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The map label for this gene is nuoL [H]

Identifier: 220915561

GI number: 220915561

Start: 500388

End: 502418

Strand: Direct

Name: nuoL [H]

Synonym: A2cp1_0442

Alternate gene names: 220915561

Gene position: 500388-502418 (Clockwise)

Preceding gene: 220915559

Following gene: 220915562

Centisome position: 9.95

GC content: 70.11

Gene sequence:

>2031_bases
ATGCCCTCGATCGTACCCTCTCCCGCTGCGGCAGAGTCCTATCTGTGGGCCATCATCCTGTTCCCGCTCGCGGGCGCCAT
CGTCAACGGTCTCACCGGCCGCAGGCTCGGTCGCGGGAACGTGACGGTGATCGCGATCGGCGTGATGGTGGGCGCGTTCC
TCGTCTCGTCGGTCGCGTTCTACCACGCGCTGACGGGCACCGTGCTCCGCTTCCGCGGTGATCCCTGGATCCAGGTGACC
GGCGCCGACGGGCGCACGATCATCTCGATCGGCTGGGGCCTGCTCGTGGACCGCCTGTCGGCGACGATGATCATGGTCGT
CACCGGCGTGGGCACGCTCATCCACGTCTACTCGGCGTCGTACATGTCGCACGAGGACGACGCGGGCTACGCGCGCTTCT
TCACGTACCTGAACCTGTTCGTCGCGGCGATGCTCACGCTCGTCCTCGGCGACTCGCTCATCCTCACCTTCGTCGGGTGG
GAGGGCGTGGGCCTCTGCAGCTACCTGCTGATCGGGTTCTGGTACACCGACCCGGCCAAGGCGTACGCCGGCCGCAAGGC
GTTCGTCACCAACCGCATCGGCGACTTCGGGTTCCTCATCGGGGTGTTCGCGCTGTTCTCGATCTTCGGGACGGTGGGCT
ACGCCGACCTCTCCGCGATCGCGCACGGCGTGGACCCCTCCGCGGCGATCCAGACCGGCGTGTTCGCCGGCCGCACCTAC
CAGGCGGCCGTCACGTTCGCGCTGATCGGCCTGTTCGTGGGCGCGTGCGGCAAGAGCGCCCAGCTGCCGCTCTACGTGTG
GCTCCCCGACGCGATGGCCGGCCCGACGCCGGTCTCCGCCCTGATCCACGCCGCCACCATGGTGACCGCCGGCGTGTACC
TGGTGGCGCGCAACGCGTACCTGTTCTCGCTCGCCCCCGCCGCCATGGCCACGGTGACGCTGGTGGGCGCGCTCACCGCG
CTGTTCGCGGCGCTGATCGCGTTCGTCCAGACCGACATCAAGAAGGTCCTCGCCTACTCCACGGTGAGCCAGCTCGGCTT
CATGTTCATCGGCGTCGGCGTCGGCGCCTGGTGGGCCGGCGTGCTGCACCTCGTCACCCACGCGTTCTTCAAGGCATGCC
TGTTCCTCGGTGCCGGCTCGGTCATGCACGGCATGAACGAGGACACCGACATCCGGAACATGGGCGGCCTGGCGAAGAAG
ATGCCGCACACCGCGGCGACGTTCGGCATCGCCACCCTGGCCATCACCGGCTTCGTGCCGCTGTCCGGCTTCTTCTCGAA
GGACGCCATCCTCGGGAACGCGCTGTTCAGCCACAACCCGGCCTGGCACCAGGTCGGCCAGATCGCGTACGTGCTCGGCT
CGCTCGCCGCGCTCGGCACCGCGTTCTACATGTCGCGCCTGTTCTTCCTGACCTTCACCGGCAAGCCGCGCACCGCGGCG
GCCGCGCACGCGCACGAGTCCTCGCCGGTCATGTACGTGCCGCTGTGGGTGCTCGCGATCCTCTCGATCGTGGCGCTGCT
GCTCGGCCTCCCCGGCCACGGCCCGCTCGCCGAGGTGTTCGCGCGCTACACCGAGCCGGTGTTCGCCGCCGGCACCGAGC
GGCTCCACGAGGTCGGCCACCTGCACGCCGGCGCGCACCCGGCCTGGCCGTTCGCGGTGGCCTGGGGCCTCGCGGCGGTG
GGCACGCTCGTCGCGTTCCTCATGTACGCGGGCGCGCTCCGCTCCGCCCCGGCCGCCCTGGCCCGCACGTTCCCGCGCCT
GTACCAGCTCGCGGTGGACAAGTTCCGGGTGGACGAGCTGTACCAGATGGTCGTCATCGAGCCGCTCAAGACCGCCGCCT
ACCTGCTCTGGCGCATCGTGGACGTGTTCGCCATCGACGGCCTGGTGGTGAACGGCGTGGCGCGGCTGGTGGGCTACGCG
GGGGCGGTGCTCCGGCTGGCCCAGAACGGCGACGTGCAGCGCTACGCCGCGATCATGGTGGTCGCCGCCGCCGTCATCCT
CTGGACCGTGGTCGGCGCAGGAGGGCGCTAG

Upstream 100 bases:

>100_bases
GCGAATTTTGGAGTGGTCATGTCCGCATGCTCCGGGAGGTTTTCGGCCGACAAGACCCTTGCTAGAGCGGCTCTATGAAG
GTAATCCTTCGCCCCACTCT

Downstream 100 bases:

>100_bases
CTCGTGAACCTGCTCACCGTCGTCACCTTCCTCCCGCTCCTGGGCGCGCTCGCGATGGTGCTCGTCCCGCGGGACGAGCC
GTCGCAGCACCGGGCGCTGG

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MPSIVPSPAAAESYLWAIILFPLAGAIVNGLTGRRLGRGNVTVIAIGVMVGAFLVSSVAFYHALTGTVLRFRGDPWIQVT
GADGRTIISIGWGLLVDRLSATMIMVVTGVGTLIHVYSASYMSHEDDAGYARFFTYLNLFVAAMLTLVLGDSLILTFVGW
EGVGLCSYLLIGFWYTDPAKAYAGRKAFVTNRIGDFGFLIGVFALFSIFGTVGYADLSAIAHGVDPSAAIQTGVFAGRTY
QAAVTFALIGLFVGACGKSAQLPLYVWLPDAMAGPTPVSALIHAATMVTAGVYLVARNAYLFSLAPAAMATVTLVGALTA
LFAALIAFVQTDIKKVLAYSTVSQLGFMFIGVGVGAWWAGVLHLVTHAFFKACLFLGAGSVMHGMNEDTDIRNMGGLAKK
MPHTAATFGIATLAITGFVPLSGFFSKDAILGNALFSHNPAWHQVGQIAYVLGSLAALGTAFYMSRLFFLTFTGKPRTAA
AAHAHESSPVMYVPLWVLAILSIVALLLGLPGHGPLAEVFARYTEPVFAAGTERLHEVGHLHAGAHPAWPFAVAWGLAAV
GTLVAFLMYAGALRSAPAALARTFPRLYQLAVDKFRVDELYQMVVIEPLKTAAYLLWRIVDVFAIDGLVVNGVARLVGYA
GAVLRLAQNGDVQRYAAIMVVAAAVILWTVVGAGGR

Sequences:

>Translated_676_residues
MPSIVPSPAAAESYLWAIILFPLAGAIVNGLTGRRLGRGNVTVIAIGVMVGAFLVSSVAFYHALTGTVLRFRGDPWIQVT
GADGRTIISIGWGLLVDRLSATMIMVVTGVGTLIHVYSASYMSHEDDAGYARFFTYLNLFVAAMLTLVLGDSLILTFVGW
EGVGLCSYLLIGFWYTDPAKAYAGRKAFVTNRIGDFGFLIGVFALFSIFGTVGYADLSAIAHGVDPSAAIQTGVFAGRTY
QAAVTFALIGLFVGACGKSAQLPLYVWLPDAMAGPTPVSALIHAATMVTAGVYLVARNAYLFSLAPAAMATVTLVGALTA
LFAALIAFVQTDIKKVLAYSTVSQLGFMFIGVGVGAWWAGVLHLVTHAFFKACLFLGAGSVMHGMNEDTDIRNMGGLAKK
MPHTAATFGIATLAITGFVPLSGFFSKDAILGNALFSHNPAWHQVGQIAYVLGSLAALGTAFYMSRLFFLTFTGKPRTAA
AAHAHESSPVMYVPLWVLAILSIVALLLGLPGHGPLAEVFARYTEPVFAAGTERLHEVGHLHAGAHPAWPFAVAWGLAAV
GTLVAFLMYAGALRSAPAALARTFPRLYQLAVDKFRVDELYQMVVIEPLKTAAYLLWRIVDVFAIDGLVVNGVARLVGYA
GAVLRLAQNGDVQRYAAIMVVAAAVILWTVVGAGGR
>Mature_675_residues
PSIVPSPAAAESYLWAIILFPLAGAIVNGLTGRRLGRGNVTVIAIGVMVGAFLVSSVAFYHALTGTVLRFRGDPWIQVTG
ADGRTIISIGWGLLVDRLSATMIMVVTGVGTLIHVYSASYMSHEDDAGYARFFTYLNLFVAAMLTLVLGDSLILTFVGWE
GVGLCSYLLIGFWYTDPAKAYAGRKAFVTNRIGDFGFLIGVFALFSIFGTVGYADLSAIAHGVDPSAAIQTGVFAGRTYQ
AAVTFALIGLFVGACGKSAQLPLYVWLPDAMAGPTPVSALIHAATMVTAGVYLVARNAYLFSLAPAAMATVTLVGALTAL
FAALIAFVQTDIKKVLAYSTVSQLGFMFIGVGVGAWWAGVLHLVTHAFFKACLFLGAGSVMHGMNEDTDIRNMGGLAKKM
PHTAATFGIATLAITGFVPLSGFFSKDAILGNALFSHNPAWHQVGQIAYVLGSLAALGTAFYMSRLFFLTFTGKPRTAAA
AHAHESSPVMYVPLWVLAILSIVALLLGLPGHGPLAEVFARYTEPVFAAGTERLHEVGHLHAGAHPAWPFAVAWGLAAVG
TLVAFLMYAGALRSAPAALARTFPRLYQLAVDKFRVDELYQMVVIEPLKTAAYLLWRIVDVFAIDGLVVNGVARLVGYAG
AVLRLAQNGDVQRYAAIMVVAAAVILWTVVGAGGR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=406, Percent_Identity=38.9162561576355, Blast_Score=256, Evalue=6e-68,
Organism=Escherichia coli, GI1788614, Length=653, Percent_Identity=40.1225114854518, Blast_Score=355, Evalue=8e-99,
Organism=Escherichia coli, GI1788829, Length=513, Percent_Identity=30.7992202729045, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1788827, Length=435, Percent_Identity=29.1954022988506, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1788831, Length=372, Percent_Identity=29.0322580645161, Blast_Score=122, Evalue=9e-29,
Organism=Escherichia coli, GI2367154, Length=486, Percent_Identity=24.2798353909465, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788613, Length=358, Percent_Identity=28.4916201117318, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71476; Mature: 71345

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIVPSPAAAESYLWAIILFPLAGAIVNGLTGRRLGRGNVTVIAIGVMVGAFLVSSVAF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
YHALTGTVLRFRGDPWIQVTGADGRTIISIGWGLLVDRLSATMIMVVTGVGTLIHVYSAS
HHHHHHHHEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMSHEDDAGYARFFTYLNLFVAAMLTLVLGDSLILTFVGWEGVGLCSYLLIGFWYTDPAK
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHCCCHHH
AYAGRKAFVTNRIGDFGFLIGVFALFSIFGTVGYADLSAIAHGVDPSAAIQTGVFAGRTY
HHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCHH
QAAVTFALIGLFVGACGKSAQLPLYVWLPDAMAGPTPVSALIHAATMVTAGVYLVARNAY
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
LFSLAPAAMATVTLVGALTALFAALIAFVQTDIKKVLAYSTVSQLGFMFIGVGVGAWWAG
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLHLVTHAFFKACLFLGAGSVMHGMNEDTDIRNMGGLAKKMPHTAATFGIATLAITGFVP
HHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHHH
LSGFFSKDAILGNALFSHNPAWHQVGQIAYVLGSLAALGTAFYMSRLFFLTFTGKPRTAA
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
AAHAHESSPVMYVPLWVLAILSIVALLLGLPGHGPLAEVFARYTEPVFAAGTERLHEVGH
HHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
LHAGAHPAWPFAVAWGLAAVGTLVAFLMYAGALRSAPAALARTFPRLYQLAVDKFRVDEL
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YQMVVIEPLKTAAYLLWRIVDVFAIDGLVVNGVARLVGYAGAVLRLAQNGDVQRYAAIMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAAAVILWTVVGAGGR
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSIVPSPAAAESYLWAIILFPLAGAIVNGLTGRRLGRGNVTVIAIGVMVGAFLVSSVAF
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
YHALTGTVLRFRGDPWIQVTGADGRTIISIGWGLLVDRLSATMIMVVTGVGTLIHVYSAS
HHHHHHHHEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMSHEDDAGYARFFTYLNLFVAAMLTLVLGDSLILTFVGWEGVGLCSYLLIGFWYTDPAK
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHCCCHHH
AYAGRKAFVTNRIGDFGFLIGVFALFSIFGTVGYADLSAIAHGVDPSAAIQTGVFAGRTY
HHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCHH
QAAVTFALIGLFVGACGKSAQLPLYVWLPDAMAGPTPVSALIHAATMVTAGVYLVARNAY
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
LFSLAPAAMATVTLVGALTALFAALIAFVQTDIKKVLAYSTVSQLGFMFIGVGVGAWWAG
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLHLVTHAFFKACLFLGAGSVMHGMNEDTDIRNMGGLAKKMPHTAATFGIATLAITGFVP
HHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHHH
LSGFFSKDAILGNALFSHNPAWHQVGQIAYVLGSLAALGTAFYMSRLFFLTFTGKPRTAA
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
AAHAHESSPVMYVPLWVLAILSIVALLLGLPGHGPLAEVFARYTEPVFAAGTERLHEVGH
HHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
LHAGAHPAWPFAVAWGLAAVGTLVAFLMYAGALRSAPAALARTFPRLYQLAVDKFRVDEL
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YQMVVIEPLKTAAYLLWRIVDVFAIDGLVVNGVARLVGYAGAVLRLAQNGDVQRYAAIMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAAAVILWTVVGAGGR
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA