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The map label for this gene is hemA [H]

Identifier: 220916565

GI number: 220916565

Start: 1632571

End: 1633911

Strand: Direct

Name: hemA [H]

Synonym: A2cp1_1459

Alternate gene names: 220916565

Gene position: 1632571-1633911 (Clockwise)

Preceding gene: 220916564

Following gene: 220916566

Centisome position: 32.46

GC content: 74.27

Gene sequence:

>1341_bases
GTGACCGGCGATCGCCGCCTCTTCCTGGTCGGGCTCTCGCACAAGAGCGCGCCCATCGACGTCCGCGAGCGCGTGGCGCT
GACCGGCGACGCGCTCAAGGCGGCGCTGTGCGAGCTGAAGGCGATGGAGGGCGTCACCGAGGCGCTGGTGGTCTCCACCT
GCAACCGGGTGGAGGTGTTCGTCCACTCGGACCGGCCCGACGCCGCCCGCCGCTTCTTCACCGAGCGCTCGCCCGCGGCA
GCCGACCACCTCTACGCGAAGGACGGGGTGGAGGCGGTCCGGCACCTGTTCCGCGTCGCCGCCAGCCTCGACTCGATGGT
GGTCGGCGAGCAGCAGATCCTCGGCCAGGTGAAGGAGGCGTACGGGCTCGCCAGCGCCGCGTCGGCGGCGGGCTCCTACT
TCTCGCGTCTGTGCAACCGCGCGTTCGCGACCGCGAAGCGCGTGCGCACCGAGACCGAGATCGGCCGCGGCGCCACCAGC
ATGTCGCAGGTGGCGGTCGAGCTGGTCGAGAAGATCTTCGGGCGGCTGGAGGGCCGGGCCATCCTGCTGGTGGGCGCCGG
GAAGATGGGCGCGCTCTCGGCCAGGGCGCTGGCGGTGCTCGGCGCGGATCGCATCCTCGTCACCAACCGCTCCCCCGAGC
GCGGCCTCGCGCTCGCGGCGCAGGTGAACGGCAGCTACCGCGGCTGGGAGGAGCTGCAGCGGCTCCTCGGCGAGGCCGAC
GTGGTGATCGTCTCGACCGGCGCGCCCACCTACGTGGTGACGCGCGAGTCGATGCAGGCCGCCATGAAGGCGCGGCGCCG
CCGCTCGATCTGCCTCATCGACCTGGCCGTGCCGCGCAACGTGGATCCCGCCTGCGCCGAGCTCTCCGACGTCTACGCCT
ACGACGTGGACGACATGGAGCGCGTCGTCGCGACCAGCAAGCAGGCGCGGCAGGGGGAGGCGATCCGCGCGGAGGCGATC
GTGGAGGCCGAGGTGATGGCCTTCGCGAAGGAGCGCGAGGCGCGCGCCGCGCTGCCGGTGCTGGCGCAGCTCCGCCGGCA
CGCCGAGCGGATCGCCCGGGCCGAGGCGGAGCGCACGCTCGCGCAGGTCGGCGGGAAGCTGGACGACAAGGGCCGCAAGA
GCGTCGAGGCCATGGCCCAGGCCATCGTGAACAAGCTCCTCCACGGGCCGACCTCGCGCCTCAAGGAGGCGGCCTCCTCC
GGCGACAGCGCGCTCCCGGGCGCCGCCGCGGAGCTGTTCGGGATCGAGAACGAGCCGGCCGGCGGGGAACGGCGGGAGGG
CGGGGCCGAGGGCGCCGCCGCCGCGCCGGGCGCCGGGCCGGTCCGCAGCCAGGGAACATGA

Upstream 100 bases:

>100_bases
TCGTGCTGGTGCTGGGCTCGATGGTGACCCTGAGGACCGTGCCGGGCGTCACGCGCCACGCCGGGGACTACGCGGGGTCG
GCCCACACCGGAGGGGCGCA

Downstream 100 bases:

>100_bases
ACGGAGACAGGATGATCCGCATCGCGACGCGCCGCAGCCCCCTCGCCAAGTGGCAGGCGAACCACGTGTCCCAGCTCCTC
CGCGACCGCGAGCCGGGGCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR 2 [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTGDRRLFLVGLSHKSAPIDVRERVALTGDALKAALCELKAMEGVTEALVVSTCNRVEVFVHSDRPDAARRFFTERSPAA
ADHLYAKDGVEAVRHLFRVAASLDSMVVGEQQILGQVKEAYGLASAASAAGSYFSRLCNRAFATAKRVRTETEIGRGATS
MSQVAVELVEKIFGRLEGRAILLVGAGKMGALSARALAVLGADRILVTNRSPERGLALAAQVNGSYRGWEELQRLLGEAD
VVIVSTGAPTYVVTRESMQAAMKARRRRSICLIDLAVPRNVDPACAELSDVYAYDVDDMERVVATSKQARQGEAIRAEAI
VEAEVMAFAKEREARAALPVLAQLRRHAERIARAEAERTLAQVGGKLDDKGRKSVEAMAQAIVNKLLHGPTSRLKEAASS
GDSALPGAAAELFGIENEPAGGERREGGAEGAAAAPGAGPVRSQGT

Sequences:

>Translated_446_residues
MTGDRRLFLVGLSHKSAPIDVRERVALTGDALKAALCELKAMEGVTEALVVSTCNRVEVFVHSDRPDAARRFFTERSPAA
ADHLYAKDGVEAVRHLFRVAASLDSMVVGEQQILGQVKEAYGLASAASAAGSYFSRLCNRAFATAKRVRTETEIGRGATS
MSQVAVELVEKIFGRLEGRAILLVGAGKMGALSARALAVLGADRILVTNRSPERGLALAAQVNGSYRGWEELQRLLGEAD
VVIVSTGAPTYVVTRESMQAAMKARRRRSICLIDLAVPRNVDPACAELSDVYAYDVDDMERVVATSKQARQGEAIRAEAI
VEAEVMAFAKEREARAALPVLAQLRRHAERIARAEAERTLAQVGGKLDDKGRKSVEAMAQAIVNKLLHGPTSRLKEAASS
GDSALPGAAAELFGIENEPAGGERREGGAEGAAAAPGAGPVRSQGT
>Mature_445_residues
TGDRRLFLVGLSHKSAPIDVRERVALTGDALKAALCELKAMEGVTEALVVSTCNRVEVFVHSDRPDAARRFFTERSPAAA
DHLYAKDGVEAVRHLFRVAASLDSMVVGEQQILGQVKEAYGLASAASAAGSYFSRLCNRAFATAKRVRTETEIGRGATSM
SQVAVELVEKIFGRLEGRAILLVGAGKMGALSARALAVLGADRILVTNRSPERGLALAAQVNGSYRGWEELQRLLGEADV
VIVSTGAPTYVVTRESMQAAMKARRRRSICLIDLAVPRNVDPACAELSDVYAYDVDDMERVVATSKQARQGEAIRAEAIV
EAEVMAFAKEREARAALPVLAQLRRHAERIARAEAERTLAQVGGKLDDKGRKSVEAMAQAIVNKLLHGPTSRLKEAASSG
DSALPGAAAELFGIENEPAGGERREGGAEGAAAAPGAGPVRSQGT

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=420, Percent_Identity=34.0476190476191, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 47397; Mature: 47265

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGDRRLFLVGLSHKSAPIDVRERVALTGDALKAALCELKAMEGVTEALVVSTCNRVEVF
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VHSDRPDAARRFFTERSPAAADHLYAKDGVEAVRHLFRVAASLDSMVVGEQQILGQVKEA
EECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
YGLASAASAAGSYFSRLCNRAFATAKRVRTETEIGRGATSMSQVAVELVEKIFGRLEGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCE
ILLVGAGKMGALSARALAVLGADRILVTNRSPERGLALAAQVNGSYRGWEELQRLLGEAD
EEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHCCCC
VVIVSTGAPTYVVTRESMQAAMKARRRRSICLIDLAVPRNVDPACAELSDVYAYDVDDME
EEEEECCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHEECHHHHH
RVVATSKQARQGEAIRAEAIVEAEVMAFAKEREARAALPVLAQLRRHAERIARAEAERTL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQVGGKLDDKGRKSVEAMAQAIVNKLLHGPTSRLKEAASSGDSALPGAAAELFGIENEPA
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
GGERREGGAEGAAAAPGAGPVRSQGT
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGDRRLFLVGLSHKSAPIDVRERVALTGDALKAALCELKAMEGVTEALVVSTCNRVEVF
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VHSDRPDAARRFFTERSPAAADHLYAKDGVEAVRHLFRVAASLDSMVVGEQQILGQVKEA
EECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
YGLASAASAAGSYFSRLCNRAFATAKRVRTETEIGRGATSMSQVAVELVEKIFGRLEGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCE
ILLVGAGKMGALSARALAVLGADRILVTNRSPERGLALAAQVNGSYRGWEELQRLLGEAD
EEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHCCCC
VVIVSTGAPTYVVTRESMQAAMKARRRRSICLIDLAVPRNVDPACAELSDVYAYDVDDME
EEEEECCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHEECHHHHH
RVVATSKQARQGEAIRAEAIVEAEVMAFAKEREARAALPVLAQLRRHAERIARAEAERTL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQVGGKLDDKGRKSVEAMAQAIVNKLLHGPTSRLKEAASSGDSALPGAAAELFGIENEPA
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
GGERREGGAEGAAAAPGAGPVRSQGT
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA