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The map label for this gene is bhbA [H]

Identifier: 220917199

GI number: 220917199

Start: 2337327

End: 2339093

Strand: Direct

Name: bhbA [H]

Synonym: A2cp1_2096

Alternate gene names: 220917199

Gene position: 2337327-2339093 (Clockwise)

Preceding gene: 220917196

Following gene: 220917200

Centisome position: 46.47

GC content: 71.36

Gene sequence:

>1767_bases
ATGGGCTCGAAGCCGGCGAAGGACCAGACGCGGCGGGTGGAGAAGCGGGGCGACACGCCGAAGGCGCCGGATCGCGCCGA
GCGGCCGCTGTTCGCCCGCGACGAGATCGCGCGGGTGCTGGAGGCCCGGGACCGCTGGACGCAGGAGGAGCTGGCGGAGG
CGCTCGCGCGCCTGCCGCGCCGCAAGGCGGCCTTCCAGACGGACTCCGGGATCCCGATCCCCGACGTGATCGACCCGGCC
CACCTGCGCGAGCACGACTTCCTGCGCGACGTGGGCTACCCGGGCGCGTACCCGTTCACCCGGGGTCCGCAGCCGACCAT
GTACCGGGGCCGGCTCTGGACCATGCGCCAGTTCGCGGGCTTCGGCACGCCCGCCGACACGAACCGGCGCTTCAAGTACC
TGCTCGAGCACGGCGTGAACGGGCTCTCCACCGCCTTCGACATGCCGGCGCTCATGGGCTACGACGCCGACCACCCGATG
AGCCGCGGCGAGGTGGGCAAGGAGGGCGTCGCCATCTCCACGCTGGAGGACTTCGAGATCCTGTTCGACGGGATCCCGCT
CGGCGACGTCACCACCTCCATGACCATCAACGCGACCGCGGTCATCGCGCTCGCGATGTACGTGGCGGTCGCGGAGAAGC
AGGGCGTGCCGCGCGCGAGGCTGGGCGGGACGCTCCAGGCGGACATGCTGAAGGAGTACATCGCGCAGAAGGAGTGGATG
ATCCCGCCCACGCCGGCGGTCCGCATCGTCTGCGACATGATCGAGTTCTGCGCGAAGGAGATGCCGCGCTGGAACCCGGT
CTCGATCAGCGGCTACCACATCCGCGAGGCGGGGGCGACGGCGCTGCAGGAGCTGGCGTTCACGCTCGCCGACGGCATCG
AGTACGTGCAGGAGTGCGTGGACCGCGGCATGGACGTGGACGCGTTCGCCCCGCGCCTCTCGTTCTTCTGGGACGTGCAC
AACGACCTGTTCGAGGAGGTCGCGAAGTTCCGCGCGGCGCGCCGGATCTGGGCGCGGACCATGAAGGAGCGCTTCGGCGC
GAAGAAGCGCGAGTCGCTGCTGCTCCGCACCCACGCGCAGACGGCCGGCGTCTCGCTCACCGCGCAGCAGCCGTACAACA
ACGTGGTCCGCGTGGCGCTGCAGGCGTTCGCGGCGGTGCTGGGCGGCACGCAGTCGCTGCACACCAACTCGCTCGACGAG
ACCTACGCGCTGCCCACCGAGGAGGCGGTCACCGTCGCGCTCCGCACCCAGCAGATCATCGCGCACGAGTCCGGCGCCGA
CCGGGTGATCGACCCGCTCGCCGGCAGCTACTACGTCGAGTACCTCACCGACGAGATGGAGCGGCGCGCCATCGAGTACC
TCCGCCGCATCGACGACATGGGCGGCATGCTCCGCGCGGTGGAGGAGGGCTACCCGCAGCGCGAGATCGCCGAGAGCGCG
TACCGCTGGCAGCGCGACGTGGAGAGCAACGATCGGCTGGTGGTCGGCGTGAACGCGTTCCAGGCGCGCGAGGAGCAGCA
GATCCCGCTGCTCCGGATCGACGAGACGGTGGCGCGCGAGCAGGTGGAGCGCCTGAAGGCGCTGAAGGGCCGGCGCAGCG
CCGCGCGGGTGGCCGAGGCGCTGGCGGGCGTGGAGCGCGCGGCGCGCGAGGGGACGAACGTGGTCCCGCCGGTCATCGAG
GCGGTGAAGGCGTACGCGACGCTCGGCGAGATCGCCGACACGTTCCGCAAGGTCCACGGCACCTACCGCGAGGACGGCCG
GTTCTAG

Upstream 100 bases:

>100_bases
CCGCACCGCGGGTCCCGGCGGCCCCGCGAGGCGACCTGACCTGCCGTCCTCCCTCGGGTTAGATCAGCGAGGCAGCCAGC
GCTCACAGCGAGGGGAATCC

Downstream 100 bases:

>100_bases
GCCGGCGCTTCCGGTACACTGGCCGGGTGGACGGCTCCCCGGCGCCGCACTGGTCCGACGGCTACTACGGCCCGCTCTAC
CTGGAGCCGGTCGCGGACCT

Product: methylmalonyl-CoA mutase, large subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MGSKPAKDQTRRVEKRGDTPKAPDRAERPLFARDEIARVLEARDRWTQEELAEALARLPRRKAAFQTDSGIPIPDVIDPA
HLREHDFLRDVGYPGAYPFTRGPQPTMYRGRLWTMRQFAGFGTPADTNRRFKYLLEHGVNGLSTAFDMPALMGYDADHPM
SRGEVGKEGVAISTLEDFEILFDGIPLGDVTTSMTINATAVIALAMYVAVAEKQGVPRARLGGTLQADMLKEYIAQKEWM
IPPTPAVRIVCDMIEFCAKEMPRWNPVSISGYHIREAGATALQELAFTLADGIEYVQECVDRGMDVDAFAPRLSFFWDVH
NDLFEEVAKFRAARRIWARTMKERFGAKKRESLLLRTHAQTAGVSLTAQQPYNNVVRVALQAFAAVLGGTQSLHTNSLDE
TYALPTEEAVTVALRTQQIIAHESGADRVIDPLAGSYYVEYLTDEMERRAIEYLRRIDDMGGMLRAVEEGYPQREIAESA
YRWQRDVESNDRLVVGVNAFQAREEQQIPLLRIDETVAREQVERLKALKGRRSAARVAEALAGVERAAREGTNVVPPVIE
AVKAYATLGEIADTFRKVHGTYREDGRF

Sequences:

>Translated_588_residues
MGSKPAKDQTRRVEKRGDTPKAPDRAERPLFARDEIARVLEARDRWTQEELAEALARLPRRKAAFQTDSGIPIPDVIDPA
HLREHDFLRDVGYPGAYPFTRGPQPTMYRGRLWTMRQFAGFGTPADTNRRFKYLLEHGVNGLSTAFDMPALMGYDADHPM
SRGEVGKEGVAISTLEDFEILFDGIPLGDVTTSMTINATAVIALAMYVAVAEKQGVPRARLGGTLQADMLKEYIAQKEWM
IPPTPAVRIVCDMIEFCAKEMPRWNPVSISGYHIREAGATALQELAFTLADGIEYVQECVDRGMDVDAFAPRLSFFWDVH
NDLFEEVAKFRAARRIWARTMKERFGAKKRESLLLRTHAQTAGVSLTAQQPYNNVVRVALQAFAAVLGGTQSLHTNSLDE
TYALPTEEAVTVALRTQQIIAHESGADRVIDPLAGSYYVEYLTDEMERRAIEYLRRIDDMGGMLRAVEEGYPQREIAESA
YRWQRDVESNDRLVVGVNAFQAREEQQIPLLRIDETVAREQVERLKALKGRRSAARVAEALAGVERAAREGTNVVPPVIE
AVKAYATLGEIADTFRKVHGTYREDGRF
>Mature_587_residues
GSKPAKDQTRRVEKRGDTPKAPDRAERPLFARDEIARVLEARDRWTQEELAEALARLPRRKAAFQTDSGIPIPDVIDPAH
LREHDFLRDVGYPGAYPFTRGPQPTMYRGRLWTMRQFAGFGTPADTNRRFKYLLEHGVNGLSTAFDMPALMGYDADHPMS
RGEVGKEGVAISTLEDFEILFDGIPLGDVTTSMTINATAVIALAMYVAVAEKQGVPRARLGGTLQADMLKEYIAQKEWMI
PPTPAVRIVCDMIEFCAKEMPRWNPVSISGYHIREAGATALQELAFTLADGIEYVQECVDRGMDVDAFAPRLSFFWDVHN
DLFEEVAKFRAARRIWARTMKERFGAKKRESLLLRTHAQTAGVSLTAQQPYNNVVRVALQAFAAVLGGTQSLHTNSLDET
YALPTEEAVTVALRTQQIIAHESGADRVIDPLAGSYYVEYLTDEMERRAIEYLRRIDDMGGMLRAVEEGYPQREIAESAY
RWQRDVESNDRLVVGVNAFQAREEQQIPLLRIDETVAREQVERLKALKGRRSAARVAEALAGVERAAREGTNVVPPVIEA
VKAYATLGEIADTFRKVHGTYREDGRF

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=497, Percent_Identity=47.0824949698189, Blast_Score=488, Evalue=1e-138,
Organism=Escherichia coli, GI1789284, Length=512, Percent_Identity=46.09375, Blast_Score=457, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI25144500, Length=518, Percent_Identity=46.1389961389961, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65995; Mature: 65864

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GSKPAKDQTRRVEKRGDTPKAPDRAERPLFARDEIARVLEARDRWTQEELAEALARLPR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCHH
RKAAFQTDSGIPIPDVIDPAHLREHDFLRDVGYPGAYPFTRGPQPTMYRGRLWTMRQFAG
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
FGTPADTNRRFKYLLEHGVNGLSTAFDMPALMGYDADHPMSRGEVGKEGVAISTLEDFEI
CCCCCCCCHHHHHHHHHCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHH
LFDGIPLGDVTTSMTINATAVIALAMYVAVAEKQGVPRARLGGTLQADMLKEYIAQKEWM
HHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCC
IPPTPAVRIVCDMIEFCAKEMPRWNPVSISGYHIREAGATALQELAFTLADGIEYVQECV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
DRGMDVDAFAPRLSFFWDVHNDLFEEVAKFRAARRIWARTMKERFGAKKRESLLLRTHAQ
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TAGVSLTAQQPYNNVVRVALQAFAAVLGGTQSLHTNSLDETYALPTEEAVTVALRTQQII
HHCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
AHESGADRVIDPLAGSYYVEYLTDEMERRAIEYLRRIDDMGGMLRAVEEGYPQREIAESA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YRWQRDVESNDRLVVGVNAFQAREEQQIPLLRIDETVAREQVERLKALKGRRSAARVAEA
HHHHHCCCCCCCEEEECHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAGVERAAREGTNVVPPVIEAVKAYATLGEIADTFRKVHGTYREDGRF
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]