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The map label for this gene is purD [H]

Identifier: 220916594

GI number: 220916594

Start: 1663378

End: 1664640

Strand: Direct

Name: purD [H]

Synonym: A2cp1_1488

Alternate gene names: 220916594

Gene position: 1663378-1664640 (Clockwise)

Preceding gene: 220916593

Following gene: 220916595

Centisome position: 33.07

GC content: 77.04

Gene sequence:

>1263_bases
ATGCGAGTCCTCGTCGTCGGATCGGGTGGCCGCGAGCACGCGCTCGCCTGGAAGATCTCGAGGAGCCCGCTGGTGCGGGC
CCTCTTCGCCGCGCCCGGAAACCCGGGCATCGCGCGCGTCGCCACGCTCGTCCCGCTCGCCGCGACCGACGTGGCCGGCC
TCGTGGCGTGGGTGCGGCAGAACGCCATCGACCTGGTGGTCGTGGGGCCCGAGGCGCCGCTCGTGGCGGGCCTGGTGGAC
CGCCTCCAGGAGGCCGGGGTCCCGGCGTTCGGGCCGGCCGCCGCCGCGGCCGAGATCGAGGGCTCGAAGGCGTTCGCGAA
GGACGTGATGCGGGCGGCCGGGATCCCGACGGCGGAGTACGAGACGTTCGAGGACGTCGCGCCCGCGGTCGCGTGGGCCA
GGGCCCGCGACGGCCGGGTGGTGGTGAAGGCCGACGGCCTCGCGGCCGGCAAGGGCGTGGTGGTGTGCGGCGACGCCGCC
GAGGCGGAGGCCGCGCTCCGCGCCATGCTGGTGGACCGGGTGCACGGCGGCGCCGGCGCCCGGGTGGTGGTGGAGGAGCG
GCTGGAGGGACCGGAGGCGAGCTGCATCTGCTTCACCGACGGCGAGCGGGTCCGGCTGCTCGCGGCCGCGCAGGACCACA
AGCGCATCTTCGACGGCGACCGCGGGCCCAACACCGGCGGCATGGGCGCGTTCTCGCCCACGCCGAACGTCACCCCGGCG
GTGGCCGGGATGGTCGAGCGCGACGTGCTGCTCCCGGCGGTGCGGGAGCTGGCCCGGCGCGGCCGCCCGTTCCGCGGCGC
GCTCTACGCCGGCCTGATGCTCACCCCGCGGGGCCCGCGGGTGCTCGAGTTCAACGCGCGCCTTGGCGACCCCGAGACCC
AGCCCATCCTGCTCCGCATGGCGAGCGACGTGGTGCCGGCGCTGCTCGCGTCGGCGCGCGGCGACCTCTCCGCCGCCGAG
ATCGCGTTCGACCCCCGCGCCGCCGTGGGCGTGGTGCTCGCGGCCGAGGGCTACCCGGGCGACGTGGCGCGCGGGGACGC
CATCGACGGGCTGGACGGCCCGTTCGACGAGGGCGTGCAGGTGTTCCACGCCGGCACCGCCGCGGACGCGGCCGGCCGGG
TGGTGACGAGCGGCGGGCGCGTGCTGACGGTGTGCGCGCTGGGCCGCGATCTCGACGACGCCGCGGCGCGGGCCTACGCC
GCCGCCGGCCGGATCCGCTTCCGCGGCATGCAGTACCGAAAGGACATCGGCAAGAAGCCATGA

Upstream 100 bases:

>100_bases
AGGCCCGCGGCGCCTGCGCCCCCGCCGCGCGGGGCCCCCTCCCTGCACGCCTCCCGCGGCCCTTCCGGCGCGGCGGCCCG
TGGTATAAGCCCGGGTTCTC

Downstream 100 bases:

>100_bases
GCGAACCCAAGGTGCTGATCCTGATGGGCTCCGACTCGGACTGGGAGGCGATGTCGGAGGCGAGGAAGGCGCTGGAGGAC
CTGGGCGTCGCGACCGAGGT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRVLVVGSGGREHALAWKISRSPLVRALFAAPGNPGIARVATLVPLAATDVAGLVAWVRQNAIDLVVVGPEAPLVAGLVD
RLQEAGVPAFGPAAAAAEIEGSKAFAKDVMRAAGIPTAEYETFEDVAPAVAWARARDGRVVVKADGLAAGKGVVVCGDAA
EAEAALRAMLVDRVHGGAGARVVVEERLEGPEASCICFTDGERVRLLAAAQDHKRIFDGDRGPNTGGMGAFSPTPNVTPA
VAGMVERDVLLPAVRELARRGRPFRGALYAGLMLTPRGPRVLEFNARLGDPETQPILLRMASDVVPALLASARGDLSAAE
IAFDPRAAVGVVLAAEGYPGDVARGDAIDGLDGPFDEGVQVFHAGTAADAAGRVVTSGGRVLTVCALGRDLDDAAARAYA
AAGRIRFRGMQYRKDIGKKP

Sequences:

>Translated_420_residues
MRVLVVGSGGREHALAWKISRSPLVRALFAAPGNPGIARVATLVPLAATDVAGLVAWVRQNAIDLVVVGPEAPLVAGLVD
RLQEAGVPAFGPAAAAAEIEGSKAFAKDVMRAAGIPTAEYETFEDVAPAVAWARARDGRVVVKADGLAAGKGVVVCGDAA
EAEAALRAMLVDRVHGGAGARVVVEERLEGPEASCICFTDGERVRLLAAAQDHKRIFDGDRGPNTGGMGAFSPTPNVTPA
VAGMVERDVLLPAVRELARRGRPFRGALYAGLMLTPRGPRVLEFNARLGDPETQPILLRMASDVVPALLASARGDLSAAE
IAFDPRAAVGVVLAAEGYPGDVARGDAIDGLDGPFDEGVQVFHAGTAADAAGRVVTSGGRVLTVCALGRDLDDAAARAYA
AAGRIRFRGMQYRKDIGKKP
>Mature_420_residues
MRVLVVGSGGREHALAWKISRSPLVRALFAAPGNPGIARVATLVPLAATDVAGLVAWVRQNAIDLVVVGPEAPLVAGLVD
RLQEAGVPAFGPAAAAAEIEGSKAFAKDVMRAAGIPTAEYETFEDVAPAVAWARARDGRVVVKADGLAAGKGVVVCGDAA
EAEAALRAMLVDRVHGGAGARVVVEERLEGPEASCICFTDGERVRLLAAAQDHKRIFDGDRGPNTGGMGAFSPTPNVTPA
VAGMVERDVLLPAVRELARRGRPFRGALYAGLMLTPRGPRVLEFNARLGDPETQPILLRMASDVVPALLASARGDLSAAE
IAFDPRAAVGVVLAAEGYPGDVARGDAIDGLDGPFDEGVQVFHAGTAADAAGRVVTSGGRVLTVCALGRDLDDAAARAYA
AAGRIRFRGMQYRKDIGKKP

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=420, Percent_Identity=45, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI209869995, Length=420, Percent_Identity=45, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI209869993, Length=420, Percent_Identity=45, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI28416899, Length=420, Percent_Identity=45, Blast_Score=352, Evalue=5e-97,
Organism=Escherichia coli, GI1790438, Length=422, Percent_Identity=51.6587677725119, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567511, Length=426, Percent_Identity=39.906103286385, Blast_Score=288, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6321203, Length=435, Percent_Identity=40.9195402298851, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI62471619, Length=427, Percent_Identity=48.9461358313817, Blast_Score=338, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24582400, Length=427, Percent_Identity=48.9461358313817, Blast_Score=338, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 43389; Mature: 43389

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVGSGGREHALAWKISRSPLVRALFAAPGNPGIARVATLVPLAATDVAGLVAWVRQ
CEEEEEECCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NAIDLVVVGPEAPLVAGLVDRLQEAGVPAFGPAAAAAEIEGSKAFAKDVMRAAGIPTAEY
CCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCHH
ETFEDVAPAVAWARARDGRVVVKADGLAAGKGVVVCGDAAEAEAALRAMLVDRVHGGAGA
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCC
RVVVEERLEGPEASCICFTDGERVRLLAAAQDHKRIFDGDRGPNTGGMGAFSPTPNVTPA
EEEEEHHCCCCCCCEEEEECCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
VAGMVERDVLLPAVRELARRGRPFRGALYAGLMLTPRGPRVLEFNARLGDPETQPILLRM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEEECCCCCEEEEECCCCCCCCCCHHHHHH
ASDVVPALLASARGDLSAAEIAFDPRAAVGVVLAAEGYPGDVARGDAIDGLDGPFDEGVQ
HHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHCEE
VFHAGTAADAAGRVVTSGGRVLTVCALGRDLDDAAARAYAAAGRIRFRGMQYRKDIGKKP
EEECCCCCCCCCCEEECCCCEEEEEECCCCCHHHHHHHHHHHCCEEECCCHHHHHCCCCC
>Mature Secondary Structure
MRVLVVGSGGREHALAWKISRSPLVRALFAAPGNPGIARVATLVPLAATDVAGLVAWVRQ
CEEEEEECCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NAIDLVVVGPEAPLVAGLVDRLQEAGVPAFGPAAAAAEIEGSKAFAKDVMRAAGIPTAEY
CCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCHH
ETFEDVAPAVAWARARDGRVVVKADGLAAGKGVVVCGDAAEAEAALRAMLVDRVHGGAGA
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCC
RVVVEERLEGPEASCICFTDGERVRLLAAAQDHKRIFDGDRGPNTGGMGAFSPTPNVTPA
EEEEEHHCCCCCCCEEEEECCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
VAGMVERDVLLPAVRELARRGRPFRGALYAGLMLTPRGPRVLEFNARLGDPETQPILLRM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEEECCCCCEEEEECCCCCCCCCCHHHHHH
ASDVVPALLASARGDLSAAEIAFDPRAAVGVVLAAEGYPGDVARGDAIDGLDGPFDEGVQ
HHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHCEE
VFHAGTAADAAGRVVTSGGRVLTVCALGRDLDDAAARAYAAAGRIRFRGMQYRKDIGKKP
EEECCCCCCCCCCEEECCCCEEEEEECCCCCHHHHHHHHHHHCCEEECCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]