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The map label for this gene is purE [H]

Identifier: 220916595

GI number: 220916595

Start: 1664637

End: 1665149

Strand: Direct

Name: purE [H]

Synonym: A2cp1_1489

Alternate gene names: 220916595

Gene position: 1664637-1665149 (Clockwise)

Preceding gene: 220916594

Following gene: 220916596

Centisome position: 33.1

GC content: 75.24

Gene sequence:

>513_bases
ATGAGCGAACCCAAGGTGCTGATCCTGATGGGCTCCGACTCGGACTGGGAGGCGATGTCGGAGGCGAGGAAGGCGCTGGA
GGACCTGGGCGTCGCGACCGAGGTCCACGTCTCCTCCGCCCACCGCACGCCGGAGCGCACCGGCAAGCTGGCGCGCGAGG
CGGCCGGGCGCGGCATCCAGGTGATCATCTGCGGGGCCGGCTCGGCCGCGCACCTCGCCGGCGTCTGCGCCGCCGAGACC
GAGCTGCCGGTGCTGGGGGTCCCGCTCGCGGCGAGCGACCTGAAGGGCCTCGACGCGCTGCTCTCCACCGCCCAGATGCC
GGCGGGCGTGCCGGTGGGCACGCTCGCCATCGGCAAGGCCGGCGCCCGCAACGCCGGCCTGCTGGCCGCGCGCATCGTGG
CCCGCGTCGATCCCGAGGTGGCGGACCGCGTGCGCGCGCAGCGCCGCAAGATGGCCGAGGAGGTCGAGGCGAAGGACGCC
GCGCTCCAGGCCAGGCTGGGCTCGAAGGGATAG

Upstream 100 bases:

>100_bases
TGGGCCGCGATCTCGACGACGCCGCGGCGCGGGCCTACGCCGCCGCCGGCCGGATCCGCTTCCGCGGCATGCAGTACCGA
AAGGACATCGGCAAGAAGCC

Downstream 100 bases:

>100_bases
CCGGGCGCGTGGGCCTGATCGATCGCTACCTGGCACGGGAGATCCTGCTCCCGTTCGCCGCGGCCCTGCTGTTCCTGACC
CAGATCCTGCTCGCCACGCA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSEPKVLILMGSDSDWEAMSEARKALEDLGVATEVHVSSAHRTPERTGKLAREAAGRGIQVIICGAGSAAHLAGVCAAET
ELPVLGVPLAASDLKGLDALLSTAQMPAGVPVGTLAIGKAGARNAGLLAARIVARVDPEVADRVRAQRRKMAEEVEAKDA
ALQARLGSKG

Sequences:

>Translated_170_residues
MSEPKVLILMGSDSDWEAMSEARKALEDLGVATEVHVSSAHRTPERTGKLAREAAGRGIQVIICGAGSAAHLAGVCAAET
ELPVLGVPLAASDLKGLDALLSTAQMPAGVPVGTLAIGKAGARNAGLLAARIVARVDPEVADRVRAQRRKMAEEVEAKDA
ALQARLGSKG
>Mature_169_residues
SEPKVLILMGSDSDWEAMSEARKALEDLGVATEVHVSSAHRTPERTGKLAREAAGRGIQVIICGAGSAAHLAGVCAAETE
LPVLGVPLAASDLKGLDALLSTAQMPAGVPVGTLAIGKAGARNAGLLAARIVARVDPEVADRVRAQRRKMAEEVEAKDAA
LQARLGSKG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=151, Percent_Identity=52.9801324503311, Blast_Score=119, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=164, Percent_Identity=48.1707317073171, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17435; Mature: 17304

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPKVLILMGSDSDWEAMSEARKALEDLGVATEVHVSSAHRTPERTGKLAREAAGRGIQ
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHEEEHHHCCCCHHHHHHHHHHHCCCCEE
VIICGAGSAAHLAGVCAAETELPVLGVPLAASDLKGLDALLSTAQMPAGVPVGTLAIGKA
EEEECCCCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
GARNAGLLAARIVARVDPEVADRVRAQRRKMAEEVEAKDAALQARLGSKG
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEPKVLILMGSDSDWEAMSEARKALEDLGVATEVHVSSAHRTPERTGKLAREAAGRGIQ
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHEEEHHHCCCCHHHHHHHHHHHCCCCEE
VIICGAGSAAHLAGVCAAETELPVLGVPLAASDLKGLDALLSTAQMPAGVPVGTLAIGKA
EEEECCCCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
GARNAGLLAARIVARVDPEVADRVRAQRRKMAEEVEAKDAALQARLGSKG
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]