Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 220916566

GI number: 220916566

Start: 1633923

End: 1634867

Strand: Direct

Name: hemC [H]

Synonym: A2cp1_1460

Alternate gene names: 220916566

Gene position: 1633923-1634867 (Clockwise)

Preceding gene: 220916565

Following gene: 220916567

Centisome position: 32.49

GC content: 76.08

Gene sequence:

>945_bases
ATGATCCGCATCGCGACGCGCCGCAGCCCCCTCGCCAAGTGGCAGGCGAACCACGTGTCCCAGCTCCTCCGCGACCGCGA
GCCGGGGCTCGAGGTCCGGCTCCACGAGCTGGTCACCCGGGGTGACAAGATCCTCGAGGTCCCCCTCGCCGACGTCGGCG
GGAAGGGGCTGTTCGTGAAGGAGATCGAGGACGCGCTCCTCAACCGCGACGCCGAGGTGGCGGTCCACTCGATGAAGGAC
CTGCCCGCCGTGCTCGCGCCCGGCCTGGTGCTCGCGGCCGTGCCGCAGCGCGAGGACCCGCGCGACGCGCTCTGCTCGCC
GCGCTGGAAGACGCTCGCCGCGCTGCCGAAGGGGGCGCGGGTGGGCACCTCCAGCCTCCGCCGCTCCGCGCAGCTCAAGG
CGCTCCGCCCCGATCTCCAGATGGAGATGGTGCGCGGCAACGTGGAGACGCGCCTCCGCAAGGCGTCGGAGGGGCTGGAC
GCGGTGGTGCTCGCCTACGCCGGCCTGCGCCGCCTGGGCCTGGCCGAGCACGCCACCTACGTGTTCCCGCCCGAGGAGAT
GCTGCCGGCGGTGGCGCAGGGCGCGCTGGCGCTGGAGGCGCGCGCCGACGACGCGCCGACGCTGGCGCGGCTCGCCGCGC
TCGAGGACCCGGACACGCGCGTCCGCATCGAGGCGGAGCGCGGCTTCCTCGCGCGCATCGAGGGCGGCTGCCAGGTGCCC
ATCGCCGGCCACGCCACGCTCGCCGGCGGCAAGGTCACCATCCGCGCGCTGGTCGCCTCGCTCGACGGCGCCCGGGTCAT
CCGCGGCGAGCGGACCGGCGCCTACGCCGAGGCGCGCGCGATGGGCGAGTCGCTGGCCGACGAGCTGCTCTCGCGCGGCG
CCGACCAGATCCTGCGCGAGACCGAGGGCAAGGCGCCCGGGCTCGCCGCGCCGAAGCGCGGGTAG

Upstream 100 bases:

>100_bases
AGCCGGCCGGCGGGGAACGGCGGGAGGGCGGGGCCGAGGGCGCCGCCGCCGCGCCGGGCGCCGGGCCGGTCCGCAGCCAG
GGAACATGAACGGAGACAGG

Downstream 100 bases:

>100_bases
GGGGACGCGGTGCCTGCCGCGCCCGCGCGGCCGCTGGCCGGCCGCACCGTGGTGGTGACCCGGGGCAAGGGCTCCGAGGG
CAAGGACGCGCTCGCGGCCC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIRIATRRSPLAKWQANHVSQLLRDREPGLEVRLHELVTRGDKILEVPLADVGGKGLFVKEIEDALLNRDAEVAVHSMKD
LPAVLAPGLVLAAVPQREDPRDALCSPRWKTLAALPKGARVGTSSLRRSAQLKALRPDLQMEMVRGNVETRLRKASEGLD
AVVLAYAGLRRLGLAEHATYVFPPEEMLPAVAQGALALEARADDAPTLARLAALEDPDTRVRIEAERGFLARIEGGCQVP
IAGHATLAGGKVTIRALVASLDGARVIRGERTGAYAEARAMGESLADELLSRGADQILRETEGKAPGLAAPKRG

Sequences:

>Translated_314_residues
MIRIATRRSPLAKWQANHVSQLLRDREPGLEVRLHELVTRGDKILEVPLADVGGKGLFVKEIEDALLNRDAEVAVHSMKD
LPAVLAPGLVLAAVPQREDPRDALCSPRWKTLAALPKGARVGTSSLRRSAQLKALRPDLQMEMVRGNVETRLRKASEGLD
AVVLAYAGLRRLGLAEHATYVFPPEEMLPAVAQGALALEARADDAPTLARLAALEDPDTRVRIEAERGFLARIEGGCQVP
IAGHATLAGGKVTIRALVASLDGARVIRGERTGAYAEARAMGESLADELLSRGADQILRETEGKAPGLAAPKRG
>Mature_314_residues
MIRIATRRSPLAKWQANHVSQLLRDREPGLEVRLHELVTRGDKILEVPLADVGGKGLFVKEIEDALLNRDAEVAVHSMKD
LPAVLAPGLVLAAVPQREDPRDALCSPRWKTLAALPKGARVGTSSLRRSAQLKALRPDLQMEMVRGNVETRLRKASEGLD
AVVLAYAGLRRLGLAEHATYVFPPEEMLPAVAQGALALEARADDAPTLARLAALEDPDTRVRIEAERGFLARIEGGCQVP
IAGHATLAGGKVTIRALVASLDGARVIRGERTGAYAEARAMGESLADELLSRGADQILRETEGKAPGLAAPKRG

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=40.6626506024096, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=40.6626506024096, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI48994974, Length=308, Percent_Identity=54.5454545454545, Blast_Score=300, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6319996, Length=315, Percent_Identity=36.8253968253968, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20130425, Length=298, Percent_Identity=40.6040268456376, Blast_Score=201, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33692; Mature: 33692

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIATRRSPLAKWQANHVSQLLRDREPGLEVRLHELVTRGDKILEVPLADVGGKGLFVK
CEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEHH
EIEDALLNRDAEVAVHSMKDLPAVLAPGLVLAAVPQREDPRDALCSPRWKTLAALPKGAR
HHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHCCCCHHHHHHCCCCCC
VGTSSLRRSAQLKALRPDLQMEMVRGNVETRLRKASEGLDAVVLAYAGLRRLGLAEHATY
CCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCHHHCCEE
VFPPEEMLPAVAQGALALEARADDAPTLARLAALEDPDTRVRIEAERGFLARIEGGCQVP
ECCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCC
IAGHATLAGGKVTIRALVASLDGARVIRGERTGAYAEARAMGESLADELLSRGADQILRE
CCCCEEECCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
TEGKAPGLAAPKRG
HCCCCCCCCCCCCC
>Mature Secondary Structure
MIRIATRRSPLAKWQANHVSQLLRDREPGLEVRLHELVTRGDKILEVPLADVGGKGLFVK
CEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEHH
EIEDALLNRDAEVAVHSMKDLPAVLAPGLVLAAVPQREDPRDALCSPRWKTLAALPKGAR
HHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHCCCCHHHHHHCCCCCC
VGTSSLRRSAQLKALRPDLQMEMVRGNVETRLRKASEGLDAVVLAYAGLRRLGLAEHATY
CCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCHHHCCEE
VFPPEEMLPAVAQGALALEARADDAPTLARLAALEDPDTRVRIEAERGFLARIEGGCQVP
ECCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCC
IAGHATLAGGKVTIRALVASLDGARVIRGERTGAYAEARAMGESLADELLSRGADQILRE
CCCCEEECCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
TEGKAPGLAAPKRG
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA