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The map label for this gene is hemE [H]

Identifier: 220916322

GI number: 220916322

Start: 1364951

End: 1366003

Strand: Direct

Name: hemE [H]

Synonym: A2cp1_1216

Alternate gene names: 220916322

Gene position: 1364951-1366003 (Clockwise)

Preceding gene: 220916321

Following gene: 220916323

Centisome position: 27.14

GC content: 71.51

Gene sequence:

>1053_bases
ATGGCGGCCCCCATGACCCACAGATTCCTCGCCGCGTGCCGCCGTGAGCCCGTCGACCGCGTTCCCGTCTGGATGATGCG
CCAGGCCGGCCGCTACCAGCCGTCCTACCGCGCCGTCCGCCAGAAGGTGAGCTTCCTGGAGCTGTGCCGCTCGCCGGAGC
TCATCGCCCAGGTGACGGTCGCGCCCATCGACGAGTTCGGCTTCGACGCCGCCATCCTGTTCTCGGACATCCTGGTCCAC
CTGCCGGCCATGGGCCTCGACCTCTCCTTCGAGAAGGGCGAGAAGGGCAAGGGCGACGGCGGGCCGAAGATCGGCAACCC
GGTGCGCACCCGCGCCGACGTGGACGCGCTGCGCGTGCCGGTCCCGAAGAAGGACCTGCCGTACGTGCTCGACGGCGTGC
GCGCCATCCGCGCCGCCCTCGCCGACCGCGTGCCGCTCATCGGCTTCGTGGGCGGTCCGTTCACGGTGGCGAGCTACGCC
GTCGAGGGCGGGAGCCAGGGCTTCACCCGGCTGAAGACCATGCTGTACGCCGAGCCGGCGACGGCGCACGCGCTGTTCGA
GAAGCTCACCCAGGCCGCGATCGTGCAGATCGAGGAGCAGGTGGCGGCCGGCGCGCACGCGGCCCAGATCTTCGAGAGCT
GGCTGGGCGAGCTGGCCCGCGAGGATCTCGAGGAGTTCAGCTTCCCGTACCTCGCCCGCATCGCCGAGGCGGTGCGCAAG
ACCGGCGTCCCGTCGATCCTGTTCTCCACCGGCACCACCGCGCACCTCGAGCCGATGGCGAAGCTCGGCTACGACGTCGT
CTCGGTGGATTGGCGCATCCCCATCGACGAGGCGCGCGCCCGGCTGCCGGGCGTGGCGGTGCAGGGCAACTACGACTCGA
CGCTGCTCCTCGGGCCTCGCGACGTCGCGGTGGCGCGGGCCCAGCAGCTGCTCCGGGCGGCCGGGCCGACCCCGGGTTAC
ATCTTCAACCTCGGCCACGGGATCCAGGTGGGCACCCCGACCGAGAACGTGAAGGCGGTGGTGGACGCGGTCCACGCCTT
CGGCTGGAAGTGA

Upstream 100 bases:

>100_bases
CGACCGGGGCGGCGGGCGTCCGGAGGGCGGCAGGGTCCCGCGCGCGGGGCCACGGAACATCGACCCGAACGGTGTGTGTT
TCGGGGGGACCTGGACTAAG

Downstream 100 bases:

>100_bases
GGCGATCGGCGTGATCCAGATCCCGTCCACGCAGCTCATCAAGAAGTACGACCGTCCCGGGCCGCGCTACACCAGCTACC
CGACCGCGCCGGAGTGGACC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MAAPMTHRFLAACRREPVDRVPVWMMRQAGRYQPSYRAVRQKVSFLELCRSPELIAQVTVAPIDEFGFDAAILFSDILVH
LPAMGLDLSFEKGEKGKGDGGPKIGNPVRTRADVDALRVPVPKKDLPYVLDGVRAIRAALADRVPLIGFVGGPFTVASYA
VEGGSQGFTRLKTMLYAEPATAHALFEKLTQAAIVQIEEQVAAGAHAAQIFESWLGELAREDLEEFSFPYLARIAEAVRK
TGVPSILFSTGTTAHLEPMAKLGYDVVSVDWRIPIDEARARLPGVAVQGNYDSTLLLGPRDVAVARAQQLLRAAGPTPGY
IFNLGHGIQVGTPTENVKAVVDAVHAFGWK

Sequences:

>Translated_350_residues
MAAPMTHRFLAACRREPVDRVPVWMMRQAGRYQPSYRAVRQKVSFLELCRSPELIAQVTVAPIDEFGFDAAILFSDILVH
LPAMGLDLSFEKGEKGKGDGGPKIGNPVRTRADVDALRVPVPKKDLPYVLDGVRAIRAALADRVPLIGFVGGPFTVASYA
VEGGSQGFTRLKTMLYAEPATAHALFEKLTQAAIVQIEEQVAAGAHAAQIFESWLGELAREDLEEFSFPYLARIAEAVRK
TGVPSILFSTGTTAHLEPMAKLGYDVVSVDWRIPIDEARARLPGVAVQGNYDSTLLLGPRDVAVARAQQLLRAAGPTPGY
IFNLGHGIQVGTPTENVKAVVDAVHAFGWK
>Mature_349_residues
AAPMTHRFLAACRREPVDRVPVWMMRQAGRYQPSYRAVRQKVSFLELCRSPELIAQVTVAPIDEFGFDAAILFSDILVHL
PAMGLDLSFEKGEKGKGDGGPKIGNPVRTRADVDALRVPVPKKDLPYVLDGVRAIRAALADRVPLIGFVGGPFTVASYAV
EGGSQGFTRLKTMLYAEPATAHALFEKLTQAAIVQIEEQVAAGAHAAQIFESWLGELAREDLEEFSFPYLARIAEAVRKT
GVPSILFSTGTTAHLEPMAKLGYDVVSVDWRIPIDEARARLPGVAVQGNYDSTLLLGPRDVAVARAQQLLRAAGPTPGYI
FNLGHGIQVGTPTENVKAVVDAVHAFGWK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=347, Percent_Identity=40.0576368876081, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=43.75, Blast_Score=281, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6320252, Length=364, Percent_Identity=35.7142857142857, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=37.7521613832853, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=37.7521613832853, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37953; Mature: 37822

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPMTHRFLAACRREPVDRVPVWMMRQAGRYQPSYRAVRQKVSFLELCRSPELIAQVTV
CCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
APIDEFGFDAAILFSDILVHLPAMGLDLSFEKGEKGKGDGGPKIGNPVRTRADVDALRVP
CCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
VPKKDLPYVLDGVRAIRAALADRVPLIGFVGGPFTVASYAVEGGSQGFTRLKTMLYAEPA
CCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCCH
TAHALFEKLTQAAIVQIEEQVAAGAHAAQIFESWLGELAREDLEEFSFPYLARIAEAVRK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TGVPSILFSTGTTAHLEPMAKLGYDVVSVDWRIPIDEARARLPGVAVQGNYDSTLLLGPR
CCCCEEEECCCCCHHHHHHHHCCCEEEEEEEECCHHHHHHHCCCEEEECCCCCEEEECCH
DVAVARAQQLLRAAGPTPGYIFNLGHGIQVGTPTENVKAVVDAVHAFGWK
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAPMTHRFLAACRREPVDRVPVWMMRQAGRYQPSYRAVRQKVSFLELCRSPELIAQVTV
CCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
APIDEFGFDAAILFSDILVHLPAMGLDLSFEKGEKGKGDGGPKIGNPVRTRADVDALRVP
CCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
VPKKDLPYVLDGVRAIRAALADRVPLIGFVGGPFTVASYAVEGGSQGFTRLKTMLYAEPA
CCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCCH
TAHALFEKLTQAAIVQIEEQVAAGAHAAQIFESWLGELAREDLEEFSFPYLARIAEAVRK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TGVPSILFSTGTTAHLEPMAKLGYDVVSVDWRIPIDEARARLPGVAVQGNYDSTLLLGPR
CCCCEEEECCCCCHHHHHHHHCCCEEEEEEEECCHHHHHHHCCCEEEECCCCCEEEECCH
DVAVARAQQLLRAAGPTPGYIFNLGHGIQVGTPTENVKAVVDAVHAFGWK
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA