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The map label for this gene is kbl [C]

Identifier: 220916967

GI number: 220916967

Start: 2086148

End: 2087347

Strand: Reverse

Name: kbl [C]

Synonym: A2cp1_1863

Alternate gene names: 220916967

Gene position: 2087347-2086148 (Counterclockwise)

Preceding gene: 220916971

Following gene: 220916966

Centisome position: 41.5

GC content: 72.33

Gene sequence:

>1200_bases
ATGAACCCAGCCTTCACCGACCACCTGCGCACCCAGCTCGACCGCCTCCAGGCGGAGGGGCTGTTCAAGCGCGAGCGCGT
CATCACCAGCCGCCAGGGCCCCTGGGTCGAGGCCGACGGCCGCCGGGTGGTGAACCTGTGCGCGAACAACTACCTCGGCC
TGGCCGGACGGCAGGAGCTAGTGGACGCCGCGGTGGCGGCGCTGCCTCGCTGGGGCTTCGGGATGTCCTCGGTGCGGTTC
ATCTGCGGCACCCAGGACGTCCACAAGGAGCTGGAGCAGCGGCTGGCGCGCTTCCTGGGCTTCGAGGACGCCATCCTGTT
CTCGTCCTGCTTCGACGCGAACGGCGGCGTGTTCGAGGCGCTGCTCGGCGAGGAGGACGCGGTCGTCTCCGACGCGCTCA
ACCACGCCTCCATCATCGACGGCATCCGGCTCTGCAAGGCCCGGCGCCACCGCTACGCGAACGGCGACATGGCCGACCTC
GCCGCGCAGCTCGCCGCCGCCGACGCGGCCGGCGCGCGCTTCAAGCTGGTGGTCACCGACGGCGTCTTCTCCATGGACGG
GTACCTCGCCAACCTGCCCGCCATCTGCGACCTGGCCGGGCGGCACGGCGCGATGGTGATGGTGGACGACAGCCACGCGG
TGGGCTTCATCGGCGAGCACGGCCGCGGCACCCACGAGCACCACCGGGTGATGGGCCGGGTCGACCTCGTCACCGGGACG
CTCGGGAAGGCGCTGGGCGGCGCGTCGGGCGGCTACGTGGCCGGCTCGCGCGAGGTGGTGGAGTGGCTCCGCCAGAAGGC
GCGCCCCTACCTGTTCTCGAACACGCTCGCGCCGGTGATCGCCGCCACCAGCATCGCGGTGCTCGACCTGCTGGAGTCCG
GCGACGCCCTGCGGCGGCAGCTCCGCGAGAACGCCCGCCACTTCCGCGCCGAGCTGACCCGGCTCGGCTTCGAGCTGCTG
CCGGGCGAGCACCCCATCATCCCGGTGATGCTCCACGAGGCGCCGCTGGCGCAGGAGATGGCCCGCCGGCTGCTCGACGA
GGGCGTCTACGTCACCGGCTTCTTCTTCCCGGTGGTGCCGAAGGGGCAGGCCCGCATCCGCACGCAGATGAGCGCGGCGC
ACTCGCGCGAGGACCTCGACCACGCCGTGGCGGCGTTCGAGAAGGTCGGCCGCGCGCTGGGCGTCATCCAGGGACGTTGA

Upstream 100 bases:

>100_bases
CACGGCCTGCGACGCGGCGCGGCGTCCCCCTCCGGACGGGCGGCGCACCCGCGCACGGCGGGTTAGAAAGGGGGCGCCCC
GCACCCGAGGACGCGCCCCC

Downstream 100 bases:

>100_bases
CCGAGAGGAAACATCACGCGATGAAGGCACTCGTCAAGGCGAAGCGCGAGGAAGGCATCTGGATGCAGCACGACGTGCCG
GTCCCCGAGGTCGGGGTCCA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNPAFTDHLRTQLDRLQAEGLFKRERVITSRQGPWVEADGRRVVNLCANNYLGLAGRQELVDAAVAALPRWGFGMSSVRF
ICGTQDVHKELEQRLARFLGFEDAILFSSCFDANGGVFEALLGEEDAVVSDALNHASIIDGIRLCKARRHRYANGDMADL
AAQLAAADAAGARFKLVVTDGVFSMDGYLANLPAICDLAGRHGAMVMVDDSHAVGFIGEHGRGTHEHHRVMGRVDLVTGT
LGKALGGASGGYVAGSREVVEWLRQKARPYLFSNTLAPVIAATSIAVLDLLESGDALRRQLRENARHFRAELTRLGFELL
PGEHPIIPVMLHEAPLAQEMARRLLDEGVYVTGFFFPVVPKGQARIRTQMSAAHSREDLDHAVAAFEKVGRALGVIQGR

Sequences:

>Translated_399_residues
MNPAFTDHLRTQLDRLQAEGLFKRERVITSRQGPWVEADGRRVVNLCANNYLGLAGRQELVDAAVAALPRWGFGMSSVRF
ICGTQDVHKELEQRLARFLGFEDAILFSSCFDANGGVFEALLGEEDAVVSDALNHASIIDGIRLCKARRHRYANGDMADL
AAQLAAADAAGARFKLVVTDGVFSMDGYLANLPAICDLAGRHGAMVMVDDSHAVGFIGEHGRGTHEHHRVMGRVDLVTGT
LGKALGGASGGYVAGSREVVEWLRQKARPYLFSNTLAPVIAATSIAVLDLLESGDALRRQLRENARHFRAELTRLGFELL
PGEHPIIPVMLHEAPLAQEMARRLLDEGVYVTGFFFPVVPKGQARIRTQMSAAHSREDLDHAVAAFEKVGRALGVIQGR
>Mature_399_residues
MNPAFTDHLRTQLDRLQAEGLFKRERVITSRQGPWVEADGRRVVNLCANNYLGLAGRQELVDAAVAALPRWGFGMSSVRF
ICGTQDVHKELEQRLARFLGFEDAILFSSCFDANGGVFEALLGEEDAVVSDALNHASIIDGIRLCKARRHRYANGDMADL
AAQLAAADAAGARFKLVVTDGVFSMDGYLANLPAICDLAGRHGAMVMVDDSHAVGFIGEHGRGTHEHHRVMGRVDLVTGT
LGKALGGASGGYVAGSREVVEWLRQKARPYLFSNTLAPVIAATSIAVLDLLESGDALRRQLRENARHFRAELTRLGFELL
PGEHPIIPVMLHEAPLAQEMARRLLDEGVYVTGFFFPVVPKGQARIRTQMSAAHSREDLDHAVAAFEKVGRALGVIQGR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=53.3333333333333, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=50, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI83977440, Length=356, Percent_Identity=35.1123595505618, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI83977442, Length=356, Percent_Identity=35.1123595505618, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI83977444, Length=356, Percent_Identity=35.1123595505618, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4758668, Length=373, Percent_Identity=31.9034852546917, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI119220554, Length=375, Percent_Identity=33.0666666666667, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=32.3699421965318, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=32.3699421965318, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI5454084, Length=379, Percent_Identity=26.9129287598945, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=64.735516372796, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=36, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=52.7777777777778, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI32566772, Length=372, Percent_Identity=31.4516129032258, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=380, Percent_Identity=30, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=380, Percent_Identity=30, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71982617, Length=279, Percent_Identity=28.673835125448, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=279, Percent_Identity=28.673835125448, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=383, Percent_Identity=33.6814621409922, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=31.0810810810811, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6323954, Length=276, Percent_Identity=27.8985507246377, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24662918, Length=391, Percent_Identity=53.7084398976982, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137420, Length=383, Percent_Identity=31.331592689295, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136286, Length=375, Percent_Identity=32, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653280, Length=395, Percent_Identity=26.3291139240506, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653276, Length=395, Percent_Identity=26.3291139240506, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653278, Length=395, Percent_Identity=26.3291139240506, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43466; Mature: 43466

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPAFTDHLRTQLDRLQAEGLFKRERVITSRQGPWVEADGRRVVNLCANNYLGLAGRQEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHH
VDAAVAALPRWGFGMSSVRFICGTQDVHKELEQRLARFLGFEDAILFSSCFDANGGVFEA
HHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHH
LLGEEDAVVSDALNHASIIDGIRLCKARRHRYANGDMADLAAQLAAADAAGARFKLVVTD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
GVFSMDGYLANLPAICDLAGRHGAMVMVDDSHAVGFIGEHGRGTHEHHRVMGRVDLVTGT
CEEECCCHHHCCCHHHHHCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LGKALGGASGGYVAGSREVVEWLRQKARPYLFSNTLAPVIAATSIAVLDLLESGDALRRQ
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LRENARHFRAELTRLGFELLPGEHPIIPVMLHEAPLAQEMARRLLDEGVYVTGFFFPVVP
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCC
KGQARIRTQMSAAHSREDLDHAVAAFEKVGRALGVIQGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNPAFTDHLRTQLDRLQAEGLFKRERVITSRQGPWVEADGRRVVNLCANNYLGLAGRQEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHH
VDAAVAALPRWGFGMSSVRFICGTQDVHKELEQRLARFLGFEDAILFSSCFDANGGVFEA
HHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHH
LLGEEDAVVSDALNHASIIDGIRLCKARRHRYANGDMADLAAQLAAADAAGARFKLVVTD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
GVFSMDGYLANLPAICDLAGRHGAMVMVDDSHAVGFIGEHGRGTHEHHRVMGRVDLVTGT
CEEECCCHHHCCCHHHHHCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LGKALGGASGGYVAGSREVVEWLRQKARPYLFSNTLAPVIAATSIAVLDLLESGDALRRQ
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LRENARHFRAELTRLGFELLPGEHPIIPVMLHEAPLAQEMARRLLDEGVYVTGFFFPVVP
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCC
KGQARIRTQMSAAHSREDLDHAVAAFEKVGRALGVIQGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]