Click here to switch to the map view.

The map label for this gene is zitB [H]

Identifier: 220915591

GI number: 220915591

Start: 542494

End: 543567

Strand: Direct

Name: zitB [H]

Synonym: A2cp1_0472

Alternate gene names: 220915591

Gene position: 542494-543567 (Clockwise)

Preceding gene: 220915590

Following gene: 220915597

Centisome position: 10.79

GC content: 75.33

Gene sequence:

>1074_bases
ATGCACCTCGAGGACCTCGGACCCTGGAAGCACGGCCACGCGTTCGGCACGGCGGTGGAAGCGAGCGGCGAGCGGCGCAC
GCGCTGGGTGGTGGCGCTCACGCTCGCGATGATGGTGGGCGAGATCGCCGCCGGGATGGTGTACGGCTCGATGGCGCTGC
TCGCCGACGGCTGGCACATGGGCACGCACGCGGCGGCGCTCGGCGTGGCGGCGTTCGCCTACGCCTACGCGCGGCGGCAC
GCCGCCGACCCGCGCTACAGCTTCGGCACCGGCAAGGTGGGCGCGCTGGGCGGGTTCGCGAGCGCGGTCGGCCTGGCGGT
GGTGGCGCTGCTCGTGCTCGGGGAGAGCGCCGTCCGCCTCGCCTCGCCGGTCGCGATCCGCTTCGACCAGGCCATCGGCG
TCGCGGTGCTCGGGCTGCTCGTGAACCTGTTCAGCGCGTTCCTGCTGCGCGACGAGGACCACGGGCACGCGCACGGCCAC
GGCGATCACGAGGACCACGACGACCACCCCGTGCACGACCACGGCGCGCACGGTCACGCGCACCACGACCACGACCACGA
CGCGCACGCTCACGCGGTCCACGACCCCGAGCTGGACCTGGAGGCCGAGCTCGGCATGGACGAGCACCGGGACCACAACC
TGCGCGCGGCCTACCTGCACGTGCTCGCCGACGCGCTCACCTCGGTGCTCGCGATCGTGGCGCTGCTCGCGGGCCGGGTG
CTCGGCTGGACCTGGATGGACCCGGTGATGGGGATCGTCGGCGCGCTGGTGATCGCGCGCTGGTCGGTGGGCCTGCTGCG
CGACACCGGCGCGGTCCTGCTCGACGCCGAGGTCGCGGAGGGACGCCGCGCCGCCATCCGCGCCGCGCTCGAGCAGGGCG
AGGACCGGGTGGCGGACCTGCACCTGTGGCGGGTGGGCCCGCGCCACCTCGCCGCGATCGTGTCGGTGGTCGCGACCGCG
CCGCGCGCGCCCGCCGAGTACAAGGAGCGGCTGCACGCGTTCCCGGACCTGGTGCACCTCACGGTCGAGGTGCACGCCTG
CGAGGCAGCGCCCGGCGCCCGGGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CTGGTTCCAGGCTACGCCGTCCCCGCGGCCCCGGCGGCGGTCCTGCGGGCTCGCCCGTTCGACCCGGATCCGGCGCCGCG
GGCGCTATACTGCCGCCCCC

Downstream 100 bases:

>100_bases
CTACCGCGGGCCGGGCCGCGCCTCGGCCTGCTTCGCGGACTGCTCCAGCGCCGCCTCGGCGGTGCGCAGCACCCGCGGCC
CGTCGTTGTACGCGGCCACC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MHLEDLGPWKHGHAFGTAVEASGERRTRWVVALTLAMMVGEIAAGMVYGSMALLADGWHMGTHAAALGVAAFAYAYARRH
AADPRYSFGTGKVGALGGFASAVGLAVVALLVLGESAVRLASPVAIRFDQAIGVAVLGLLVNLFSAFLLRDEDHGHAHGH
GDHEDHDDHPVHDHGAHGHAHHDHDHDAHAHAVHDPELDLEAELGMDEHRDHNLRAAYLHVLADALTSVLAIVALLAGRV
LGWTWMDPVMGIVGALVIARWSVGLLRDTGAVLLDAEVAEGRRAAIRAALEQGEDRVADLHLWRVGPRHLAAIVSVVATA
PRAPAEYKERLHAFPDLVHLTVEVHACEAAPGARAAR

Sequences:

>Translated_357_residues
MHLEDLGPWKHGHAFGTAVEASGERRTRWVVALTLAMMVGEIAAGMVYGSMALLADGWHMGTHAAALGVAAFAYAYARRH
AADPRYSFGTGKVGALGGFASAVGLAVVALLVLGESAVRLASPVAIRFDQAIGVAVLGLLVNLFSAFLLRDEDHGHAHGH
GDHEDHDDHPVHDHGAHGHAHHDHDHDAHAHAVHDPELDLEAELGMDEHRDHNLRAAYLHVLADALTSVLAIVALLAGRV
LGWTWMDPVMGIVGALVIARWSVGLLRDTGAVLLDAEVAEGRRAAIRAALEQGEDRVADLHLWRVGPRHLAAIVSVVATA
PRAPAEYKERLHAFPDLVHLTVEVHACEAAPGARAAR
>Mature_357_residues
MHLEDLGPWKHGHAFGTAVEASGERRTRWVVALTLAMMVGEIAAGMVYGSMALLADGWHMGTHAAALGVAAFAYAYARRH
AADPRYSFGTGKVGALGGFASAVGLAVVALLVLGESAVRLASPVAIRFDQAIGVAVLGLLVNLFSAFLLRDEDHGHAHGH
GDHEDHDDHPVHDHGAHGHAHHDHDHDAHAHAVHDPELDLEAELGMDEHRDHNLRAAYLHVLADALTSVLAIVALLAGRV
LGWTWMDPVMGIVGALVIARWSVGLLRDTGAVLLDAEVAEGRRAAIRAALEQGEDRVADLHLWRVGPRHLAAIVSVVATA
PRAPAEYKERLHAFPDLVHLTVEVHACEAAPGARAAR

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=304, Percent_Identity=29.6052631578947, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI222080086, Length=326, Percent_Identity=23.3128834355828, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40255009, Length=326, Percent_Identity=23.3128834355828, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786966, Length=294, Percent_Identity=29.5918367346939, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564488, Length=130, Percent_Identity=36.1538461538462, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=423, Percent_Identity=23.1678486997636, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17550440, Length=423, Percent_Identity=23.1678486997636, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=340, Percent_Identity=26.1764705882353, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=336, Percent_Identity=24.1071428571429, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24645863, Length=264, Percent_Identity=28.030303030303, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 38035; Mature: 38035

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLEDLGPWKHGHAFGTAVEASGERRTRWVVALTLAMMVGEIAAGMVYGSMALLADGWHM
CCCCCCCCCCCCCHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GTHAAALGVAAFAYAYARRHAADPRYSFGTGKVGALGGFASAVGLAVVALLVLGESAVRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
ASPVAIRFDQAIGVAVLGLLVNLFSAFLLRDEDHGHAHGHGDHEDHDDHPVHDHGAHGHA
HCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HHDHDHDAHAHAVHDPELDLEAELGMDEHRDHNLRAAYLHVLADALTSVLAIVALLAGRV
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGWTWMDPVMGIVGALVIARWSVGLLRDTGAVLLDAEVAEGRRAAIRAALEQGEDRVADL
HCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCHHHHHHHHHHCCCHHHHHH
HLWRVGPRHLAAIVSVVATAPRAPAEYKERLHAFPDLVHLTVEVHACEAAPGARAAR
HEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MHLEDLGPWKHGHAFGTAVEASGERRTRWVVALTLAMMVGEIAAGMVYGSMALLADGWHM
CCCCCCCCCCCCCHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GTHAAALGVAAFAYAYARRHAADPRYSFGTGKVGALGGFASAVGLAVVALLVLGESAVRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
ASPVAIRFDQAIGVAVLGLLVNLFSAFLLRDEDHGHAHGHGDHEDHDDHPVHDHGAHGHA
HCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HHDHDHDAHAHAVHDPELDLEAELGMDEHRDHNLRAAYLHVLADALTSVLAIVALLAGRV
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGWTWMDPVMGIVGALVIARWSVGLLRDTGAVLLDAEVAEGRRAAIRAALEQGEDRVADL
HCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCHHHHHHHHHHCCCHHHHHH
HLWRVGPRHLAAIVSVVATAPRAPAEYKERLHAFPDLVHLTVEVHACEAAPGARAAR
HEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]