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The map label for this gene is adk

Identifier: 220917142

GI number: 220917142

Start: 2282800

End: 2283444

Strand: Direct

Name: adk

Synonym: A2cp1_2039

Alternate gene names: 220917142

Gene position: 2282800-2283444 (Clockwise)

Preceding gene: 220917141

Following gene: 220917143

Centisome position: 45.39

GC content: 71.01

Gene sequence:

>645_bases
ATGATCCTCATCCTCCTCGGCCCGCCCGGCGCGGGCAAGGGCACGCAGGCCAAGCTCCTCTCCTCGGAGCTCGGCATCCC
GCACATCTCGACCGGCGACATGTTCCGCGACCACAAGGCGCGCGGGACCGAGATCGGCAAGCAGGTCCAGGCCATCATGG
ACGCCGGCGGGCTCGTCACCGACGACATCACCAACGCCATGGTGAAGGAGCGGCTCTCCCGCCCCGACGTGGCGCCGGGC
TTCATCCTCGACGGCTACCCGCGCACGGTGGTGCAGGCGGAGTACCTCGACGGCCTGCTGCGCTCGCTGGGCCGGTCCAT
CGACCGCGCGCTCTCGTACGAGGTCCCCGAGGAGCTCGTGGTCGAGCGGATCAGCGGCCGCCGGAGCTGCCCGAGGTGCG
GGGCGGTCTACCACGTGTCGCAGAACCCGCCGCACCGCGCCGGCTTCTGCGACCGCGACGACGCCGCCCTGGTGCAGCGC
GAGGACGACAAGCCGGAGAACGTCCGCAAGCGCATGCAGGAGTACGGCACCAAGACCGAGCCGCTGAAGCGCTACTACCG
CGATCGCGGCGAGCTGTCGGACGTCGAGGGCGTCGGCACGCCCGAGGGCATCCTCGCCGTGACGAAGAAGGTCCTGGGCC
GCTAG

Upstream 100 bases:

>100_bases
ATCCGCGGGCGGCGCATGACGACGGGGCAGGCGGTCGGCGCGTGACACGCCGCAGGGGCCTCGCCGCGGCGGGGCCCCTC
GCGCATCCGGAGGCGACGCG

Downstream 100 bases:

>100_bases
GCCCGGCCCGCACCGCCAGCGCATGTACGGGACGACCCGCGAACGCGCCGCCACGCGGACCTCCGCCGACGTGGCCGGGA
TCCGCGCCGCCGGCCGCGTC

Product: Adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MILILLGPPGAGKGTQAKLLSSELGIPHISTGDMFRDHKARGTEIGKQVQAIMDAGGLVTDDITNAMVKERLSRPDVAPG
FILDGYPRTVVQAEYLDGLLRSLGRSIDRALSYEVPEELVVERISGRRSCPRCGAVYHVSQNPPHRAGFCDRDDAALVQR
EDDKPENVRKRMQEYGTKTEPLKRYYRDRGELSDVEGVGTPEGILAVTKKVLGR

Sequences:

>Translated_214_residues
MILILLGPPGAGKGTQAKLLSSELGIPHISTGDMFRDHKARGTEIGKQVQAIMDAGGLVTDDITNAMVKERLSRPDVAPG
FILDGYPRTVVQAEYLDGLLRSLGRSIDRALSYEVPEELVVERISGRRSCPRCGAVYHVSQNPPHRAGFCDRDDAALVQR
EDDKPENVRKRMQEYGTKTEPLKRYYRDRGELSDVEGVGTPEGILAVTKKVLGR
>Mature_214_residues
MILILLGPPGAGKGTQAKLLSSELGIPHISTGDMFRDHKARGTEIGKQVQAIMDAGGLVTDDITNAMVKERLSRPDVAPG
FILDGYPRTVVQAEYLDGLLRSLGRSIDRALSYEVPEELVVERISGRRSCPRCGAVYHVSQNPPHRAGFCDRDDAALVQR
EDDKPENVRKRMQEYGTKTEPLKRYYRDRGELSDVEGVGTPEGILAVTKKVLGR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=203, Percent_Identity=41.871921182266, Blast_Score=173, Evalue=9e-44,
Organism=Homo sapiens, GI4502013, Length=203, Percent_Identity=41.871921182266, Blast_Score=173, Evalue=9e-44,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=37.5634517766497, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4502011, Length=206, Percent_Identity=27.1844660194175, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=29.1891891891892, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=30.188679245283, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=30.188679245283, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=45.8715596330275, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17552384, Length=187, Percent_Identity=39.572192513369, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=209, Percent_Identity=29.6650717703349, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=31.1557788944724, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=197, Percent_Identity=25.3807106598985, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=24.2990654205607, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=42.2535211267606, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.5329949238579, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=38.8625592417062, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=33.1658291457286, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=33.1658291457286, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=29.5698924731183, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=29.5698924731183, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221459597, Length=214, Percent_Identity=23.8317757009346, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356893, Length=214, Percent_Identity=23.8317757009346, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ANAD2 (B8J881)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492446.1
- ProteinModelPortal:   B8J881
- SMR:   B8J881
- GeneID:   7300166
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2039
- HOGENOM:   HBG630208
- ProtClustDB:   CLSK945928
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23555; Mature: 23555

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILILLGPPGAGKGTQAKLLSSELGIPHISTGDMFRDHKARGTEIGKQVQAIMDAGGLVT
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDITNAMVKERLSRPDVAPGFILDGYPRTVVQAEYLDGLLRSLGRSIDRALSYEVPEELV
HHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VERISGRRSCPRCGAVYHVSQNPPHRAGFCDRDDAALVQREDDKPENVRKRMQEYGTKTE
HHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCH
PLKRYYRDRGELSDVEGVGTPEGILAVTKKVLGR
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MILILLGPPGAGKGTQAKLLSSELGIPHISTGDMFRDHKARGTEIGKQVQAIMDAGGLVT
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDITNAMVKERLSRPDVAPGFILDGYPRTVVQAEYLDGLLRSLGRSIDRALSYEVPEELV
HHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VERISGRRSCPRCGAVYHVSQNPPHRAGFCDRDDAALVQREDDKPENVRKRMQEYGTKTE
HHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCH
PLKRYYRDRGELSDVEGVGTPEGILAVTKKVLGR
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA