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The map label for this gene is icd [H]

Identifier: 220917423

GI number: 220917423

Start: 2574567

End: 2575880

Strand: Reverse

Name: icd [H]

Synonym: A2cp1_2323

Alternate gene names: 220917423

Gene position: 2575880-2574567 (Counterclockwise)

Preceding gene: 220917424

Following gene: 220917422

Centisome position: 51.22

GC content: 68.65

Gene sequence:

>1314_bases
ATGGCGGACGCGAAGCCGGTGGTCCCGAAGGATGGAGCGAAGATCTCGCTCGTCGACGGGAAGCTGAACGTTCCCGACCG
GCCCATCCTGCCGTTCATCGAGGGCGACGGCACGGGCCGCGACATCTGGCGCGCCAGCGTGCGGGTGCTCGACGCGGCGG
TGGAGAAGGCCTACCGCGGCCGCCGGAAGATCGCCTGGACCGAGGTCTACGCCGGCGAGAAGGCGTTCACCAAGTTCAAC
AACTGGCTGCCGGACGAGACGATCCAGGCGTTCCGCGAGTACCTCATCGGCATCAAGGGGCCGCTCACCACGCCGATCGG
CGGCGGCATCCGATCGCTCAACGTCGCGCTGCGGCAGCTCCTCGATCTCTACGTCTGCCTCCGCCCCGTGCGCTGGTTCC
GCGGCGTGCCCTCTCCGGTGAAGCGCCCGGAGAAGGTGAACATGGTGATCTTCCGGGAGAACACGGAGGACATCTACGCC
GGGATCGAGTGGGAGGCGGGCTCCGAGCAGGCGAAGAAGCTGCTCGCGTTCCTCGAGCAGGAGTTCCCGAAGGAGTACCG
GAAGATCCGCTTCCCGGCGACGTCCGGCGTGGGCGTGAAGCCGGTCTCGCGCGAGGGGACCGAGCGGCTCGTCCGCGCGG
CGCTCGAGTACGCCGTCCGCGAGCGGCGCCGGAGCGTCACCTTCGTGCACAAGGGCAACATCATGAAGTTCACGGAGGGT
GCGTTCCGGAACTGGGGCTACGCGCTCGCCGAGCGGGAGTTCGCCGACCGCGTCTACACCTGGGAGCAGTGGGAGCGCAC
CAAGGCGTCGCGCGGCGAGGAGGCGGCGAACGCCGAGAAGCAGGCCGCCGTCGCCGAGGGCCGCATCCTGGTCAAGGACG
CGATCGCCGACATCACGCTGCAGCAGGTGCTGACCCGGCCCGAGGACTTCGACGTGGTCGCGACGCCGAACCTGAACGGC
GACTACCTGTCCGACGCGCTCGCGGCGCAGGTGGGCGGCATCGGCATCGCGCCCGGCGGCAACGCCAACTACGTCACCGG
CCACGCCATCTTCGAGGCCACCCACGGCACCGCGCCGAAGTACGCGGACCTCGACAAGGTGAACCCGGGCTCGATGATCC
TCTCCGGCGAGATGATGTTCCGCCACCTCGGCTGGAACGAGGCGGCCGATCTCATCGTCAAGGGCGTGGACGGCGCCATC
GCGGGTCACCGCGTCACCTACGACTTCGCGCGCCTCATGAAGGCAGAGGGGGTGACGGACGCGGTCGAGGTGAAGTGCTC
CGAGTTCGGCGACGAGATCATCAGGCACATGTAG

Upstream 100 bases:

>100_bases
CCGCGAATTCCAAATGTTGGAGCGGTCGGCGCCTTTACACCCCACGCGGCGCGATGCTAAGACCCCGGCTCCACCTCTCC
CCAACGCGAGGACGCTCGTC

Downstream 100 bases:

>100_bases
CGTAGCGGCTTCCCAACCCCGGAGAGACCACATGGCCCAGCGGAAGAAGATCGCGCTCATCGGCGCGGGACAGATCGGCG
GCACGCTCGCGCTCCTGGCC

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MADAKPVVPKDGAKISLVDGKLNVPDRPILPFIEGDGTGRDIWRASVRVLDAAVEKAYRGRRKIAWTEVYAGEKAFTKFN
NWLPDETIQAFREYLIGIKGPLTTPIGGGIRSLNVALRQLLDLYVCLRPVRWFRGVPSPVKRPEKVNMVIFRENTEDIYA
GIEWEAGSEQAKKLLAFLEQEFPKEYRKIRFPATSGVGVKPVSREGTERLVRAALEYAVRERRRSVTFVHKGNIMKFTEG
AFRNWGYALAEREFADRVYTWEQWERTKASRGEEAANAEKQAAVAEGRILVKDAIADITLQQVLTRPEDFDVVATPNLNG
DYLSDALAAQVGGIGIAPGGNANYVTGHAIFEATHGTAPKYADLDKVNPGSMILSGEMMFRHLGWNEAADLIVKGVDGAI
AGHRVTYDFARLMKAEGVTDAVEVKCSEFGDEIIRHM

Sequences:

>Translated_437_residues
MADAKPVVPKDGAKISLVDGKLNVPDRPILPFIEGDGTGRDIWRASVRVLDAAVEKAYRGRRKIAWTEVYAGEKAFTKFN
NWLPDETIQAFREYLIGIKGPLTTPIGGGIRSLNVALRQLLDLYVCLRPVRWFRGVPSPVKRPEKVNMVIFRENTEDIYA
GIEWEAGSEQAKKLLAFLEQEFPKEYRKIRFPATSGVGVKPVSREGTERLVRAALEYAVRERRRSVTFVHKGNIMKFTEG
AFRNWGYALAEREFADRVYTWEQWERTKASRGEEAANAEKQAAVAEGRILVKDAIADITLQQVLTRPEDFDVVATPNLNG
DYLSDALAAQVGGIGIAPGGNANYVTGHAIFEATHGTAPKYADLDKVNPGSMILSGEMMFRHLGWNEAADLIVKGVDGAI
AGHRVTYDFARLMKAEGVTDAVEVKCSEFGDEIIRHM
>Mature_436_residues
ADAKPVVPKDGAKISLVDGKLNVPDRPILPFIEGDGTGRDIWRASVRVLDAAVEKAYRGRRKIAWTEVYAGEKAFTKFNN
WLPDETIQAFREYLIGIKGPLTTPIGGGIRSLNVALRQLLDLYVCLRPVRWFRGVPSPVKRPEKVNMVIFRENTEDIYAG
IEWEAGSEQAKKLLAFLEQEFPKEYRKIRFPATSGVGVKPVSREGTERLVRAALEYAVRERRRSVTFVHKGNIMKFTEGA
FRNWGYALAEREFADRVYTWEQWERTKASRGEEAANAEKQAAVAEGRILVKDAIADITLQQVLTRPEDFDVVATPNLNGD
YLSDALAAQVGGIGIAPGGNANYVTGHAIFEATHGTAPKYADLDKVNPGSMILSGEMMFRHLGWNEAADLIVKGVDGAIA
GHRVTYDFARLMKAEGVTDAVEVKCSEFGDEIIRHM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=409, Percent_Identity=31.2958435207824, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI28178838, Length=323, Percent_Identity=27.8637770897833, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4758582, Length=312, Percent_Identity=28.525641025641, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787381, Length=438, Percent_Identity=60.5022831050228, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI1788101, Length=403, Percent_Identity=27.5434243176179, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87081683, Length=419, Percent_Identity=26.0143198090692, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71986051, Length=378, Percent_Identity=31.7460317460317, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=420, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324709, Length=400, Percent_Identity=31, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=399, Percent_Identity=29.5739348370927, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324291, Length=349, Percent_Identity=30.0859598853868, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24661184, Length=411, Percent_Identity=28.9537712895377, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24643270, Length=409, Percent_Identity=30.5623471882641, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24643268, Length=409, Percent_Identity=30.5623471882641, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 48599; Mature: 48468

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAKPVVPKDGAKISLVDGKLNVPDRPILPFIEGDGTGRDIWRASVRVLDAAVEKAYRG
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
RRKIAWTEVYAGEKAFTKFNNWLPDETIQAFREYLIGIKGPLTTPIGGGIRSLNVALRQL
CCCEEEEHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
LDLYVCLRPVRWFRGVPSPVKRPEKVNMVIFRENTEDIYAGIEWEAGSEQAKKLLAFLEQ
HHHHHHHHHHHHHCCCCCHHCCCCCEEEEEEECCCCCEEECEECCCCHHHHHHHHHHHHH
EFPKEYRKIRFPATSGVGVKPVSREGTERLVRAALEYAVRERRRSVTFVHKGNIMKFTEG
HHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCH
AFRNWGYALAEREFADRVYTWEQWERTKASRGEEAANAEKQAAVAEGRILVKDAIADITL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHCCCEEEHHHHHHHHH
QQVLTRPEDFDVVATPNLNGDYLSDALAAQVGGIGIAPGGNANYVTGHAIFEATHGTAPK
HHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCCEEECCCCCCCEEECCEEEEECCCCCCC
YADLDKVNPGSMILSGEMMFRHLGWNEAADLIVKGVDGAIAGHRVTYDFARLMKAEGVTD
CCCCCCCCCCCEEEEHHHHHHHCCCCHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCH
AVEVKCSEFGDEIIRHM
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADAKPVVPKDGAKISLVDGKLNVPDRPILPFIEGDGTGRDIWRASVRVLDAAVEKAYRG
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
RRKIAWTEVYAGEKAFTKFNNWLPDETIQAFREYLIGIKGPLTTPIGGGIRSLNVALRQL
CCCEEEEHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
LDLYVCLRPVRWFRGVPSPVKRPEKVNMVIFRENTEDIYAGIEWEAGSEQAKKLLAFLEQ
HHHHHHHHHHHHHCCCCCHHCCCCCEEEEEEECCCCCEEECEECCCCHHHHHHHHHHHHH
EFPKEYRKIRFPATSGVGVKPVSREGTERLVRAALEYAVRERRRSVTFVHKGNIMKFTEG
HHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCH
AFRNWGYALAEREFADRVYTWEQWERTKASRGEEAANAEKQAAVAEGRILVKDAIADITL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHCCCEEEHHHHHHHHH
QQVLTRPEDFDVVATPNLNGDYLSDALAAQVGGIGIAPGGNANYVTGHAIFEATHGTAPK
HHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCCEEECCCCCCCEEECCEEEEECCCCCCC
YADLDKVNPGSMILSGEMMFRHLGWNEAADLIVKGVDGAIAGHRVTYDFARLMKAEGVTD
CCCCCCCCCCCEEEEHHHHHHHCCCCHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCH
AVEVKCSEFGDEIIRHM
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]