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The map label for this gene is atoC [H]

Identifier: 220917159

GI number: 220917159

Start: 2294275

End: 2295696

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_2056

Alternate gene names: 220917159

Gene position: 2295696-2294275 (Counterclockwise)

Preceding gene: 220917160

Following gene: 220917114

Centisome position: 45.65

GC content: 70.89

Gene sequence:

>1422_bases
GTGGCCCACGTCCTCATCGTAGACGACGAGGTGAACATCCGCCGGGTCCTCGCGGCCATGCTGAAGCGCGAGGGCTACGA
GGTCACCACCGCGGCCGACGGCGAGCAGGCGCTCGGCGTGCTGCACCGCACGCCGGTGCACGTGGTGGTCACCGACCTCG
TCATGCCGCGGGTGGGCGGGATGGAGCTCCTGCGCCGCGTCTCGCAGGACTTCCCCGACGTGCCGGTCATCCTCATCACC
GCGCACGGCTCGGTGGACAGCGCGGTGGCCGCCCTCAAGGCGGGCGCCTTCGACTACATCACCAAGCCCTTCGAGCAGGA
GGAGCTGAAGAAGGTCATCGCCAAGGCGGCGCGCGCGCACGACCTCGAGCGCCAGAACCTGCACGCGATGCTGAACGACG
GCGACGGCCCGCCGCTCATCGGCCAGTCGCCGCCCATGCGCGCCATCTACGACATGGTGGCCCGGGTGGCGGACTCGCCC
TCCACCGTGCTCATCACCGGCGAGAGCGGCACCGGCAAGGAGCTCATCGCCAAGGCGCTCCACCGCGGCTCCTCGCGCCG
CGACAAGCCGCTCATCAAGGTGAACTGCGCCGCGATCCCCAAGGACCTGGTGGAGAGCGAGCTGTTCGGCTACGAGCGCG
GCGCGTTCACCGGCGCGGTCGGCTCGAAGCCCGGGCGCTTCGAGCTGGCCGACGGGGGCACGCTGTTCCTGGACGAGATC
GGCGAGGTGCCGGTCGAGATGCAGGTGAAGCTGCTGCGCGCCATCCAGGAGTCCGAGTTCGAGCGCGTCGGCGGCATCAA
GACGCTCCAGGTCGACGTGCGCCTCATCGCCGCCACCAACCGCGACCTGAAGCAGCTCATCGCCGACGGGCGCTTCCGCG
AGGATCTCTACTACCGGCTGGCGGTGGTCCCCATCGCCCTGCCCCCGCTGCGCGACCGGCGCGAGGACGTGCCGCTGCTG
GTCCGGTACTTCATCGAGAAGTACGACCAGCGGCTGGGCAAGAAGGTCGAGGGCATCGAGGACGAGGCGCTGGAGCTGCT
CGCGAACTACTCCTGGCCGGGCAACATCCGCGAGCTGGAGAACCTGATGGAGCGCTCGGTGCTGTTCGCCGACGGCCCGC
TCATCCAGGCGAGCGCGCTCCCCGACGCGCTCCGCGAGAAGGGCGCGCAGGCGTCGGTGCCGATCGCCGCGGTGGGCCCG
CTGGGCGCCATCGCCGCGCCGAGCGGCGCGTCCATGAAGGAGATCGTCCGCCAGGCCCAGGCCGAGCTGGAGCGCGAGCT
GATCACGCGGGCGCTGGAGGAGACCGGCGGCAACGTCACGCGCGCGGCCAAGCGGCTCCAGATCAGCCGCAAGTCGCTCC
AGGTGAAGATGAAGGAGCTGGGCCTGCGCGGCGCCGTGGACGTCGAGGACGACCGGAGCTGA

Upstream 100 bases:

>100_bases
AGCGGCGCCGGGCCCGGGCCGAGGCGCGCCTCCGCGGCCGCCGGCGCCGGAAGAAGCACGCCTGATGCGTACCCCTGCCC
TTCCGTGGTAACGAGGCGCC

Downstream 100 bases:

>100_bases
GCCGCGCCTAGCCCTGGCCGCCGTGCTTCAGCCGCTCCAGGGCGGCGTACACGTCGGAGCGGACCAGCCCGCGGGCCCGG
GCCACCTCGCGTGCCACCGC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MAHVLIVDDEVNIRRVLAAMLKREGYEVTTAADGEQALGVLHRTPVHVVVTDLVMPRVGGMELLRRVSQDFPDVPVILIT
AHGSVDSAVAALKAGAFDYITKPFEQEELKKVIAKAARAHDLERQNLHAMLNDGDGPPLIGQSPPMRAIYDMVARVADSP
STVLITGESGTGKELIAKALHRGSSRRDKPLIKVNCAAIPKDLVESELFGYERGAFTGAVGSKPGRFELADGGTLFLDEI
GEVPVEMQVKLLRAIQESEFERVGGIKTLQVDVRLIAATNRDLKQLIADGRFREDLYYRLAVVPIALPPLRDRREDVPLL
VRYFIEKYDQRLGKKVEGIEDEALELLANYSWPGNIRELENLMERSVLFADGPLIQASALPDALREKGAQASVPIAAVGP
LGAIAAPSGASMKEIVRQAQAELERELITRALEETGGNVTRAAKRLQISRKSLQVKMKELGLRGAVDVEDDRS

Sequences:

>Translated_473_residues
MAHVLIVDDEVNIRRVLAAMLKREGYEVTTAADGEQALGVLHRTPVHVVVTDLVMPRVGGMELLRRVSQDFPDVPVILIT
AHGSVDSAVAALKAGAFDYITKPFEQEELKKVIAKAARAHDLERQNLHAMLNDGDGPPLIGQSPPMRAIYDMVARVADSP
STVLITGESGTGKELIAKALHRGSSRRDKPLIKVNCAAIPKDLVESELFGYERGAFTGAVGSKPGRFELADGGTLFLDEI
GEVPVEMQVKLLRAIQESEFERVGGIKTLQVDVRLIAATNRDLKQLIADGRFREDLYYRLAVVPIALPPLRDRREDVPLL
VRYFIEKYDQRLGKKVEGIEDEALELLANYSWPGNIRELENLMERSVLFADGPLIQASALPDALREKGAQASVPIAAVGP
LGAIAAPSGASMKEIVRQAQAELERELITRALEETGGNVTRAAKRLQISRKSLQVKMKELGLRGAVDVEDDRS
>Mature_472_residues
AHVLIVDDEVNIRRVLAAMLKREGYEVTTAADGEQALGVLHRTPVHVVVTDLVMPRVGGMELLRRVSQDFPDVPVILITA
HGSVDSAVAALKAGAFDYITKPFEQEELKKVIAKAARAHDLERQNLHAMLNDGDGPPLIGQSPPMRAIYDMVARVADSPS
TVLITGESGTGKELIAKALHRGSSRRDKPLIKVNCAAIPKDLVESELFGYERGAFTGAVGSKPGRFELADGGTLFLDEIG
EVPVEMQVKLLRAIQESEFERVGGIKTLQVDVRLIAATNRDLKQLIADGRFREDLYYRLAVVPIALPPLRDRREDVPLLV
RYFIEKYDQRLGKKVEGIEDEALELLANYSWPGNIRELENLMERSVLFADGPLIQASALPDALREKGAQASVPIAAVGPL
GAIAAPSGASMKEIVRQAQAELERELITRALEETGGNVTRAAKRLQISRKSLQVKMKELGLRGAVDVEDDRS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=463, Percent_Identity=44.4924406047516, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=46.2719298245614, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=42.2413793103448, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1788905, Length=447, Percent_Identity=39.5973154362416, Blast_Score=316, Evalue=3e-87,
Organism=Escherichia coli, GI1789087, Length=333, Percent_Identity=50.1501501501502, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI87082117, Length=385, Percent_Identity=46.4935064935065, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=44.7852760736196, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI87082152, Length=358, Percent_Identity=41.6201117318436, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI87081872, Length=328, Percent_Identity=42.3780487804878, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1786524, Length=354, Percent_Identity=39.2655367231638, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1787583, Length=326, Percent_Identity=37.7300613496933, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87081858, Length=319, Percent_Identity=33.5423197492163, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1789828, Length=309, Percent_Identity=34.6278317152104, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789809, Length=106, Percent_Identity=35.8490566037736, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=35.5932203389831, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI2367329, Length=141, Percent_Identity=35.4609929078014, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790863, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788394, Length=137, Percent_Identity=28.4671532846715, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=121, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=114, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787375, Length=123, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786911, Length=120, Percent_Identity=36.6666666666667, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51744; Mature: 51613

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHVLIVDDEVNIRRVLAAMLKREGYEVTTAADGEQALGVLHRTPVHVVVTDLVMPRVGG
CEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCH
MELLRRVSQDFPDVPVILITAHGSVDSAVAALKAGAFDYITKPFEQEELKKVIAKAARAH
HHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHH
DLERQNLHAMLNDGDGPPLIGQSPPMRAIYDMVARVADSPSTVLITGESGTGKELIAKAL
CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
HRGSSRRDKPLIKVNCAAIPKDLVESELFGYERGAFTGAVGSKPGRFELADGGTLFLDEI
HCCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCEECCCCCCCCEEEECCCCEEEHHHH
GEVPVEMQVKLLRAIQESEFERVGGIKTLQVDVRLIAATNRDLKQLIADGRFREDLYYRL
CCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCHHHHHHHHCCCHHHHHHHHH
AVVPIALPPLRDRREDVPLLVRYFIEKYDQRLGKKVEGIEDEALELLANYSWPGNIRELE
HHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHCCCCCCCHHHHH
NLMERSVLFADGPLIQASALPDALREKGAQASVPIAAVGPLGAIAAPSGASMKEIVRQAQ
HHHHHHEEECCCCEEEHHCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
AELERELITRALEETGGNVTRAAKRLQISRKSLQVKMKELGLRGAVDVEDDRS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AHVLIVDDEVNIRRVLAAMLKREGYEVTTAADGEQALGVLHRTPVHVVVTDLVMPRVGG
EEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCH
MELLRRVSQDFPDVPVILITAHGSVDSAVAALKAGAFDYITKPFEQEELKKVIAKAARAH
HHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHH
DLERQNLHAMLNDGDGPPLIGQSPPMRAIYDMVARVADSPSTVLITGESGTGKELIAKAL
CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
HRGSSRRDKPLIKVNCAAIPKDLVESELFGYERGAFTGAVGSKPGRFELADGGTLFLDEI
HCCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCEECCCCCCCCEEEECCCCEEEHHHH
GEVPVEMQVKLLRAIQESEFERVGGIKTLQVDVRLIAATNRDLKQLIADGRFREDLYYRL
CCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCHHHHHHHHCCCHHHHHHHHH
AVVPIALPPLRDRREDVPLLVRYFIEKYDQRLGKKVEGIEDEALELLANYSWPGNIRELE
HHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHCCCCCCCHHHHH
NLMERSVLFADGPLIQASALPDALREKGAQASVPIAAVGPLGAIAAPSGASMKEIVRQAQ
HHHHHHEEECCCCEEEHHCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
AELERELITRALEETGGNVTRAAKRLQISRKSLQVKMKELGLRGAVDVEDDRS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]