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The map label for this gene is 220905612

Identifier: 220905612

GI number: 220905612

Start: 2832835

End: 2834619

Strand: Reverse

Name: 220905612

Synonym: Ddes_2352

Alternate gene names: NA

Gene position: 2834619-2832835 (Counterclockwise)

Preceding gene: 220905613

Following gene: 220905605

Centisome position: 98.65

GC content: 33.56

Gene sequence:

>1785_bases
ATGAAAGATATAGCAAAACGTATTGATCTATTTAGAAAGGCAAAGACAAAGCAAGAGCTGGCCGCATCTATCGGGTATAA
CTATAAATTTATTGTATACTTTATATACGCAAAAGATGTTGAAGCCCACTATACAGAATACAATATATCAAAAAAATACA
AAGGCGAGAGGGTTATTTCAGCGCCAAATGAAAAGCTAAAGCAAATACAAAAAAATATTGCTGAAATATTACTCAATATT
TATAGCCCTAAGCATTGTGTCAACTCTTTCGTTAAGGGGAAAAATGTTGCCACTAATGCAAAGCCACATTTACAAGCACG
GCATGTTTTACGGCTCGACCTTGAGAATTTTTTCCCGTCGATCCATTTTGGACGTGTTCGTAACTTATTTGAAGCAGTGT
TTGAATTTCCTCGAGATGTATCAACTCTTCTTGCTAGAATTTGCTGCTATAAAGGCAGCTTGCCGCAAGGAGCGCCCACG
TCACCTATCATATCAAACATGATTTGCCTCAGGCTAGATGCACAACTAACACGTCTAGCAAATAGTTGCCACTGCAAATA
CACTCGATATGCCGATGATATTACATTTTCGACAAAAAAAGAGTCATTCAATGAAAAAATTTTGCAGTCTCACAATCCAC
TTGTTATATCAAATAAAATTATCGATATAATAGAGTGCAACAACTACTTCAAAATCAACAAAAATAAAACACATCTTTGC
TCAAACAATGATAGCAAATTTATAACTGGCGTTAAGGTAAATAAAATACTTAACATCTCAAGAAGTAAATACCGAGAAAT
TCGCGCAATGCTTCATGCCGTAAGAGAATATGGACATGACAAAGCCCTTGCTGAGCACATTGAAAACTATTCAAGAAGAA
AAACAACCATTCAGAGAAAAAACTTTTTTAATATAATACAAGGAAAAATTTCGTATTTGAGCATGGTAAGAGGGAAAAAT
GATGAGATTGTTGCAAAATTAAAAATACAACTTTCTCAACTGCGAGAAGTTTATGGCTATAAGTGCAATAAAATTTCAGT
TGAACACGCTCAAAATATAATTTCAAATCAATTTATTCTTATATTTACAGAAGGCAAAACAGATAGGATGTATTTATCTT
TTGCTTTTAGGAAATTGCGAAGTCAGGGACATTTTCGCAATCTTAAACTTTTATTTTATATTTGGCCATCTTCTGAAGGA
TCTAGTGCTGGCATAAACGACTTGATTGCTTTATCAAGGAAAGGTTATTTTCGAAAATATTCATCTTGTCCCAAGATTTA
CATTTTTGACAGGGATGTTGATAAACCTCAAAATTATGTGAATACAACAATTGTAGAAGGAGAGAAGCACGAGGGACCTA
GATATTGGGGAGAAAACACATGGTCGCTTCTTTTGCATGAGCCAGAATTCCGTACTGGCTATGGCAATAGTATTTCTACA
GAGCATTTCTTTTCTGATGCTATTATTTTTGCTCCAGATGAAGAAGGAAGGCGCTTATACTGCTGTTCGCAGTTTGATGA
AGGAACTCCCATAGACGAAAAAAATGAAAACAGCAAAAAAACATTCAAACTTAAAGAGAATGCCGAAGTATATTTCGAAA
GTAAAAAAAAGAAAGGCAAATTTGTAATTATGGATGATGGAATTTTTTCCAATGGAAAGAATATTGCTCGATCTAAATTC
AGTCTTGCTAAATCTATTTTATGCTCAAATAAGATCGAAGATACAACATTAAAAGAGTTTAAAAAAATATTTGATACTAT
TGATGGAATTGCAAAAAAGTTTTAA

Upstream 100 bases:

>100_bases
GTATTGGATAATCATTTGCCCTGCTTTCCAGGCCAGGATGGGTTACGCCATGTGCGATAGGCTCGCTCCGGGAAATGAAT
GAACACCCCTGCCCACAGTT

Downstream 100 bases:

>100_bases
GTACGCACATCGAATTATGAAAATATAACTATTTTACTAAGCTGCAAAATGTAGAAGAGGACATAGACGCCTTTTCTTGC
GCATTTAATTCACTATGCAT

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: ORF4-EC67 RT; RNA-directed DNA polymerase; Reverse transcriptase; Ribonuclease H; RNase H [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MKDIAKRIDLFRKAKTKQELAASIGYNYKFIVYFIYAKDVEAHYTEYNISKKYKGERVISAPNEKLKQIQKNIAEILLNI
YSPKHCVNSFVKGKNVATNAKPHLQARHVLRLDLENFFPSIHFGRVRNLFEAVFEFPRDVSTLLARICCYKGSLPQGAPT
SPIISNMICLRLDAQLTRLANSCHCKYTRYADDITFSTKKESFNEKILQSHNPLVISNKIIDIIECNNYFKINKNKTHLC
SNNDSKFITGVKVNKILNISRSKYREIRAMLHAVREYGHDKALAEHIENYSRRKTTIQRKNFFNIIQGKISYLSMVRGKN
DEIVAKLKIQLSQLREVYGYKCNKISVEHAQNIISNQFILIFTEGKTDRMYLSFAFRKLRSQGHFRNLKLLFYIWPSSEG
SSAGINDLIALSRKGYFRKYSSCPKIYIFDRDVDKPQNYVNTTIVEGEKHEGPRYWGENTWSLLLHEPEFRTGYGNSIST
EHFFSDAIIFAPDEEGRRLYCCSQFDEGTPIDEKNENSKKTFKLKENAEVYFESKKKKGKFVIMDDGIFSNGKNIARSKF
SLAKSILCSNKIEDTTLKEFKKIFDTIDGIAKKF

Sequences:

>Translated_594_residues
MKDIAKRIDLFRKAKTKQELAASIGYNYKFIVYFIYAKDVEAHYTEYNISKKYKGERVISAPNEKLKQIQKNIAEILLNI
YSPKHCVNSFVKGKNVATNAKPHLQARHVLRLDLENFFPSIHFGRVRNLFEAVFEFPRDVSTLLARICCYKGSLPQGAPT
SPIISNMICLRLDAQLTRLANSCHCKYTRYADDITFSTKKESFNEKILQSHNPLVISNKIIDIIECNNYFKINKNKTHLC
SNNDSKFITGVKVNKILNISRSKYREIRAMLHAVREYGHDKALAEHIENYSRRKTTIQRKNFFNIIQGKISYLSMVRGKN
DEIVAKLKIQLSQLREVYGYKCNKISVEHAQNIISNQFILIFTEGKTDRMYLSFAFRKLRSQGHFRNLKLLFYIWPSSEG
SSAGINDLIALSRKGYFRKYSSCPKIYIFDRDVDKPQNYVNTTIVEGEKHEGPRYWGENTWSLLLHEPEFRTGYGNSIST
EHFFSDAIIFAPDEEGRRLYCCSQFDEGTPIDEKNENSKKTFKLKENAEVYFESKKKKGKFVIMDDGIFSNGKNIARSKF
SLAKSILCSNKIEDTTLKEFKKIFDTIDGIAKKF
>Mature_594_residues
MKDIAKRIDLFRKAKTKQELAASIGYNYKFIVYFIYAKDVEAHYTEYNISKKYKGERVISAPNEKLKQIQKNIAEILLNI
YSPKHCVNSFVKGKNVATNAKPHLQARHVLRLDLENFFPSIHFGRVRNLFEAVFEFPRDVSTLLARICCYKGSLPQGAPT
SPIISNMICLRLDAQLTRLANSCHCKYTRYADDITFSTKKESFNEKILQSHNPLVISNKIIDIIECNNYFKINKNKTHLC
SNNDSKFITGVKVNKILNISRSKYREIRAMLHAVREYGHDKALAEHIENYSRRKTTIQRKNFFNIIQGKISYLSMVRGKN
DEIVAKLKIQLSQLREVYGYKCNKISVEHAQNIISNQFILIFTEGKTDRMYLSFAFRKLRSQGHFRNLKLLFYIWPSSEG
SSAGINDLIALSRKGYFRKYSSCPKIYIFDRDVDKPQNYVNTTIVEGEKHEGPRYWGENTWSLLLHEPEFRTGYGNSIST
EHFFSDAIIFAPDEEGRRLYCCSQFDEGTPIDEKNENSKKTFKLKENAEVYFESKKKKGKFVIMDDGIFSNGKNIARSKF
SLAKSILCSNKIEDTTLKEFKKIFDTIDGIAKKF

Specific function: Participates in the synthesis of a msDNA (a branched RNA linked by a 2',5'-phosphodiester linkage to a single-stranded DNA) of unknown function. The retron transcript serves as primer and template to the reaction, and codes for the RT [H]

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000123
- InterPro:   IPR000477 [H]

Pfam domain/function: PF00078 RVT_1 [H]

EC number: =2.7.7.49; =3.1.26.4 [H]

Molecular weight: Translated: 68880; Mature: 68880

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIAKRIDLFRKAKTKQELAASIGYNYKFIVYFIYAKDVEAHYTEYNISKKYKGERVIS
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHEECCCHHCCCCEEEC
APNEKLKQIQKNIAEILLNIYSPKHCVNSFVKGKNVATNAKPHLQARHVLRLDLENFFPS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEEHHHHCCC
IHFGRVRNLFEAVFEFPRDVSTLLARICCYKGSLPQGAPTSPIISNMICLRLDAQLTRLA
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEEECHHHHHHH
NSCHCKYTRYADDITFSTKKESFNEKILQSHNPLVISNKIIDIIECNNYFKINKNKTHLC
HHCCCEEEECCCCCEECCCHHHHHHHHHHCCCCEEEECCEEEEEECCCEEEECCCCEEEE
SNNDSKFITGVKVNKILNISRSKYREIRAMLHAVREYGHDKALAEHIENYSRRKTTIQRK
CCCCCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NFFNIIQGKISYLSMVRGKNDEIVAKLKIQLSQLREVYGYKCNKISVEHAQNIISNQFIL
HHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCEEE
IFTEGKTDRMYLSFAFRKLRSQGHFRNLKLLFYIWPSSEGSSAGINDLIALSRKGYFRKY
EEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHH
SSCPKIYIFDRDVDKPQNYVNTTIVEGEKHEGPRYWGENTWSLLLHEPEFRTGYGNSIST
CCCCEEEEEECCCCCCCHHHCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
EHFFSDAIIFAPDEEGRRLYCCSQFDEGTPIDEKNENSKKTFKLKENAEVYFESKKKKGK
HHHHCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCC
FVIMDDGIFSNGKNIARSKFSLAKSILCSNKIEDTTLKEFKKIFDTIDGIAKKF
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKDIAKRIDLFRKAKTKQELAASIGYNYKFIVYFIYAKDVEAHYTEYNISKKYKGERVIS
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHEECCCHHCCCCEEEC
APNEKLKQIQKNIAEILLNIYSPKHCVNSFVKGKNVATNAKPHLQARHVLRLDLENFFPS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEEHHHHCCC
IHFGRVRNLFEAVFEFPRDVSTLLARICCYKGSLPQGAPTSPIISNMICLRLDAQLTRLA
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEEECHHHHHHH
NSCHCKYTRYADDITFSTKKESFNEKILQSHNPLVISNKIIDIIECNNYFKINKNKTHLC
HHCCCEEEECCCCCEECCCHHHHHHHHHHCCCCEEEECCEEEEEECCCEEEECCCCEEEE
SNNDSKFITGVKVNKILNISRSKYREIRAMLHAVREYGHDKALAEHIENYSRRKTTIQRK
CCCCCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NFFNIIQGKISYLSMVRGKNDEIVAKLKIQLSQLREVYGYKCNKISVEHAQNIISNQFIL
HHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCEEE
IFTEGKTDRMYLSFAFRKLRSQGHFRNLKLLFYIWPSSEGSSAGINDLIALSRKGYFRKY
EEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHH
SSCPKIYIFDRDVDKPQNYVNTTIVEGEKHEGPRYWGENTWSLLLHEPEFRTGYGNSIST
CCCCEEEEEECCCCCCCHHHCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
EHFFSDAIIFAPDEEGRRLYCCSQFDEGTPIDEKNENSKKTFKLKENAEVYFESKKKKGK
HHHHCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCC
FVIMDDGIFSNGKNIARSKFSLAKSILCSNKIEDTTLKEFKKIFDTIDGIAKKF
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2466332; 1701261; 1722556 [H]