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The map label for this gene is lon [H]

Identifier: 220917331

GI number: 220917331

Start: 2474188

End: 2476695

Strand: Reverse

Name: lon [H]

Synonym: A2cp1_2231

Alternate gene names: 220917331

Gene position: 2476695-2474188 (Counterclockwise)

Preceding gene: 220917332

Following gene: 220917330

Centisome position: 49.25

GC content: 68.74

Gene sequence:

>2508_bases
ATGTCCGACAAGGAAAAGAAGGGCGCGGGGGCAGGGGCGCAGGTCGCCCCGGCCATGGGACCTCCGGTCCTCATCAACAA
GGAGGACATCCCGGCGGTGCTGCCGATCCTCCCGCTGCGGAACTCGGTGTTCTTCCCCGGGGGCGTGCTGCCCCTGGCGG
TGGGCCGCCAGAAGACCATCGCGCTCATCAAGGACGCGGTCCGCGACGAGCAGGTGATCGGCGTGGTCACGCAGCGCCGG
GCCGAGGAGGAGGACCCGGGCGCGGCCGACCTGTACACGGTCGGGACGGTGGCGCGGGTGGTGAAGCTCCTGAAGATGGG
CGAGGACAACTACTCGCTCGTCGTGCAGGGGCTCGCCCGGTTCAAGGTGCTCGAGCTCGTGCAGGAGAGCCCCTACCTCA
AGGCGCGCATCGAGCCGGTCGAGGATCGCTCGGTGGTGGACGACGTCGAGGTCGAGGCGCTCGCCATCAACCTGAAGAAG
CTGGCGCGCGAGGTCATCGAGCTCATGCCCGAGCTCCCGGCGGCCGCGACCGAGCTGGTCGAGTCCATCACGCACCCGGG
CCACCTCGCCGATCTCATCGCGGCGAACGTGGACGTGCCCATCGAGGAGAAGCAGCAGGTCCTCGAGACCGTCGAGCTCA
AGGCGCGCATGAAGCTCGTGCTCGAGCTGCTCAACCGCAAGCGCGAGATCCTCAAGCTCTCGAACAAGATCGACTCCGCC
GTGAAGGGCGAGATGTCGAAGACGCAGCGCGAGTACTACCTGCGCCAGCAGCTCAAGGCCATCAAGGAGGAGCTGGGCGA
GCTGGGCGAGGAGGAGGAGGAGCTCGACGAGCTGCAGGAGCGCCTGAAGAAGGCCGGGCTCCCGCCCGAGGTCGAGAAGG
TCGCGCAGAAGGAGCTGAACCGGCTGAAGTCGATCCCGACCGCCAGCTCCGAGTACACGGTCGCCCGCACCTACCTCGAC
TGGATCGCCGACCTGCCCTGGGCCAAGCGCACCGACGACAACCTCGACATCGAGAACGCGCGGCAGATCCTCGACTCCGA
CCACTACGCGCTGGAGAAGATCAAGAAGCGCATCCTCGAGTACCTGGCGGTCCGCAAGCTGAAGAACGACATGCGCGGGC
CGATCCTGTGCTTCGTGGGCCCGCCGGGCGTCGGCAAGACCTCCCTCGGCCAGTCGATCGCGCGCGCCACCGGCCGCAAG
TTCGTGCGGCTCTCGCTGGGCGGCGTCCGCGACGAGGCCGAGATCCGCGGGCACCGGCGCACCTACGTGGGCGCCCTCCC
CGGCCGCATCATCCAGTCGATGAAGAAGGCCGGGACGGTGAACCCGGTGATGATGCTCGACGAGATCGACAAGCTCGGGG
CGGACTTCCGGGGCGATCCCTCGGCGGCCCTGCTCGAGGTGCTCGACCCCGAGCAGAACCACGCGTTCTCCGACCACTAC
CTCGACCTGTCCTACGATCTGTCGAAGGTGATGTTCATCGGCACCGCGAACCTGCTCGATCCCATCCCCGGCCCGCTCAA
GGACCGCATGGAGATCCTGGAGCTGCCGGGGTACACGTTCGAGGAGAAGGTGCACATCGCGCAGAACCACCTGATCCCGA
AGCAGCTCAGGGAGCACGGGCTCAGCGCCGACGCCATCGCCATCACCGAGAAGGCGCTCATCAAGATCATCATGGCGTAC
ACGCGCGAGGCCGGCGTCCGGAACCTCGAGCGGCGCATCGCCGACGTGTGCCGCGCCATCGCGGTGGAGGTGGCGAGCGG
CAAGATCGGCGCCGCCGCCAAGCGCGCCATCGAGGAGGCCGACGTCCTCGAGATCCTCGGGCCGGAGAAGTTCTACAACG
AGACCGCCGAGCGGACCGAGATCGCGGGCGTCGCGACCGGCCTCGCCTGGACCGCCGCGGGCGGCGACATCCTGTTCATC
GAGGCCACCAAGATGCCGGGCAAGGGGGCGCTGACCCTCACCGGCCAGCTCGGCGACGTGATGAAGGAGTCGGCGCAGGC
CGCGCTCTCGTACCTGCGCTCGAAGTCCGACTCGCTCGGCATCCCGGTCAACTTCCTCGAGAAGACCGACCTGCACATCC
ACTTCCCGGCGGGCGCGATCCCGAAGGACGGTCCCAGCGCCGGCGTGACCATCCTCACCGCGCTCGTGTCGTTGCTCACC
GGCATCCGGGTGCGCTCCGACGTCGCCATGACCGGCGAGGTCACGCTGCGCGGCCTGGTGCTCCCGGTGGGCGGCATCAA
GGAGAAGGTGCTCGCCGCGCACCGGGCCGGCATCAAGCGGATCATCATCCCGGCCCGCAACGAGAAGGACCTGCTGGACG
TGCCCGAGCAGGCGCGCAAGGAGGTCGAGTTCGTCTTCGCGGCGCACATGGACGAGGTGCTGGCGGCGGCGCTGGAGGAG
AACCCGGTCGGCCGCAAGCCGCCGGCGGCGCCCGAGCCCGAGGGCGAGAAGAAGCCCGGGGCGACGCCGACGCCTCCCGC
CAAGAAGCCGGACGAGATCCGGGTCTAG

Upstream 100 bases:

>100_bases
AAACGGGCGCAAGCGCTCGGAAGACCACTTGCTTCTTGTTGATAACGGCGCAGGCGACGGGTATCCCTGATCGGTGCGCG
AGCAGCGGAAGGAGACGGCG

Downstream 100 bases:

>100_bases
GTCCAGGTCCCCGCCGGCAGGCCCCCGGGCATGCTTCGACGGGGCCACGGCGCTCGGGGCGGCGCGGTCCGCCCCGGGCG
CCTGCTACACTCGCGGCATG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MSDKEKKGAGAGAQVAPAMGPPVLINKEDIPAVLPILPLRNSVFFPGGVLPLAVGRQKTIALIKDAVRDEQVIGVVTQRR
AEEEDPGAADLYTVGTVARVVKLLKMGEDNYSLVVQGLARFKVLELVQESPYLKARIEPVEDRSVVDDVEVEALAINLKK
LAREVIELMPELPAAATELVESITHPGHLADLIAANVDVPIEEKQQVLETVELKARMKLVLELLNRKREILKLSNKIDSA
VKGEMSKTQREYYLRQQLKAIKEELGELGEEEEELDELQERLKKAGLPPEVEKVAQKELNRLKSIPTASSEYTVARTYLD
WIADLPWAKRTDDNLDIENARQILDSDHYALEKIKKRILEYLAVRKLKNDMRGPILCFVGPPGVGKTSLGQSIARATGRK
FVRLSLGGVRDEAEIRGHRRTYVGALPGRIIQSMKKAGTVNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNHAFSDHY
LDLSYDLSKVMFIGTANLLDPIPGPLKDRMEILELPGYTFEEKVHIAQNHLIPKQLREHGLSADAIAITEKALIKIIMAY
TREAGVRNLERRIADVCRAIAVEVASGKIGAAAKRAIEEADVLEILGPEKFYNETAERTEIAGVATGLAWTAAGGDILFI
EATKMPGKGALTLTGQLGDVMKESAQAALSYLRSKSDSLGIPVNFLEKTDLHIHFPAGAIPKDGPSAGVTILTALVSLLT
GIRVRSDVAMTGEVTLRGLVLPVGGIKEKVLAAHRAGIKRIIIPARNEKDLLDVPEQARKEVEFVFAAHMDEVLAAALEE
NPVGRKPPAAPEPEGEKKPGATPTPPAKKPDEIRV

Sequences:

>Translated_835_residues
MSDKEKKGAGAGAQVAPAMGPPVLINKEDIPAVLPILPLRNSVFFPGGVLPLAVGRQKTIALIKDAVRDEQVIGVVTQRR
AEEEDPGAADLYTVGTVARVVKLLKMGEDNYSLVVQGLARFKVLELVQESPYLKARIEPVEDRSVVDDVEVEALAINLKK
LAREVIELMPELPAAATELVESITHPGHLADLIAANVDVPIEEKQQVLETVELKARMKLVLELLNRKREILKLSNKIDSA
VKGEMSKTQREYYLRQQLKAIKEELGELGEEEEELDELQERLKKAGLPPEVEKVAQKELNRLKSIPTASSEYTVARTYLD
WIADLPWAKRTDDNLDIENARQILDSDHYALEKIKKRILEYLAVRKLKNDMRGPILCFVGPPGVGKTSLGQSIARATGRK
FVRLSLGGVRDEAEIRGHRRTYVGALPGRIIQSMKKAGTVNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNHAFSDHY
LDLSYDLSKVMFIGTANLLDPIPGPLKDRMEILELPGYTFEEKVHIAQNHLIPKQLREHGLSADAIAITEKALIKIIMAY
TREAGVRNLERRIADVCRAIAVEVASGKIGAAAKRAIEEADVLEILGPEKFYNETAERTEIAGVATGLAWTAAGGDILFI
EATKMPGKGALTLTGQLGDVMKESAQAALSYLRSKSDSLGIPVNFLEKTDLHIHFPAGAIPKDGPSAGVTILTALVSLLT
GIRVRSDVAMTGEVTLRGLVLPVGGIKEKVLAAHRAGIKRIIIPARNEKDLLDVPEQARKEVEFVFAAHMDEVLAAALEE
NPVGRKPPAAPEPEGEKKPGATPTPPAKKPDEIRV
>Mature_834_residues
SDKEKKGAGAGAQVAPAMGPPVLINKEDIPAVLPILPLRNSVFFPGGVLPLAVGRQKTIALIKDAVRDEQVIGVVTQRRA
EEEDPGAADLYTVGTVARVVKLLKMGEDNYSLVVQGLARFKVLELVQESPYLKARIEPVEDRSVVDDVEVEALAINLKKL
AREVIELMPELPAAATELVESITHPGHLADLIAANVDVPIEEKQQVLETVELKARMKLVLELLNRKREILKLSNKIDSAV
KGEMSKTQREYYLRQQLKAIKEELGELGEEEEELDELQERLKKAGLPPEVEKVAQKELNRLKSIPTASSEYTVARTYLDW
IADLPWAKRTDDNLDIENARQILDSDHYALEKIKKRILEYLAVRKLKNDMRGPILCFVGPPGVGKTSLGQSIARATGRKF
VRLSLGGVRDEAEIRGHRRTYVGALPGRIIQSMKKAGTVNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNHAFSDHYL
DLSYDLSKVMFIGTANLLDPIPGPLKDRMEILELPGYTFEEKVHIAQNHLIPKQLREHGLSADAIAITEKALIKIIMAYT
REAGVRNLERRIADVCRAIAVEVASGKIGAAAKRAIEEADVLEILGPEKFYNETAERTEIAGVATGLAWTAAGGDILFIE
ATKMPGKGALTLTGQLGDVMKESAQAALSYLRSKSDSLGIPVNFLEKTDLHIHFPAGAIPKDGPSAGVTILTALVSLLTG
IRVRSDVAMTGEVTLRGLVLPVGGIKEKVLAAHRAGIKRIIIPARNEKDLLDVPEQARKEVEFVFAAHMDEVLAAALEEN
PVGRKPPAAPEPEGEKKPGATPTPPAKKPDEIRV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=838, Percent_Identity=44.8687350835322, Blast_Score=677, Evalue=0.0,
Organism=Homo sapiens, GI21396489, Length=836, Percent_Identity=39.2344497607655, Blast_Score=563, Evalue=1e-160,
Organism=Escherichia coli, GI1786643, Length=771, Percent_Identity=47.2114137483787, Blast_Score=723, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556486, Length=800, Percent_Identity=37.125, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17505831, Length=658, Percent_Identity=41.7933130699088, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319449, Length=729, Percent_Identity=39.917695473251, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24666867, Length=686, Percent_Identity=43.731778425656, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221513036, Length=686, Percent_Identity=43.731778425656, Blast_Score=553, Evalue=1e-157,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91279; Mature: 91148

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKEKKGAGAGAQVAPAMGPPVLINKEDIPAVLPILPLRNSVFFPGGVLPLAVGRQKTI
CCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHCCCCCEECCCCCHHHCCCCHHHH
ALIKDAVRDEQVIGVVTQRRAEEEDPGAADLYTVGTVARVVKLLKMGEDNYSLVVQGLAR
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FKVLELVQESPYLKARIEPVEDRSVVDDVEVEALAINLKKLAREVIELMPELPAAATELV
HHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ESITHPGHLADLIAANVDVPIEEKQQVLETVELKARMKLVLELLNRKREILKLSNKIDSA
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKGEMSKTQREYYLRQQLKAIKEELGELGEEEEELDELQERLKKAGLPPEVEKVAQKELN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLKSIPTASSEYTVARTYLDWIADLPWAKRTDDNLDIENARQILDSDHYALEKIKKRILE
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
YLAVRKLKNDMRGPILCFVGPPGVGKTSLGQSIARATGRKFVRLSLGGVRDEAEIRGHRR
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHH
TYVGALPGRIIQSMKKAGTVNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNHAFSDHY
HHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
LDLSYDLSKVMFIGTANLLDPIPGPLKDRMEILELPGYTFEEKVHIAQNHLIPKQLREHG
EEECCCHHHHHHEECHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHCC
LSADAIAITEKALIKIIMAYTREAGVRNLERRIADVCRAIAVEVASGKIGAAAKRAIEEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DVLEILGPEKFYNETAERTEIAGVATGLAWTAAGGDILFIEATKMPGKGALTLTGQLGDV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCEEEEECHHHHH
MKESAQAALSYLRSKSDSLGIPVNFLEKTDLHIHFPAGAIPKDGPSAGVTILTALVSLLT
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
GIRVRSDVAMTGEVTLRGLVLPVGGIKEKVLAAHRAGIKRIIIPARNEKDLLDVPEQARK
CCHHHCCEEEECCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHH
EVEFVFAAHMDEVLAAALEENPVGRKPPAAPEPEGEKKPGATPTPPAKKPDEIRV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDKEKKGAGAGAQVAPAMGPPVLINKEDIPAVLPILPLRNSVFFPGGVLPLAVGRQKTI
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHCCCCCEECCCCCHHHCCCCHHHH
ALIKDAVRDEQVIGVVTQRRAEEEDPGAADLYTVGTVARVVKLLKMGEDNYSLVVQGLAR
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FKVLELVQESPYLKARIEPVEDRSVVDDVEVEALAINLKKLAREVIELMPELPAAATELV
HHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ESITHPGHLADLIAANVDVPIEEKQQVLETVELKARMKLVLELLNRKREILKLSNKIDSA
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKGEMSKTQREYYLRQQLKAIKEELGELGEEEEELDELQERLKKAGLPPEVEKVAQKELN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLKSIPTASSEYTVARTYLDWIADLPWAKRTDDNLDIENARQILDSDHYALEKIKKRILE
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
YLAVRKLKNDMRGPILCFVGPPGVGKTSLGQSIARATGRKFVRLSLGGVRDEAEIRGHRR
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHH
TYVGALPGRIIQSMKKAGTVNPVMMLDEIDKLGADFRGDPSAALLEVLDPEQNHAFSDHY
HHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
LDLSYDLSKVMFIGTANLLDPIPGPLKDRMEILELPGYTFEEKVHIAQNHLIPKQLREHG
EEECCCHHHHHHEECHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHCC
LSADAIAITEKALIKIIMAYTREAGVRNLERRIADVCRAIAVEVASGKIGAAAKRAIEEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DVLEILGPEKFYNETAERTEIAGVATGLAWTAAGGDILFIEATKMPGKGALTLTGQLGDV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCEEEEECHHHHH
MKESAQAALSYLRSKSDSLGIPVNFLEKTDLHIHFPAGAIPKDGPSAGVTILTALVSLLT
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
GIRVRSDVAMTGEVTLRGLVLPVGGIKEKVLAAHRAGIKRIIIPARNEKDLLDVPEQARK
CCHHHCCEEEECCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHH
EVEFVFAAHMDEVLAAALEENPVGRKPPAAPEPEGEKKPGATPTPPAKKPDEIRV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA