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The map label for this gene is lpxD

Identifier: 220916317

GI number: 220916317

Start: 1361403

End: 1362467

Strand: Direct

Name: lpxD

Synonym: A2cp1_1211

Alternate gene names: 220916317

Gene position: 1361403-1362467 (Clockwise)

Preceding gene: 220916316

Following gene: 220916318

Centisome position: 27.07

GC content: 73.24

Gene sequence:

>1065_bases
GTGGCGTCCTACACGCTCGCGGAGCTCGCCGCCCGCGTCGGCGGCGCGGTGGAGGGCGACGGGAGCCTGCGGCTCGACGG
CATCTCGCCGCTCGAGGAGGCCTCCGCGTCCGAGATCTCGTTCTTCTCGAACCGCAAGTACCGCAAGGCGTTCGAGGCGT
CGCGCGCCGGCGCGGTGGTGGTCGAGCCGGACGAGCAGGTCGCGGCCGGCCGCACGGTGCTGCGCGTCGCGAACGCGTAC
CTCGCGTTCGCGAAGATCTCGACGCTGTTCCACCCGCCCCGCGAGGCGGTGCCGGAGGTGGCGCCGACCGCGGTGATCCA
CCCGACCGCGCGGGTCCACCCGAGCGCGCAGGTGATGCCGCTCGCATGCGTCGGGCCCGACGCGCAGGTGGGCGCGCGCA
CCATCCTGTTCCCGGGCGTGCACGTGGCCGACGGGGCGCGGGTGGGCGAGGACTGCGTGTTCTACCACAACGTGGTGGTG
CGCGAGCGCTGCGCCGTGGGCAACCGCGTCATCCTGCAGCCGGGCTGCGTGATCGGCTCCGACGGCTTCGGGTTCGCGTT
CGATCCGGAGGGCGAGGGCAAGGGCCCCCGCCACTACAAGGTCCCGCAGGTCGGGAACGTGGTGATCGAGGACGACGTGG
AGGTGGGCGCGAACACGTGCGTGGATCGCGCCACCCTCGGCACCACGCGCATCGGCCGCGGCGCCAAGATCGACAACCTG
GTGCAGATCGCGCACAACGTCCAGGTCGGCCCGCTCAGCCTGCTCGTGTCGCAGGTGGGCGTCGCCGGCTCCACCAAGCT
CGGCATGGGCGTGGTGGCGGGCGGCCAGGCCGGCATCGTCGGCCACCTCGAGATCGGCGACGGCGTGCGGATCGGCGCGC
AGTCCGGCGTGATGGCCGACGTGGAGGCCGGTGAGACCGTGTCCGGCTCGCCGGCCGTGCCCCACGGCAACTGGCTGAAG
GCGATGGCGTCGCTCGATCACCTGCACGACATGCGCAAGGAACTGCGCAGCCTGCGCCGCGAGGTGGAGCGGCTGCGCGC
GGACGCCGGCGAGGACGAGCCATGA

Upstream 100 bases:

>100_bases
GCAAGTACAACGCCCGCTTCGGCGCCGGGAGCAAGGCCGCCGGGCAGGCGAAGAAGGCCGAGCCGGCCAAGCCGGCCGCC
GGGAAGAAGTAGGCGCGGCC

Downstream 100 bases:

>100_bases
GCGAGAGCGCGGAGCGCAAGTCGATCCTCGACGTGGTCGGGATCCAGAAGCTGCTGCCGCACCGGCCGCCGTTCCTGCTG
GTGGACCGGGTGGTGGAGTT

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MASYTLAELAARVGGAVEGDGSLRLDGISPLEEASASEISFFSNRKYRKAFEASRAGAVVVEPDEQVAAGRTVLRVANAY
LAFAKISTLFHPPREAVPEVAPTAVIHPTARVHPSAQVMPLACVGPDAQVGARTILFPGVHVADGARVGEDCVFYHNVVV
RERCAVGNRVILQPGCVIGSDGFGFAFDPEGEGKGPRHYKVPQVGNVVIEDDVEVGANTCVDRATLGTTRIGRGAKIDNL
VQIAHNVQVGPLSLLVSQVGVAGSTKLGMGVVAGGQAGIVGHLEIGDGVRIGAQSGVMADVEAGETVSGSPAVPHGNWLK
AMASLDHLHDMRKELRSLRREVERLRADAGEDEP

Sequences:

>Translated_354_residues
MASYTLAELAARVGGAVEGDGSLRLDGISPLEEASASEISFFSNRKYRKAFEASRAGAVVVEPDEQVAAGRTVLRVANAY
LAFAKISTLFHPPREAVPEVAPTAVIHPTARVHPSAQVMPLACVGPDAQVGARTILFPGVHVADGARVGEDCVFYHNVVV
RERCAVGNRVILQPGCVIGSDGFGFAFDPEGEGKGPRHYKVPQVGNVVIEDDVEVGANTCVDRATLGTTRIGRGAKIDNL
VQIAHNVQVGPLSLLVSQVGVAGSTKLGMGVVAGGQAGIVGHLEIGDGVRIGAQSGVMADVEAGETVSGSPAVPHGNWLK
AMASLDHLHDMRKELRSLRREVERLRADAGEDEP
>Mature_353_residues
ASYTLAELAARVGGAVEGDGSLRLDGISPLEEASASEISFFSNRKYRKAFEASRAGAVVVEPDEQVAAGRTVLRVANAYL
AFAKISTLFHPPREAVPEVAPTAVIHPTARVHPSAQVMPLACVGPDAQVGARTILFPGVHVADGARVGEDCVFYHNVVVR
ERCAVGNRVILQPGCVIGSDGFGFAFDPEGEGKGPRHYKVPQVGNVVIEDDVEVGANTCVDRATLGTTRIGRGAKIDNLV
QIAHNVQVGPLSLLVSQVGVAGSTKLGMGVVAGGQAGIVGHLEIGDGVRIGAQSGVMADVEAGETVSGSPAVPHGNWLKA
MASLDHLHDMRKELRSLRREVERLRADAGEDEP

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=345, Percent_Identity=34.4927536231884, Blast_Score=198, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_ANAD2 (B8JFW7)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491621.1
- ProteinModelPortal:   B8JFW7
- SMR:   B8JFW7
- GeneID:   7299077
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1211
- HOGENOM:   HBG469615
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37036; Mature: 36905

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00101 HEXAPEP_TRANSFERASES; PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYTLAELAARVGGAVEGDGSLRLDGISPLEEASASEISFFSNRKYRKAFEASRAGAVV
CCCCHHHHHHHHHCCCEECCCCEEECCCCCHHHCCCHHHHHHHCCHHHHHHHHCCCCEEE
VEPDEQVAAGRTVLRVANAYLAFAKISTLFHPPREAVPEVAPTAVIHPTARVHPSAQVMP
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEECCCCCCCCCCCEEE
LACVGPDAQVGARTILFPGVHVADGARVGEDCVFYHNVVVRERCAVGNRVILQPGCVIGS
EEEECCCCCCCCEEEEECCEEECCCCCCCCCCEEHHHHHHHHHHCCCCEEEEECCEEECC
DGFGFAFDPEGEGKGPRHYKVPQVGNVVIEDDVEVGANTCVDRATLGTTRIGRGAKIDNL
CCCCEEECCCCCCCCCCCEECCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHH
VQIAHNVQVGPLSLLVSQVGVAGSTKLGMGVVAGGQAGIVGHLEIGDGVRIGAQSGVMAD
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCCEEECCCCCEEEE
VEAGETVSGSPAVPHGNWLKAMASLDHLHDMRKELRSLRREVERLRADAGEDEP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASYTLAELAARVGGAVEGDGSLRLDGISPLEEASASEISFFSNRKYRKAFEASRAGAVV
CCCHHHHHHHHHCCCEECCCCEEECCCCCHHHCCCHHHHHHHCCHHHHHHHHCCCCEEE
VEPDEQVAAGRTVLRVANAYLAFAKISTLFHPPREAVPEVAPTAVIHPTARVHPSAQVMP
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEECCCCCCCCCCCEEE
LACVGPDAQVGARTILFPGVHVADGARVGEDCVFYHNVVVRERCAVGNRVILQPGCVIGS
EEEECCCCCCCCEEEEECCEEECCCCCCCCCCEEHHHHHHHHHHCCCCEEEEECCEEECC
DGFGFAFDPEGEGKGPRHYKVPQVGNVVIEDDVEVGANTCVDRATLGTTRIGRGAKIDNL
CCCCEEECCCCCCCCCCCEECCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHH
VQIAHNVQVGPLSLLVSQVGVAGSTKLGMGVVAGGQAGIVGHLEIGDGVRIGAQSGVMAD
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCCEEECCCCCEEEE
VEAGETVSGSPAVPHGNWLKAMASLDHLHDMRKELRSLRREVERLRADAGEDEP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA