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The map label for this gene is xseA [H]

Identifier: 220916327

GI number: 220916327

Start: 1371278

End: 1372906

Strand: Direct

Name: xseA [H]

Synonym: A2cp1_1221

Alternate gene names: 220916327

Gene position: 1371278-1372906 (Clockwise)

Preceding gene: 220916326

Following gene: 220916328

Centisome position: 27.27

GC content: 79.01

Gene sequence:

>1629_bases
GTGAGCCGGCCGAAGCCCCCCGGCGCCGGCGCCACCGGCGACCTGTTCGCGCGCGCCGCCGAGCGGGCCGCCGCGGAGCG
CGTCCGCGCGGAGCCTCCCGCCGCGGAGCGCCCCGATCCCGAGCGTTCCGACGCCGAGCGCGCCGCGGCCGGGCGCGAGG
CCGAGCCGTCCCGGCCCGCCGCCGCCGAGCGCGAGCGCGCCGCCGTCGAGAAGGCGCTGCCGCGCCCGTACACCGTCCGC
GAGCTGACCCGCGCGCTGAAGAGCGCGATCGAGCCGCGGTTCCGCGACGTGTGGGTGGCGGGCGAGGTGGCGAACCTGCG
GCGGCAGGCCAGCGGGCACGTCTACTTCTCGCTCAAGGACGACGACGCGGTGATCGGCGCGGTCATGTGGGCCTCGCAGG
CGCGCCGGCTGGCCTTCGCGCCCGGGGAAGGCCTGGAGGTGCTGGCCCGCGGCTTCGTCGAGATCTACCCGCCGCACGGC
AAGTACCAGCTCGTGGTCCAGGAGCTGGAGCCGCGCGGGGCCGGGGCCCAGGCGCTCCAGCTCCAGCAGCTCAAGGAGCG
GCTCCAGGCCGAGGGGCTGCTCGATCCGGCCCGCAAGCGTCCGCTGCCGTTCCTCCCGGCGCGCGTCGGCGTGGCCACCA
GCCCGACCGGCGCGGCGCTCCGCGATCTCCTGCGCGTGCTCCACGCGCGTTTCCCCGGCGCGCCGGTGCTGATCGCGCCC
TGCCGCGTGCAGGGCGAGGGCGCGGCCGCGACGGTGATCTCGGCGGTGCGCGCGCTCTGCCGCGCCGGGGTGGACGTGGT
CGTGGTCACGCGCGGCGGCGGCTCGCAGGAGGACCTGTGGGCGTTCAACGACGAGCGGCTGGCGCGCGCCATCGCCGCCT
GCCCGGTGCCGGTGGTGTCGGCGGTCGGGCACGAGGTGGACGTCACCGTCGCCGACCTCGTGGCCGACGTTCGCGCCGCC
ACCCCCACCCACGCCGCGCAGCTGGTGGTGCCGGTGCGGGACGAGCTGGTCGAGCGGGTGGCCGCGCTCCGCGCGCGGCT
GGCGCGGGCACAGGCCGGCGCCGTCGAGGGCCGGCGCCGCACCCTGCGCGCGCTGCGGGCCGAGCTGGCCGACCCGAAGC
ACCTGCTCTCGCGCGAGCGCCACCGGCTCGACGATCTCGCCCACCGGGCCGAGGCGGCGGTGCGCGGGCCGCGGCGCCGC
GAGCGGGCGGCCCTGGACGCCCTGCGCGGCCGGCTGACCCGGCTCGAGCCCCGGGCACGGGTGCGCGCGCTCCGGGCACG
CATGGAGTCGGCGACGCGCCGCCTGGGGGGCTGGCAGGCGGCCACCTTCCGGCGCGAGGCCATGCGCCTCGAGCGGCTGG
GGGCGCGCCTCGAGCCGGCCAACGTGGCGAAGCTGCTGGCCCGCGGGTTCGCGCTCGCCCTGCGCGACGGGCACCTGCTC
CTGCGCAGCGCCGATGCACAGGTGGGAGACGGGGTCCGGGTGGCCCTCGCGGAGGGCTGGCTCGATGCTCGCATCACCGG
GCGGGATGCGGGCGACGACCCGTTGCCGGGGCGCTCCGGGCCCGCGGGGGAACCCGAAAGGCCCGGCCACGGCGGGGAGG
CCGTTGACCCCCCTTTGCGGCGTCGTTAA

Upstream 100 bases:

>100_bases
CCTGGTGCCTGCGCGCGCAGGAGGACGTGGACGCGTTGCTGGAGCGGCTGGTGGAGGCGCGCGCCGGGGCACGGCCGAGG
CGCGCGGCGGGGCGGGCGCG

Downstream 100 bases:

>100_bases
GTAAGGAAATCGCGGAGGAAGCGTGAGCGAGGCGAGCGAGCGTCGATCGGACACCGAGGCGGCCGGAGCCGCAGAGCCCT
ACGATGCGCTCGTGGCGCGC

Product: exodeoxyribonuclease VII, large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSRPKPPGAGATGDLFARAAERAAAERVRAEPPAAERPDPERSDAERAAAGREAEPSRPAAAERERAAVEKALPRPYTVR
ELTRALKSAIEPRFRDVWVAGEVANLRRQASGHVYFSLKDDDAVIGAVMWASQARRLAFAPGEGLEVLARGFVEIYPPHG
KYQLVVQELEPRGAGAQALQLQQLKERLQAEGLLDPARKRPLPFLPARVGVATSPTGAALRDLLRVLHARFPGAPVLIAP
CRVQGEGAAATVISAVRALCRAGVDVVVVTRGGGSQEDLWAFNDERLARAIAACPVPVVSAVGHEVDVTVADLVADVRAA
TPTHAAQLVVPVRDELVERVAALRARLARAQAGAVEGRRRTLRALRAELADPKHLLSRERHRLDDLAHRAEAAVRGPRRR
ERAALDALRGRLTRLEPRARVRALRARMESATRRLGGWQAATFRREAMRLERLGARLEPANVAKLLARGFALALRDGHLL
LRSADAQVGDGVRVALAEGWLDARITGRDAGDDPLPGRSGPAGEPERPGHGGEAVDPPLRRR

Sequences:

>Translated_542_residues
MSRPKPPGAGATGDLFARAAERAAAERVRAEPPAAERPDPERSDAERAAAGREAEPSRPAAAERERAAVEKALPRPYTVR
ELTRALKSAIEPRFRDVWVAGEVANLRRQASGHVYFSLKDDDAVIGAVMWASQARRLAFAPGEGLEVLARGFVEIYPPHG
KYQLVVQELEPRGAGAQALQLQQLKERLQAEGLLDPARKRPLPFLPARVGVATSPTGAALRDLLRVLHARFPGAPVLIAP
CRVQGEGAAATVISAVRALCRAGVDVVVVTRGGGSQEDLWAFNDERLARAIAACPVPVVSAVGHEVDVTVADLVADVRAA
TPTHAAQLVVPVRDELVERVAALRARLARAQAGAVEGRRRTLRALRAELADPKHLLSRERHRLDDLAHRAEAAVRGPRRR
ERAALDALRGRLTRLEPRARVRALRARMESATRRLGGWQAATFRREAMRLERLGARLEPANVAKLLARGFALALRDGHLL
LRSADAQVGDGVRVALAEGWLDARITGRDAGDDPLPGRSGPAGEPERPGHGGEAVDPPLRRR
>Mature_541_residues
SRPKPPGAGATGDLFARAAERAAAERVRAEPPAAERPDPERSDAERAAAGREAEPSRPAAAERERAAVEKALPRPYTVRE
LTRALKSAIEPRFRDVWVAGEVANLRRQASGHVYFSLKDDDAVIGAVMWASQARRLAFAPGEGLEVLARGFVEIYPPHGK
YQLVVQELEPRGAGAQALQLQQLKERLQAEGLLDPARKRPLPFLPARVGVATSPTGAALRDLLRVLHARFPGAPVLIAPC
RVQGEGAAATVISAVRALCRAGVDVVVVTRGGGSQEDLWAFNDERLARAIAACPVPVVSAVGHEVDVTVADLVADVRAAT
PTHAAQLVVPVRDELVERVAALRARLARAQAGAVEGRRRTLRALRAELADPKHLLSRERHRLDDLAHRAEAAVRGPRRRE
RAALDALRGRLTRLEPRARVRALRARMESATRRLGGWQAATFRREAMRLERLGARLEPANVAKLLARGFALALRDGHLLL
RSADAQVGDGVRVALAEGWLDARITGRDAGDDPLPGRSGPAGEPERPGHGGEAVDPPLRRR

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=443, Percent_Identity=38.6004514672686, Blast_Score=285, Evalue=6e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 58520; Mature: 58388

Theoretical pI: Translated: 11.46; Mature: 11.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPKPPGAGATGDLFARAAERAAAERVRAEPPAAERPDPERSDAERAAAGREAEPSRPA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
AAERERAAVEKALPRPYTVRELTRALKSAIEPRFRDVWVAGEVANLRRQASGHVYFSLKD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHEEECCHHHHHHHHCCCCEEEEECC
DDAVIGAVMWASQARRLAFAPGEGLEVLARGFVEIYPPHGKYQLVVQELEPRGAGAQALQ
CCHHHHHHHHHHHHCCEEECCCCCHHHHHCCHHEECCCCCCEEEEEEHHCCCCCCHHHHH
LQQLKERLQAEGLLDPARKRPLPFLPARVGVATSPTGAALRDLLRVLHARFPGAPVLIAP
HHHHHHHHHHCCCCCHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEC
CRVQGEGAAATVISAVRALCRAGVDVVVVTRGGGSQEDLWAFNDERLARAIAACPVPVVS
CEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
AVGHEVDVTVADLVADVRAATPTHAAQLVVPVRDELVERVAALRARLARAQAGAVEGRRR
HCCCCCCHHHHHHHHHHHHCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLRALRAELADPKHLLSRERHRLDDLAHRAEAAVRGPRRRERAALDALRGRLTRLEPRAR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHH
VRALRARMESATRRLGGWQAATFRREAMRLERLGARLEPANVAKLLARGFALALRDGHLL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCEEE
LRSADAQVGDGVRVALAEGWLDARITGRDAGDDPLPGRSGPAGEPERPGHGGEAVDPPLR
EEECCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RR
CC
>Mature Secondary Structure 
SRPKPPGAGATGDLFARAAERAAAERVRAEPPAAERPDPERSDAERAAAGREAEPSRPA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
AAERERAAVEKALPRPYTVRELTRALKSAIEPRFRDVWVAGEVANLRRQASGHVYFSLKD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHEEECCHHHHHHHHCCCCEEEEECC
DDAVIGAVMWASQARRLAFAPGEGLEVLARGFVEIYPPHGKYQLVVQELEPRGAGAQALQ
CCHHHHHHHHHHHHCCEEECCCCCHHHHHCCHHEECCCCCCEEEEEEHHCCCCCCHHHHH
LQQLKERLQAEGLLDPARKRPLPFLPARVGVATSPTGAALRDLLRVLHARFPGAPVLIAP
HHHHHHHHHHCCCCCHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEC
CRVQGEGAAATVISAVRALCRAGVDVVVVTRGGGSQEDLWAFNDERLARAIAACPVPVVS
CEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
AVGHEVDVTVADLVADVRAATPTHAAQLVVPVRDELVERVAALRARLARAQAGAVEGRRR
HCCCCCCHHHHHHHHHHHHCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLRALRAELADPKHLLSRERHRLDDLAHRAEAAVRGPRRRERAALDALRGRLTRLEPRAR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHH
VRALRARMESATRRLGGWQAATFRREAMRLERLGARLEPANVAKLLARGFALALRDGHLL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCEEE
LRSADAQVGDGVRVALAEGWLDARITGRDAGDDPLPGRSGPAGEPERPGHGGEAVDPPLR
EEECCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA