Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 220915266

GI number: 220915266

Start: 160994

End: 161521

Strand: Direct

Name: hpt [H]

Synonym: A2cp1_0145

Alternate gene names: 220915266

Gene position: 160994-161521 (Clockwise)

Preceding gene: 220915265

Following gene: 220915267

Centisome position: 3.2

GC content: 68.18

Gene sequence:

>528_bases
ATGTCTAGCAGCCGCGCCGGCCTCGACGTGCTCATCTCCGAGGCGGACCTCCGGGCCCGCGTCGCGCAGATGGGCGCCGA
CATCACCCGCGACTACGCGGGGAAGAACCTCGTCGTCATCGGCGTGCTGAAGGGCAGCTTCATCTTCCTCGCCGACCTGG
TGCGCGCGGTCGACCTGCCGCTGTCGGTGGACTTCATCGGCATCAGCTCGTACCAGGGCACCCGCACCACCGGCGTCGTC
CAGATCACGAGCGACCTCACCCGGCCCATCGACGGCAAGGACGTGCTGCTCGTCGAGGACATCATCGACACCGGCCTCAC
CATGCGGTACCTGCTCGAGAACCTCTCGACCCGCAAGCCGGCCAGCGTGCGCATCGCCGCGCTCCTCGAGAAGCCCGCGC
GCGCGCAGGTGAAGATCCCCATCGACTACCGCGGCTTCGTCATCGGCGACGAGTTCGTGGTCGGCTACGGGCTCGACTGG
GACGGCAAGATGCGGAACCTGCCGTTCATCGGGGTGCCGCGGACCTGA

Upstream 100 bases:

>100_bases
ACCGTCCCCGGCACGCGCTGGGACGAGGAGCGCGGGCTCGACGACCACCAGTACATCGTCCCCGGGGGCGGCGGCTTCGG
GGAGATCATGAACAACGCCT

Downstream 100 bases:

>100_bases
GCCGCGGGCGCGGCGCCGTCGCGCAGCCCCTCTCTCTCGGCAACCGGAGGACCTTCGACATGGCGGACGAGACCCCGCGC
GCGCGCGCCGGATCCGGCGT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MSSSRAGLDVLISEADLRARVAQMGADITRDYAGKNLVVIGVLKGSFIFLADLVRAVDLPLSVDFIGISSYQGTRTTGVV
QITSDLTRPIDGKDVLLVEDIIDTGLTMRYLLENLSTRKPASVRIAALLEKPARAQVKIPIDYRGFVIGDEFVVGYGLDW
DGKMRNLPFIGVPRT

Sequences:

>Translated_175_residues
MSSSRAGLDVLISEADLRARVAQMGADITRDYAGKNLVVIGVLKGSFIFLADLVRAVDLPLSVDFIGISSYQGTRTTGVV
QITSDLTRPIDGKDVLLVEDIIDTGLTMRYLLENLSTRKPASVRIAALLEKPARAQVKIPIDYRGFVIGDEFVVGYGLDW
DGKMRNLPFIGVPRT
>Mature_174_residues
SSSRAGLDVLISEADLRARVAQMGADITRDYAGKNLVVIGVLKGSFIFLADLVRAVDLPLSVDFIGISSYQGTRTTGVVQ
ITSDLTRPIDGKDVLLVEDIIDTGLTMRYLLENLSTRKPASVRIAALLEKPARAQVKIPIDYRGFVIGDEFVVGYGLDWD
GKMRNLPFIGVPRT

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=173, Percent_Identity=36.9942196531792, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=36.4161849710983, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI87081689, Length=170, Percent_Identity=48.2352941176471, Blast_Score=163, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17510817, Length=172, Percent_Identity=38.3720930232558, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19084; Mature: 18953

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSRAGLDVLISEADLRARVAQMGADITRDYAGKNLVVIGVLKGSFIFLADLVRAVDLP
CCCCCCCEEEEEECHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCC
LSVDFIGISSYQGTRTTGVVQITSDLTRPIDGKDVLLVEDIIDTGLTMRYLLENLSTRKP
CEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHCCCCC
ASVRIAALLEKPARAQVKIPIDYRGFVIGDEFVVGYGLDWDGKMRNLPFIGVPRT
CCEEEEEECCCCCCCEEEEEECCCCEEECCCEEEEECCCCCCCCCCCCEEECCCC
>Mature Secondary Structure 
SSSRAGLDVLISEADLRARVAQMGADITRDYAGKNLVVIGVLKGSFIFLADLVRAVDLP
CCCCCCEEEEEECHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCC
LSVDFIGISSYQGTRTTGVVQITSDLTRPIDGKDVLLVEDIIDTGLTMRYLLENLSTRKP
CEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHCCCCC
ASVRIAALLEKPARAQVKIPIDYRGFVIGDEFVVGYGLDWDGKMRNLPFIGVPRT
CCEEEEEECCCCCCCEEEEEECCCCEEECCCEEEEECCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]