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The map label for this gene is mdh1 [H]

Identifier: 220917422

GI number: 220917422

Start: 2573597

End: 2574535

Strand: Reverse

Name: mdh1 [H]

Synonym: A2cp1_2322

Alternate gene names: 220917422

Gene position: 2574535-2573597 (Counterclockwise)

Preceding gene: 220917423

Following gene: 220917421

Centisome position: 51.19

GC content: 69.97

Gene sequence:

>939_bases
ATGGCCCAGCGGAAGAAGATCGCGCTCATCGGCGCGGGACAGATCGGCGGCACGCTCGCGCTCCTGGCCGGCCAGAAGGA
GCTCGGCGACGTCGTCCTGGTGGACATCATGGAGGGCGTCGCCAAGGGCAAGGCGCTCGACCTGCAGGAGACGCGCGGCG
TCGGCAAGTGGGACGTGGACGTGACCGGCGGCGGCACGACCGACTACTCGGTGATCCGCGACGCCGACGTGTGCATCGTG
ACCGCGGGCGTGCCGCGGAAGCCGGGCATGAGCCGCGAGGATCTCCTCAAGGTGAACCTCGACGCGATCACCAAGGTCGC
GCACGGCATCAAGCAGTACGCGCCGAACGCGTTCGTCATCGTCATCACGAACCCGCTCGATTCGATGGTGTACGCCATGT
ACAAGGTCACCGGGTTCCCCAAGAACCGGGTGGTCGGCATGGCCGGCGTGCTCGACACCGCGCGGTTCCAGTACTTCGTG
GGCGACGCGGCCGGGGTCTCGCCGCAGGACGTGCAGGCGATGGTGCTCGGCGGCCACGGCGACGACATGGTCCCGCTGCT
CCGCTACTCCTCGGTCGCCGGCGTGCCGCTCACCCGGCTGCTCGACAAGGCCCGGCTCGACGCCATCGTCGAGCGCACGC
GCAAGGGCGGCGGCGAGATCGTCGCGCTGCTCGGCACCGGCTCGGCGTTCTACGCGCCGGCCGCCGCGGCGATCTCGATG
GCGGAGGCGTACCTGCGCGACAAGAAGCGCGTGCTGCCCTGCTCGGCGCTGCTCGAGGGCCAGTACGGGGTGAAGGGGCT
CTTCGTCGGCGTCCCGGTGGTGATCGGCGCCGGGGGCGTGGAGCGGGTGCTCGAGGTCGAGCTGAACGACGACGAGCGCG
CCATGCTCCAGCGGTCCGTGGACAGCGTGAAGAAGTCCGTCGCAGAGACCAAGCTGTAG

Upstream 100 bases:

>100_bases
GAGGGGGTGACGGACGCGGTCGAGGTGAAGTGCTCCGAGTTCGGCGACGAGATCATCAGGCACATGTAGCGTAGCGGCTT
CCCAACCCCGGAGAGACCAC

Downstream 100 bases:

>100_bases
TAGGTTTCTCGGGCCGGTCGTCCACCCCATCCGGGGGCGACCGGCCTTCGTCGTCCCAACGAGAGCGAGCTCGGCTTGAA
GATCCACGAGTACCAGGCGA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAQRKKIALIGAGQIGGTLALLAGQKELGDVVLVDIMEGVAKGKALDLQETRGVGKWDVDVTGGGTTDYSVIRDADVCIV
TAGVPRKPGMSREDLLKVNLDAITKVAHGIKQYAPNAFVIVITNPLDSMVYAMYKVTGFPKNRVVGMAGVLDTARFQYFV
GDAAGVSPQDVQAMVLGGHGDDMVPLLRYSSVAGVPLTRLLDKARLDAIVERTRKGGGEIVALLGTGSAFYAPAAAAISM
AEAYLRDKKRVLPCSALLEGQYGVKGLFVGVPVVIGAGGVERVLEVELNDDERAMLQRSVDSVKKSVAETKL

Sequences:

>Translated_312_residues
MAQRKKIALIGAGQIGGTLALLAGQKELGDVVLVDIMEGVAKGKALDLQETRGVGKWDVDVTGGGTTDYSVIRDADVCIV
TAGVPRKPGMSREDLLKVNLDAITKVAHGIKQYAPNAFVIVITNPLDSMVYAMYKVTGFPKNRVVGMAGVLDTARFQYFV
GDAAGVSPQDVQAMVLGGHGDDMVPLLRYSSVAGVPLTRLLDKARLDAIVERTRKGGGEIVALLGTGSAFYAPAAAAISM
AEAYLRDKKRVLPCSALLEGQYGVKGLFVGVPVVIGAGGVERVLEVELNDDERAMLQRSVDSVKKSVAETKL
>Mature_311_residues
AQRKKIALIGAGQIGGTLALLAGQKELGDVVLVDIMEGVAKGKALDLQETRGVGKWDVDVTGGGTTDYSVIRDADVCIVT
AGVPRKPGMSREDLLKVNLDAITKVAHGIKQYAPNAFVIVITNPLDSMVYAMYKVTGFPKNRVVGMAGVLDTARFQYFVG
DAAGVSPQDVQAMVLGGHGDDMVPLLRYSSVAGVPLTRLLDKARLDAIVERTRKGGGEIVALLGTGSAFYAPAAAAISMA
EAYLRDKKRVLPCSALLEGQYGVKGLFVGVPVVIGAGGVERVLEVELNDDERAMLQRSVDSVKKSVAETKL

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 3 family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=319, Percent_Identity=33.2288401253918, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI221136809, Length=319, Percent_Identity=33.2288401253918, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI260099723, Length=309, Percent_Identity=32.6860841423948, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI5031857, Length=309, Percent_Identity=32.6860841423948, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI9257228, Length=307, Percent_Identity=32.5732899022801, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI4504973, Length=307, Percent_Identity=32.5732899022801, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI15082234, Length=317, Percent_Identity=29.3375394321767, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI291575128, Length=309, Percent_Identity=31.3915857605178, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI4557032, Length=309, Percent_Identity=31.3915857605178, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI260099727, Length=198, Percent_Identity=36.3636363636364, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI260099725, Length=198, Percent_Identity=36.3636363636364, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI207028494, Length=191, Percent_Identity=33.5078534031414, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI21735621, Length=317, Percent_Identity=29.6529968454259, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI103472011, Length=315, Percent_Identity=25.3968253968254, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI103472015, Length=181, Percent_Identity=27.0718232044199, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789632, Length=319, Percent_Identity=31.974921630094, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17535107, Length=284, Percent_Identity=26.7605633802817, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17554310, Length=320, Percent_Identity=32.1875, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6322765, Length=300, Percent_Identity=29.6666666666667, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320125, Length=279, Percent_Identity=29.0322580645161, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324446, Length=270, Percent_Identity=31.4814814814815, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136226, Length=306, Percent_Identity=30.3921568627451, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24647881, Length=321, Percent_Identity=33.0218068535826, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45550422, Length=305, Percent_Identity=29.1803278688525, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24663599, Length=317, Percent_Identity=31.5457413249211, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24663595, Length=291, Percent_Identity=30.2405498281787, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR011275
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 32914; Mature: 32783

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRKKIALIGAGQIGGTLALLAGQKELGDVVLVDIMEGVAKGKALDLQETRGVGKWDVD
CCCCCEEEEEECCCCCCEEEEEECCHHHCCCHHHHHHHHHHCCCEECHHHHCCCCEEEEE
VTGGGTTDYSVIRDADVCIVTAGVPRKPGMSREDLLKVNLDAITKVAHGIKQYAPNAFVI
ECCCCCCCCCEEECCCEEEEECCCCCCCCCCHHHHEEECHHHHHHHHHHHHHHCCCEEEE
VITNPLDSMVYAMYKVTGFPKNRVVGMAGVLDTARFQYFVGDAAGVSPQDVQAMVLGGHG
EEECCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCC
DDMVPLLRYSSVAGVPLTRLLDKARLDAIVERTRKGGGEIVALLGTGSAFYAPAAAAISM
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
AEAYLRDKKRVLPCSALLEGQYGVKGLFVGVPVVIGAGGVERVLEVELNDDERAMLQRSV
HHHHHHHCCCCCCHHHHHCCCCCCCEEEEECEEEECCCCCCEEEEEEECCCHHHHHHHHH
DSVKKSVAETKL
HHHHHHHHHCCC
>Mature Secondary Structure 
AQRKKIALIGAGQIGGTLALLAGQKELGDVVLVDIMEGVAKGKALDLQETRGVGKWDVD
CCCCEEEEEECCCCCCEEEEEECCHHHCCCHHHHHHHHHHCCCEECHHHHCCCCEEEEE
VTGGGTTDYSVIRDADVCIVTAGVPRKPGMSREDLLKVNLDAITKVAHGIKQYAPNAFVI
ECCCCCCCCCEEECCCEEEEECCCCCCCCCCHHHHEEECHHHHHHHHHHHHHHCCCEEEE
VITNPLDSMVYAMYKVTGFPKNRVVGMAGVLDTARFQYFVGDAAGVSPQDVQAMVLGGHG
EEECCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCC
DDMVPLLRYSSVAGVPLTRLLDKARLDAIVERTRKGGGEIVALLGTGSAFYAPAAAAISM
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
AEAYLRDKKRVLPCSALLEGQYGVKGLFVGVPVVIGAGGVERVLEVELNDDERAMLQRSV
HHHHHHHCCCCCCHHHHHCCCCCCCEEEEECEEEECCCCCCEEEEEEECCCHHHHHHHHH
DSVKKSVAETKL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA