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The map label for this gene is barA [H]

Identifier: 220916971

GI number: 220916971

Start: 2093586

End: 2095877

Strand: Reverse

Name: barA [H]

Synonym: A2cp1_1867

Alternate gene names: 220916971

Gene position: 2095877-2093586 (Counterclockwise)

Preceding gene: 220916975

Following gene: 220916967

Centisome position: 41.67

GC content: 77.44

Gene sequence:

>2292_bases
ATGCCCAACCGCCGCCGCCCGCCCGTCGTCGTCCTCCGCACGCACGCGGTGCCCGCGGCGGTGGCCGCCATCAGCCTCGC
CGCCGCGCTCGCGTCGTGGCAGTACGTCCGCGCCGCGGTCCAGGCCCAGGAGGCGGCGCGCTTTCGCGAGCGCGCCACCG
CCGGCACCGACGCGATCCGCGACCGGATGAACGCGTACGTGGCGATGCTGCGCGCCACGCGCGGCTTCGTCGAGGCGACC
GGCGGCGAGCCGGACCGGATCGGCTTCCGCGCCTACGTCCAGAGCACGGAGCTCACCCGCTACTACCGCGGCATCCAGGG
CCTCGGCTGGAGCCGGGCGCTCCTGCCCCGCGACCTGGAGGCGCACGTGGCCGCGGTGCGGGCGCAGTGGGACCCCGGCT
ACCGCGTCTGGCCGGAGGGCGAGCGCGCGCTCTACTCCAGCATCGTCTTCCTCGAGCCGCTGGACTGGCGCAACCGCCGG
GCGATCGGCTTCGACATGTTCTCCGAGCCGGTCCGGCGCGCGGCGATGGAGCGGGCGCGCGACAGCGGCGACGTGGCCGC
GTCCGGGCCGGTGGAGCTGGTGCAGGAGGCCGGCAGCGAGCGCCAGGCCGGGTTCCTCGTCTACCTGCCGGTGTACGCTC
GGGCGCCGCGCTCGCTGCAGGAGCGGCGCGAGCTGCTGCGCGGGTGGGTGTACGCGCCGTTCCGCGCCACCGACCTGCTG
CGCTCCACGCTCGACGACGCGCCGGCGCGCACCATCGGGCTGGCGGTGTACGACGGCGAGGCGGAGACGACCGATGCCCT
GCTGTACGACGACGGGACCGCCGCCCGGGGCGGCGCGCTCACGACCGCGCAGCGCCTGGAGGTGGCCGGCCGCACCTGGA
CCGTGCGCCACACCGCCACCGCCGCGTTCGTCTCGCTCACCGACCGCGCGCTCCCGGGCCTGGTGCTGGGGGTGGGCGCG
GCGCTCACGGTGCTGCTGTTCTGGATCACCCGGTCCGAGGTGATGGCGCGCGGCCGCGCCGAGCAGGACGCGCGCCGCAC
CGCGTTCCTCGCCGCCGCCAGCCAGCGGCTGGCCTCGGACCTCGACTACCGGCGCACGCTGCCGGAGGTGGCCCGGCTCG
CCGCCGAGCGGGTGGCGGACGCGTGCGTGGGCTGCGTGGTCGAGCCCACCGGGCCGCTGTGGTTCGCCGGCCACCGCGAG
CCGGCGCGGGCCGAGGGCTGGCTGGCCGCGGCCGCCGCCGCCGGGCTGGATCCGGAGGGGCGCACCGGGATCGCGGCCGC
CCTGTCCACCGGCCAGCCGCACGAGGTGGACCACGCGCCGGACCGCCTGCCCCACTTCGCGCGCTCGCCGGCGGTCGCGG
CGCGGCTGCGCGAGGAGCGGGTGGAGGCGCTGCTCAGCGTGCCGCTGGTGGTCCGGGGCGAGCCGGTCGGCGCCGTGACC
CTGCTCTCCGCGCACGGCCCGTTCGACGCCCACGACCGCGCGCTCGCCGAGGACCTGGCCCGGCTGCTCGCCGCCGCGGT
CGACACCGCGCGGCTCACCTGGCGCGCCCAGGACGCGGTGCGCGTCCGCGACGAGTTCCTCTCCATCGCCTCGCACGAGC
TGAAGACCCCGCTCACCTCGCTCGCGCTCCAGTCCGACAGCCTGCGCGCCAGCGCCGGGCGCGGCGACGCGGACGCGCTC
GTGCGCAAGTCCGAGGTGATCCGGCGCAGCGTGGACCGGCTCACCCGGCTGGTGGCGAGCCTGCTCGACCTCTCGCGCAT
CAACGCGGGCCGGCTGGAGCTGGAGCTCGAGCCGGTGGACCTCGCCGAGGTGGCGCGCGACGTGGTGGCGCGGTTCGAGG
AGGAGGCCTCGCGGGCGGCGTGCCCGCTCTCGCTGGAGGCGCCCGAGCCGGTGGTGGGGCGCTGGGACCGGGTGCGGCTC
GACCAGGTGCTCACCAACCTGCTCGGGAACGCGGTGAAGTACGGGCCGGGCCGCCCGGTCGAGGTGCGCGTGCGGACCGA
CGGAGACCGGGCGCTGCTCTCGGTCCGCGACCACGGCATCGGCATCTCCGCCGCCGACCAGCGGCGCATCTTCGAGCGGT
TCGAGCGCGCGGTGTCGCGCCGCCACTACGGCGGGTTCGGACTGGGGCTGTGGATCGTGCGGGAGATCGTCGAGGTGCTG
GGCGGGACCGTCCGCGTCGAGAGCACGCCCGGCGCCGGCTCGACCTTCACCGTGACGCTGTCGCGCGCGCCCGAGGCCGC
CGCGACGCACCGGGCCGGCGCCGCCACCACCAGCCCGCCCCCCACCGCCTGA

Upstream 100 bases:

>100_bases
GCCGACGCGCGCCCGGGGGCGCCCGCGCGATGCCTCCCTGCCCGGCCCGCACAACGGGCATACTTTGACGAGGCGGGGCC
GCGGGCCCGGCCAGACGCCC

Downstream 100 bases:

>100_bases
CCGCGCTACGCCGGCCCCGGCTGGCACCGCGGACACCACCAGGTGCCCTGGGCGTGCGGGCCCTGGCGCGCGAACGCGAT
GGGCGCGCCGCACCGGCGGC

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MPNRRRPPVVVLRTHAVPAAVAAISLAAALASWQYVRAAVQAQEAARFRERATAGTDAIRDRMNAYVAMLRATRGFVEAT
GGEPDRIGFRAYVQSTELTRYYRGIQGLGWSRALLPRDLEAHVAAVRAQWDPGYRVWPEGERALYSSIVFLEPLDWRNRR
AIGFDMFSEPVRRAAMERARDSGDVAASGPVELVQEAGSERQAGFLVYLPVYARAPRSLQERRELLRGWVYAPFRATDLL
RSTLDDAPARTIGLAVYDGEAETTDALLYDDGTAARGGALTTAQRLEVAGRTWTVRHTATAAFVSLTDRALPGLVLGVGA
ALTVLLFWITRSEVMARGRAEQDARRTAFLAAASQRLASDLDYRRTLPEVARLAAERVADACVGCVVEPTGPLWFAGHRE
PARAEGWLAAAAAAGLDPEGRTGIAAALSTGQPHEVDHAPDRLPHFARSPAVAARLREERVEALLSVPLVVRGEPVGAVT
LLSAHGPFDAHDRALAEDLARLLAAAVDTARLTWRAQDAVRVRDEFLSIASHELKTPLTSLALQSDSLRASAGRGDADAL
VRKSEVIRRSVDRLTRLVASLLDLSRINAGRLELELEPVDLAEVARDVVARFEEEASRAACPLSLEAPEPVVGRWDRVRL
DQVLTNLLGNAVKYGPGRPVEVRVRTDGDRALLSVRDHGIGISAADQRRIFERFERAVSRRHYGGFGLGLWIVREIVEVL
GGTVRVESTPGAGSTFTVTLSRAPEAAATHRAGAATTSPPPTA

Sequences:

>Translated_763_residues
MPNRRRPPVVVLRTHAVPAAVAAISLAAALASWQYVRAAVQAQEAARFRERATAGTDAIRDRMNAYVAMLRATRGFVEAT
GGEPDRIGFRAYVQSTELTRYYRGIQGLGWSRALLPRDLEAHVAAVRAQWDPGYRVWPEGERALYSSIVFLEPLDWRNRR
AIGFDMFSEPVRRAAMERARDSGDVAASGPVELVQEAGSERQAGFLVYLPVYARAPRSLQERRELLRGWVYAPFRATDLL
RSTLDDAPARTIGLAVYDGEAETTDALLYDDGTAARGGALTTAQRLEVAGRTWTVRHTATAAFVSLTDRALPGLVLGVGA
ALTVLLFWITRSEVMARGRAEQDARRTAFLAAASQRLASDLDYRRTLPEVARLAAERVADACVGCVVEPTGPLWFAGHRE
PARAEGWLAAAAAAGLDPEGRTGIAAALSTGQPHEVDHAPDRLPHFARSPAVAARLREERVEALLSVPLVVRGEPVGAVT
LLSAHGPFDAHDRALAEDLARLLAAAVDTARLTWRAQDAVRVRDEFLSIASHELKTPLTSLALQSDSLRASAGRGDADAL
VRKSEVIRRSVDRLTRLVASLLDLSRINAGRLELELEPVDLAEVARDVVARFEEEASRAACPLSLEAPEPVVGRWDRVRL
DQVLTNLLGNAVKYGPGRPVEVRVRTDGDRALLSVRDHGIGISAADQRRIFERFERAVSRRHYGGFGLGLWIVREIVEVL
GGTVRVESTPGAGSTFTVTLSRAPEAAATHRAGAATTSPPPTA
>Mature_762_residues
PNRRRPPVVVLRTHAVPAAVAAISLAAALASWQYVRAAVQAQEAARFRERATAGTDAIRDRMNAYVAMLRATRGFVEATG
GEPDRIGFRAYVQSTELTRYYRGIQGLGWSRALLPRDLEAHVAAVRAQWDPGYRVWPEGERALYSSIVFLEPLDWRNRRA
IGFDMFSEPVRRAAMERARDSGDVAASGPVELVQEAGSERQAGFLVYLPVYARAPRSLQERRELLRGWVYAPFRATDLLR
STLDDAPARTIGLAVYDGEAETTDALLYDDGTAARGGALTTAQRLEVAGRTWTVRHTATAAFVSLTDRALPGLVLGVGAA
LTVLLFWITRSEVMARGRAEQDARRTAFLAAASQRLASDLDYRRTLPEVARLAAERVADACVGCVVEPTGPLWFAGHREP
ARAEGWLAAAAAAGLDPEGRTGIAAALSTGQPHEVDHAPDRLPHFARSPAVAARLREERVEALLSVPLVVRGEPVGAVTL
LSAHGPFDAHDRALAEDLARLLAAAVDTARLTWRAQDAVRVRDEFLSIASHELKTPLTSLALQSDSLRASAGRGDADALV
RKSEVIRRSVDRLTRLVASLLDLSRINAGRLELELEPVDLAEVARDVVARFEEEASRAACPLSLEAPEPVVGRWDRVRLD
QVLTNLLGNAVKYGPGRPVEVRVRTDGDRALLSVRDHGIGISAADQRRIFERFERAVSRRHYGGFGLGLWIVREIVEVLG
GTVRVESTPGAGSTFTVTLSRAPEAAATHRAGAATTSPPPTA

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=258, Percent_Identity=34.8837209302326, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786912, Length=262, Percent_Identity=36.2595419847328, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI145693157, Length=286, Percent_Identity=29.7202797202797, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=29.535864978903, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=32.3770491803279, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=31.9148936170213, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=32.7354260089686, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=244, Percent_Identity=29.0983606557377, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=229, Percent_Identity=31.0043668122271, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1789808, Length=214, Percent_Identity=27.1028037383178, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=29.3388429752066, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=30.0847457627119, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=249, Percent_Identity=27.3092369477912, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1789403, Length=220, Percent_Identity=32.2727272727273, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788279, Length=200, Percent_Identity=24.5, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=249, Percent_Identity=29.718875502008, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 82836; Mature: 82705

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50839 CHASE ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNRRRPPVVVLRTHAVPAAVAAISLAAALASWQYVRAAVQAQEAARFRERATAGTDAIR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DRMNAYVAMLRATRGFVEATGGEPDRIGFRAYVQSTELTRYYRGIQGLGWSRALLPRDLE
HHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AHVAAVRAQWDPGYRVWPEGERALYSSIVFLEPLDWRNRRAIGFDMFSEPVRRAAMERAR
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCEECHHHHHHHHHHHHHHHCC
DSGDVAASGPVELVQEAGSERQAGFLVYLPVYARAPRSLQERRELLRGWVYAPFRATDLL
CCCCCCCCCHHHHHHHCCCCCCCCEEEEECCHHCCCHHHHHHHHHHHHHCCCCHHHHHHH
RSTLDDAPARTIGLAVYDGEAETTDALLYDDGTAARGGALTTAQRLEVAGRTWTVRHTAT
HHHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEHHHH
AAFVSLTDRALPGLVLGVGAALTVLLFWITRSEVMARGRAEQDARRTAFLAAASQRLASD
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LDYRRTLPEVARLAAERVADACVGCVVEPTGPLWFAGHREPARAEGWLAAAAAAGLDPEG
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCC
RTGIAAALSTGQPHEVDHAPDRLPHFARSPAVAARLREERVEALLSVPLVVRGEPVGAVT
CCCHHEEECCCCCCCCCCCCHHCCHHHCCHHHHHHHHHHHHHHHHHCCEEEECCCCCEEE
LLSAHGPFDAHDRALAEDLARLLAAAVDTARLTWRAQDAVRVRDEFLSIASHELKTPLTS
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHCCHHH
LALQSDSLRASAGRGDADALVRKSEVIRRSVDRLTRLVASLLDLSRINAGRLELELEPVD
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
LAEVARDVVARFEEEASRAACPLSLEAPEPVVGRWDRVRLDQVLTNLLGNAVKYGPGRPV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCE
EVRVRTDGDRALLSVRDHGIGISAADQRRIFERFERAVSRRHYGGFGLGLWIVREIVEVL
EEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GGTVRVESTPGAGSTFTVTLSRAPEAAATHRAGAATTSPPPTA
CCEEEEECCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PNRRRPPVVVLRTHAVPAAVAAISLAAALASWQYVRAAVQAQEAARFRERATAGTDAIR
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DRMNAYVAMLRATRGFVEATGGEPDRIGFRAYVQSTELTRYYRGIQGLGWSRALLPRDLE
HHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AHVAAVRAQWDPGYRVWPEGERALYSSIVFLEPLDWRNRRAIGFDMFSEPVRRAAMERAR
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCEECHHHHHHHHHHHHHHHCC
DSGDVAASGPVELVQEAGSERQAGFLVYLPVYARAPRSLQERRELLRGWVYAPFRATDLL
CCCCCCCCCHHHHHHHCCCCCCCCEEEEECCHHCCCHHHHHHHHHHHHHCCCCHHHHHHH
RSTLDDAPARTIGLAVYDGEAETTDALLYDDGTAARGGALTTAQRLEVAGRTWTVRHTAT
HHHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEHHHH
AAFVSLTDRALPGLVLGVGAALTVLLFWITRSEVMARGRAEQDARRTAFLAAASQRLASD
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LDYRRTLPEVARLAAERVADACVGCVVEPTGPLWFAGHREPARAEGWLAAAAAAGLDPEG
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCC
RTGIAAALSTGQPHEVDHAPDRLPHFARSPAVAARLREERVEALLSVPLVVRGEPVGAVT
CCCHHEEECCCCCCCCCCCCHHCCHHHCCHHHHHHHHHHHHHHHHHCCEEEECCCCCEEE
LLSAHGPFDAHDRALAEDLARLLAAAVDTARLTWRAQDAVRVRDEFLSIASHELKTPLTS
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHCCHHH
LALQSDSLRASAGRGDADALVRKSEVIRRSVDRLTRLVASLLDLSRINAGRLELELEPVD
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
LAEVARDVVARFEEEASRAACPLSLEAPEPVVGRWDRVRLDQVLTNLLGNAVKYGPGRPV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCE
EVRVRTDGDRALLSVRDHGIGISAADQRRIFERFERAVSRRHYGGFGLGLWIVREIVEVL
EEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GGTVRVESTPGAGSTFTVTLSRAPEAAATHRAGAATTSPPPTA
CCEEEEECCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]