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The map label for this gene is kdpD [H]

Identifier: 220916056

GI number: 220916056

Start: 1062844

End: 1064436

Strand: Reverse

Name: kdpD [H]

Synonym: A2cp1_0943

Alternate gene names: 220916056

Gene position: 1064436-1062844 (Counterclockwise)

Preceding gene: 220916057

Following gene: 220916055

Centisome position: 21.16

GC content: 76.33

Gene sequence:

>1593_bases
ATGACGTCAGCGCCCGAGCGAGCAGACCCGGACCGCCGCCCAGCGCGGACGCCCGACCTCGGGACGCCCGCGCGCGAGTA
CCTGCGCGCGGCCGGCGTCATCGGCGCCACCACCGCGCTGGCCGCGGCGGCGCGCGCGCTCCTCCACGTCCCCGATGTCG
AGATGCTGTTCCTGCTGGGCGTGATGGTGGTGGCGCTCACCAGCGGCCGCCGGGCCTCCACCCTCGCCGCCGCGCTCGCG
GTCGTCTGCTACGACTTCTTCTTCGTCCCGCCCCCGTTCACCCTCGACGTCGCCGACGCCCGCTACGTCCTGACGTTCGC
GATGATGCTCGGCATCGGCGTGGTCATCGGGACGCTCACGCTGCGGCTCCGCGAGCAGCGGCGGGAGGCGATCGTCCGGG
AACGGCGCACCGCCGCGGTGTACGCGCTCGGCAAGGAGCTGGCGGCGGCGATGGACTCGACCGGGGTGGGCGCCGCGTGT
GTGCGCGCGGTCGCGGAGGCCTTCGACTGCGCGGCGCTGTTCTTCCTGGCGCGGGATCGCGACACGCTCGACGCGGTGGC
TTCCGCGCCCGCCGACCAGTCGCTCGGGACCGGCGAGCTCGCCGTCGCCCGGTGGGCGTCCGAGCACGGACGTCCCGCCG
GCTGCGGCACCGACGCGCTCCCGGGCGAGTCCGTGCTCTGCATCCCGCTCCGGACCTGGGGCGACGTCCTGGCGGTGATC
GCGCTGCGGCCCGTGAACGAGCGCAGCCTCGGCGGCGAGCAGCAGGAGCTCGTCGAGGCGCTGGCGCGGCACGCCGCCGT
CGCGCTGGATCGGGTACGCCTCGCCGACGAGGCGCGGCGGGCCGCGCTCCGGGCCAGGACGGAGGAGCTGCGCAGCGGCC
TGCTGTCCTCCGTCTCGCACGATCTCCGGACCCCGCTCGCCGCCATCACCGGCGCCGGCACGCTCCTCCTCGACGACGGC
GTGAACGATCCGGCGATCCGGAGGGACCTGGCCGCCACGGTGGTCGACGAGGCGGAGCGGCTCGAGCGGCTCGTCTCGAA
CCTCCTCGACATGACGCGCCTCGAGGGGGGCGCGGTCGAGCCGAAGCGGGAGTGGGTCCCGCTGACCGAGGTGGTCGGCG
CCGCCATGAACCGCCTGGAGCGGCCGCTCGCGGCACGCCCGGTCGCCGTCGCCATCCCGGACGAGCTCCCGCTGCTCTCC
GTCGACCCGATCCTGGTCCAGCAGCTGTTCGTGAACCTGCTCGAGAACGCGACCAAGCACACGCCGCCGGGTTCCGAGAT
CGCGGTCCGCGCCGCCCGCGAGGGCGGGATGGTCGCGATCGAGGTGGCCGATCGCGGCCCCGGCCTCCCCGAGGGCGAGG
AGGAGCGCATCTTCGACCGGTTCCAGCGGGCCGCCCGTCCCGGCGTGCGAGGCGTCGGGCTGGGGCTCCCCATCGCGCGG
GCGATCGCCCAGGCGCACGGAGGCCGCCTCACGGCGGCGAACCGGGCCGGCGGCGGGGCGGTGTTCCGCCTGACCCTGCC
CGTCGGGGCGCCTCCTGCCGCACCGCCGGAGCCCCCCGGCGAGCGCCTGCCGGAGCGAGGGGGCGGGCCGTGA

Upstream 100 bases:

>100_bases
TCCGAGCACGTTGCGTGAATCCACCGCCGCCCGGGTCGCGCTTGACGGGCCTGGCGCCGCGAGCCTTGATGAACGGAGGA
TCGAGCCGGGGGCCCCCGAC

Downstream 100 bases:

>100_bases
CCGGCGGCGGCCCGCTCGTGCTCGTCGTCGAGGACGAGGCGCCGGTACGCCGCTTCCTGCGCGCCGCGCTGGCCGCGCAC
GGCTACCGGATCGAGGAGGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MTSAPERADPDRRPARTPDLGTPAREYLRAAGVIGATTALAAAARALLHVPDVEMLFLLGVMVVALTSGRRASTLAAALA
VVCYDFFFVPPPFTLDVADARYVLTFAMMLGIGVVIGTLTLRLREQRREAIVRERRTAAVYALGKELAAAMDSTGVGAAC
VRAVAEAFDCAALFFLARDRDTLDAVASAPADQSLGTGELAVARWASEHGRPAGCGTDALPGESVLCIPLRTWGDVLAVI
ALRPVNERSLGGEQQELVEALARHAAVALDRVRLADEARRAALRARTEELRSGLLSSVSHDLRTPLAAITGAGTLLLDDG
VNDPAIRRDLAATVVDEAERLERLVSNLLDMTRLEGGAVEPKREWVPLTEVVGAAMNRLERPLAARPVAVAIPDELPLLS
VDPILVQQLFVNLLENATKHTPPGSEIAVRAAREGGMVAIEVADRGPGLPEGEEERIFDRFQRAARPGVRGVGLGLPIAR
AIAQAHGGRLTAANRAGGGAVFRLTLPVGAPPAAPPEPPGERLPERGGGP

Sequences:

>Translated_530_residues
MTSAPERADPDRRPARTPDLGTPAREYLRAAGVIGATTALAAAARALLHVPDVEMLFLLGVMVVALTSGRRASTLAAALA
VVCYDFFFVPPPFTLDVADARYVLTFAMMLGIGVVIGTLTLRLREQRREAIVRERRTAAVYALGKELAAAMDSTGVGAAC
VRAVAEAFDCAALFFLARDRDTLDAVASAPADQSLGTGELAVARWASEHGRPAGCGTDALPGESVLCIPLRTWGDVLAVI
ALRPVNERSLGGEQQELVEALARHAAVALDRVRLADEARRAALRARTEELRSGLLSSVSHDLRTPLAAITGAGTLLLDDG
VNDPAIRRDLAATVVDEAERLERLVSNLLDMTRLEGGAVEPKREWVPLTEVVGAAMNRLERPLAARPVAVAIPDELPLLS
VDPILVQQLFVNLLENATKHTPPGSEIAVRAAREGGMVAIEVADRGPGLPEGEEERIFDRFQRAARPGVRGVGLGLPIAR
AIAQAHGGRLTAANRAGGGAVFRLTLPVGAPPAAPPEPPGERLPERGGGP
>Mature_529_residues
TSAPERADPDRRPARTPDLGTPAREYLRAAGVIGATTALAAAARALLHVPDVEMLFLLGVMVVALTSGRRASTLAAALAV
VCYDFFFVPPPFTLDVADARYVLTFAMMLGIGVVIGTLTLRLREQRREAIVRERRTAAVYALGKELAAAMDSTGVGAACV
RAVAEAFDCAALFFLARDRDTLDAVASAPADQSLGTGELAVARWASEHGRPAGCGTDALPGESVLCIPLRTWGDVLAVIA
LRPVNERSLGGEQQELVEALARHAAVALDRVRLADEARRAALRARTEELRSGLLSSVSHDLRTPLAAITGAGTLLLDDGV
NDPAIRRDLAATVVDEAERLERLVSNLLDMTRLEGGAVEPKREWVPLTEVVGAAMNRLERPLAARPVAVAIPDELPLLSV
DPILVQQLFVNLLENATKHTPPGSEIAVRAAREGGMVAIEVADRGPGLPEGEEERIFDRFQRAARPGVRGVGLGLPIARA
IAQAHGGRLTAANRAGGGAVFRLTLPVGAPPAAPPEPPGERLPERGGGP

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=485, Percent_Identity=38.7628865979381, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=30.7053941908714, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081816, Length=288, Percent_Identity=31.5972222222222, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=27.4900398406374, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=29.5275590551181, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI145693157, Length=288, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788279, Length=213, Percent_Identity=29.5774647887324, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=30.8370044052863, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=28.5140562248996, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=27.3542600896861, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=27.8195488721804, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=27.3504273504274, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=219, Percent_Identity=32.4200913242009, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.4774774774775, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790551, Length=204, Percent_Identity=31.8627450980392, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787374, Length=309, Percent_Identity=26.8608414239482, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=27.6785714285714, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=26.953125, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=28.3185840707965, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55891; Mature: 55760

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAPERADPDRRPARTPDLGTPAREYLRAAGVIGATTALAAAARALLHVPDVEMLFLLG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VMVVALTSGRRASTLAAALAVVCYDFFFVPPPFTLDVADARYVLTFAMMLGIGVVIGTLT
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
LRLREQRREAIVRERRTAAVYALGKELAAAMDSTGVGAACVRAVAEAFDCAALFFLARDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DTLDAVASAPADQSLGTGELAVARWASEHGRPAGCGTDALPGESVLCIPLRTWGDVLAVI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHH
ALRPVNERSLGGEQQELVEALARHAAVALDRVRLADEARRAALRARTEELRSGLLSSVSH
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRTPLAAITGAGTLLLDDGVNDPAIRRDLAATVVDEAERLERLVSNLLDMTRLEGGAVE
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PKREWVPLTEVVGAAMNRLERPLAARPVAVAIPDELPLLSVDPILVQQLFVNLLENATKH
CHHHCCCHHHHHHHHHHHHHCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
TPPGSEIAVRAAREGGMVAIEVADRGPGLPEGEEERIFDRFQRAARPGVRGVGLGLPIAR
CCCCCHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
AIAQAHGGRLTAANRAGGGAVFRLTLPVGAPPAAPPEPPGERLPERGGGP
HHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure 
TSAPERADPDRRPARTPDLGTPAREYLRAAGVIGATTALAAAARALLHVPDVEMLFLLG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VMVVALTSGRRASTLAAALAVVCYDFFFVPPPFTLDVADARYVLTFAMMLGIGVVIGTLT
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
LRLREQRREAIVRERRTAAVYALGKELAAAMDSTGVGAACVRAVAEAFDCAALFFLARDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DTLDAVASAPADQSLGTGELAVARWASEHGRPAGCGTDALPGESVLCIPLRTWGDVLAVI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHH
ALRPVNERSLGGEQQELVEALARHAAVALDRVRLADEARRAALRARTEELRSGLLSSVSH
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRTPLAAITGAGTLLLDDGVNDPAIRRDLAATVVDEAERLERLVSNLLDMTRLEGGAVE
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PKREWVPLTEVVGAAMNRLERPLAARPVAVAIPDELPLLSVDPILVQQLFVNLLENATKH
CHHHCCCHHHHHHHHHHHHHCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
TPPGSEIAVRAAREGGMVAIEVADRGPGLPEGEEERIFDRFQRAARPGVRGVGLGLPIAR
CCCCCHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
AIAQAHGGRLTAANRAGGGAVFRLTLPVGAPPAAPPEPPGERLPERGGGP
HHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]