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The map label for this gene is degP [H]

Identifier: 220917263

GI number: 220917263

Start: 2400909

End: 2402483

Strand: Direct

Name: degP [H]

Synonym: A2cp1_2161

Alternate gene names: 220917263

Gene position: 2400909-2402483 (Clockwise)

Preceding gene: 220917262

Following gene: 220917265

Centisome position: 47.74

GC content: 72.83

Gene sequence:

>1575_bases
ATGCGCCTCATCACCCGAATCGTCACCGTCTCTCTCGCAGCCGCAGCGATCTTCGCGTGCACGCGGGACGGCAGCGCGGC
GACCGCGTCCGCCGCGCCCGCGGCGGCGCCGGCCCAGCAGCTGTTCCGCGACGCCGCGGCGGCCGCGCCCGGCCCCGAGG
CCGCCATCCCGGTGCAGACCTCGCTCGCGCCGCTCATCGACAAGCTCCGCCCGGCGGTGGTGAACATCTCCACCACCACC
GTCACCAAGCACCCGCGCGTCCAGCGCGGCCCGCGCGGCCAGAACCCGCACGGCGGCGGCACGCCGGACGAGGGCTTCGA
GGACTTCTTCGAGCGCTACTTCGGCCGCCCCGCGCCGGAGATGCCCGAGGAGTTCAAGGGCTCGTCGCTCGGCTCCGGGT
TCCTGCTCAACACCGAGGGCTACATCCTCACCAACAACCACGTGGTGAAGGACGCCACCGACATCCGCGTGCGCCTCTCG
GACGACCGCGAGTTCGGCGCCAGGATCGTCGGCCGTGACCCGCTCACCGACGTGGCGCTCATCCAGCTCGTGAACCCTCC
GAAGAACCTGCCGACGGTGGTGCTGGGCGACTCCGATGCGCTCCGCCAGGGCGACTTCGTGCTCGCGCTGGGCAGCCCGT
TCGGCCTGCGCGACACCGCCACGCTCGGCATCGTGTCGGCGAAGCACCGCCCCGGTATCAACCCCGGCGGCACCTACGAC
GACTTCATCCAGACCGACGCCGCCATCAACCCGGGCAACTCGGGCGGCCCCCTCTTCAACCTCCGCGGCGAGGTGGTCGG
CATCAACACCGCCATCGTGTCGCCGCAGATCGGCCAGGGCATCGGCTTCGCGGTGCCCATCAACATGGCGAAGGCGCTGC
TGCCGCAGCTCAAGGAGAAGGGCAAGGTCACGCGCGGCTTCCTGGGGGTGTCGGTGTCCGACCTCTCGCCGGATCTCATC
CAGGGCTTCGGCCTGCAGTCCGGCACCAAGGGCGCGCTGGTCCAGAACGTGGTCCCGCGCTCGCCGGCCGACAAGGCGGG
GCTGCAGCCCGGCGACGTGGTGGTCGCGCTGAACGACAAGACCGTCGAGACCGCCGGCGCGCTCACCCGCGGCGTCGCCC
TGGTCTCCCCTGGCCAGACCGCGAACCTGACCGTGCTGCGCGGCGGCCAGAAGAAGCAGTTCGCGGTGAAGGTGGTGCAG
CGGCCCGAGGACGGCGAGGCCGTCGGCCGCAACGAGCAGGGCGGCGGCGACGAGGGCGGCGGGCAGGGCGCCCGCGATCA
GTCGCCGAAGCTCGGCGTCTCCATCGCGCCCATCACCCCGGACGTCGCGCGCCAGTTCGGCGTCGAGCCGGGCGAGGGCG
TGGTGGTGGCGGACGTCACCGAGGGCGGCCCGGCCGATCGCGCCGGCATCCGCCGCGGCGACGTCATCCTCGAGGCGAAC
CGCCAGAAGGTGGCGCGGCCGGAGGACATGCGGTCGGCGGTGGCGAAGCTGAAGGAGGGCGACATGGCGCTGCTGCGCGT
TCGCCGCGGCGACGCCGCCGTGTTCATCGCCGTGCCGGTGGGCGGCGGCAAGTAG

Upstream 100 bases:

>100_bases
CCGTGCCCGCCGGGCGCCGGCGCGGGGAATAGAATCCGGGCCCGAGCGTCCTTGGAACGTGACTGACCGTCTCTACATGA
CCAACCCCAGGAGAGGGGCC

Downstream 100 bases:

>100_bases
CTCGATCCCTTGCGATCGTTCCCGCGCCGCCCTCCGGATCCGGGGGGCGGCGCGGCCGTCAGCGGGTCAGAACACCTTCG
AGGCGATGGGCGCGCCGGTG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MRLITRIVTVSLAAAAIFACTRDGSAATASAAPAAAPAQQLFRDAAAAAPGPEAAIPVQTSLAPLIDKLRPAVVNISTTT
VTKHPRVQRGPRGQNPHGGGTPDEGFEDFFERYFGRPAPEMPEEFKGSSLGSGFLLNTEGYILTNNHVVKDATDIRVRLS
DDREFGARIVGRDPLTDVALIQLVNPPKNLPTVVLGDSDALRQGDFVLALGSPFGLRDTATLGIVSAKHRPGINPGGTYD
DFIQTDAAINPGNSGGPLFNLRGEVVGINTAIVSPQIGQGIGFAVPINMAKALLPQLKEKGKVTRGFLGVSVSDLSPDLI
QGFGLQSGTKGALVQNVVPRSPADKAGLQPGDVVVALNDKTVETAGALTRGVALVSPGQTANLTVLRGGQKKQFAVKVVQ
RPEDGEAVGRNEQGGGDEGGGQGARDQSPKLGVSIAPITPDVARQFGVEPGEGVVVADVTEGGPADRAGIRRGDVILEAN
RQKVARPEDMRSAVAKLKEGDMALLRVRRGDAAVFIAVPVGGGK

Sequences:

>Translated_524_residues
MRLITRIVTVSLAAAAIFACTRDGSAATASAAPAAAPAQQLFRDAAAAAPGPEAAIPVQTSLAPLIDKLRPAVVNISTTT
VTKHPRVQRGPRGQNPHGGGTPDEGFEDFFERYFGRPAPEMPEEFKGSSLGSGFLLNTEGYILTNNHVVKDATDIRVRLS
DDREFGARIVGRDPLTDVALIQLVNPPKNLPTVVLGDSDALRQGDFVLALGSPFGLRDTATLGIVSAKHRPGINPGGTYD
DFIQTDAAINPGNSGGPLFNLRGEVVGINTAIVSPQIGQGIGFAVPINMAKALLPQLKEKGKVTRGFLGVSVSDLSPDLI
QGFGLQSGTKGALVQNVVPRSPADKAGLQPGDVVVALNDKTVETAGALTRGVALVSPGQTANLTVLRGGQKKQFAVKVVQ
RPEDGEAVGRNEQGGGDEGGGQGARDQSPKLGVSIAPITPDVARQFGVEPGEGVVVADVTEGGPADRAGIRRGDVILEAN
RQKVARPEDMRSAVAKLKEGDMALLRVRRGDAAVFIAVPVGGGK
>Mature_524_residues
MRLITRIVTVSLAAAAIFACTRDGSAATASAAPAAAPAQQLFRDAAAAAPGPEAAIPVQTSLAPLIDKLRPAVVNISTTT
VTKHPRVQRGPRGQNPHGGGTPDEGFEDFFERYFGRPAPEMPEEFKGSSLGSGFLLNTEGYILTNNHVVKDATDIRVRLS
DDREFGARIVGRDPLTDVALIQLVNPPKNLPTVVLGDSDALRQGDFVLALGSPFGLRDTATLGIVSAKHRPGINPGGTYD
DFIQTDAAINPGNSGGPLFNLRGEVVGINTAIVSPQIGQGIGFAVPINMAKALLPQLKEKGKVTRGFLGVSVSDLSPDLI
QGFGLQSGTKGALVQNVVPRSPADKAGLQPGDVVVALNDKTVETAGALTRGVALVSPGQTANLTVLRGGQKKQFAVKVVQ
RPEDGEAVGRNEQGGGDEGGGQGARDQSPKLGVSIAPITPDVARQFGVEPGEGVVVADVTEGGPADRAGIRRGDVILEAN
RQKVARPEDMRSAVAKLKEGDMALLRVRRGDAAVFIAVPVGGGK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=306, Percent_Identity=35.9477124183007, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4506141, Length=287, Percent_Identity=36.2369337979094, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI7019477, Length=250, Percent_Identity=40.4, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI24308541, Length=270, Percent_Identity=36.2962962962963, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1786356, Length=516, Percent_Identity=36.6279069767442, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1789629, Length=480, Percent_Identity=37.9166666666667, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789630, Length=284, Percent_Identity=37.6760563380282, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24646839, Length=317, Percent_Identity=38.1703470031546, Blast_Score=172, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 54311; Mature: 54311

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLITRIVTVSLAAAAIFACTRDGSAATASAAPAAAPAQQLFRDAAAAAPGPEAAIPVQT
CHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
SLAPLIDKLRPAVVNISTTTVTKHPRVQRGPRGQNPHGGGTPDEGFEDFFERYFGRPAPE
HHHHHHHHHCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
MPEEFKGSSLGSGFLLNTEGYILTNNHVVKDATDIRVRLSDDREFGARIVGRDPLTDVAL
CCHHHCCCCCCCCEEECCCCEEEECCEEEECCCEEEEEECCCCCCCCEEECCCCCCCEEE
IQLVNPPKNLPTVVLGDSDALRQGDFVLALGSPFGLRDTATLGIVSAKHRPGINPGGTYD
EEEECCCCCCCEEEECCCHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHH
DFIQTDAAINPGNSGGPLFNLRGEVVGINTAIVSPQIGQGIGFAVPINMAKALLPQLKEK
HHHHCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHHHC
GKVTRGFLGVSVSDLSPDLIQGFGLQSGTKGALVQNVVPRSPADKAGLQPGDVVVALNDK
CCEEEEEEEEEHHCCCHHHHHHCCCCCCCCCHHHHHCCCCCCCHHCCCCCCCEEEEECCC
TVETAGALTRGVALVSPGQTANLTVLRGGQKKQFAVKVVQRPEDGEAVGRNEQGGGDEGG
CHHHHHHHHHCEEEECCCCCCEEEEEECCCCCEEEEHEECCCCCCCCCCCCCCCCCCCCC
GQGARDQSPKLGVSIAPITPDVARQFGVEPGEGVVVADVTEGGPADRAGIRRGDVILEAN
CCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECC
RQKVARPEDMRSAVAKLKEGDMALLRVRRGDAAVFIAVPVGGGK
CHHCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCC
>Mature Secondary Structure
MRLITRIVTVSLAAAAIFACTRDGSAATASAAPAAAPAQQLFRDAAAAAPGPEAAIPVQT
CHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
SLAPLIDKLRPAVVNISTTTVTKHPRVQRGPRGQNPHGGGTPDEGFEDFFERYFGRPAPE
HHHHHHHHHCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
MPEEFKGSSLGSGFLLNTEGYILTNNHVVKDATDIRVRLSDDREFGARIVGRDPLTDVAL
CCHHHCCCCCCCCEEECCCCEEEECCEEEECCCEEEEEECCCCCCCCEEECCCCCCCEEE
IQLVNPPKNLPTVVLGDSDALRQGDFVLALGSPFGLRDTATLGIVSAKHRPGINPGGTYD
EEEECCCCCCCEEEECCCHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHH
DFIQTDAAINPGNSGGPLFNLRGEVVGINTAIVSPQIGQGIGFAVPINMAKALLPQLKEK
HHHHCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHHHC
GKVTRGFLGVSVSDLSPDLIQGFGLQSGTKGALVQNVVPRSPADKAGLQPGDVVVALNDK
CCEEEEEEEEEHHCCCHHHHHHCCCCCCCCCHHHHHCCCCCCCHHCCCCCCCEEEEECCC
TVETAGALTRGVALVSPGQTANLTVLRGGQKKQFAVKVVQRPEDGEAVGRNEQGGGDEGG
CHHHHHHHHHCEEEECCCCCCEEEEEECCCCCEEEEHEECCCCCCCCCCCCCCCCCCCCC
GQGARDQSPKLGVSIAPITPDVARQFGVEPGEGVVVADVTEGGPADRAGIRRGDVILEAN
CCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECC
RQKVARPEDMRSAVAKLKEGDMALLRVRRGDAAVFIAVPVGGGK
CHHCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]