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The map label for this gene is ruvA

Identifier: 220916123

GI number: 220916123

Start: 1136667

End: 1137260

Strand: Direct

Name: ruvA

Synonym: A2cp1_1010

Alternate gene names: 220916123

Gene position: 1136667-1137260 (Clockwise)

Preceding gene: 220916122

Following gene: 220916124

Centisome position: 22.6

GC content: 75.59

Gene sequence:

>594_bases
GTGATCGCGCGCCTGGCCGGGCGGATCGCCGAGAAGCGCGACGACCACGCCATCGTGGACGTGGGCGGGGTCGGCTACCT
CGTGCACCTCTCGCAGCTCTCGCTGGCCTCGCTCCCGCCGCCGGGCGAGCCCGCCGCGCTCCGCGTCTACACCCACGTCC
GCGAGGACGCGCTCGACCTGTACGGCTTCGCGACCGAGGACGAGGAGGCGGTGTTCCGCGCCCTCATCGACGTGAAGGGG
GTGGGGCCGCGCGCGGCGCAGAACATCCTCTCCGGCATCGAGGCGCGCGAGCTGGCGCAGGCGGTGGCGCAGGGCGACGT
CGCCCGGCTCACCAAGGTCCAGGGCATCGGGAAGAAGACCGCCGAGCGGCTGGTGCTGGAGCTGAAGGAGAAGCTGGTCG
CGCTGGCGCGCGCTGCCGGGCCCGCCCGCGCCGGCGCGGAGGCGGACGTGCTCGAGCAGCTCCGGACCGCGCTGCTCAAC
CTCGGCTACCGGCCGCCGCAGGCGGAGGGCGTGGCGGAGGCGCTGCGCGACTCGGCCGAGGGCCGGCCGCTCGACGAGCT
GCTGCGCGAGGCGCTGAAGCTGCTGCGCGGGTAG

Upstream 100 bases:

>100_bases
GCGCCTTCGCGGTGCCGGCGGCCGGCGCCGGCCGCGCCGCCGCGGCGCGCGCGGCCGCGGCCCGGCTCCGCCCCTCGCGC
CGCGACCACCGGGGGACCCC

Downstream 100 bases:

>100_bases
GGAGCGACCATGACCGTGAAGCCGCTCCGCGACGTGACCCCGAAGCCGCTCGAGGGCGAGGAGCGCCTGGAGCAGTCGCT
CCGCCCGGCCACCTTCGACG

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIARLAGRIAEKRDDHAIVDVGGVGYLVHLSQLSLASLPPPGEPAALRVYTHVREDALDLYGFATEDEEAVFRALIDVKG
VGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKTAERLVLELKEKLVALARAAGPARAGAEADVLEQLRTALLN
LGYRPPQAEGVAEALRDSAEGRPLDELLREALKLLRG

Sequences:

>Translated_197_residues
MIARLAGRIAEKRDDHAIVDVGGVGYLVHLSQLSLASLPPPGEPAALRVYTHVREDALDLYGFATEDEEAVFRALIDVKG
VGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKTAERLVLELKEKLVALARAAGPARAGAEADVLEQLRTALLN
LGYRPPQAEGVAEALRDSAEGRPLDELLREALKLLRG
>Mature_197_residues
MIARLAGRIAEKRDDHAIVDVGGVGYLVHLSQLSLASLPPPGEPAALRVYTHVREDALDLYGFATEDEEAVFRALIDVKG
VGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKTAERLVLELKEKLVALARAAGPARAGAEADVLEQLRTALLN
LGYRPPQAEGVAEALRDSAEGRPLDELLREALKLLRG

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=207, Percent_Identity=39.1304347826087, Blast_Score=126, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_ANAD2 (B8JF04)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491427.1
- ProteinModelPortal:   B8JF04
- SMR:   B8JF04
- GeneID:   7297056
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1010
- HOGENOM:   HBG635309
- ProtClustDB:   CLSK945366
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278
- TIGRFAMs:   TIGR00084

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like; SSF46929 RuvA_C-like

EC number: =3.6.4.12

Molecular weight: Translated: 21020; Mature: 21020

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARLAGRIAEKRDDHAIVDVGGVGYLVHLSQLSLASLPPPGEPAALRVYTHVREDALDL
CHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YGFATEDEEAVFRALIDVKGVGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKT
HCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHCCHHH
AERLVLELKEKLVALARAAGPARAGAEADVLEQLRTALLNLGYRPPQAEGVAEALRDSAE
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
GRPLDELLREALKLLRG
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIARLAGRIAEKRDDHAIVDVGGVGYLVHLSQLSLASLPPPGEPAALRVYTHVREDALDL
CHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YGFATEDEEAVFRALIDVKGVGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKT
HCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHCCHHH
AERLVLELKEKLVALARAAGPARAGAEADVLEQLRTALLNLGYRPPQAEGVAEALRDSAE
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
GRPLDELLREALKLLRG
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA