVLALAGAPVRAARLRLTPVQLGATLRIQDSLQAGK
SRFYAEITRLKQLMDLAGGRFPLLFLLDEILHGTNSHDRRIGAEAVVRGLVARGALGLVTTHDLALTELAGQDGALGNAH
FEDQVQGGEIAFDYRLRPGVVGHSNALALMRAVGLRV

Sequences:

>Translated_597_residues
MADPSALLRARLAERAARVARLDGADAWVARARLAVAVGAVAMAVLVFGTHALHARWLALPAAAFLALVVVHDRVFHARD
RARRAVAFHQAGLDRIEGRFAGHGTAGERFTDPAHPYAEDLDLFGPGSLFELLCAARTRAGEDRLAAWLRAPADAAEVRA
RQAAVRELAPRLDLREDLAVLGEDVRAAVDPARLAAWGEAPRLLPAFVVPAALALAAAAVATAWAWGAGYGPVPFLAALL
ATWAFGRALRDPIARVLGGAGRPAAELRVLSLLLARLEREPFGDPRLLRLQQMLGVQPKDGGRASARIARLERLAARAEW
AHNQVFAPVAFALQWTPLHAALVERWRAAHGGAVRGWLEAVADLEALSSLAGYAFEHPADAFPEVVDPGAEPRALLDGDA
VRHPLLAAAVANDVRLGGDAPAVLLVSGSNMSGKSTYLRTVGVNVVLALAGAPVRAARLRLTPVQLGATLRIQDSLQAGK
SRFYAEITRLKQLMDLAGGRFPLLFLLDEILHGTNSHDRRIGAEAVVRGLVARGALGLVTTHDLALTELAGQDGALGNAH
FEDQVQGGEIAFDYRLRPGVVGHSNALALMRAVGLRV
>Mature_596_residues
ADPSALLRARLAERAARVARLDGADAWVARARLAVAVGAVAMAVLVFGTHALHARWLALPAAAFLALVVVHDRVFHARDR
ARRAVAFHQAGLDRIEGRFAGHGTAGERFTDPAHPYAEDLDLFGPGSLFELLCAARTRAGEDRLAAWLRAPADAAEVRAR
QAAVRELAPRLDLREDLAVLGEDVRAAVDPARLAAWGEAPRLLPAFVVPAALALAAAAVATAWAWGAGYGPVPFLAALLA
TWAFGRALRDPIARVLGGAGRPAAELRVLSLLLARLEREPFGDPRLLRLQQMLGVQPKDGGRASARIARLERLAARAEWA
HNQVFAPVAFALQWTPLHAALVERWRAAHGGAVRGWLEAVADLEALSSLAGYAFEHPADAFPEVVDPGAEPRALLDGDAV
RHPLLAAAVANDVRLGGDAPAVLLVSGSNMSGKSTYLRTVGVNVVLALAGAPVRAARLRLTPVQLGATLRIQDSLQAGKS
RFYAEITRLKQLMDLAGGRFPLLFLLDEILHGTNSHDRRIGAEAVVRGLVARGALGLVTTHDLALTELAGQDGALGNAHF
EDQVQGGEIAFDYRLRPGVVGHSNALALMRAVGLRV

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=271, Percent_Identity=28.7822878228782, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789089, Length=249, Percent_Identity=28.5140562248996, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=208, Percent_Identity=28.3653846153846, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320302, Length=220, Percent_Identity=27.7272727272727, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=203, Percent_Identity=29.064039408867, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664545, Length=266, Percent_Identity=28.9473684210526, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584320, Length=242, Percent_Identity=27.6859504132231, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 63409; Mature: 63278

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPSALLRARLAERAARVARLDGADAWVARARLAVAVGAVAMAVLVFGTHALHARWLAL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAAAFLALVVVHDRVFHARDRARRAVAFHQAGLDRIEGRFAGHGTAGERFTDPAHPYAED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCHHC
LDLFGPGSLFELLCAARTRAGEDRLAAWLRAPADAAEVRARQAAVRELAPRLDLREDLAV
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
LGEDVRAAVDPARLAAWGEAPRLLPAFVVPAALALAAAAVATAWAWGAGYGPVPFLAALL
HHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ATWAFGRALRDPIARVLGGAGRPAAELRVLSLLLARLEREPFGDPRLLRLQQMLGVQPKD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GGRASARIARLERLAARAEWAHNQVFAPVAFALQWTPLHAALVERWRAAHGGAVRGWLEA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCHHHHHHHHHHHHHCCCHHHHHHHH
VADLEALSSLAGYAFEHPADAFPEVVDPGAEPRALLDGDAVRHPLLAAAVANDVRLGGDA
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCC
PAVLLVSGSNMSGKSTYLRTVGVNVVLALAGAPVRAARLRLTPVQLGATLRIQDSLQAGK
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEHHCCEEEEHHHHHHHH
SRFYAEITRLKQLMDLAGGRFPLLFLLDEILHGTNSHDRRIGAEAVVRGLVARGALGLVT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHEEE
THDLALTELAGQDGALGNAHFEDQVQGGEIAFDYRLRPGVVGHSNALALMRAVGLRV
ECHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADPSALLRARLAERAARVARLDGADAWVARARLAVAVGAVAMAVLVFGTHALHARWLAL
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAAAFLALVVVHDRVFHARDRARRAVAFHQAGLDRIEGRFAGHGTAGERFTDPAHPYAED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCHHC
LDLFGPGSLFELLCAARTRAGEDRLAAWLRAPADAAEVRARQAAVRELAPRLDLREDLAV
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
LGEDVRAAVDPARLAAWGEAPRLLPAFVVPAALALAAAAVATAWAWGAGYGPVPFLAALL
HHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ATWAFGRALRDPIARVLGGAGRPAAELRVLSLLLARLEREPFGDPRLLRLQQMLGVQPKD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GGRASARIARLERLAARAEWAHNQVFAPVAFALQWTPLHAALVERWRAAHGGAVRGWLEA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCHHHHHHHHHHHHHCCCHHHHHHHH
VADLEALSSLAGYAFEHPADAFPEVVDPGAEPRALLDGDAVRHPLLAAAVANDVRLGGDA
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCC
PAVLLVSGSNMSGKSTYLRTVGVNVVLALAGAPVRAARLRLTPVQLGATLRIQDSLQAGK
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEHHCCEEEEHHHHHHHH
SRFYAEITRLKQLMDLAGGRFPLLFLLDEILHGTNSHDRRIGAEAVVRGLVARGALGLVT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHEEE
THDLALTELAGQDGALGNAHFEDQVQGGEIAFDYRLRPGVVGHSNALALMRAVGLRV
ECHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]