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The map label for this gene is otsA [H]

Identifier: 220915597

GI number: 220915597

Start: 546990

End: 549161

Strand: Direct

Name: otsA [H]

Synonym: A2cp1_0478

Alternate gene names: 220915597

Gene position: 546990-549161 (Clockwise)

Preceding gene: 220915591

Following gene: 220915598

Centisome position: 10.88

GC content: 74.95

Gene sequence:

>2172_bases
ATGTCGCGCGTGGTGATCGTATCGAACCGGCTGCCCGTCACCGTGGAGCGCGCGGGCGAGGCCGTTCGCGTGGTGCCCAG
CGTGGGAGGCCTCGCCACGGGCCTGCGGCGGCCGCACGAGCAAGGCGGCGGGCCCTGGGTCGGCTGGCCGGGCGACCTGG
CCGGGCTGGATCCCGAGCAGCAGGCGCGCGTGGAGGCGCGGCTCTCGGACCTGCGGCTCGCGCCGGTGCACCTCACCTCC
GAGGAGGTGCAGCGCTACTACCAGGACTACTCGAACGCGCTGCTCTGGCCGGTGTTCCACTCGTTCCCCGGCGAGGTGCC
GCTGGAGATGGGCGGCGCCGCCGAGTACGAGCGGGTCAACGGGCGCTTCGCCGACGCGGTCGCAGCCACCGCGCGGCCGG
GCGACGTGATCTGGATCCACGACTACCAGCTGCTCCGGCTGCCGGCGCTCCTGCGCGAGCGGCTCCCCGAGGCGCGCATC
GGCTTCTTCCTGCACATCCCCTTCCCGTCGTCCGACCTGTTCCGCGTGCTCCCGCAGCGCGAGGCGCTGCTCGAGGGCAT
GCTCGGCGCGGATCTGATCGGGTTTCACACAGCGTCGTACATGCGCCACTTCTCCTCGTCGGTCCTGCGCGTCCTGGGCG
CCTGGACCGACGTGGACCGCATCCGCTGGCGCGGGCGCGAGGTCCGCATCGGCGTGTTCCCGATGGGCGTGGACGCGGCC
GACTTCGCCGGCACCGCGCACGGCGCCGACATGGACGAGGAGGTCCGCGCGCTCCGCCGGGACGGGAGCCGGCTCATCGT
GGGGATCGACCGGCTCGACTACACGAAGGGCATCCCCCGCCGCCTGCTCGCCTACGAGCGGCTGCTCCGCGAGCACCCGG
AGCTGCGCGGCAAGGTGCGGCTGGTGCAGGTGGCGGTCCCGTCGCGCACCGAGGTGGGCGCATACCAGGAGTTCCGGGAC
CAGGTCGACGGGCTGGTGGGCCGCATCCACGGCGCGTTCGCCACGCCGACCTGGTCGCCCATCCACTACCTCTCGCGCGG
GCTCGACCGCGCGCAGGTGGTGGCGCTGTACCGCGCCGCCGACGTCATGCTGGTCACGCCCATCCGCGACGGGATGAACC
TGGTCGCGAAGGAGTTCGTGGCCGTGCGCGACGACGGCGACGGCGTGCTGGTGCTGTCCGAGTTCACCGGCGCGGCGGCC
GAGCTGGCCGAGGCGGTGCAGGTGAACCCGTACGACGAGGCGGGCACCGCGGCGGCGATCCAGCGCGCGCTGGAGATGCC
GGAGGACGAGCGGCGCACGCGCATGACCGGGCTGCGGCGGCGCGTCACGCGCTACGACGTCCACTGGTGGGCGCGGACGT
TCCTCGAGCGGCTGCGCGAGGCCCCCGCGCCGGTGCGGCCGCAGGGGCTGGAGGTGTCGCCGCGCGCGGCCGTCCAGGAC
GCGCTCTCCCGGCTCCGCGCGGCGCCGCACGCGACGCTGCTGCTCGACTACGACGGCACGCTGGTGCCGTTCGCGCCCAC
CCCCGAGCTGGCGCGGCCGGACCGCGAGCTGCGCGACCTGCTGCGCGACCTCGCCCGCCACCCGCGCCTCGCCGTGCACC
TCGTCACCGGGCGCCAGCGCGACACGGTGGACCGCTGGTTCGGGGACCTCGGCATCGGCCTCCACGCGGAGCACGGCTTC
TGGTCGAAGCTGCCCGGCAACGGCTGGCAGCTCGCCGCCCCGGTGTCCACCGCCTGGCGCGAGCCGGCCCGCGCCATCCT
GGAGGAGTTCGCCGCGCGCACGCCGGGGTCGCTCGTGGAGGAGAAGTCGGCCGGGTTCGCCTGGCACTACCGCACCGCCG
ACCCCGACTTCGGGGCGGCGCAGGCGCACGACCTCATGCTCCACCTCTCCACGGTGCTGTCGAACGCGCCGGTGGAGATC
CTGCCCGGCGCCCTGGTGGTCGAGGTACGTCCGCAGGGCGTGGACAAGGGCAAGGTGGTCGCCCGCGCCGCCGCCGCCTC
GCCCGAGGGAAGCCTGCTCGCCGCCCTCGGGGATGACCGGACCGACGAGGACATGTTCGCGGCCCTGCCGGACGGCGCCA
TCGCGGTCCACGTCGGGCCGTCGCCGAGCCGCGCCCCGCTGCGCCTCGCCGGCGTGCCGGAGTCACGGGCGTTCCTGCGC
GGGTTGCTGTAG

Upstream 100 bases:

>100_bases
ACCAACGGACCGGGCTGGTAGGATCGACGTCACCGCGACCGGTTGCCGCGCCCCGGGCGCGCCGGGCGCGGATCTCCGGC
TCCTGCGAAGGAAAGGTGCG

Downstream 100 bases:

>100_bases
GGCGGCCGGGCCCCGGCTGGGCGGCTCAACGTCCCGGGAGCCTGGCGAGCCTGCGCCGGCGTGCCGGAGTCACGCCGGCG
GGAGCCCCGGGTGCCGGGAG

Product: bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB

Products: NA

Alternate protein names: Osmoregulatory trehalose synthesis protein A; Trehalose-6-phosphate synthase; UDP-glucose-glucosephosphate glucosyltransferase [H]

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MSRVVIVSNRLPVTVERAGEAVRVVPSVGGLATGLRRPHEQGGGPWVGWPGDLAGLDPEQQARVEARLSDLRLAPVHLTS
EEVQRYYQDYSNALLWPVFHSFPGEVPLEMGGAAEYERVNGRFADAVAATARPGDVIWIHDYQLLRLPALLRERLPEARI
GFFLHIPFPSSDLFRVLPQREALLEGMLGADLIGFHTASYMRHFSSSVLRVLGAWTDVDRIRWRGREVRIGVFPMGVDAA
DFAGTAHGADMDEEVRALRRDGSRLIVGIDRLDYTKGIPRRLLAYERLLREHPELRGKVRLVQVAVPSRTEVGAYQEFRD
QVDGLVGRIHGAFATPTWSPIHYLSRGLDRAQVVALYRAADVMLVTPIRDGMNLVAKEFVAVRDDGDGVLVLSEFTGAAA
ELAEAVQVNPYDEAGTAAAIQRALEMPEDERRTRMTGLRRRVTRYDVHWWARTFLERLREAPAPVRPQGLEVSPRAAVQD
ALSRLRAAPHATLLLDYDGTLVPFAPTPELARPDRELRDLLRDLARHPRLAVHLVTGRQRDTVDRWFGDLGIGLHAEHGF
WSKLPGNGWQLAAPVSTAWREPARAILEEFAARTPGSLVEEKSAGFAWHYRTADPDFGAAQAHDLMLHLSTVLSNAPVEI
LPGALVVEVRPQGVDKGKVVARAAAASPEGSLLAALGDDRTDEDMFAALPDGAIAVHVGPSPSRAPLRLAGVPESRAFLR
GLL

Sequences:

>Translated_723_residues
MSRVVIVSNRLPVTVERAGEAVRVVPSVGGLATGLRRPHEQGGGPWVGWPGDLAGLDPEQQARVEARLSDLRLAPVHLTS
EEVQRYYQDYSNALLWPVFHSFPGEVPLEMGGAAEYERVNGRFADAVAATARPGDVIWIHDYQLLRLPALLRERLPEARI
GFFLHIPFPSSDLFRVLPQREALLEGMLGADLIGFHTASYMRHFSSSVLRVLGAWTDVDRIRWRGREVRIGVFPMGVDAA
DFAGTAHGADMDEEVRALRRDGSRLIVGIDRLDYTKGIPRRLLAYERLLREHPELRGKVRLVQVAVPSRTEVGAYQEFRD
QVDGLVGRIHGAFATPTWSPIHYLSRGLDRAQVVALYRAADVMLVTPIRDGMNLVAKEFVAVRDDGDGVLVLSEFTGAAA
ELAEAVQVNPYDEAGTAAAIQRALEMPEDERRTRMTGLRRRVTRYDVHWWARTFLERLREAPAPVRPQGLEVSPRAAVQD
ALSRLRAAPHATLLLDYDGTLVPFAPTPELARPDRELRDLLRDLARHPRLAVHLVTGRQRDTVDRWFGDLGIGLHAEHGF
WSKLPGNGWQLAAPVSTAWREPARAILEEFAARTPGSLVEEKSAGFAWHYRTADPDFGAAQAHDLMLHLSTVLSNAPVEI
LPGALVVEVRPQGVDKGKVVARAAAASPEGSLLAALGDDRTDEDMFAALPDGAIAVHVGPSPSRAPLRLAGVPESRAFLR
GLL
>Mature_722_residues
SRVVIVSNRLPVTVERAGEAVRVVPSVGGLATGLRRPHEQGGGPWVGWPGDLAGLDPEQQARVEARLSDLRLAPVHLTSE
EVQRYYQDYSNALLWPVFHSFPGEVPLEMGGAAEYERVNGRFADAVAATARPGDVIWIHDYQLLRLPALLRERLPEARIG
FFLHIPFPSSDLFRVLPQREALLEGMLGADLIGFHTASYMRHFSSSVLRVLGAWTDVDRIRWRGREVRIGVFPMGVDAAD
FAGTAHGADMDEEVRALRRDGSRLIVGIDRLDYTKGIPRRLLAYERLLREHPELRGKVRLVQVAVPSRTEVGAYQEFRDQ
VDGLVGRIHGAFATPTWSPIHYLSRGLDRAQVVALYRAADVMLVTPIRDGMNLVAKEFVAVRDDGDGVLVLSEFTGAAAE
LAEAVQVNPYDEAGTAAAIQRALEMPEDERRTRMTGLRRRVTRYDVHWWARTFLERLREAPAPVRPQGLEVSPRAAVQDA
LSRLRAAPHATLLLDYDGTLVPFAPTPELARPDRELRDLLRDLARHPRLAVHLVTGRQRDTVDRWFGDLGIGLHAEHGFW
SKLPGNGWQLAAPVSTAWREPARAILEEFAARTPGSLVEEKSAGFAWHYRTADPDFGAAQAHDLMLHLSTVLSNAPVEIL
PGALVVEVRPQGVDKGKVVARAAAASPEGSLLAALGDDRTDEDMFAALPDGAIAVHVGPSPSRAPLRLAGVPESRAFLRG
LL

Specific function: Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor [H]

COG id: COG0380

COG function: function code G; Trehalose-6-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 20 family [H]

Homologues:

Organism=Escherichia coli, GI1788206, Length=493, Percent_Identity=37.7281947261663, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1788207, Length=232, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987012, Length=431, Percent_Identity=31.7865429234339, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI115533558, Length=387, Percent_Identity=32.0413436692506, Blast_Score=188, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI115533560, Length=387, Percent_Identity=32.0413436692506, Blast_Score=188, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319602, Length=465, Percent_Identity=39.7849462365591, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320279, Length=691, Percent_Identity=31.1143270622287, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323537, Length=624, Percent_Identity=31.5705128205128, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6323917, Length=583, Percent_Identity=30.3602058319039, Blast_Score=277, Evalue=3e-75,
Organism=Drosophila melanogaster, GI19920676, Length=727, Percent_Identity=35.0756533700138, Blast_Score=387, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001830
- InterPro:   IPR012766 [H]

Pfam domain/function: PF00982 Glyco_transf_20 [H]

EC number: =2.4.1.15 [H]

Molecular weight: Translated: 79698; Mature: 79567

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVVIVSNRLPVTVERAGEAVRVVPSVGGLATGLRRPHEQGGGPWVGWPGDLAGLDPEQ
CCEEEEECCCCCEEEECCCCEEEEECCCCHHHHHHCCCHHCCCCCCCCCCCCCCCCCCHH
QARVEARLSDLRLAPVHLTSEEVQRYYQDYSNALLWPVFHSFPGEVPLEMGGAAEYERVN
HHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCEEEHHHHCCCCCCCCCCCCCCHHHHHC
GRFADAVAATARPGDVIWIHDYQLLRLPALLRERLPEARIGFFLHIPFPSSDLFRVLPQR
CCHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCHH
EALLEGMLGADLIGFHTASYMRHFSSSVLRVLGAWTDVDRIRWRGREVRIGVFPMGVDAA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEECCCCHH
DFAGTAHGADMDEEVRALRRDGSRLIVGIDRLDYTKGIPRRLLAYERLLREHPELRGKVR
HHCCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCCCEE
LVQVAVPSRTEVGAYQEFRDQVDGLVGRIHGAFATPTWSPIHYLSRGLDRAQVVALYRAA
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHC
DVMLVTPIRDGMNLVAKEFVAVRDDGDGVLVLSEFTGAAAELAEAVQVNPYDEAGTAAAI
CEEEEECCHHHHHHHHHHHEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHH
QRALEMPEDERRTRMTGLRRRVTRYDVHWWARTFLERLREAPAPVRPQGLEVSPRAAVQD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
ALSRLRAAPHATLLLDYDGTLVPFAPTPELARPDRELRDLLRDLARHPRLAVHLVTGRQR
HHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCC
DTVDRWFGDLGIGLHAEHGFWSKLPGNGWQLAAPVSTAWREPARAILEEFAARTPGSLVE
HHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCHHHH
EKSAGFAWHYRTADPDFGAAQAHDLMLHLSTVLSNAPVEILPGALVVEVRPQGVDKGKVV
HCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCEEEEEECCCCCCCCHHH
ARAAAASPEGSLLAALGDDRTDEDMFAALPDGAIAVHVGPSPSRAPLRLAGVPESRAFLR
HHHHCCCCCCCEEEECCCCCCCCCCEEECCCCEEEEEECCCCCCCCEEEECCCCHHHHHH
GLL
CCC
>Mature Secondary Structure 
SRVVIVSNRLPVTVERAGEAVRVVPSVGGLATGLRRPHEQGGGPWVGWPGDLAGLDPEQ
CEEEEECCCCCEEEECCCCEEEEECCCCHHHHHHCCCHHCCCCCCCCCCCCCCCCCCHH
QARVEARLSDLRLAPVHLTSEEVQRYYQDYSNALLWPVFHSFPGEVPLEMGGAAEYERVN
HHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCEEEHHHHCCCCCCCCCCCCCCHHHHHC
GRFADAVAATARPGDVIWIHDYQLLRLPALLRERLPEARIGFFLHIPFPSSDLFRVLPQR
CCHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCHH
EALLEGMLGADLIGFHTASYMRHFSSSVLRVLGAWTDVDRIRWRGREVRIGVFPMGVDAA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEECCCCHH
DFAGTAHGADMDEEVRALRRDGSRLIVGIDRLDYTKGIPRRLLAYERLLREHPELRGKVR
HHCCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCCCEE
LVQVAVPSRTEVGAYQEFRDQVDGLVGRIHGAFATPTWSPIHYLSRGLDRAQVVALYRAA
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHC
DVMLVTPIRDGMNLVAKEFVAVRDDGDGVLVLSEFTGAAAELAEAVQVNPYDEAGTAAAI
CEEEEECCHHHHHHHHHHHEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHH
QRALEMPEDERRTRMTGLRRRVTRYDVHWWARTFLERLREAPAPVRPQGLEVSPRAAVQD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
ALSRLRAAPHATLLLDYDGTLVPFAPTPELARPDRELRDLLRDLARHPRLAVHLVTGRQR
HHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCC
DTVDRWFGDLGIGLHAEHGFWSKLPGNGWQLAAPVSTAWREPARAILEEFAARTPGSLVE
HHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCHHHH
EKSAGFAWHYRTADPDFGAAQAHDLMLHLSTVLSNAPVEILPGALVVEVRPQGVDKGKVV
HCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCEEEEEECCCCCCCCHHH
ARAAAASPEGSLLAALGDDRTDEDMFAALPDGAIAVHVGPSPSRAPLRLAGVPESRAFLR
HHHHCCCCCCCEEEECCCCCCCCCCEEECCCCEEEEEECCCCCCCCEEEECCCCHHHHHH
GLL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA